Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 7 - putative

Species:

Leishmania infantum

UniProt:

A4HV17_LEIIN

TriTrypDb:

LINF_110017100

Length:

465

Annotations

Annotations by Jardim et al.

Protein pamitoylation, Palmitoyltransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HV17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV17

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016409	palmitoyltransferase activity	5	11
GO:0016417	S-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	11
GO:0019707	protein-cysteine S-acyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.380
CLV_NRD_NRD_1	111	113	PF00675	0.670
CLV_NRD_NRD_1	223	225	PF00675	0.683
CLV_NRD_NRD_1	235	237	PF00675	0.617
CLV_NRD_NRD_1	325	327	PF00675	0.633
CLV_PCSK_FUR_1	233	237	PF00082	0.601
CLV_PCSK_KEX2_1	111	113	PF00082	0.670
CLV_PCSK_KEX2_1	223	225	PF00082	0.702
CLV_PCSK_KEX2_1	235	237	PF00082	0.628
CLV_PCSK_KEX2_1	324	326	PF00082	0.636
CLV_PCSK_KEX2_1	443	445	PF00082	0.694
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.694
CLV_PCSK_SKI1_1	13	17	PF00082	0.647
CLV_PCSK_SKI1_1	236	240	PF00082	0.698
DOC_CKS1_1	66	71	PF01111	0.487
DOC_MAPK_MEF2A_6	401	409	PF00069	0.518
DOC_PP4_FxxP_1	239	242	PF00568	0.514
DOC_PP4_FxxP_1	448	451	PF00568	0.407
DOC_USP7_MATH_1	118	122	PF00917	0.445
DOC_USP7_MATH_1	146	150	PF00917	0.477
DOC_USP7_MATH_1	200	204	PF00917	0.462
DOC_USP7_MATH_1	214	218	PF00917	0.539
DOC_USP7_MATH_1	242	246	PF00917	0.497
DOC_USP7_MATH_1	34	38	PF00917	0.505
DOC_USP7_UBL2_3	335	339	PF12436	0.435
DOC_WW_Pin1_4	180	185	PF00397	0.413
DOC_WW_Pin1_4	24	29	PF00397	0.572
DOC_WW_Pin1_4	57	62	PF00397	0.483
DOC_WW_Pin1_4	65	70	PF00397	0.485
DOC_WW_Pin1_4	74	79	PF00397	0.504
LIG_14-3-3_CanoR_1	241	247	PF00244	0.431
LIG_14-3-3_CanoR_1	433	438	PF00244	0.324
LIG_Actin_WH2_2	419	435	PF00022	0.365
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_BIR_III_4	187	191	PF00653	0.482
LIG_BRCT_BRCA1_1	101	105	PF00533	0.455
LIG_BRCT_BRCA1_1	262	266	PF00533	0.530
LIG_BRCT_BRCA1_1	287	291	PF00533	0.258
LIG_BRCT_BRCA1_1	396	400	PF00533	0.580
LIG_FHA_1	181	187	PF00498	0.412
LIG_FHA_1	25	31	PF00498	0.495
LIG_FHA_1	445	451	PF00498	0.419
LIG_FHA_2	325	331	PF00498	0.380
LIG_LIR_Apic_2	445	451	PF02991	0.391
LIG_LIR_Gen_1	358	367	PF02991	0.404
LIG_LIR_Gen_1	370	378	PF02991	0.338
LIG_LIR_Gen_1	434	441	PF02991	0.388
LIG_LIR_Nem_3	263	269	PF02991	0.512
LIG_LIR_Nem_3	358	363	PF02991	0.407
LIG_LIR_Nem_3	370	375	PF02991	0.350
LIG_LIR_Nem_3	434	440	PF02991	0.373
LIG_MLH1_MIPbox_1	396	400	PF16413	0.580
LIG_PCNA_yPIPBox_3	277	285	PF02747	0.624
LIG_Pex14_1	262	266	PF04695	0.530
LIG_Pex14_2	287	291	PF04695	0.310
LIG_Pex14_2	303	307	PF04695	0.288
LIG_SH2_CRK	253	257	PF00017	0.358
LIG_SH2_PTP2	269	272	PF00017	0.530
LIG_SH2_SRC	246	249	PF00017	0.317
LIG_SH2_SRC	437	440	PF00017	0.408
LIG_SH2_STAT5	253	256	PF00017	0.398
LIG_SH2_STAT5	269	272	PF00017	0.398
LIG_SH2_STAT5	273	276	PF00017	0.555
LIG_SH2_STAT5	360	363	PF00017	0.317
LIG_SH2_STAT5	399	402	PF00017	0.547
LIG_SH2_STAT5	427	430	PF00017	0.426
LIG_SH3_2	40	45	PF14604	0.466
LIG_SH3_3	176	182	PF00018	0.504
LIG_SH3_3	25	31	PF00018	0.545
LIG_SH3_3	37	43	PF00018	0.499
LIG_SH3_3	66	72	PF00018	0.542
LIG_SUMO_SIM_par_1	192	197	PF11976	0.453
LIG_TRAF2_1	451	454	PF00917	0.392
LIG_TYR_ITSM	433	440	PF00017	0.408
LIG_WRC_WIRS_1	372	377	PF05994	0.417
MOD_CDK_SPK_2	180	185	PF00069	0.413
MOD_CDK_SPK_2	57	62	PF00069	0.474
MOD_CDK_SPK_2	68	73	PF00069	0.457
MOD_CDK_SPxxK_3	68	75	PF00069	0.473
MOD_CDK_SPxxK_3	78	85	PF00069	0.450
MOD_CK1_1	155	161	PF00069	0.440
MOD_CK1_1	370	376	PF00069	0.450
MOD_CK2_1	206	212	PF00069	0.470
MOD_CK2_1	78	84	PF00069	0.525
MOD_Cter_Amidation	441	444	PF01082	0.563
MOD_GlcNHglycan	1	4	PF01048	0.696
MOD_GlcNHglycan	10	13	PF01048	0.669
MOD_GlcNHglycan	117	121	PF01048	0.655
MOD_GlcNHglycan	152	157	PF01048	0.721
MOD_GlcNHglycan	166	170	PF01048	0.678
MOD_GlcNHglycan	315	318	PF01048	0.580
MOD_GlcNHglycan	367	370	PF01048	0.530
MOD_GlcNHglycan	396	399	PF01048	0.380
MOD_GSK3_1	225	232	PF00069	0.530
MOD_GSK3_1	324	331	PF00069	0.435
MOD_GSK3_1	367	374	PF00069	0.359
MOD_GSK3_1	74	81	PF00069	0.532
MOD_N-GLC_2	338	340	PF02516	0.636
MOD_N-GLC_2	352	354	PF02516	0.470
MOD_NEK2_1	165	170	PF00069	0.564
MOD_NEK2_1	260	265	PF00069	0.530
MOD_NEK2_1	303	308	PF00069	0.504
MOD_NEK2_1	432	437	PF00069	0.382
MOD_NEK2_1	56	61	PF00069	0.522
MOD_NEK2_2	286	291	PF00069	0.306
MOD_PIKK_1	271	277	PF00454	0.599
MOD_PKA_1	324	330	PF00069	0.435
MOD_PKA_1	458	464	PF00069	0.401
MOD_PKA_2	110	116	PF00069	0.434
MOD_PKA_2	229	235	PF00069	0.545
MOD_PKA_2	324	330	PF00069	0.435
MOD_PKA_2	394	400	PF00069	0.566
MOD_PKA_2	432	438	PF00069	0.290
MOD_Plk_1	444	450	PF00069	0.405
MOD_Plk_1	45	51	PF00069	0.533
MOD_Plk_4	261	267	PF00069	0.530
MOD_Plk_4	286	292	PF00069	0.431
MOD_Plk_4	367	373	PF00069	0.436
MOD_Plk_4	377	383	PF00069	0.395
MOD_Plk_4	99	105	PF00069	0.472
MOD_ProDKin_1	180	186	PF00069	0.413
MOD_ProDKin_1	24	30	PF00069	0.573
MOD_ProDKin_1	57	63	PF00069	0.484
MOD_ProDKin_1	65	71	PF00069	0.487
MOD_ProDKin_1	74	80	PF00069	0.503
TRG_ENDOCYTIC_2	253	256	PF00928	0.391
TRG_ENDOCYTIC_2	269	272	PF00928	0.398
TRG_ENDOCYTIC_2	299	302	PF00928	0.530
TRG_ENDOCYTIC_2	360	363	PF00928	0.435
TRG_ENDOCYTIC_2	427	430	PF00928	0.435
TRG_ENDOCYTIC_2	437	440	PF00928	0.317
TRG_ER_diArg_1	111	114	PF00400	0.468
TRG_ER_diArg_1	223	225	PF00400	0.499
TRG_ER_diArg_1	233	236	PF00400	0.468
TRG_ER_diArg_1	324	326	PF00400	0.380
TRG_ER_diArg_1	72	75	PF00400	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6J6	Leishmania donovani	100%	100%
A0A3S7WRS6	Leishmania donovani	53%	89%
A4H6N2	Leishmania braziliensis	41%	100%
A4H6N3	Leishmania braziliensis	64%	100%
A4HV16	Leishmania infantum	53%	89%
E9ANQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	74%
E9ANQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QGX1	Leishmania major	90%	96%
Q4QGX2	Leishmania major	52%	89%