Putative inositol-1,4,5-trisphosphate (IP3) 5-phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol-1 -4 -5-trisphosphate (IP3) 5-phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4HV10_LEIIN

TriTrypDb:

LINF_110016100

Length:

688

Annotations

Annotations by Jardim et al.

Phosphatase, inositol-1,4,5-trisphosphate (IP3) 5-phosphatase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HV10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV10

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0006066	alcohol metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019751	polyol metabolic process	4	1
GO:0019932	second-messenger-mediated signaling	4	1
GO:0035556	intracellular signal transduction	3	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046164	alcohol catabolic process	4	1
GO:0046174	polyol catabolic process	5	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	1
GO:0046855	obsolete inositol phosphate dephosphorylation	5	1
GO:0048016	inositol phosphate-mediated signaling	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0071545	inositol phosphate catabolic process	5	1
GO:0071704	organic substance metabolic process	2	2
GO:1901575	organic substance catabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901616	organic hydroxy compound catabolic process	4	1
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0030258	lipid modification	4	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0046839	phospholipid dephosphorylation	5	1
GO:0046856	phosphatidylinositol dephosphorylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004445	inositol-polyphosphate 5-phosphatase activity	8	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8
GO:0046030	inositol trisphosphate phosphatase activity	7	8
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	8	7
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	8	7
GO:0052743	inositol tetrakisphosphate phosphatase activity	7	7
GO:0052745	inositol phosphate phosphatase activity	6	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.547
CLV_C14_Caspase3-7	96	100	PF00656	0.575
CLV_NRD_NRD_1	256	258	PF00675	0.773
CLV_NRD_NRD_1	360	362	PF00675	0.350
CLV_NRD_NRD_1	403	405	PF00675	0.394
CLV_NRD_NRD_1	478	480	PF00675	0.385
CLV_PCSK_KEX2_1	256	258	PF00082	0.774
CLV_PCSK_KEX2_1	403	405	PF00082	0.394
CLV_PCSK_KEX2_1	457	459	PF00082	0.541
CLV_PCSK_KEX2_1	480	482	PF00082	0.361
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.526
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.401
CLV_PCSK_PC7_1	453	459	PF00082	0.457
CLV_PCSK_SKI1_1	362	366	PF00082	0.377
CLV_PCSK_SKI1_1	390	394	PF00082	0.433
CLV_PCSK_SKI1_1	406	410	PF00082	0.403
CLV_PCSK_SKI1_1	617	621	PF00082	0.413
DEG_APCC_DBOX_1	119	127	PF00400	0.375
DEG_APCC_DBOX_1	181	189	PF00400	0.421
DEG_SCF_FBW7_1	578	584	PF00400	0.533
DEG_SPOP_SBC_1	523	527	PF00917	0.592
DOC_AGCK_PIF_3	685	688	PF00069	0.390
DOC_CKS1_1	578	583	PF01111	0.607
DOC_CYCLIN_yCln2_LP_2	421	427	PF00134	0.378
DOC_MAPK_gen_1	359	369	PF00069	0.528
DOC_MAPK_JIP1_4	33	39	PF00069	0.410
DOC_MAPK_MEF2A_6	182	190	PF00069	0.375
DOC_MAPK_MEF2A_6	29	38	PF00069	0.461
DOC_MAPK_MEF2A_6	361	369	PF00069	0.470
DOC_MAPK_NFAT4_5	362	370	PF00069	0.383
DOC_PP1_RVXF_1	615	621	PF00149	0.319
DOC_PP2B_LxvP_1	324	327	PF13499	0.460
DOC_PP2B_PxIxI_1	183	189	PF00149	0.340
DOC_PP4_FxxP_1	312	315	PF00568	0.392
DOC_PP4_FxxP_1	469	472	PF00568	0.441
DOC_PP4_FxxP_1	86	89	PF00568	0.589
DOC_SPAK_OSR1_1	20	24	PF12202	0.542
DOC_SPAK_OSR1_1	481	485	PF12202	0.411
DOC_USP7_MATH_1	136	140	PF00917	0.605
DOC_USP7_MATH_1	306	310	PF00917	0.328
DOC_USP7_MATH_1	357	361	PF00917	0.434
DOC_USP7_MATH_1	392	396	PF00917	0.438
DOC_USP7_MATH_1	413	417	PF00917	0.421
DOC_USP7_MATH_1	581	585	PF00917	0.587
DOC_USP7_MATH_1	588	592	PF00917	0.506
DOC_USP7_MATH_1	642	646	PF00917	0.688
DOC_USP7_MATH_1	78	82	PF00917	0.658
DOC_USP7_MATH_1	9	13	PF00917	0.618
DOC_USP7_UBL2_3	199	203	PF12436	0.465
DOC_WW_Pin1_4	102	107	PF00397	0.606
DOC_WW_Pin1_4	153	158	PF00397	0.697
DOC_WW_Pin1_4	159	164	PF00397	0.742
DOC_WW_Pin1_4	175	180	PF00397	0.402
DOC_WW_Pin1_4	2	7	PF00397	0.630
DOC_WW_Pin1_4	311	316	PF00397	0.433
DOC_WW_Pin1_4	393	398	PF00397	0.382
DOC_WW_Pin1_4	538	543	PF00397	0.656
DOC_WW_Pin1_4	577	582	PF00397	0.625
DOC_WW_Pin1_4	584	589	PF00397	0.639
DOC_WW_Pin1_4	597	602	PF00397	0.503
DOC_WW_Pin1_4	63	68	PF00397	0.733
LIG_14-3-3_CanoR_1	125	129	PF00244	0.388
LIG_14-3-3_CanoR_1	20	24	PF00244	0.542
LIG_14-3-3_CanoR_1	214	218	PF00244	0.425
LIG_14-3-3_CanoR_1	247	253	PF00244	0.620
LIG_14-3-3_CanoR_1	256	261	PF00244	0.578
LIG_14-3-3_CanoR_1	575	581	PF00244	0.632
LIG_14-3-3_CanoR_1	632	637	PF00244	0.603
LIG_14-3-3_CanoR_1	662	671	PF00244	0.475
LIG_APCC_ABBA_1	381	386	PF00400	0.381
LIG_APCC_ABBA_1	425	430	PF00400	0.307
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	21	25	PF00533	0.536
LIG_BRCT_BRCA1_1	308	312	PF00533	0.325
LIG_BRCT_BRCA1_1	350	354	PF00533	0.418
LIG_BRCT_BRCA1_1	75	79	PF00533	0.616
LIG_deltaCOP1_diTrp_1	463	469	PF00928	0.381
LIG_eIF4E_1	671	677	PF01652	0.327
LIG_FHA_1	176	182	PF00498	0.515
LIG_FHA_1	213	219	PF00498	0.523
LIG_FHA_1	222	228	PF00498	0.493
LIG_FHA_1	291	297	PF00498	0.598
LIG_FHA_1	3	9	PF00498	0.646
LIG_FHA_1	38	44	PF00498	0.369
LIG_FHA_2	256	262	PF00498	0.623
LIG_FHA_2	472	478	PF00498	0.443
LIG_FHA_2	548	554	PF00498	0.629
LIG_FHA_2	57	63	PF00498	0.652
LIG_FHA_2	677	683	PF00498	0.374
LIG_GSK3_LRP6_1	157	162	PF00069	0.628
LIG_LIR_Apic_2	309	315	PF02991	0.388
LIG_LIR_Apic_2	467	472	PF02991	0.445
LIG_LIR_Apic_2	84	89	PF02991	0.575
LIG_LIR_Gen_1	301	312	PF02991	0.413
LIG_LIR_Gen_1	463	473	PF02991	0.427
LIG_LIR_Gen_1	511	517	PF02991	0.410
LIG_LIR_Gen_1	682	688	PF02991	0.329
LIG_LIR_Gen_1	76	86	PF02991	0.577
LIG_LIR_Gen_1	90	98	PF02991	0.474
LIG_LIR_Nem_3	301	307	PF02991	0.434
LIG_LIR_Nem_3	330	334	PF02991	0.356
LIG_LIR_Nem_3	463	469	PF02991	0.426
LIG_LIR_Nem_3	511	515	PF02991	0.459
LIG_LIR_Nem_3	666	671	PF02991	0.509
LIG_LIR_Nem_3	682	688	PF02991	0.383
LIG_LIR_Nem_3	76	82	PF02991	0.569
LIG_LIR_Nem_3	90	94	PF02991	0.495
LIG_Pex14_2	205	209	PF04695	0.425
LIG_Pex14_2	21	25	PF04695	0.606
LIG_Pex14_2	465	469	PF04695	0.410
LIG_PTB_Apo_2	199	206	PF02174	0.458
LIG_Rb_LxCxE_1	455	477	PF01857	0.450
LIG_SH2_CRK	512	516	PF00017	0.467
LIG_SH2_NCK_1	512	516	PF00017	0.454
LIG_SH2_NCK_1	671	675	PF00017	0.400
LIG_SH2_PTP2	331	334	PF00017	0.432
LIG_SH2_PTP2	91	94	PF00017	0.583
LIG_SH2_SRC	331	334	PF00017	0.432
LIG_SH2_SRC	669	672	PF00017	0.391
LIG_SH2_SRC	91	94	PF00017	0.583
LIG_SH2_STAP1	512	516	PF00017	0.454
LIG_SH2_STAP1	669	673	PF00017	0.384
LIG_SH2_STAT5	177	180	PF00017	0.526
LIG_SH2_STAT5	208	211	PF00017	0.477
LIG_SH2_STAT5	303	306	PF00017	0.462
LIG_SH2_STAT5	331	334	PF00017	0.450
LIG_SH2_STAT5	400	403	PF00017	0.434
LIG_SH2_STAT5	91	94	PF00017	0.583
LIG_SH3_1	634	640	PF00018	0.621
LIG_SH3_3	155	161	PF00018	0.595
LIG_SH3_3	178	184	PF00018	0.490
LIG_SH3_3	3	9	PF00018	0.613
LIG_SH3_3	332	338	PF00018	0.500
LIG_SH3_3	58	64	PF00018	0.655
LIG_SH3_3	634	640	PF00018	0.634
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.293
LIG_SUMO_SIM_anti_2	35	40	PF11976	0.396
LIG_SUMO_SIM_anti_2	491	498	PF11976	0.447
LIG_SUMO_SIM_par_1	35	40	PF11976	0.340
LIG_SUMO_SIM_par_1	416	423	PF11976	0.409
LIG_TRAF2_1	474	477	PF00917	0.418
LIG_WRC_WIRS_1	82	87	PF05994	0.479
LIG_WW_2	6	9	PF00397	0.612
MOD_CDC14_SPxK_1	600	603	PF00782	0.496
MOD_CDK_SPK_2	311	316	PF00069	0.396
MOD_CDK_SPxK_1	597	603	PF00069	0.496
MOD_CDK_SPxxK_3	102	109	PF00069	0.594
MOD_CDK_SPxxK_3	175	182	PF00069	0.516
MOD_CK1_1	127	133	PF00069	0.431
MOD_CK1_1	2	8	PF00069	0.630
MOD_CK1_1	234	240	PF00069	0.683
MOD_CK1_1	263	269	PF00069	0.697
MOD_CK1_1	287	293	PF00069	0.656
MOD_CK1_1	32	38	PF00069	0.423
MOD_CK1_1	322	328	PF00069	0.369
MOD_CK1_1	395	401	PF00069	0.447
MOD_CK1_1	577	583	PF00069	0.640
MOD_CK1_1	584	590	PF00069	0.615
MOD_CK1_1	649	655	PF00069	0.654
MOD_CK1_1	663	669	PF00069	0.499
MOD_CK1_1	81	87	PF00069	0.534
MOD_CK2_1	255	261	PF00069	0.658
MOD_CK2_1	436	442	PF00069	0.355
MOD_CK2_1	471	477	PF00069	0.476
MOD_CK2_1	494	500	PF00069	0.394
MOD_CK2_1	56	62	PF00069	0.646
MOD_Cter_Amidation	401	404	PF01082	0.404
MOD_DYRK1A_RPxSP_1	175	179	PF00069	0.501
MOD_DYRK1A_RPxSP_1	63	67	PF00069	0.598
MOD_GlcNHglycan	129	132	PF01048	0.555
MOD_GlcNHglycan	137	141	PF01048	0.531
MOD_GlcNHglycan	143	146	PF01048	0.540
MOD_GlcNHglycan	15	18	PF01048	0.573
MOD_GlcNHglycan	2	5	PF01048	0.619
MOD_GlcNHglycan	224	227	PF01048	0.428
MOD_GlcNHglycan	233	236	PF01048	0.609
MOD_GlcNHglycan	270	273	PF01048	0.643
MOD_GlcNHglycan	350	353	PF01048	0.384
MOD_GlcNHglycan	414	418	PF01048	0.415
MOD_GlcNHglycan	52	55	PF01048	0.616
MOD_GlcNHglycan	526	529	PF01048	0.661
MOD_GlcNHglycan	628	631	PF01048	0.468
MOD_GlcNHglycan	648	651	PF01048	0.610
MOD_GlcNHglycan	662	665	PF01048	0.555
MOD_GlcNHglycan	74	78	PF01048	0.686
MOD_GSK3_1	136	143	PF00069	0.498
MOD_GSK3_1	153	160	PF00069	0.529
MOD_GSK3_1	173	180	PF00069	0.518
MOD_GSK3_1	234	241	PF00069	0.667
MOD_GSK3_1	25	32	PF00069	0.437
MOD_GSK3_1	256	263	PF00069	0.787
MOD_GSK3_1	280	287	PF00069	0.701
MOD_GSK3_1	302	309	PF00069	0.397
MOD_GSK3_1	467	474	PF00069	0.450
MOD_GSK3_1	518	525	PF00069	0.605
MOD_GSK3_1	577	584	PF00069	0.636
MOD_GSK3_1	588	595	PF00069	0.531
MOD_GSK3_1	626	633	PF00069	0.457
MOD_GSK3_1	642	649	PF00069	0.605
MOD_GSK3_1	9	16	PF00069	0.734
MOD_N-GLC_1	13	18	PF02516	0.503
MOD_N-GLC_1	268	273	PF02516	0.693
MOD_N-GLC_1	287	292	PF02516	0.630
MOD_N-GLC_2	377	379	PF02516	0.368
MOD_N-GLC_2	605	607	PF02516	0.450
MOD_NEK2_1	238	243	PF00069	0.721
MOD_NEK2_1	255	260	PF00069	0.486
MOD_NEK2_1	348	353	PF00069	0.421
MOD_NEK2_1	365	370	PF00069	0.321
MOD_NEK2_1	37	42	PF00069	0.406
MOD_NEK2_1	448	453	PF00069	0.474
MOD_NEK2_1	50	55	PF00069	0.636
MOD_NEK2_1	56	61	PF00069	0.665
MOD_PIKK_1	37	43	PF00454	0.335
MOD_PIKK_1	471	477	PF00454	0.604
MOD_PKA_1	256	262	PF00069	0.657
MOD_PKA_2	124	130	PF00069	0.408
MOD_PKA_2	19	25	PF00069	0.536
MOD_PKA_2	213	219	PF00069	0.427
MOD_PKA_2	231	237	PF00069	0.455
MOD_PKA_2	255	261	PF00069	0.614
MOD_PKA_2	280	286	PF00069	0.675
MOD_PKA_2	574	580	PF00069	0.600
MOD_PKB_1	245	253	PF00069	0.612
MOD_Plk_1	413	419	PF00069	0.418
MOD_Plk_2-3	436	442	PF00069	0.349
MOD_Plk_4	124	130	PF00069	0.408
MOD_Plk_4	213	219	PF00069	0.449
MOD_Plk_4	306	312	PF00069	0.326
MOD_Plk_4	32	38	PF00069	0.446
MOD_Plk_4	395	401	PF00069	0.469
MOD_Plk_4	81	87	PF00069	0.658
MOD_ProDKin_1	102	108	PF00069	0.596
MOD_ProDKin_1	153	159	PF00069	0.698
MOD_ProDKin_1	175	181	PF00069	0.521
MOD_ProDKin_1	2	8	PF00069	0.630
MOD_ProDKin_1	311	317	PF00069	0.432
MOD_ProDKin_1	393	399	PF00069	0.386
MOD_ProDKin_1	538	544	PF00069	0.654
MOD_ProDKin_1	577	583	PF00069	0.624
MOD_ProDKin_1	584	590	PF00069	0.641
MOD_ProDKin_1	597	603	PF00069	0.496
MOD_ProDKin_1	63	69	PF00069	0.727
MOD_SUMO_rev_2	26	35	PF00179	0.508
MOD_SUMO_rev_2	430	440	PF00179	0.384
MOD_SUMO_rev_2	442	448	PF00179	0.449
TRG_DiLeu_BaEn_1	485	490	PF01217	0.358
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.445
TRG_ENDOCYTIC_2	331	334	PF00928	0.432
TRG_ENDOCYTIC_2	512	515	PF00928	0.414
TRG_ENDOCYTIC_2	671	674	PF00928	0.342
TRG_ENDOCYTIC_2	91	94	PF00928	0.583
TRG_ER_diArg_1	255	257	PF00400	0.713
TRG_ER_diArg_1	403	406	PF00400	0.349
TRG_ER_diArg_1	478	481	PF00400	0.470
TRG_ER_diArg_1	517	520	PF00400	0.523
TRG_ER_diArg_1	572	575	PF00400	0.670
TRG_NLS_MonoExtN_4	456	461	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E4	Leptomonas seymouri	51%	100%
A0A3S5H6J4	Leishmania donovani	100%	100%
A0A422NRL6	Trypanosoma rangeli	30%	100%
A4H6M7	Leishmania braziliensis	75%	100%
E9ANP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QGX8	Leishmania major	93%	100%