LeishMANIAdb
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Pyruvate, phosphate dikinase

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Pyruvate, phosphate dikinase
Gene product:
pyruvate phosphate dikinase - putative
Species:
Leishmania infantum
UniProt:
A4HV09_LEIIN
TriTrypDb:
LINF_110016000
Length:
914

Annotations

Annotations by Jardim et al.

Gluconeogensis, pyruvate phosphate dikinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 103

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HV09
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV09

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 12
GO:0006090 pyruvate metabolic process 7 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0032787 monocarboxylic acid metabolic process 6 12
GO:0043436 oxoacid metabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044281 small molecule metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:0005975 carbohydrate metabolic process 3 1
GO:0006091 generation of precursor metabolites and energy 3 1
GO:0006096 glycolytic process 5 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006163 purine nucleotide metabolic process 5 1
GO:0006165 obsolete nucleoside diphosphate phosphorylation 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006753 nucleoside phosphate metabolic process 4 1
GO:0006757 obsolete ATP generation from ADP 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0009056 catabolic process 2 1
GO:0009117 nucleotide metabolic process 5 1
GO:0009132 nucleoside diphosphate metabolic process 5 1
GO:0009135 purine nucleoside diphosphate metabolic process 6 1
GO:0009141 nucleoside triphosphate metabolic process 5 1
GO:0009144 purine nucleoside triphosphate metabolic process 6 1
GO:0009150 purine ribonucleotide metabolic process 6 1
GO:0009179 purine ribonucleoside diphosphate metabolic process 7 1
GO:0009185 ribonucleoside diphosphate metabolic process 6 1
GO:0009199 ribonucleoside triphosphate metabolic process 6 1
GO:0009205 purine ribonucleoside triphosphate metabolic process 7 1
GO:0009259 ribonucleotide metabolic process 5 1
GO:0016052 carbohydrate catabolic process 4 1
GO:0019637 organophosphate metabolic process 3 1
GO:0019693 ribose phosphate metabolic process 4 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0046031 ADP metabolic process 7 1
GO:0046034 ATP metabolic process 7 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046939 obsolete nucleotide phosphorylation 6 1
GO:0055086 nucleobase-containing small molecule metabolic process 3 1
GO:0072521 purine-containing compound metabolic process 4 1
GO:1901135 carbohydrate derivative metabolic process 3 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016781 phosphotransferase activity, paired acceptors 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0050242 pyruvate, phosphate dikinase activity 5 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 13 17 PF00656 0.558
CLV_C14_Caspase3-7 596 600 PF00656 0.499
CLV_NRD_NRD_1 126 128 PF00675 0.281
CLV_NRD_NRD_1 140 142 PF00675 0.239
CLV_NRD_NRD_1 229 231 PF00675 0.275
CLV_NRD_NRD_1 317 319 PF00675 0.324
CLV_NRD_NRD_1 74 76 PF00675 0.292
CLV_PCSK_FUR_1 315 319 PF00082 0.335
CLV_PCSK_KEX2_1 126 128 PF00082 0.284
CLV_PCSK_KEX2_1 140 142 PF00082 0.237
CLV_PCSK_KEX2_1 229 231 PF00082 0.275
CLV_PCSK_KEX2_1 315 317 PF00082 0.283
CLV_PCSK_KEX2_1 368 370 PF00082 0.275
CLV_PCSK_KEX2_1 558 560 PF00082 0.275
CLV_PCSK_KEX2_1 904 906 PF00082 0.637
CLV_PCSK_PC1ET2_1 126 128 PF00082 0.324
CLV_PCSK_PC1ET2_1 368 370 PF00082 0.275
CLV_PCSK_PC1ET2_1 558 560 PF00082 0.275
CLV_PCSK_PC1ET2_1 904 906 PF00082 0.621
CLV_PCSK_SKI1_1 141 145 PF00082 0.275
CLV_PCSK_SKI1_1 19 23 PF00082 0.463
CLV_PCSK_SKI1_1 214 218 PF00082 0.335
CLV_PCSK_SKI1_1 255 259 PF00082 0.269
CLV_PCSK_SKI1_1 303 307 PF00082 0.258
CLV_PCSK_SKI1_1 415 419 PF00082 0.602
CLV_PCSK_SKI1_1 533 537 PF00082 0.518
CLV_PCSK_SKI1_1 618 622 PF00082 0.380
CLV_PCSK_SKI1_1 773 777 PF00082 0.380
CLV_PCSK_SKI1_1 79 83 PF00082 0.357
CLV_PCSK_SKI1_1 845 849 PF00082 0.299
CLV_Separin_Metazoa 770 774 PF03568 0.486
DEG_APCC_DBOX_1 870 878 PF00400 0.580
DEG_APCC_KENBOX_2 70 74 PF00400 0.561
DEG_Nend_UBRbox_2 1 3 PF02207 0.554
DOC_CKS1_1 290 295 PF01111 0.475
DOC_MAPK_gen_1 386 396 PF00069 0.570
DOC_MAPK_gen_1 735 741 PF00069 0.498
DOC_MAPK_gen_1 845 855 PF00069 0.501
DOC_MAPK_MEF2A_6 450 457 PF00069 0.479
DOC_PP1_RVXF_1 862 869 PF00149 0.557
DOC_PP2B_LxvP_1 645 648 PF13499 0.475
DOC_PP4_FxxP_1 882 885 PF00568 0.499
DOC_USP7_MATH_1 100 104 PF00917 0.475
DOC_USP7_MATH_1 129 133 PF00917 0.573
DOC_USP7_MATH_1 824 828 PF00917 0.487
DOC_USP7_UBL2_3 168 172 PF12436 0.515
DOC_USP7_UBL2_3 418 422 PF12436 0.472
DOC_USP7_UBL2_3 533 537 PF12436 0.512
DOC_USP7_UBL2_3 79 83 PF12436 0.557
DOC_USP7_UBL2_3 848 852 PF12436 0.499
DOC_WW_Pin1_4 196 201 PF00397 0.580
DOC_WW_Pin1_4 262 267 PF00397 0.475
DOC_WW_Pin1_4 289 294 PF00397 0.475
DOC_WW_Pin1_4 424 429 PF00397 0.409
DOC_WW_Pin1_4 457 462 PF00397 0.475
DOC_WW_Pin1_4 565 570 PF00397 0.471
DOC_WW_Pin1_4 87 92 PF00397 0.580
DOC_WW_Pin1_4 877 882 PF00397 0.495
LIG_14-3-3_CanoR_1 118 122 PF00244 0.580
LIG_14-3-3_CanoR_1 140 146 PF00244 0.474
LIG_14-3-3_CanoR_1 477 487 PF00244 0.474
LIG_14-3-3_CanoR_1 539 544 PF00244 0.501
LIG_14-3-3_CanoR_1 694 700 PF00244 0.467
LIG_14-3-3_CanoR_1 773 781 PF00244 0.494
LIG_AP2alpha_2 204 206 PF02296 0.561
LIG_AP2alpha_2 823 825 PF02296 0.499
LIG_APCC_ABBA_1 143 148 PF00400 0.475
LIG_APCC_ABBA_1 379 384 PF00400 0.580
LIG_APCC_ABBA_1 652 657 PF00400 0.515
LIG_APCC_ABBA_1 811 816 PF00400 0.510
LIG_CtBP_PxDLS_1 461 465 PF00389 0.475
LIG_deltaCOP1_diTrp_1 204 210 PF00928 0.561
LIG_EH1_1 762 770 PF00400 0.486
LIG_FHA_1 233 239 PF00498 0.475
LIG_FHA_1 47 53 PF00498 0.480
LIG_FHA_1 525 531 PF00498 0.527
LIG_FHA_1 790 796 PF00498 0.499
LIG_FHA_2 169 175 PF00498 0.469
LIG_FHA_2 176 182 PF00498 0.463
LIG_FHA_2 351 357 PF00498 0.483
LIG_FHA_2 386 392 PF00498 0.484
LIG_FHA_2 457 463 PF00498 0.475
LIG_FHA_2 566 572 PF00498 0.477
LIG_FHA_2 59 65 PF00498 0.563
LIG_FHA_2 696 702 PF00498 0.486
LIG_FHA_2 765 771 PF00498 0.486
LIG_Integrin_RGD_1 625 627 PF01839 0.299
LIG_LIR_Apic_2 219 223 PF02991 0.486
LIG_LIR_Apic_2 880 885 PF02991 0.499
LIG_LIR_Gen_1 144 153 PF02991 0.475
LIG_LIR_Gen_1 187 193 PF02991 0.468
LIG_LIR_Gen_1 204 213 PF02991 0.499
LIG_LIR_Gen_1 823 833 PF02991 0.499
LIG_LIR_Nem_3 137 142 PF02991 0.475
LIG_LIR_Nem_3 144 149 PF02991 0.475
LIG_LIR_Nem_3 187 192 PF02991 0.468
LIG_LIR_Nem_3 204 209 PF02991 0.473
LIG_LIR_Nem_3 226 231 PF02991 0.531
LIG_LIR_Nem_3 328 333 PF02991 0.475
LIG_LIR_Nem_3 544 550 PF02991 0.492
LIG_LIR_Nem_3 627 631 PF02991 0.475
LIG_LIR_Nem_3 698 702 PF02991 0.475
LIG_LIR_Nem_3 784 790 PF02991 0.486
LIG_LIR_Nem_3 823 828 PF02991 0.499
LIG_LYPXL_yS_3 319 322 PF13949 0.486
LIG_LYPXL_yS_3 699 702 PF13949 0.475
LIG_PCNA_yPIPBox_3 633 645 PF02747 0.552
LIG_PDZ_Class_1 909 914 PF00595 0.640
LIG_Pex14_1 206 210 PF04695 0.561
LIG_Pex14_2 628 632 PF04695 0.486
LIG_SH2_CRK 228 232 PF00017 0.486
LIG_SH2_CRK 330 334 PF00017 0.475
LIG_SH2_SRC 146 149 PF00017 0.481
LIG_SH2_STAP1 146 150 PF00017 0.475
LIG_SH2_STAT3 703 706 PF00017 0.475
LIG_SH2_STAT5 189 192 PF00017 0.475
LIG_SH2_STAT5 272 275 PF00017 0.509
LIG_SH2_STAT5 277 280 PF00017 0.459
LIG_SH2_STAT5 763 766 PF00017 0.486
LIG_SH2_STAT5 820 823 PF00017 0.563
LIG_SH2_STAT5 876 879 PF00017 0.499
LIG_SH2_STAT5 9 12 PF00017 0.405
LIG_SH3_3 199 205 PF00018 0.475
LIG_SH3_3 38 44 PF00018 0.465
LIG_SH3_3 85 91 PF00018 0.448
LIG_SH3_4 418 425 PF00018 0.438
LIG_SH3_4 848 855 PF00018 0.499
LIG_SUMO_SIM_par_1 520 525 PF11976 0.561
LIG_TRAF2_1 311 314 PF00917 0.513
LIG_TRAF2_1 321 324 PF00917 0.367
LIG_TRAF2_1 388 391 PF00917 0.442
LIG_TRAF2_1 659 662 PF00917 0.522
LIG_TRAF2_2 622 627 PF00917 0.475
LIG_TRAF2_2 824 829 PF00917 0.499
LIG_TYR_ITIM 697 702 PF00017 0.327
LIG_TYR_ITSM 142 149 PF00017 0.327
LIG_UBA3_1 728 736 PF00899 0.343
LIG_WRC_WIRS_1 787 792 PF05994 0.362
MOD_CDC14_SPxK_1 880 883 PF00782 0.362
MOD_CDK_SPxK_1 877 883 PF00069 0.362
MOD_CK1_1 265 271 PF00069 0.343
MOD_CK1_1 789 795 PF00069 0.346
MOD_CK1_1 95 101 PF00069 0.327
MOD_CK2_1 308 314 PF00069 0.342
MOD_CK2_1 318 324 PF00069 0.217
MOD_CK2_1 385 391 PF00069 0.437
MOD_CK2_1 456 462 PF00069 0.400
MOD_CK2_1 597 603 PF00069 0.433
MOD_CK2_1 695 701 PF00069 0.327
MOD_CK2_1 764 770 PF00069 0.343
MOD_Cter_Amidation 366 369 PF01082 0.343
MOD_Cter_Amidation 733 736 PF01082 0.343
MOD_GlcNHglycan 254 258 PF01048 0.322
MOD_GlcNHglycan 440 443 PF01048 0.414
MOD_GlcNHglycan 496 499 PF01048 0.327
MOD_GlcNHglycan 656 660 PF01048 0.456
MOD_GlcNHglycan 669 672 PF01048 0.230
MOD_GlcNHglycan 97 100 PF01048 0.327
MOD_GSK3_1 168 175 PF00069 0.329
MOD_GSK3_1 520 527 PF00069 0.327
MOD_GSK3_1 789 796 PF00069 0.339
MOD_GSK3_1 835 842 PF00069 0.438
MOD_N-GLC_1 308 313 PF02516 0.418
MOD_NEK2_1 10 15 PF00069 0.521
MOD_NEK2_1 107 112 PF00069 0.327
MOD_NEK2_1 237 242 PF00069 0.313
MOD_NEK2_1 332 337 PF00069 0.409
MOD_NEK2_1 46 51 PF00069 0.447
MOD_NEK2_1 524 529 PF00069 0.395
MOD_NEK2_1 695 700 PF00069 0.327
MOD_NEK2_1 739 744 PF00069 0.348
MOD_NEK2_1 835 840 PF00069 0.452
MOD_NEK2_1 909 914 PF00069 0.646
MOD_NEK2_1 92 97 PF00069 0.289
MOD_PIKK_1 65 71 PF00454 0.396
MOD_PIKK_1 793 799 PF00454 0.357
MOD_PK_1 597 603 PF00069 0.396
MOD_PKA_1 168 174 PF00069 0.362
MOD_PKA_2 117 123 PF00069 0.469
MOD_PKA_2 385 391 PF00069 0.584
MOD_PKA_2 612 618 PF00069 0.427
MOD_PKB_1 316 324 PF00069 0.339
MOD_Plk_1 129 135 PF00069 0.377
MOD_Plk_1 298 304 PF00069 0.363
MOD_Plk_1 350 356 PF00069 0.327
MOD_Plk_1 737 743 PF00069 0.343
MOD_Plk_1 793 799 PF00069 0.362
MOD_Plk_2-3 520 526 PF00069 0.327
MOD_Plk_2-3 862 868 PF00069 0.447
MOD_Plk_4 107 113 PF00069 0.327
MOD_Plk_4 764 770 PF00069 0.343
MOD_ProDKin_1 196 202 PF00069 0.474
MOD_ProDKin_1 262 268 PF00069 0.327
MOD_ProDKin_1 289 295 PF00069 0.327
MOD_ProDKin_1 424 430 PF00069 0.404
MOD_ProDKin_1 457 463 PF00069 0.327
MOD_ProDKin_1 565 571 PF00069 0.321
MOD_ProDKin_1 87 93 PF00069 0.474
MOD_ProDKin_1 877 883 PF00069 0.355
MOD_SUMO_rev_2 16 24 PF00179 0.511
MOD_SUMO_rev_2 164 171 PF00179 0.376
MOD_SUMO_rev_2 176 185 PF00179 0.245
MOD_SUMO_rev_2 542 550 PF00179 0.398
MOD_SUMO_rev_2 78 84 PF00179 0.435
TRG_DiLeu_BaEn_1 328 333 PF01217 0.343
TRG_DiLeu_BaEn_1 831 836 PF01217 0.474
TRG_DiLeu_BaLyEn_6 640 645 PF01217 0.327
TRG_DiLeu_BaLyEn_6 88 93 PF01217 0.316
TRG_ENDOCYTIC_2 139 142 PF00928 0.327
TRG_ENDOCYTIC_2 146 149 PF00928 0.327
TRG_ENDOCYTIC_2 189 192 PF00928 0.327
TRG_ENDOCYTIC_2 228 231 PF00928 0.327
TRG_ENDOCYTIC_2 319 322 PF00928 0.335
TRG_ENDOCYTIC_2 330 333 PF00928 0.311
TRG_ENDOCYTIC_2 344 347 PF00928 0.327
TRG_ENDOCYTIC_2 699 702 PF00928 0.327
TRG_ENDOCYTIC_2 814 817 PF00928 0.362
TRG_ER_diArg_1 139 141 PF00400 0.389
TRG_ER_diArg_1 228 230 PF00400 0.327
TRG_ER_diArg_1 315 318 PF00400 0.362
TRG_ER_diArg_1 336 339 PF00400 0.447
TRG_ER_diArg_1 674 677 PF00400 0.343
TRG_NES_CRM1_1 181 194 PF08389 0.449
TRG_NES_CRM1_1 596 608 PF08389 0.474
TRG_Pf-PMV_PEXEL_1 679 683 PF00026 0.343
TRG_Pf-PMV_PEXEL_1 708 712 PF00026 0.362
TRG_Pf-PMV_PEXEL_1 752 756 PF00026 0.357
TRG_PTS1 911 914 PF00515 0.609

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I112 Leptomonas seymouri 86% 100%
A0A0S4IJT3 Bodo saltans 71% 100%
A0A1X0NUY0 Trypanosomatidae 78% 100%
A0A3Q8I917 Leishmania donovani 100% 100%
A0A3R7KK46 Trypanosoma rangeli 77% 100%
A4H6M6 Leishmania braziliensis 93% 100%
D0A7D9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 100%
E9ANP4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O23404 Arabidopsis thaliana 53% 95%
O27190 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 28% 100%
O29548 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 27% 100%
O57830 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 27% 100%
O83026 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) 25% 100%
O83728 Treponema pallidum (strain Nichols) 33% 100%
P11155 Zea mays 53% 97%
P22221 Flaveria trinervia 54% 96%
P22983 Clostridium symbiosum 57% 100%
P23538 Escherichia coli (strain K12) 24% 100%
P37213 Entamoeba histolytica 49% 100%
P42850 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 28% 100%
P46893 Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) 25% 100%
P51776 Giardia intestinalis 51% 100%
P56070 Helicobacter pylori (strain ATCC 700392 / 26695) 24% 100%
Q1RH78 Rickettsia bellii (strain RML369-C) 46% 100%
Q39734 Flaveria brownii 53% 96%
Q39735 Flaveria bidentis 53% 96%
Q42368 Zea mays 54% 100%
Q42736 Flaveria pringlei 54% 96%
Q42910 Mesembryanthemum crystallinum 53% 96%
Q4QGX9 Leishmania major 99% 100%
Q4ULI7 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 46% 100%
Q55905 Synechocystis sp. (strain PCC 6803 / Kazusa) 23% 100%
Q59754 Rhizobium meliloti (strain 1021) 55% 100%
Q68WP2 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 46% 100%
Q6AVA8 Oryza sativa subsp. japonica 54% 97%
Q75KR1 Oryza sativa subsp. japonica 53% 100%
Q92HI8 Rickettsia conorii (strain ATCC VR-613 / Malish 7) 47% 100%
Q9K0I2 Neisseria meningitidis serogroup B (strain MC58) 25% 100%
Q9V2H7 Pyrococcus abyssi (strain GE5 / Orsay) 27% 100%
Q9YEC5 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 25% 100%
Q9ZD55 Rickettsia prowazekii (strain Madrid E) 46% 100%
Q9ZMV4 Helicobacter pylori (strain J99 / ATCC 700824) 24% 100%
V5BBD4 Trypanosoma cruzi 78% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS