Mitochondrial carrier protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HV12_LEIIN

TriTrypDb:

LINF_110016300

Length:

268

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 5
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HV12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	84	86	PF00675	0.340
CLV_PCSK_KEX2_1	84	86	PF00082	0.340
CLV_PCSK_SKI1_1	119	123	PF00082	0.440
CLV_PCSK_SKI1_1	129	133	PF00082	0.367
CLV_PCSK_SKI1_1	141	145	PF00082	0.327
CLV_PCSK_SKI1_1	79	83	PF00082	0.288
CLV_PCSK_SKI1_1	93	97	PF00082	0.348
DEG_SPOP_SBC_1	168	172	PF00917	0.301
DOC_MAPK_gen_1	129	138	PF00069	0.386
DOC_MAPK_gen_1	84	92	PF00069	0.349
DOC_MAPK_MEF2A_6	132	140	PF00069	0.427
DOC_MAPK_RevD_3	71	85	PF00069	0.312
DOC_USP7_MATH_1	22	26	PF00917	0.370
DOC_USP7_UBL2_3	141	145	PF12436	0.391
DOC_WW_Pin1_4	257	262	PF00397	0.529
LIG_14-3-3_CanoR_1	135	139	PF00244	0.394
LIG_APCC_ABBA_1	180	185	PF00400	0.369
LIG_BIR_II_1	1	5	PF00653	0.369
LIG_FHA_1	156	162	PF00498	0.374
LIG_FHA_1	175	181	PF00498	0.386
LIG_FHA_1	26	32	PF00498	0.303
LIG_FHA_1	73	79	PF00498	0.369
LIG_FHA_1	87	93	PF00498	0.490
LIG_FHA_2	142	148	PF00498	0.505
LIG_FHA_2	63	69	PF00498	0.324
LIG_GBD_Chelix_1	233	241	PF00786	0.417
LIG_LIR_Gen_1	144	153	PF02991	0.451
LIG_LIR_Nem_3	144	149	PF02991	0.359
LIG_LIR_Nem_3	229	233	PF02991	0.374
LIG_LIR_Nem_3	67	73	PF02991	0.387
LIG_SH2_CRK	230	234	PF00017	0.415
LIG_SH2_CRK	56	60	PF00017	0.385
LIG_SH2_CRK	70	74	PF00017	0.266
LIG_SH2_NCK_1	217	221	PF00017	0.468
LIG_SH2_NCK_1	56	60	PF00017	0.483
LIG_SH2_STAP1	56	60	PF00017	0.411
LIG_SH2_STAT5	217	220	PF00017	0.404
LIG_SH3_3	136	142	PF00018	0.437
LIG_SH3_3	56	62	PF00018	0.370
LIG_SH3_4	141	148	PF00018	0.480
LIG_SUMO_SIM_anti_2	134	140	PF11976	0.371
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.360
LIG_SUMO_SIM_par_1	188	195	PF11976	0.275
MOD_CDK_SPK_2	257	262	PF00069	0.445
MOD_CK1_1	102	108	PF00069	0.418
MOD_CK1_1	167	173	PF00069	0.470
MOD_CK1_1	229	235	PF00069	0.324
MOD_CK1_1	25	31	PF00069	0.371
MOD_CK1_1	39	45	PF00069	0.320
MOD_CK1_1	64	70	PF00069	0.459
MOD_CK2_1	141	147	PF00069	0.503
MOD_GlcNHglycan	101	104	PF01048	0.456
MOD_GlcNHglycan	20	23	PF01048	0.372
MOD_GlcNHglycan	38	41	PF01048	0.304
MOD_GSK3_1	153	160	PF00069	0.476
MOD_GSK3_1	164	171	PF00069	0.343
MOD_GSK3_1	18	25	PF00069	0.379
MOD_GSK3_1	211	218	PF00069	0.348
MOD_GSK3_1	35	42	PF00069	0.428
MOD_NEK2_1	1	6	PF00069	0.416
MOD_NEK2_1	131	136	PF00069	0.430
MOD_NEK2_1	153	158	PF00069	0.406
MOD_NEK2_1	35	40	PF00069	0.464
MOD_PKA_2	134	140	PF00069	0.408
MOD_PKA_2	153	159	PF00069	0.446
MOD_Plk_4	134	140	PF00069	0.382
MOD_Plk_4	176	182	PF00069	0.481
MOD_Plk_4	185	191	PF00069	0.461
MOD_Plk_4	212	218	PF00069	0.413
MOD_Plk_4	72	78	PF00069	0.353
MOD_ProDKin_1	257	263	PF00069	0.530
MOD_SUMO_for_1	246	249	PF00179	0.472
MOD_SUMO_for_1	251	254	PF00179	0.476
TRG_DiLeu_BaEn_4	239	245	PF01217	0.394
TRG_ENDOCYTIC_2	146	149	PF00928	0.367
TRG_ENDOCYTIC_2	230	233	PF00928	0.404
TRG_ENDOCYTIC_2	56	59	PF00928	0.385
TRG_ENDOCYTIC_2	70	73	PF00928	0.262
TRG_ER_diArg_1	83	85	PF00400	0.327
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X8	Leptomonas seymouri	73%	100%
A0A0S4IPH5	Bodo saltans	46%	100%
A0A1X0NV63	Trypanosomatidae	51%	100%
A0A3Q8I815	Leishmania donovani	99%	100%
A0A3R7NL41	Trypanosoma rangeli	51%	100%
A4H6M9	Leishmania braziliensis	89%	100%
D0A7D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ANP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QGX6	Leishmania major	96%	100%