LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative pretranslocation protein, alpha subunit

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative pretranslocation protein, alpha subunit
Gene product:
pretranslocation protein - alpha subunit - putative
Species:
Leishmania infantum
UniProt:
A4HV14_LEIIN
TriTrypDb:
LINF_110016500
Length:
486

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, pretranslocation , alpha subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005784 Sec61 translocon complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0071256 translocon complex 3 1
GO:0098796 membrane protein complex 2 1
GO:0140534 endoplasmic reticulum protein-containing complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HV14
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV14

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0045184 establishment of protein localization 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation 5 1
GO:0006886 intracellular protein transport 4 1
GO:0031204 post-translational protein targeting to membrane, translocation 5 1
GO:0046907 intracellular transport 3 1
GO:0051649 establishment of localization in cell 3 1
GO:0055085 transmembrane transport 2 1
GO:0065002 intracellular protein transmembrane transport 4 1
GO:0071806 protein transmembrane transport 3 1
Molecular functions
Term Name Level Count
GO:0005048 signal sequence binding 4 1
GO:0005215 transporter activity 1 1
GO:0005488 binding 1 1
GO:0008320 protein transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1
GO:0022884 macromolecule transmembrane transporter activity 3 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1
GO:0043021 ribonucleoprotein complex binding 3 1
GO:0043022 ribosome binding 4 1
GO:0044877 protein-containing complex binding 2 1
GO:0140318 protein transporter activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 311 317 PF00089 0.390
CLV_NRD_NRD_1 25 27 PF00675 0.367
CLV_NRD_NRD_1 313 315 PF00675 0.390
CLV_PCSK_KEX2_1 25 27 PF00082 0.367
CLV_PCSK_KEX2_1 313 315 PF00082 0.390
CLV_PCSK_SKI1_1 100 104 PF00082 0.210
CLV_PCSK_SKI1_1 112 116 PF00082 0.201
CLV_PCSK_SKI1_1 12 16 PF00082 0.363
CLV_PCSK_SKI1_1 234 238 PF00082 0.398
CLV_PCSK_SKI1_1 318 322 PF00082 0.496
CLV_PCSK_SKI1_1 68 72 PF00082 0.390
DEG_APCC_DBOX_1 238 246 PF00400 0.190
DEG_APCC_DBOX_1 317 325 PF00400 0.292
DEG_MDM2_SWIB_1 381 388 PF02201 0.227
DOC_CYCLIN_yCln2_LP_2 351 354 PF00134 0.207
DOC_CYCLIN_yCln2_LP_2 361 367 PF00134 0.190
DOC_MAPK_MEF2A_6 75 83 PF00069 0.190
DOC_PP1_RVXF_1 31 37 PF00149 0.449
DOC_PP2B_LxvP_1 351 354 PF13499 0.201
DOC_PP4_FxxP_1 237 240 PF00568 0.190
DOC_PP4_FxxP_1 264 267 PF00568 0.390
DOC_USP7_MATH_1 133 137 PF00917 0.242
DOC_USP7_MATH_1 410 414 PF00917 0.420
DOC_USP7_MATH_1 448 452 PF00917 0.190
DOC_USP7_MATH_1 85 89 PF00917 0.370
DOC_WW_Pin1_4 197 202 PF00397 0.190
DOC_WW_Pin1_4 81 86 PF00397 0.227
LIG_14-3-3_CanoR_1 100 105 PF00244 0.454
LIG_14-3-3_CanoR_1 33 43 PF00244 0.384
LIG_AP2alpha_2 62 64 PF02296 0.190
LIG_APCC_ABBA_1 439 444 PF00400 0.227
LIG_BRCT_BRCA1_1 311 315 PF00533 0.201
LIG_BRCT_BRCA1_1 60 64 PF00533 0.190
LIG_EVH1_2 353 357 PF00568 0.257
LIG_FHA_1 225 231 PF00498 0.292
LIG_FHA_1 249 255 PF00498 0.245
LIG_FHA_1 296 302 PF00498 0.287
LIG_FHA_1 416 422 PF00498 0.410
LIG_FHA_1 451 457 PF00498 0.227
LIG_FHA_2 125 131 PF00498 0.227
LIG_FHA_2 354 360 PF00498 0.205
LIG_FHA_2 75 81 PF00498 0.190
LIG_GBD_Chelix_1 160 168 PF00786 0.311
LIG_IRF3_LxIS_1 78 84 PF10401 0.190
LIG_LIR_Apic_2 137 143 PF02991 0.292
LIG_LIR_Apic_2 235 240 PF02991 0.190
LIG_LIR_Gen_1 116 126 PF02991 0.492
LIG_LIR_Gen_1 305 315 PF02991 0.380
LIG_LIR_Gen_1 356 365 PF02991 0.191
LIG_LIR_Gen_1 382 393 PF02991 0.391
LIG_LIR_Gen_1 440 449 PF02991 0.227
LIG_LIR_Nem_3 193 199 PF02991 0.241
LIG_LIR_Nem_3 305 310 PF02991 0.343
LIG_LIR_Nem_3 356 361 PF02991 0.218
LIG_LIR_Nem_3 382 388 PF02991 0.391
LIG_LIR_Nem_3 422 427 PF02991 0.390
LIG_LIR_Nem_3 430 434 PF02991 0.390
LIG_LIR_Nem_3 440 445 PF02991 0.227
LIG_LIR_Nem_3 475 481 PF02991 0.553
LIG_NRBOX 167 173 PF00104 0.242
LIG_NRBOX 320 326 PF00104 0.201
LIG_Pex14_2 260 264 PF04695 0.227
LIG_Pex14_2 369 373 PF04695 0.236
LIG_Pex14_2 381 385 PF04695 0.210
LIG_PTB_Apo_2 300 307 PF02174 0.227
LIG_PTB_Apo_2 314 321 PF02174 0.292
LIG_PTB_Apo_2 460 467 PF02174 0.227
LIG_PTB_Phospho_1 460 466 PF10480 0.287
LIG_SH2_CRK 358 362 PF00017 0.280
LIG_SH2_CRK 478 482 PF00017 0.569
LIG_SH2_PTP2 424 427 PF00017 0.390
LIG_SH2_SRC 424 427 PF00017 0.390
LIG_SH2_STAP1 288 292 PF00017 0.407
LIG_SH2_STAP1 358 362 PF00017 0.309
LIG_SH2_STAT3 238 241 PF00017 0.190
LIG_SH2_STAT5 134 137 PF00017 0.227
LIG_SH2_STAT5 288 291 PF00017 0.416
LIG_SH2_STAT5 350 353 PF00017 0.207
LIG_SH2_STAT5 370 373 PF00017 0.152
LIG_SH2_STAT5 424 427 PF00017 0.390
LIG_SH3_3 237 243 PF00018 0.200
LIG_SUMO_SIM_par_1 292 299 PF11976 0.287
LIG_SUMO_SIM_par_1 455 460 PF11976 0.227
LIG_TRFH_1 349 353 PF08558 0.215
LIG_TYR_ITAM 463 481 PF00017 0.448
LIG_TYR_ITIM 347 352 PF00017 0.292
LIG_TYR_ITIM 476 481 PF00017 0.538
LIG_UBA3_1 14 23 PF00899 0.591
LIG_UBA3_1 167 174 PF00899 0.242
LIG_UBA3_1 8 12 PF00899 0.585
LIG_Vh1_VBS_1 373 391 PF01044 0.303
MOD_CK1_1 180 186 PF00069 0.447
MOD_CK1_1 200 206 PF00069 0.162
MOD_CK1_1 299 305 PF00069 0.227
MOD_CK2_1 124 130 PF00069 0.227
MOD_CK2_1 74 80 PF00069 0.190
MOD_GlcNHglycan 136 139 PF01048 0.415
MOD_GlcNHglycan 179 182 PF01048 0.244
MOD_GlcNHglycan 450 453 PF01048 0.227
MOD_GlcNHglycan 87 90 PF01048 0.317
MOD_GSK3_1 199 206 PF00069 0.219
MOD_GSK3_1 243 250 PF00069 0.310
MOD_GSK3_1 295 302 PF00069 0.260
MOD_GSK3_1 305 312 PF00069 0.180
MOD_GSK3_1 384 391 PF00069 0.428
MOD_GSK3_1 70 77 PF00069 0.195
MOD_GSK3_1 81 88 PF00069 0.236
MOD_N-GLC_1 243 248 PF02516 0.401
MOD_N-GLC_1 302 307 PF02516 0.303
MOD_N-GLC_1 58 63 PF02516 0.459
MOD_N-GLC_2 189 191 PF02516 0.227
MOD_NEK2_1 124 129 PF00069 0.227
MOD_NEK2_1 159 164 PF00069 0.270
MOD_NEK2_1 185 190 PF00069 0.226
MOD_NEK2_1 222 227 PF00069 0.201
MOD_NEK2_1 269 274 PF00069 0.391
MOD_NEK2_1 286 291 PF00069 0.390
MOD_NEK2_1 296 301 PF00069 0.227
MOD_NEK2_1 373 378 PF00069 0.296
MOD_NEK2_1 384 389 PF00069 0.390
MOD_NEK2_1 457 462 PF00069 0.227
MOD_NEK2_2 437 442 PF00069 0.227
MOD_NEK2_2 7 12 PF00069 0.586
MOD_PIKK_1 305 311 PF00454 0.227
MOD_PIKK_1 399 405 PF00454 0.499
MOD_PKA_2 410 416 PF00069 0.390
MOD_Plk_1 302 308 PF00069 0.303
MOD_Plk_1 415 421 PF00069 0.410
MOD_Plk_4 159 165 PF00069 0.250
MOD_Plk_4 180 186 PF00069 0.390
MOD_Plk_4 190 196 PF00069 0.227
MOD_Plk_4 296 302 PF00069 0.251
MOD_Plk_4 353 359 PF00069 0.207
MOD_Plk_4 437 443 PF00069 0.227
MOD_Plk_4 457 463 PF00069 0.098
MOD_Plk_4 74 80 PF00069 0.190
MOD_Plk_4 87 93 PF00069 0.238
MOD_ProDKin_1 197 203 PF00069 0.190
MOD_ProDKin_1 81 87 PF00069 0.227
TRG_DiLeu_BaLyEn_6 416 421 PF01217 0.401
TRG_ENDOCYTIC_2 349 352 PF00928 0.219
TRG_ENDOCYTIC_2 358 361 PF00928 0.162
TRG_ENDOCYTIC_2 370 373 PF00928 0.227
TRG_ENDOCYTIC_2 424 427 PF00928 0.390
TRG_ENDOCYTIC_2 465 468 PF00928 0.452
TRG_ENDOCYTIC_2 478 481 PF00928 0.588
TRG_ER_diArg_1 24 26 PF00400 0.552
TRG_ER_diArg_1 313 315 PF00400 0.191
TRG_ER_diLys_1 482 486 PF00400 0.550
TRG_Pf-PMV_PEXEL_1 100 105 PF00026 0.280
TRG_Pf-PMV_PEXEL_1 231 235 PF00026 0.390
TRG_Pf-PMV_PEXEL_1 405 409 PF00026 0.190

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4G7 Leptomonas seymouri 93% 100%
A0A0S4INX1 Bodo saltans 75% 100%
A0A1X0NWC0 Trypanosomatidae 82% 100%
A0A3R7MTY8 Trypanosoma rangeli 82% 100%
A0A3S5H6J5 Leishmania donovani 100% 100%
A4H6N1 Leishmania braziliensis 96% 100%
D0A7D4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 77% 100%
E9ANP9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O26134 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 36% 100%
O28377 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 29% 99%
O42965 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
O59442 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 34% 100%
P28541 Methanococcus vannielii 33% 100%
P28542 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 28% 100%
P32915 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 47% 100%
P38353 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 99%
P38377 Canis lupus familiaris 57% 100%
P38379 Pyrenomonas salina 54% 98%
P49978 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 28% 100%
P61619 Homo sapiens 57% 100%
P61620 Mus musculus 57% 100%
P61621 Rattus norvegicus 57% 100%
P78979 Yarrowia lipolytica (strain CLIB 122 / E 150) 48% 100%
P79088 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 47% 100%
Q25147 Halocynthia roretzi 55% 100%
Q2KHX4 Bos taurus 57% 100%
Q4QGX4 Leishmania major 99% 100%
Q54XK2 Dictyostelium discoideum 53% 100%
Q5EA68 Bos taurus 57% 100%
Q5NVM7 Pongo abelii 57% 100%
Q5R5L5 Pongo abelii 57% 100%
Q60175 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 33% 100%
Q6BN08 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 51% 100%
Q6CPY9 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 48% 100%
Q6FRY3 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 47% 100%
Q752H7 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 47% 100%
Q7T277 Dissostichus mawsoni 57% 100%
Q7T278 Harpagifer antarcticus 57% 100%
Q870W0 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 50% 100%
Q8AY31 Bovichtus variegatus 57% 100%
Q8AY32 Gadus ogac 57% 100%
Q8AY33 Boreogadus saida 57% 100%
Q8AY34 Hemitripterus americanus 57% 100%
Q8AY35 Notothenia angustata 57% 100%
Q8AY36 Pagothenia borchgrevinki 57% 100%
Q8U019 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 33% 100%
Q90YL4 Danio rerio 58% 100%
Q90ZM2 Danio rerio 57% 100%
Q96TW8 Wickerhamomyces anomalus 49% 100%
Q977V3 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) 28% 99%
Q98SN8 Oncorhynchus mykiss 57% 100%
Q98SN9 Oncorhynchus mykiss 57% 100%
Q9H9S3 Homo sapiens 57% 100%
Q9HPB1 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 28% 99%
Q9JLR1 Mus musculus 57% 100%
Q9P8E3 Candida albicans (strain SC5314 / ATCC MYA-2876) 49% 100%
Q9UX84 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 28% 100%
Q9V1V8 Pyrococcus abyssi (strain GE5 / Orsay) 34% 100%
Q9YDD0 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 33% 100%
V5BBD8 Trypanosoma cruzi 80% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS