LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

WD_REPEATS_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
WD_REPEATS_REGION domain-containing protein
Gene product:
protein transport protein SEC31 - putative
Species:
Leishmania infantum
UniProt:
A4HV22_LEIIN
TriTrypDb:
LINF_110017600 *
Length:
578

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, transport SEC31 Uncharacterized (Fragment)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 1, no: 0
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HV22
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV22

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 2
GO:0009987 cellular process 1 2
GO:0016192 vesicle-mediated transport 4 2
GO:0046907 intracellular transport 3 2
GO:0048193 Golgi vesicle transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 160 164 PF00656 0.236
CLV_NRD_NRD_1 534 536 PF00675 0.241
CLV_PCSK_KEX2_1 491 493 PF00082 0.335
CLV_PCSK_KEX2_1 552 554 PF00082 0.290
CLV_PCSK_PC1ET2_1 491 493 PF00082 0.335
CLV_PCSK_PC1ET2_1 552 554 PF00082 0.290
CLV_PCSK_SKI1_1 120 124 PF00082 0.249
CLV_PCSK_SKI1_1 215 219 PF00082 0.248
CLV_PCSK_SKI1_1 553 557 PF00082 0.264
CLV_Separin_Metazoa 532 536 PF03568 0.244
DEG_APCC_DBOX_1 119 127 PF00400 0.242
DEG_Nend_UBRbox_1 1 4 PF02207 0.215
DOC_MAPK_HePTP_8 502 514 PF00069 0.242
DOC_MAPK_MEF2A_6 505 514 PF00069 0.227
DOC_PP1_RVXF_1 118 125 PF00149 0.253
DOC_PP1_RVXF_1 71 77 PF00149 0.198
DOC_USP7_MATH_1 26 30 PF00917 0.193
DOC_USP7_MATH_1 337 341 PF00917 0.179
DOC_USP7_MATH_1 381 385 PF00917 0.251
DOC_USP7_MATH_1 441 445 PF00917 0.262
DOC_USP7_MATH_1 560 564 PF00917 0.274
DOC_USP7_UBL2_3 366 370 PF12436 0.309
DOC_WW_Pin1_4 12 17 PF00397 0.173
DOC_WW_Pin1_4 401 406 PF00397 0.355
DOC_WW_Pin1_4 421 426 PF00397 0.309
DOC_WW_Pin1_4 546 551 PF00397 0.300
DOC_WW_Pin1_4 74 79 PF00397 0.207
LIG_14-3-3_CanoR_1 157 162 PF00244 0.391
LIG_14-3-3_CanoR_1 2 12 PF00244 0.190
LIG_14-3-3_CanoR_1 219 225 PF00244 0.228
LIG_14-3-3_CanoR_1 496 502 PF00244 0.284
LIG_Actin_WH2_2 201 217 PF00022 0.197
LIG_AP2alpha_1 519 523 PF02296 0.218
LIG_AP2alpha_2 480 482 PF02296 0.293
LIG_BRCT_BRCA1_1 39 43 PF00533 0.222
LIG_BRCT_BRCA1_1 562 566 PF00533 0.278
LIG_CSL_BTD_1 13 16 PF09270 0.163
LIG_deltaCOP1_diTrp_1 152 159 PF00928 0.343
LIG_FHA_1 164 170 PF00498 0.280
LIG_FHA_1 200 206 PF00498 0.185
LIG_FHA_1 243 249 PF00498 0.198
LIG_FHA_1 263 269 PF00498 0.256
LIG_FHA_1 275 281 PF00498 0.343
LIG_FHA_1 426 432 PF00498 0.274
LIG_FHA_1 495 501 PF00498 0.282
LIG_FHA_2 147 153 PF00498 0.343
LIG_FHA_2 158 164 PF00498 0.401
LIG_FHA_2 347 353 PF00498 0.253
LIG_FHA_2 354 360 PF00498 0.383
LIG_FHA_2 387 393 PF00498 0.297
LIG_FHA_2 405 411 PF00498 0.347
LIG_FHA_2 432 438 PF00498 0.289
LIG_LIR_Apic_2 302 307 PF02991 0.343
LIG_LIR_Apic_2 77 82 PF02991 0.241
LIG_LIR_Gen_1 40 51 PF02991 0.202
LIG_LIR_Gen_1 479 488 PF02991 0.343
LIG_LIR_LC3C_4 245 249 PF02991 0.192
LIG_LIR_Nem_3 325 331 PF02991 0.185
LIG_LIR_Nem_3 338 344 PF02991 0.202
LIG_LIR_Nem_3 40 46 PF02991 0.199
