LeishMANIAdb
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Putative eukaryotic release factor 3

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative eukaryotic release factor 3
Gene product:
eukaryotic release factor 3 - putative
Species:
Leishmania infantum
UniProt:
A4HV24_LEIIN
TriTrypDb:
LINF_110017700
Length:
756

Annotations

Annotations by Jardim et al.

Translation, eukaryotic release factor 3

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. yes yes: 1
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0018444 translation release factor complex 2 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HV24
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV24

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 1
GO:0006518 peptide metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0019538 protein metabolic process 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043043 peptide biosynthetic process 5 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0003924 GTPase activity 7 10
GO:0005488 binding 1 10
GO:0005525 GTP binding 5 10
GO:0016462 pyrophosphatase activity 5 10
GO:0016787 hydrolase activity 2 10
GO:0016817 hydrolase activity, acting on acid anhydrides 3 10
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 10
GO:0017076 purine nucleotide binding 4 10
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 10
GO:0019001 guanyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032561 guanyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10
GO:0003676 nucleic acid binding 3 1
GO:0003747 translation release factor activity 5 1
GO:0008079 translation termination factor activity 4 1
GO:0008135 translation factor activity, RNA binding 3 1
GO:0045182 translation regulator activity 1 1
GO:0090079 translation regulator activity, nucleic acid binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 171 175 PF00656 0.697
CLV_C14_Caspase3-7 400 404 PF00656 0.440
CLV_NRD_NRD_1 293 295 PF00675 0.549
CLV_NRD_NRD_1 355 357 PF00675 0.240
CLV_NRD_NRD_1 397 399 PF00675 0.237
CLV_NRD_NRD_1 682 684 PF00675 0.311
CLV_PCSK_KEX2_1 293 295 PF00082 0.549
CLV_PCSK_KEX2_1 313 315 PF00082 0.297
CLV_PCSK_KEX2_1 355 357 PF00082 0.240
CLV_PCSK_KEX2_1 396 398 PF00082 0.238
CLV_PCSK_PC1ET2_1 313 315 PF00082 0.585
CLV_PCSK_PC1ET2_1 396 398 PF00082 0.237
CLV_PCSK_SKI1_1 381 385 PF00082 0.240
CLV_PCSK_SKI1_1 397 401 PF00082 0.240
CLV_PCSK_SKI1_1 485 489 PF00082 0.240
CLV_PCSK_SKI1_1 660 664 PF00082 0.240
CLV_PCSK_SKI1_1 725 729 PF00082 0.240
DEG_SPOP_SBC_1 262 266 PF00917 0.722
DOC_ANK_TNKS_1 732 739 PF00023 0.541
DOC_CKS1_1 147 152 PF01111 0.570
DOC_CKS1_1 237 242 PF01111 0.667
DOC_CYCLIN_yCln2_LP_2 708 714 PF00134 0.511
DOC_MAPK_gen_1 192 201 PF00069 0.590
DOC_MAPK_gen_1 203 209 PF00069 0.557
DOC_MAPK_gen_1 313 324 PF00069 0.297
DOC_MAPK_gen_1 497 506 PF00069 0.457
DOC_MAPK_gen_1 527 534 PF00069 0.498
DOC_MAPK_MEF2A_6 733 741 PF00069 0.462
DOC_PP1_RVXF_1 497 504 PF00149 0.440
DOC_PP1_RVXF_1 635 642 PF00149 0.393
DOC_PP2B_LxvP_1 402 405 PF13499 0.440
DOC_PP2B_LxvP_1 538 541 PF13499 0.435
DOC_PP4_FxxP_1 550 553 PF00568 0.415
DOC_USP7_MATH_1 161 165 PF00917 0.672
DOC_USP7_MATH_1 168 172 PF00917 0.597
DOC_USP7_MATH_1 221 225 PF00917 0.747
DOC_USP7_MATH_1 235 239 PF00917 0.737
DOC_USP7_MATH_1 330 334 PF00917 0.440
DOC_USP7_MATH_1 64 68 PF00917 0.695
DOC_USP7_MATH_2 214 220 PF00917 0.670
DOC_USP7_UBL2_3 283 287 PF12436 0.639
DOC_USP7_UBL2_3 309 313 PF12436 0.576
DOC_USP7_UBL2_3 559 563 PF12436 0.503
DOC_USP7_UBL2_3 676 680 PF12436 0.440
DOC_USP7_UBL2_3 718 722 PF12436 0.440
DOC_WW_Pin1_4 146 151 PF00397 0.662
DOC_WW_Pin1_4 15 20 PF00397 0.662
DOC_WW_Pin1_4 219 224 PF00397 0.730
DOC_WW_Pin1_4 236 241 PF00397 0.705
DOC_WW_Pin1_4 246 251 PF00397 0.710
DOC_WW_Pin1_4 286 291 PF00397 0.552
LIG_14-3-3_CanoR_1 397 402 PF00244 0.479
LIG_APCC_ABBA_1 714 719 PF00400 0.480
LIG_APCC_ABBAyCdc20_2 80 86 PF00400 0.666
LIG_BIR_II_1 1 5 PF00653 0.589
LIG_BIR_III_2 234 238 PF00653 0.637
LIG_BIR_III_4 403 407 PF00653 0.440
LIG_BRCT_BRCA1_1 598 602 PF00533 0.471
LIG_BRCT_BRCA1_2 598 604 PF00533 0.463
LIG_FHA_1 196 202 PF00498 0.622
LIG_FHA_1 452 458 PF00498 0.440
LIG_FHA_1 683 689 PF00498 0.440
LIG_FHA_1 732 738 PF00498 0.440
LIG_FHA_2 210 216 PF00498 0.692
LIG_FHA_2 223 229 PF00498 0.774
LIG_FHA_2 258 264 PF00498 0.740
LIG_FHA_2 279 285 PF00498 0.626
LIG_FHA_2 287 293 PF00498 0.501
LIG_FHA_2 398 404 PF00498 0.440
LIG_FHA_2 417 423 PF00498 0.440
LIG_FHA_2 435 441 PF00498 0.440
LIG_FHA_2 528 534 PF00498 0.479
LIG_FHA_2 543 549 PF00498 0.394
LIG_FHA_2 584 590 PF00498 0.434
LIG_FHA_2 598 604 PF00498 0.323
LIG_FXI_DFP_1 717 721 PF00024 0.257
LIG_IRF3_LxIS_1 423 429 PF10401 0.440
LIG_LIR_Apic_2 2 6 PF02991 0.608
LIG_LIR_Apic_2 547 553 PF02991 0.388
LIG_LIR_Gen_1 367 374 PF02991 0.440
LIG_LIR_Gen_1 475 484 PF02991 0.457
LIG_LIR_Gen_1 671 681 PF02991 0.440
LIG_LIR_Gen_1 719 728 PF02991 0.440
LIG_LIR_Nem_3 367 371 PF02991 0.440
LIG_LIR_Nem_3 475 480 PF02991 0.445
LIG_LIR_Nem_3 564 570 PF02991 0.452
LIG_LIR_Nem_3 671 677 PF02991 0.440
LIG_LIR_Nem_3 719 723 PF02991 0.511
LIG_PCNA_APIM_2 723 729 PF02747 0.440
LIG_Pex14_1 366 370 PF04695 0.440
LIG_Pex14_2 320 324 PF04695 0.457
LIG_Pex14_2 435 439 PF04695 0.440
LIG_REV1ctd_RIR_1 639 649 PF16727 0.511
LIG_SH2_CRK 100 104 PF00017 0.682
LIG_SH2_CRK 368 372 PF00017 0.440
LIG_SH2_GRB2like 24 27 PF00017 0.640
LIG_SH2_GRB2like 63 66 PF00017 0.646
LIG_SH2_SRC 368 371 PF00017 0.440
LIG_SH2_SRC 84 87 PF00017 0.698
LIG_SH2_STAP1 368 372 PF00017 0.440
LIG_SH2_STAT3 122 125 PF00017 0.724
LIG_SH2_STAT3 140 143 PF00017 0.390
LIG_SH2_STAT3 28 31 PF00017 0.633
LIG_SH2_STAT3 49 52 PF00017 0.556
LIG_SH2_STAT3 74 77 PF00017 0.695
LIG_SH2_STAT5 17 20 PF00017 0.668
LIG_SH2_STAT5 370 373 PF00017 0.440
LIG_SH2_STAT5 391 394 PF00017 0.439
LIG_SH2_STAT5 627 630 PF00017 0.345
LIG_SH3_3 144 150 PF00018 0.571
LIG_SH3_3 185 191 PF00018 0.587
LIG_SH3_3 234 240 PF00018 0.714
LIG_SH3_3 710 716 PF00018 0.480
LIG_SUMO_SIM_par_1 424 430 PF11976 0.428
LIG_SUMO_SIM_par_1 645 650 PF11976 0.440
LIG_SUMO_SIM_par_1 709 715 PF11976 0.511
LIG_SxIP_EBH_1 625 637 PF03271 0.382
LIG_TRAF2_1 213 216 PF00917 0.701
LIG_TRAF2_1 250 253 PF00917 0.661
LIG_TRAF2_1 289 292 PF00917 0.503
LIG_TRAF2_1 375 378 PF00917 0.480
LIG_TRAF2_1 667 670 PF00917 0.440
LIG_UBA3_1 460 466 PF00899 0.457
LIG_UBA3_1 531 539 PF00899 0.541
LIG_UBA3_1 677 684 PF00899 0.511
MOD_CDK_SPxxK_3 286 293 PF00069 0.659
MOD_CK1_1 184 190 PF00069 0.665
MOD_CK1_1 219 225 PF00069 0.732
MOD_CK1_1 333 339 PF00069 0.440
MOD_CK1_1 429 435 PF00069 0.457
MOD_CK1_1 596 602 PF00069 0.453
MOD_CK1_1 631 637 PF00069 0.359
MOD_CK1_1 656 662 PF00069 0.511
MOD_CK2_1 209 215 PF00069 0.687
MOD_CK2_1 222 228 PF00069 0.624
MOD_CK2_1 257 263 PF00069 0.683
MOD_CK2_1 286 292 PF00069 0.524
MOD_CK2_1 372 378 PF00069 0.440
MOD_CK2_1 434 440 PF00069 0.440
MOD_CK2_1 527 533 PF00069 0.461
MOD_CK2_1 540 546 PF00069 0.342
MOD_CK2_1 583 589 PF00069 0.390
MOD_CK2_1 597 603 PF00069 0.365
MOD_CK2_1 664 670 PF00069 0.541
MOD_CK2_1 743 749 PF00069 0.423
MOD_Cter_Amidation 201 204 PF01082 0.625
MOD_GlcNHglycan 110 113 PF01048 0.704
MOD_GlcNHglycan 170 173 PF01048 0.638
MOD_GlcNHglycan 183 186 PF01048 0.627
MOD_GlcNHglycan 255 258 PF01048 0.692
MOD_GlcNHglycan 269 272 PF01048 0.635
MOD_GlcNHglycan 335 338 PF01048 0.240
MOD_GlcNHglycan 571 574 PF01048 0.347
MOD_GlcNHglycan 60 63 PF01048 0.516
MOD_GlcNHglycan 655 658 PF01048 0.311
MOD_GlcNHglycan 666 669 PF01048 0.311
MOD_GSK3_1 219 226 PF00069 0.647
MOD_GSK3_1 253 260 PF00069 0.740
MOD_GSK3_1 263 270 PF00069 0.668
MOD_GSK3_1 377 384 PF00069 0.457
MOD_GSK3_1 593 600 PF00069 0.382
MOD_GSK3_1 627 634 PF00069 0.356
MOD_GSK3_1 743 750 PF00069 0.428
MOD_GSK3_1 9 16 PF00069 0.513
MOD_N-GLC_1 64 69 PF02516 0.644
MOD_NEK2_1 426 431 PF00069 0.428
MOD_NEK2_1 451 456 PF00069 0.440
MOD_NEK2_1 743 748 PF00069 0.413
MOD_PIKK_1 216 222 PF00454 0.657
MOD_PIKK_1 257 263 PF00454 0.752
MOD_PIKK_1 416 422 PF00454 0.426
MOD_PKA_1 397 403 PF00069 0.440
MOD_PKA_2 384 390 PF00069 0.440
MOD_PKA_2 397 403 PF00069 0.440
MOD_PKA_2 682 688 PF00069 0.511
MOD_PKB_1 303 311 PF00069 0.644
MOD_Plk_1 670 676 PF00069 0.457
MOD_Plk_2-3 542 548 PF00069 0.429
MOD_Plk_2-3 593 599 PF00069 0.379
MOD_Plk_4 184 190 PF00069 0.519
MOD_Plk_4 397 403 PF00069 0.451
MOD_Plk_4 410 416 PF00069 0.416
MOD_Plk_4 527 533 PF00069 0.457
MOD_ProDKin_1 146 152 PF00069 0.663
MOD_ProDKin_1 15 21 PF00069 0.664
MOD_ProDKin_1 219 225 PF00069 0.731
MOD_ProDKin_1 236 242 PF00069 0.706
MOD_ProDKin_1 246 252 PF00069 0.710
MOD_ProDKin_1 286 292 PF00069 0.547
MOD_SUMO_for_1 229 232 PF00179 0.682
MOD_SUMO_for_1 297 300 PF00179 0.520
MOD_SUMO_rev_2 222 231 PF00179 0.719
MOD_SUMO_rev_2 468 473 PF00179 0.515
MOD_SUMO_rev_2 533 541 PF00179 0.529
MOD_SUMO_rev_2 560 564 PF00179 0.496
TRG_DiLeu_BaEn_1 447 452 PF01217 0.440
TRG_ENDOCYTIC_2 368 371 PF00928 0.440
TRG_ENDOCYTIC_2 477 480 PF00928 0.440
TRG_ENDOCYTIC_2 567 570 PF00928 0.356
TRG_ER_diArg_1 354 356 PF00400 0.440
TRG_ER_diArg_1 397 399 PF00400 0.435
TRG_NLS_Bipartite_1 192 207 PF00514 0.726
TRG_NLS_MonoExtN_4 191 196 PF00514 0.579
TRG_Pf-PMV_PEXEL_1 616 620 PF00026 0.453

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAZ5 Leptomonas seymouri 80% 100%
A0A1X0NV54 Trypanosomatidae 71% 100%
A0A3Q8ICH2 Leishmania donovani 99% 100%
A0A3R7MLL0 Trypanosoma rangeli 70% 100%
A0A3S7X9T0 Leishmania donovani 32% 100%
A4H6P3 Leishmania braziliensis 89% 100%
A4HN87 Leishmania braziliensis 31% 100%
A4IBV5 Leishmania infantum 31% 100%
C9ZYQ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
D0A7C5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9AFP2 Leishmania major 32% 100%
E9AGP5 Leishmania infantum 36% 100%
E9ANQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B6U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O74718 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
P23637 Ogataea pini 40% 100%
Q4QGW5 Leishmania major 94% 100%
Q5R6Y0 Pongo abelii 37% 100%
Q69ZS7 Mus musculus 35% 100%
Q6AXM7 Rattus norvegicus 36% 100%
Q9HGI6 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 41% 100%
Q9HGI7 Candida maltosa 38% 100%
Q9W074 Drosophila melanogaster 35% 100%
Q9Y450 Homo sapiens 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS