ABC transporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette subfamily A - member 1 - putative

Species:

Leishmania infantum

UniProt:

A4HV30_LEIIN

TriTrypDb:

LINF_110018200

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HV30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV30

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0005215	transporter activity	1	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0015399	primary active transmembrane transporter activity	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0022804	active transmembrane transporter activity	3	6
GO:0022857	transmembrane transporter activity	2	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0042626	ATPase-coupled transmembrane transporter activity	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140359	ABC-type transporter activity	3	6
GO:0140657	ATP-dependent activity	1	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	297	299	PF00675	0.326
CLV_NRD_NRD_1	466	468	PF00675	0.328
CLV_NRD_NRD_1	479	481	PF00675	0.217
CLV_NRD_NRD_1	509	511	PF00675	0.344
CLV_NRD_NRD_1	601	603	PF00675	0.355
CLV_PCSK_KEX2_1	297	299	PF00082	0.326
CLV_PCSK_KEX2_1	349	351	PF00082	0.390
CLV_PCSK_KEX2_1	479	481	PF00082	0.264
CLV_PCSK_KEX2_1	509	511	PF00082	0.344
CLV_PCSK_KEX2_1	601	603	PF00082	0.355
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.390
CLV_PCSK_SKI1_1	12	16	PF00082	0.445
CLV_PCSK_SKI1_1	359	363	PF00082	0.365
CLV_PCSK_SKI1_1	411	415	PF00082	0.338
CLV_PCSK_SKI1_1	468	472	PF00082	0.325
CLV_PCSK_SKI1_1	55	59	PF00082	0.365
DEG_APCC_DBOX_1	296	304	PF00400	0.541
DOC_ANK_TNKS_1	594	601	PF00023	0.645
DOC_CYCLIN_yCln2_LP_2	270	276	PF00134	0.412
DOC_MAPK_gen_1	479	488	PF00069	0.469
DOC_MAPK_MEF2A_6	25	33	PF00069	0.538
DOC_MAPK_MEF2A_6	479	488	PF00069	0.469
DOC_PP1_RVXF_1	357	364	PF00149	0.460
DOC_PP4_FxxP_1	158	161	PF00568	0.538
DOC_PP4_FxxP_1	72	75	PF00568	0.538
DOC_USP7_MATH_1	593	597	PF00917	0.564
DOC_USP7_MATH_1	76	80	PF00917	0.493
DOC_USP7_UBL2_3	556	560	PF12436	0.530
LIG_14-3-3_CanoR_1	12	20	PF00244	0.659
LIG_14-3-3_CanoR_1	467	471	PF00244	0.525
LIG_14-3-3_CanoR_1	479	485	PF00244	0.432
LIG_14-3-3_CanoR_1	572	581	PF00244	0.523
LIG_AP2alpha_1	613	617	PF02296	0.618
LIG_APCC_ABBA_1	69	74	PF00400	0.486
LIG_APCC_ABBAyCdc20_2	68	74	PF00400	0.460
LIG_BIR_III_2	308	312	PF00653	0.631
LIG_BRCT_BRCA1_1	185	189	PF00533	0.314
LIG_Clathr_ClatBox_1	249	253	PF01394	0.412
LIG_Clathr_ClatBox_1	429	433	PF01394	0.565
LIG_EH1_1	138	146	PF00400	0.297
LIG_eIF4E_1	139	145	PF01652	0.412
LIG_eIF4E_1	183	189	PF01652	0.412
LIG_FHA_1	13	19	PF00498	0.532
LIG_FHA_1	140	146	PF00498	0.324
LIG_FHA_1	165	171	PF00498	0.314
LIG_FHA_1	336	342	PF00498	0.614
LIG_FHA_1	360	366	PF00498	0.565
LIG_FHA_1	380	386	PF00498	0.354
LIG_FHA_1	424	430	PF00498	0.541
LIG_FHA_1	469	475	PF00498	0.525
LIG_FHA_1	527	533	PF00498	0.512
LIG_FHA_2	335	341	PF00498	0.624
LIG_FHA_2	429	435	PF00498	0.469
LIG_FHA_2	457	463	PF00498	0.538
LIG_FHA_2	46	52	PF00498	0.538
LIG_GBD_Chelix_1	205	213	PF00786	0.332
LIG_LIR_Apic_2	157	161	PF02991	0.538
LIG_LIR_Apic_2	70	75	PF02991	0.538
LIG_LIR_Gen_1	133	141	PF02991	0.320
LIG_LIR_Gen_1	167	176	PF02991	0.429
LIG_LIR_Gen_1	362	371	PF02991	0.538
LIG_LIR_Gen_1	48	58	PF02991	0.509
LIG_LIR_Gen_1	580	590	PF02991	0.519
LIG_LIR_Gen_1	615	622	PF02991	0.636
LIG_LIR_Nem_3	123	127	PF02991	0.365
LIG_LIR_Nem_3	133	137	PF02991	0.302
LIG_LIR_Nem_3	167	171	PF02991	0.429
LIG_LIR_Nem_3	233	237	PF02991	0.286
LIG_LIR_Nem_3	362	366	PF02991	0.493
LIG_LIR_Nem_3	369	374	PF02991	0.446
LIG_LIR_Nem_3	437	442	PF02991	0.460
LIG_LIR_Nem_3	449	453	PF02991	0.460
LIG_LIR_Nem_3	48	53	PF02991	0.509
LIG_LIR_Nem_3	580	585	PF02991	0.518
LIG_LIR_Nem_3	61	67	PF02991	0.495
LIG_LIR_Nem_3	610	616	PF02991	0.569
LIG_LIR_Nem_3	642	647	PF02991	0.607
LIG_NRBOX	245	251	PF00104	0.412
LIG_Pex14_1	128	132	PF04695	0.269
LIG_Pex14_1	272	276	PF04695	0.449
LIG_Pex14_2	124	128	PF04695	0.269
LIG_Pex14_2	20	24	PF04695	0.683
LIG_Pex14_2	204	208	PF04695	0.314
LIG_Pex14_2	53	57	PF04695	0.538
LIG_Pex14_2	563	567	PF04695	0.604
LIG_Pex14_2	613	617	PF04695	0.618
LIG_SH2_CRK	4	8	PF00017	0.646
LIG_SH2_CRK	439	443	PF00017	0.469
LIG_SH2_CRK	605	609	PF00017	0.637
LIG_SH2_NCK_1	404	408	PF00017	0.538
LIG_SH2_SRC	404	407	PF00017	0.538
LIG_SH2_STAP1	132	136	PF00017	0.412
LIG_SH2_STAP1	183	187	PF00017	0.314
LIG_SH2_STAP1	50	54	PF00017	0.538
LIG_SH2_STAT3	419	422	PF00017	0.469
LIG_SH2_STAT5	132	135	PF00017	0.436
LIG_SH2_STAT5	139	142	PF00017	0.473
LIG_SH2_STAT5	215	218	PF00017	0.403
LIG_SH2_STAT5	240	243	PF00017	0.382
LIG_SH2_STAT5	400	403	PF00017	0.590
LIG_SH2_STAT5	419	422	PF00017	0.364
LIG_SH2_STAT5	549	552	PF00017	0.568
LIG_SH3_3	276	282	PF00018	0.412
LIG_SH3_3	288	294	PF00018	0.329
LIG_SH3_3	308	314	PF00018	0.448
LIG_SH3_3	486	492	PF00018	0.538
LIG_SH3_3	87	93	PF00018	0.412
LIG_SH3_3	95	101	PF00018	0.309
LIG_SUMO_SIM_anti_2	426	431	PF11976	0.538
LIG_SUMO_SIM_anti_2	540	546	PF11976	0.566
LIG_SUMO_SIM_par_1	215	220	PF11976	0.312
LIG_SUMO_SIM_par_1	248	254	PF11976	0.412
LIG_SUMO_SIM_par_1	424	431	PF11976	0.467
LIG_TRAF2_1	431	434	PF00917	0.469
LIG_TRFH_1	234	238	PF08558	0.412
LIG_TYR_ITIM	274	279	PF00017	0.412
LIG_UBA3_1	246	255	PF00899	0.412
LIG_WRC_WIRS_1	54	59	PF05994	0.538
LIG_WRC_WIRS_1	582	587	PF05994	0.589
LIG_WRC_WIRS_1	617	622	PF05994	0.586
LIG_WRC_WIRS_1	644	649	PF05994	0.534
MOD_CK1_1	194	200	PF00069	0.338
MOD_CK1_1	472	478	PF00069	0.525
MOD_CK1_1	645	651	PF00069	0.620
MOD_CK2_1	316	322	PF00069	0.631
MOD_CK2_1	428	434	PF00069	0.469
MOD_CK2_1	456	462	PF00069	0.538
MOD_CK2_1	562	568	PF00069	0.536
MOD_CK2_1	593	599	PF00069	0.534
MOD_Cter_Amidation	599	602	PF01082	0.452
MOD_GlcNHglycan	193	196	PF01048	0.563
MOD_GlcNHglycan	262	265	PF01048	0.437
MOD_GlcNHglycan	397	400	PF01048	0.274
MOD_GlcNHglycan	471	474	PF01048	0.277
MOD_GlcNHglycan	498	503	PF01048	0.269
MOD_GlcNHglycan	564	567	PF01048	0.324
MOD_GlcNHglycan	574	577	PF01048	0.333
MOD_GlcNHglycan	61	64	PF01048	0.325
MOD_GlcNHglycan	639	642	PF01048	0.357
MOD_GSK3_1	126	133	PF00069	0.271
MOD_GSK3_1	190	197	PF00069	0.309
MOD_GSK3_1	219	226	PF00069	0.452
MOD_GSK3_1	312	319	PF00069	0.644
MOD_GSK3_1	379	386	PF00069	0.469
MOD_GSK3_1	468	475	PF00069	0.491
MOD_GSK3_1	521	528	PF00069	0.509
MOD_GSK3_1	630	637	PF00069	0.539
MOD_N-GLC_1	12	17	PF02516	0.447
MOD_N-GLC_1	130	135	PF02516	0.526
MOD_N-GLC_1	34	39	PF02516	0.269
MOD_NEK2_1	140	145	PF00069	0.443
MOD_NEK2_1	176	181	PF00069	0.412
MOD_NEK2_1	251	256	PF00069	0.328
MOD_NEK2_1	33	38	PF00069	0.505
MOD_NEK2_1	334	339	PF00069	0.645
MOD_NEK2_1	373	378	PF00069	0.469
MOD_NEK2_1	53	58	PF00069	0.354
MOD_NEK2_1	567	572	PF00069	0.585
MOD_NEK2_1	581	586	PF00069	0.506
MOD_NEK2_1	627	632	PF00069	0.521
MOD_NEK2_2	120	125	PF00069	0.273
MOD_NEK2_2	461	466	PF00069	0.525
MOD_PIKK_1	632	638	PF00454	0.542
MOD_PIKK_1	74	80	PF00454	0.560
MOD_PK_1	480	486	PF00069	0.469
MOD_PKA_1	480	486	PF00069	0.469
MOD_PKA_2	24	30	PF00069	0.655
MOD_PKA_2	466	472	PF00069	0.552
MOD_PKA_2	59	65	PF00069	0.474
MOD_Plk_1	12	18	PF00069	0.649
MOD_Plk_1	130	136	PF00069	0.338
MOD_Plk_1	423	429	PF00069	0.538
MOD_Plk_1	461	467	PF00069	0.456
MOD_Plk_1	567	573	PF00069	0.591
MOD_Plk_2-3	316	322	PF00069	0.585
MOD_Plk_2-3	428	434	PF00069	0.469
MOD_Plk_4	120	126	PF00069	0.390
MOD_Plk_4	140	146	PF00069	0.154
MOD_Plk_4	164	170	PF00069	0.314
MOD_Plk_4	183	189	PF00069	0.314
MOD_Plk_4	194	200	PF00069	0.237
MOD_Plk_4	45	51	PF00069	0.472
MOD_Plk_4	461	467	PF00069	0.459
MOD_Plk_4	521	527	PF00069	0.511
MOD_Plk_4	53	59	PF00069	0.478
MOD_Plk_4	581	587	PF00069	0.591
TRG_DiLeu_BaEn_1	449	454	PF01217	0.525
TRG_DiLeu_BaEn_1	599	604	PF01217	0.552
TRG_DiLeu_BaEn_2	368	374	PF01217	0.465
TRG_DiLeu_BaEn_4	433	439	PF01217	0.565
TRG_DiLeu_BaEn_4	533	539	PF01217	0.504
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.412
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.394
TRG_ENDOCYTIC_2	276	279	PF00928	0.449
TRG_ENDOCYTIC_2	4	7	PF00928	0.642
TRG_ENDOCYTIC_2	404	407	PF00928	0.538
TRG_ENDOCYTIC_2	439	442	PF00928	0.469
TRG_ENDOCYTIC_2	49	52	PF00928	0.463
TRG_ER_diArg_1	296	298	PF00400	0.522
TRG_ER_diArg_1	302	305	PF00400	0.525
TRG_ER_diArg_1	601	603	PF00400	0.623
TRG_NES_CRM1_1	268	280	PF08389	0.349
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	601	606	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KM38	Bodo saltans	47%	98%
A0A3S5H6J8	Leishmania donovani	100%	99%
A0A3S7WRU9	Leishmania donovani	100%	100%
E9AYZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q1PEH6	Arabidopsis thaliana	26%	71%
Q552P3	Dictyostelium discoideum	28%	79%
Q84K47	Arabidopsis thaliana	28%	67%
Q8LPK0	Arabidopsis thaliana	25%	73%
Q8T6J0	Dictyostelium discoideum	28%	78%
Q9FLT4	Arabidopsis thaliana	28%	72%
Q9FLT8	Arabidopsis thaliana	27%	72%
Q9STT6	Arabidopsis thaliana	27%	71%
Q9STT7	Arabidopsis thaliana	27%	70%
Q9STT8	Arabidopsis thaliana	27%	70%
V5BQS2	Trypanosoma cruzi	24%	100%