Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 7 - putative

Species:

Leishmania infantum

UniProt:

A4HV16_LEIIN

TriTrypDb:

LINF_110017000

Length:

520

Annotations

Annotations by Jardim et al.

Protein pamitoylation, Palmitoyltransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HV16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV16

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.699
CLV_C14_Caspase3-7	276	280	PF00656	0.545
CLV_C14_Caspase3-7	379	383	PF00656	0.533
CLV_NRD_NRD_1	257	259	PF00675	0.421
CLV_NRD_NRD_1	287	289	PF00675	0.369
CLV_NRD_NRD_1	29	31	PF00675	0.589
CLV_NRD_NRD_1	377	379	PF00675	0.312
CLV_NRD_NRD_1	494	496	PF00675	0.361
CLV_NRD_NRD_1	510	512	PF00675	0.389
CLV_NRD_NRD_1	514	516	PF00675	0.442
CLV_PCSK_FUR_1	511	515	PF00082	0.408
CLV_PCSK_KEX2_1	287	289	PF00082	0.390
CLV_PCSK_KEX2_1	376	378	PF00082	0.313
CLV_PCSK_KEX2_1	494	496	PF00082	0.394
CLV_PCSK_KEX2_1	513	515	PF00082	0.357
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.394
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.357
CLV_PCSK_PC7_1	509	515	PF00082	0.437
CLV_PCSK_SKI1_1	105	109	PF00082	0.470
CLV_PCSK_SKI1_1	288	292	PF00082	0.382
DEG_SPOP_SBC_1	48	52	PF00917	0.663
DOC_MAPK_gen_1	494	501	PF00069	0.635
DOC_PP1_RVXF_1	495	502	PF00149	0.619
DOC_PP4_FxxP_1	291	294	PF00568	0.579
DOC_USP7_MATH_1	266	270	PF00917	0.647
DOC_USP7_MATH_1	294	298	PF00917	0.556
DOC_USP7_MATH_1	80	84	PF00917	0.728
DOC_USP7_MATH_2	130	136	PF00917	0.715
DOC_USP7_UBL2_3	387	391	PF12436	0.517
DOC_WW_Pin1_4	136	141	PF00397	0.734
DOC_WW_Pin1_4	16	21	PF00397	0.777
DOC_WW_Pin1_4	35	40	PF00397	0.735
DOC_WW_Pin1_4	95	100	PF00397	0.714
LIG_14-3-3_CanoR_1	12	20	PF00244	0.698
LIG_14-3-3_CanoR_1	121	131	PF00244	0.703
LIG_14-3-3_CanoR_1	233	238	PF00244	0.713
LIG_14-3-3_CanoR_1	282	286	PF00244	0.636
LIG_14-3-3_CanoR_1	293	299	PF00244	0.535
LIG_14-3-3_CanoR_1	495	500	PF00244	0.594
LIG_BRCT_BRCA1_1	134	138	PF00533	0.721
LIG_BRCT_BRCA1_1	314	318	PF00533	0.352
LIG_BRCT_BRCA1_1	448	452	PF00533	0.333
LIG_deltaCOP1_diTrp_1	246	253	PF00928	0.679
LIG_eIF4E_1	351	357	PF01652	0.306
LIG_EVH1_1	127	131	PF00568	0.675
LIG_FHA_1	168	174	PF00498	0.717
LIG_FHA_1	180	186	PF00498	0.699
LIG_FHA_1	350	356	PF00498	0.487
LIG_FHA_1	426	432	PF00498	0.297
LIG_FHA_1	459	465	PF00498	0.317
LIG_FHA_2	107	113	PF00498	0.724
LIG_FHA_2	377	383	PF00498	0.589
LIG_LIR_Gen_1	409	419	PF02991	0.509
LIG_LIR_Gen_1	478	483	PF02991	0.549
LIG_LIR_Gen_1	486	492	PF02991	0.525
LIG_LIR_Nem_3	315	321	PF02991	0.377
LIG_LIR_Nem_3	409	415	PF02991	0.520
LIG_LIR_Nem_3	478	482	PF02991	0.544
LIG_LIR_Nem_3	486	491	PF02991	0.522
LIG_MLH1_MIPbox_1	448	452	PF16413	0.333
LIG_PCNA_yPIPBox_3	329	337	PF02747	0.380
LIG_Pex14_1	314	318	PF04695	0.352
LIG_SH2_CRK	351	355	PF00017	0.380
LIG_SH2_PTP2	321	324	PF00017	0.405
LIG_SH2_SRC	488	491	PF00017	0.504
LIG_SH2_STAP1	351	355	PF00017	0.317
LIG_SH2_STAT5	113	116	PF00017	0.723
LIG_SH2_STAT5	321	324	PF00017	0.317
LIG_SH2_STAT5	325	328	PF00017	0.349
LIG_SH2_STAT5	351	354	PF00017	0.315
LIG_SH2_STAT5	436	439	PF00017	0.375
LIG_SH2_STAT5	451	454	PF00017	0.281
LIG_SH2_STAT5	479	482	PF00017	0.524
LIG_SH3_3	111	117	PF00018	0.697
LIG_SH3_3	125	131	PF00018	0.718
LIG_SH3_3	17	23	PF00018	0.741
LIG_SH3_3	192	198	PF00018	0.669
LIG_SH3_3	34	40	PF00018	0.726
LIG_SH3_3	43	49	PF00018	0.671
LIG_SH3_3	496	502	PF00018	0.634
LIG_SH3_3	70	76	PF00018	0.704
LIG_Sin3_3	340	347	PF02671	0.317
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.311
LIG_SUMO_SIM_anti_2	352	358	PF11976	0.377
LIG_SUMO_SIM_anti_2	461	466	PF11976	0.317
LIG_SUMO_SIM_par_1	106	112	PF11976	0.629
LIG_SUMO_SIM_par_1	352	358	PF11976	0.377
LIG_SUMO_SIM_par_1	93	98	PF11976	0.668
LIG_TRAF2_1	130	133	PF00917	0.719
LIG_TYR_ITSM	484	491	PF00017	0.504
LIG_UBA3_1	107	115	PF00899	0.670
LIG_UBA3_1	354	360	PF00899	0.425
LIG_WRC_WIRS_1	356	361	PF05994	0.375
LIG_WRC_WIRS_1	415	420	PF05994	0.487
MOD_CK1_1	106	112	PF00069	0.668
MOD_CK1_1	136	142	PF00069	0.725
MOD_CK1_1	417	423	PF00069	0.500
MOD_CK1_1	503	509	PF00069	0.672
MOD_CK1_1	83	89	PF00069	0.786
MOD_CK2_1	106	112	PF00069	0.732
MOD_CK2_1	139	145	PF00069	0.726
MOD_CK2_1	173	179	PF00069	0.714
MOD_CK2_1	57	63	PF00069	0.689
MOD_GlcNHglycan	14	17	PF01048	0.532
MOD_GlcNHglycan	221	224	PF01048	0.566
MOD_GlcNHglycan	367	370	PF01048	0.333
MOD_GlcNHglycan	419	422	PF01048	0.357
MOD_GlcNHglycan	448	451	PF01048	0.533
MOD_GlcNHglycan	502	505	PF01048	0.456
MOD_GSK3_1	12	19	PF00069	0.831
MOD_GSK3_1	132	139	PF00069	0.725
MOD_GSK3_1	22	29	PF00069	0.735
MOD_GSK3_1	277	284	PF00069	0.647
MOD_GSK3_1	376	383	PF00069	0.513
MOD_GSK3_1	48	55	PF00069	0.687
MOD_N-GLC_1	272	277	PF02516	0.391
MOD_N-GLC_2	390	392	PF02516	0.313
MOD_N-GLC_2	404	406	PF02516	0.313
MOD_NEK2_1	103	108	PF00069	0.698
MOD_NEK2_1	219	224	PF00069	0.746
MOD_NEK2_1	312	317	PF00069	0.377
MOD_NEK2_1	350	355	PF00069	0.383
MOD_NEK2_1	414	419	PF00069	0.327
MOD_NEK2_1	475	480	PF00069	0.401
MOD_PIKK_1	281	287	PF00454	0.592
MOD_PIKK_1	323	329	PF00454	0.366
MOD_PKA_1	30	36	PF00069	0.716
MOD_PKA_1	376	382	PF00069	0.513
MOD_PKA_1	495	501	PF00069	0.647
MOD_PKA_2	281	287	PF00069	0.660
MOD_PKA_2	376	382	PF00069	0.513
MOD_PKA_2	446	452	PF00069	0.321
MOD_PKA_2	80	86	PF00069	0.713
MOD_PKA_2	90	96	PF00069	0.672
MOD_PKB_1	10	18	PF00069	0.714
MOD_PKB_1	231	239	PF00069	0.712
MOD_Plk_1	103	109	PF00069	0.692
MOD_Plk_1	83	89	PF00069	0.728
MOD_Plk_4	103	109	PF00069	0.672
MOD_Plk_4	133	139	PF00069	0.746
MOD_Plk_4	30	36	PF00069	0.687
MOD_Plk_4	313	319	PF00069	0.352
MOD_Plk_4	350	356	PF00069	0.374
MOD_Plk_4	432	438	PF00069	0.373
MOD_Plk_4	458	464	PF00069	0.322
MOD_Plk_4	475	481	PF00069	0.261
MOD_Plk_4	90	96	PF00069	0.666
MOD_ProDKin_1	136	142	PF00069	0.732
MOD_ProDKin_1	16	22	PF00069	0.776
MOD_ProDKin_1	35	41	PF00069	0.737
MOD_ProDKin_1	95	101	PF00069	0.713
TRG_ENDOCYTIC_2	321	324	PF00928	0.437
TRG_ENDOCYTIC_2	351	354	PF00928	0.352
TRG_ENDOCYTIC_2	412	415	PF00928	0.513
TRG_ENDOCYTIC_2	479	482	PF00928	0.573
TRG_ENDOCYTIC_2	488	491	PF00928	0.485
TRG_ER_diArg_1	10	13	PF00400	0.712
TRG_ER_diArg_1	286	288	PF00400	0.628
TRG_ER_diArg_1	376	378	PF00400	0.494
TRG_ER_diArg_1	514	516	PF00400	0.649
TRG_NLS_Bipartite_1	494	516	PF00514	0.639
TRG_NLS_MonoCore_2	510	515	PF00514	0.634
TRG_NLS_MonoExtC_3	494	500	PF00514	0.549
TRG_NLS_MonoExtC_3	510	515	PF00514	0.615
TRG_NLS_MonoExtN_4	494	499	PF00514	0.574
TRG_NLS_MonoExtN_4	509	516	PF00514	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWJ0	Leptomonas seymouri	46%	69%
A0A3S7WRS6	Leishmania donovani	100%	100%
A4H6N2	Leishmania braziliensis	65%	100%
A4H6N3	Leishmania braziliensis	47%	100%
A4HV17	Leishmania infantum	53%	100%
E9ANQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9ANQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4QGX2	Leishmania major	88%	100%