Cytochrome c oxidase assembly protein COX18, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60Kd inner membrane protein - putative

Species:

Leishmania infantum

UniProt:

A4HV25_LEIIN

TriTrypDb:

LINF_110017800

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HV25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV25

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0032978	protein insertion into membrane from inner side	6	1
GO:0032979	protein insertion into mitochondrial inner membrane from matrix	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051205	protein insertion into membrane	5	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061024	membrane organization	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0090151	establishment of protein localization to mitochondrial membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0032977	membrane insertase activity	3	12
GO:0140104	molecular carrier activity	1	12
GO:0140597	protein carrier chaperone	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	258	260	PF00675	0.455
CLV_NRD_NRD_1	36	38	PF00675	0.709
CLV_NRD_NRD_1	405	407	PF00675	0.442
CLV_NRD_NRD_1	70	72	PF00675	0.697
CLV_PCSK_KEX2_1	215	217	PF00082	0.255
CLV_PCSK_KEX2_1	258	260	PF00082	0.455
CLV_PCSK_KEX2_1	36	38	PF00082	0.709
CLV_PCSK_KEX2_1	70	72	PF00082	0.697
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.255
CLV_PCSK_SKI1_1	115	119	PF00082	0.555
CLV_PCSK_SKI1_1	170	174	PF00082	0.329
CLV_PCSK_SKI1_1	216	220	PF00082	0.255
CLV_PCSK_SKI1_1	226	230	PF00082	0.255
CLV_PCSK_SKI1_1	239	243	PF00082	0.271
CLV_PCSK_SKI1_1	276	280	PF00082	0.480
CLV_PCSK_SKI1_1	363	367	PF00082	0.344
CLV_Separin_Metazoa	140	144	PF03568	0.346
DEG_Nend_Nbox_1	1	3	PF02207	0.517
DOC_CDC14_PxL_1	172	180	PF14671	0.358
DOC_CDC14_PxL_1	267	275	PF14671	0.266
DOC_CKS1_1	245	250	PF01111	0.358
DOC_CKS1_1	25	30	PF01111	0.437
DOC_CYCLIN_RxL_1	167	177	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.314
DOC_MAPK_FxFP_2	366	369	PF00069	0.552
DOC_MAPK_gen_1	143	153	PF00069	0.375
DOC_MAPK_gen_1	307	317	PF00069	0.455
DOC_MAPK_gen_1	53	63	PF00069	0.470
DOC_MAPK_MEF2A_6	322	331	PF00069	0.358
DOC_MAPK_MEF2A_6	56	65	PF00069	0.467
DOC_PP1_RVXF_1	68	75	PF00149	0.412
DOC_PP2B_LxvP_1	278	281	PF13499	0.262
DOC_PP4_FxxP_1	131	134	PF00568	0.340
DOC_PP4_FxxP_1	245	248	PF00568	0.382
DOC_PP4_FxxP_1	366	369	PF00568	0.541
DOC_USP7_MATH_1	113	117	PF00917	0.366
DOC_USP7_MATH_1	12	16	PF00917	0.485
DOC_USP7_MATH_1	374	378	PF00917	0.627
DOC_USP7_UBL2_3	215	219	PF12436	0.455
DOC_WW_Pin1_4	24	29	PF00397	0.513
DOC_WW_Pin1_4	244	249	PF00397	0.358
LIG_14-3-3_CanoR_1	170	175	PF00244	0.299
LIG_14-3-3_CanoR_1	182	186	PF00244	0.455
LIG_14-3-3_CanoR_1	208	218	PF00244	0.469
LIG_14-3-3_CanoR_1	307	317	PF00244	0.455
LIG_14-3-3_CanoR_1	322	327	PF00244	0.390
LIG_14-3-3_CanoR_1	410	418	PF00244	0.695
LIG_14-3-3_CanoR_1	56	63	PF00244	0.507
LIG_14-3-3_CanoR_1	70	75	PF00244	0.366
LIG_AP2alpha_1	362	366	PF02296	0.557
LIG_BRCT_BRCA1_1	336	340	PF00533	0.266
LIG_Clathr_ClatBox_1	296	300	PF01394	0.334
LIG_deltaCOP1_diTrp_1	122	131	PF00928	0.337
LIG_EVH1_1	368	372	PF00568	0.542
LIG_FHA_1	15	21	PF00498	0.438
LIG_FHA_1	244	250	PF00498	0.299
LIG_FHA_1	282	288	PF00498	0.255
LIG_FHA_1	346	352	PF00498	0.314
LIG_FHA_2	263	269	PF00498	0.271
LIG_FHA_2	277	283	PF00498	0.230
LIG_FHA_2	393	399	PF00498	0.619
LIG_FHA_2	418	424	PF00498	0.690
LIG_LIR_Apic_2	108	113	PF02991	0.396
LIG_LIR_Apic_2	130	134	PF02991	0.352
LIG_LIR_Apic_2	243	248	PF02991	0.382
LIG_LIR_Apic_2	282	288	PF02991	0.255
LIG_LIR_Apic_2	364	369	PF02991	0.557
LIG_LIR_Gen_1	116	124	PF02991	0.334
LIG_LIR_Gen_1	148	155	PF02991	0.425
LIG_LIR_Gen_1	220	229	PF02991	0.466
LIG_LIR_Gen_1	252	262	PF02991	0.346
LIG_LIR_Gen_1	387	394	PF02991	0.654
LIG_LIR_Gen_1	42	47	PF02991	0.480
LIG_LIR_Gen_1	422	432	PF02991	0.640
LIG_LIR_Nem_3	116	121	PF02991	0.337
LIG_LIR_Nem_3	148	153	PF02991	0.406
LIG_LIR_Nem_3	236	241	PF02991	0.584
LIG_LIR_Nem_3	252	257	PF02991	0.290
LIG_LIR_Nem_3	364	368	PF02991	0.558
LIG_LIR_Nem_3	387	392	PF02991	0.658
LIG_LIR_Nem_3	42	46	PF02991	0.488
LIG_LIR_Nem_3	422	427	PF02991	0.634
LIG_LIR_Nem_3	73	77	PF02991	0.471
LIG_NRP_CendR_1	440	441	PF00754	0.570
LIG_Pex14_1	127	131	PF04695	0.360
LIG_Pex14_1	158	162	PF04695	0.255
LIG_Pex14_2	241	245	PF04695	0.382
LIG_Pex14_2	295	299	PF04695	0.299
LIG_Pex14_2	362	366	PF04695	0.531
LIG_SH2_CRK	285	289	PF00017	0.334
LIG_SH2_NCK_1	285	289	PF00017	0.419
LIG_SH2_NCK_1	424	428	PF00017	0.691
LIG_SH2_PTP2	110	113	PF00017	0.461
LIG_SH2_STAP1	263	267	PF00017	0.255
LIG_SH2_STAP1	389	393	PF00017	0.655
LIG_SH2_STAP1	424	428	PF00017	0.624
LIG_SH2_STAT5	110	113	PF00017	0.461
LIG_SH2_STAT5	316	319	PF00017	0.455
LIG_SH2_STAT5	330	333	PF00017	0.351
LIG_SH3_3	22	28	PF00018	0.467
LIG_SH3_3	366	372	PF00018	0.545
LIG_SUMO_SIM_par_1	103	109	PF11976	0.439
LIG_SxIP_EBH_1	168	182	PF03271	0.334
LIG_TRAF2_1	394	397	PF00917	0.551
LIG_UBA3_1	379	384	PF00899	0.624
LIG_WRC_WIRS_1	150	155	PF05994	0.374
LIG_WRC_WIRS_1	242	247	PF05994	0.266
MOD_CDK_SPxxK_3	24	31	PF00069	0.438
MOD_CK1_1	177	183	PF00069	0.467
MOD_CK1_1	195	201	PF00069	0.467
MOD_CK1_1	240	246	PF00069	0.317
MOD_CK2_1	113	119	PF00069	0.361
MOD_CK2_1	208	214	PF00069	0.460
MOD_CK2_1	262	268	PF00069	0.258
MOD_CK2_1	384	390	PF00069	0.569
MOD_CK2_1	392	398	PF00069	0.575
MOD_GlcNHglycan	14	17	PF01048	0.708
MOD_GlcNHglycan	211	214	PF01048	0.297
MOD_GlcNHglycan	251	254	PF01048	0.299
MOD_GlcNHglycan	310	313	PF01048	0.296
MOD_GlcNHglycan	336	339	PF01048	0.468
MOD_GlcNHglycan	413	416	PF01048	0.474
MOD_GlcNHglycan	436	439	PF01048	0.524
MOD_GlcNHglycan	58	61	PF01048	0.706
MOD_GSK3_1	170	177	PF00069	0.299
MOD_GSK3_1	233	240	PF00069	0.591
MOD_GSK3_1	243	250	PF00069	0.301
MOD_GSK3_1	374	381	PF00069	0.620
MOD_N-GLC_1	233	238	PF02516	0.264
MOD_NEK2_1	19	24	PF00069	0.536
MOD_NEK2_1	2	7	PF00069	0.516
MOD_NEK2_1	241	246	PF00069	0.343
MOD_NEK2_2	113	118	PF00069	0.371
MOD_NEK2_2	253	258	PF00069	0.299
MOD_PIKK_1	233	239	PF00454	0.486
MOD_PIKK_1	392	398	PF00454	0.631
MOD_PK_1	31	37	PF00069	0.400
MOD_PK_1	322	328	PF00069	0.382
MOD_PKA_1	70	76	PF00069	0.404
MOD_PKA_2	181	187	PF00069	0.490
MOD_PKA_2	321	327	PF00069	0.433
MOD_PKA_2	55	61	PF00069	0.511
MOD_PKA_2	70	76	PF00069	0.478
MOD_PKA_2	85	91	PF00069	0.422
MOD_Plk_1	113	119	PF00069	0.355
MOD_Plk_1	206	212	PF00069	0.455
MOD_Plk_1	233	239	PF00069	0.464
MOD_Plk_1	276	282	PF00069	0.259
MOD_Plk_1	397	403	PF00069	0.634
MOD_Plk_4	113	119	PF00069	0.366
MOD_Plk_4	127	133	PF00069	0.351
MOD_Plk_4	170	176	PF00069	0.305
MOD_Plk_4	237	243	PF00069	0.476
MOD_Plk_4	322	328	PF00069	0.334
MOD_Plk_4	384	390	PF00069	0.566
MOD_ProDKin_1	24	30	PF00069	0.514
MOD_ProDKin_1	244	250	PF00069	0.358
MOD_SUMO_rev_2	377	386	PF00179	0.634
TRG_DiLeu_BaEn_2	267	273	PF01217	0.255
TRG_DiLeu_BaEn_4	397	403	PF01217	0.617
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.424
TRG_ENDOCYTIC_2	222	225	PF00928	0.466
TRG_ENDOCYTIC_2	389	392	PF00928	0.654
TRG_ENDOCYTIC_2	424	427	PF00928	0.622
TRG_ER_diArg_1	257	259	PF00400	0.255
TRG_ER_diArg_1	35	37	PF00400	0.509
TRG_ER_diArg_1	70	72	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.266

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y9	Leptomonas seymouri	84%	98%
A0A0S4IZY1	Bodo saltans	62%	100%
A0A1X0NWK5	Trypanosomatidae	70%	100%
A0A3R7NUU3	Trypanosoma rangeli	71%	99%
A0A3S7WRQ0	Leishmania donovani	100%	100%
A4H6P4	Leishmania braziliensis	90%	100%
D0A7C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9ANQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QGW4	Leishmania major	97%	100%
V5C1D0	Trypanosoma cruzi	67%	100%