LIG_LIR_Nem_3 479 485 PF02991 0.330
LIG_LIR_Nem_3 563 569 PF02991 0.275
LIG_LIR_Nem_3 75 79 PF02991 0.209
LIG_Pex14_1 192 196 PF04695 0.190
LIG_Pex14_2 519 523 PF04695 0.218
LIG_SH2_CRK 79 83 PF00017 0.248
LIG_SH2_NCK_1 196 200 PF00017 0.181
LIG_SH2_SRC 196 199 PF00017 0.184
LIG_SH2_STAP1 196 200 PF00017 0.181
LIG_SH2_STAT5 322 325 PF00017 0.190
LIG_SH2_STAT5 541 544 PF00017 0.262
LIG_SH2_STAT5 96 99 PF00017 0.165
LIG_SH3_3 138 144 PF00018 0.343
LIG_SH3_3 166 172 PF00018 0.268
LIG_SH3_3 327 333 PF00018 0.199
LIG_SH3_3 399 405 PF00018 0.357
LIG_SH3_3 62 68 PF00018 0.228
LIG_SUMO_SIM_anti_2 173 179 PF11976 0.280
LIG_TRAF2_1 286 289 PF00917 0.343
LIG_TRAF2_1 474 477 PF00917 0.454
MOD_CDC14_SPxK_1 424 427 PF00782 0.288
MOD_CDC14_SPxK_1 549 552 PF00782 0.299
MOD_CDK_SPxK_1 421 427 PF00069 0.303
MOD_CDK_SPxK_1 546 552 PF00069 0.298
MOD_CDK_SPxxK_3 546 553 PF00069 0.297
MOD_CK1_1 226 232 PF00069 0.254
MOD_CK1_1 274 280 PF00069 0.343
MOD_CK1_1 404 410 PF00069 0.345
MOD_CK2_1 283 289 PF00069 0.343
MOD_CK2_1 431 437 PF00069 0.282
MOD_CK2_1 526 532 PF00069 0.262
MOD_CK2_1 96 102 PF00069 0.179
MOD_CMANNOS 156 159 PF00535 0.143
MOD_Cter_Amidation 309 312 PF01082 0.273
MOD_GlcNHglycan 131 134 PF01048 0.143
MOD_GlcNHglycan 183 186 PF01048 0.252
MOD_GlcNHglycan 272 276 PF01048 0.143
MOD_GlcNHglycan 30 33 PF01048 0.243
MOD_GlcNHglycan 443 446 PF01048 0.274
MOD_GlcNHglycan 470 473 PF01048 0.471
MOD_GlcNHglycan 502 505 PF01048 0.287
MOD_GlcNHglycan 528 531 PF01048 0.275
MOD_GlcNHglycan 562 565 PF01048 0.279
MOD_GlcNHglycan 98 101 PF01048 0.177
MOD_GSK3_1 24 31 PF00069 0.195
MOD_GSK3_1 274 281 PF00069 0.343
MOD_GSK3_1 283 290 PF00069 0.343
MOD_GSK3_1 372 379 PF00069 0.290
MOD_GSK3_1 401 408 PF00069 0.350
MOD_GSK3_1 421 428 PF00069 0.296
MOD_GSK3_1 441 448 PF00069 0.281
MOD_N-GLC_1 223 228 PF02516 0.242
MOD_N-GLC_1 36 41 PF02516 0.276
MOD_N-GLC_1 376 381 PF02516 0.290
MOD_N-GLC_2 92 94 PF02516 0.184
MOD_NEK2_1 146 151 PF00069 0.343
MOD_NEK2_1 223 228 PF00069 0.242
MOD_NEK2_1 24 29 PF00069 0.187
MOD_NEK2_1 292 297 PF00069 0.343
MOD_NEK2_1 3 8 PF00069 0.198
MOD_NEK2_1 345 350 PF00069 0.200
MOD_NEK2_1 431 436 PF00069 0.282
MOD_NEK2_1 500 505 PF00069 0.277
MOD_PIKK_1 242 248 PF00454 0.208
MOD_PIKK_1 425 431 PF00454 0.278
MOD_PKA_2 218 224 PF00069 0.234
MOD_PKA_2 431 437 PF00069 0.282
MOD_PKA_2 495 501 PF00069 0.282
MOD_Plk_1 288 294 PF00069 0.343
MOD_Plk_1 376 382 PF00069 0.282
MOD_Plk_1 425 431 PF00069 0.278
MOD_Plk_4 288 294 PF00069 0.343
MOD_ProDKin_1 12 18 PF00069 0.186
MOD_ProDKin_1 401 407 PF00069 0.353
MOD_ProDKin_1 421 427 PF00069 0.303
MOD_ProDKin_1 546 552 PF00069 0.298
MOD_ProDKin_1 74 80 PF00069 0.211
MOD_SUMO_rev_2 45 54 PF00179 0.223
TRG_DiLeu_BaEn_4 507 513 PF01217 0.224
TRG_DiLeu_BaLyEn_6 20 25 PF01217 0.212
TRG_DiLeu_BaLyEn_6 340 345 PF01217 0.210
TRG_DiLeu_BaLyEn_6 565 570 PF01217 0.280
TRG_ENDOCYTIC_2 196 199 PF00928 0.184
TRG_ER_diArg_1 64 67 PF00400 0.222
TRG_NES_CRM1_1 58 69 PF08389 0.232
TRG_Pf-PMV_PEXEL_1 311 315 PF00026 0.263
TRG_Pf-PMV_PEXEL_1 567 571 PF00026 0.297

Homologs

Protein Taxonomy Sequence identity Coverage
A1C6X5 ASPCL 27% 45%
A1DHK2 NEOFI 28% 46%
A1Z8D0 DROME 23% 100%
A2QBZ0 ASPNC 25% 46%
A3GFK8 PICST 25% 46%
A4RD35 MAGO7 26% 46%
A5DB75 PICGU 24% 46%
A5DTX3 LODEL 31% 61%
A8QB65 BRUMA 23% 100%
C4R6H3 KOMPG 26% 100%
F4ICD9 ARATH 25% 60%
O00628 HUMAN 29% 100%
O13637 SCHPO 24% 47%
O14021 SCHPO 21% 100%
O14186 SCHPO 26% 68%
O22466 SOLLC 20% 100%
O22468 ARATH 25% 100%
O22469 ARATH 23% 100%
O35828 RAT 27% 63%
O93377 XENLA 22% 100%
O94244 SCHPO 29% 100%
O94979 HUMAN 31% 47%
P0CS36 CRYNJ 26% 100%
P0CS37 CRYNB 26% 100%
P13712 YEAST 26% 100%
P38968 YEAST 25% 45%
P57737 HUMAN 28% 62%
P90916 CAEEL 22% 100%
Q03897 YEAST 23% 50%
Q04225 YEAST 25% 100%
Q09028 HUMAN 22% 100%
Q0CYG9 ASPTN 25% 46%
Q0ULF5 PHANO 23% 46%
Q0V8F1 BOVIN 30% 63%
Q16576 HUMAN 23% 100%
Q1DX43 COCIM 25% 46%
Q1JQD2 BOVIN 25% 100%
Q24572 DROME 24% 100%
Q2GVT8 CHAGB 29% 46%
Q2UA71 ASPOR 25% 100%
Q2UF60 ASPOR 28% 45%
Q3MHL3 BOVIN 22% 100%
Q3SWX8 BOVIN 23% 100%
Q3TZ89 MOUSE 28% 50%
Q3UPL0 MOUSE 30% 47%
Q4I7L0 GIBZE 22% 100%
Q4P2B6 USTMA 29% 41%
Q4P553 USTMA 27% 100%
Q4R304 MACFA 23% 100%
Q4WEI5 ASPFU 26% 100%
Q4X0M4 ASPFU 24% 46%
Q54ED4 DICDI 25% 100%
Q54JS5 DICDI 24% 57%
Q54WA3 DICDI 25% 100%
Q55CT5 DICDI 27% 43%
Q55E54 DICDI 22% 60%
Q5AAU3 CANAL 24% 46%
Q5AZM3 EMENI 28% 45%
Q5F3X8 CHICK 31% 47%
Q5M7K4 XENTR 22% 100%
Q5R4F4 PONAB 31% 52%
Q5RBW3 PONAB 27% 62%
Q5RF92 PONAB 22% 100%
Q5S580 AJECA 25% 45%
Q5XI13 RAT 24% 100%
Q5ZJW8 CHICK 27% 80%
Q60972 MOUSE 22% 100%
Q60973 MOUSE 23% 100%
Q61Y48 CAEBR 22% 100%
Q6BRR2 DEBHA 25% 46%
Q6C414 YARLI 25% 49%
Q6C7Q4 YARLI 20% 100%
Q6CL75 KLULA 29% 47%
Q6CSI1 KLULA 22% 100%
Q6FNU4 CANGA 25% 45%
Q6FXI8 CANGA 22% 100%
Q6GPU3 XENLA 27% 81%
Q6INH0 XENLA 22% 100%
Q6P315 XENTR 23% 100%
Q6P3H7 DANRE 23% 100%
Q71UF4 RAT 23% 100%
Q75A30 ASHGO 27% 47%
Q7S7N3 NEUCR 23% 100%
Q7SYD5 DANRE 32% 46%
Q7ZTY4 DANRE 22% 100%
Q810D6 MOUSE 23% 100%
Q873A1 NEUCR 31% 46%
Q8AVH1 XENLA 23% 100%
Q8CFD5 MOUSE 21% 100%
Q8IZU2 HUMAN 22% 44%
Q8L611 ARATH 29% 52%
Q9BQ67 HUMAN 24% 100%
Q9D2V7 MOUSE 26% 63%
Q9I8G9 CHICK 23% 100%
Q9NQW1 HUMAN 28% 49%
Q9P783 SCHPO 27% 100%
Q9VKK2 DROME 21% 60%
Q9W7I5 CHICK 22% 100%
Q9XF57 ARATH 22% 100%
Q9XGN1 ARATH 22% 100%
Q9Z2Q1 RAT 30% 46%
Q9ZUN8 ARATH 31% 100%
U4PCM1 CAEEL 27% 71%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS