Adaptin-related protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adaptin-related protein-like protein

Species:

Leishmania infantum

UniProt:

A4HV08_LEIIN

TriTrypDb:

LINF_110015900

Length:

991

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	14
GO:0032991	protein-containing complex	1	14
GO:0098796	membrane protein complex	2	14

Expansion

Sequence features

A4HV08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV08

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	14
GO:0006886	intracellular protein transport	4	14
GO:0008104	protein localization	4	14
GO:0009987	cellular process	1	14
GO:0015031	protein transport	4	14
GO:0016192	vesicle-mediated transport	4	14
GO:0033036	macromolecule localization	2	14
GO:0045184	establishment of protein localization	3	14
GO:0046907	intracellular transport	3	14
GO:0051179	localization	1	14
GO:0051234	establishment of localization	2	14
GO:0051641	cellular localization	2	14
GO:0051649	establishment of localization in cell	3	14
GO:0070727	cellular macromolecule localization	3	14
GO:0071702	organic substance transport	4	14
GO:0071705	nitrogen compound transport	4	14

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0030276	clathrin binding	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	527	531	PF00656	0.274
CLV_C14_Caspase3-7	700	704	PF00656	0.757
CLV_NRD_NRD_1	141	143	PF00675	0.260
CLV_NRD_NRD_1	248	250	PF00675	0.252
CLV_NRD_NRD_1	292	294	PF00675	0.242
CLV_NRD_NRD_1	838	840	PF00675	0.397
CLV_NRD_NRD_1	925	927	PF00675	0.479
CLV_PCSK_FUR_1	245	249	PF00082	0.238
CLV_PCSK_KEX2_1	141	143	PF00082	0.260
CLV_PCSK_KEX2_1	247	249	PF00082	0.251
CLV_PCSK_KEX2_1	292	294	PF00082	0.242
CLV_PCSK_KEX2_1	624	626	PF00082	0.498
CLV_PCSK_KEX2_1	69	71	PF00082	0.252
CLV_PCSK_KEX2_1	925	927	PF00082	0.475
CLV_PCSK_PC1ET2_1	624	626	PF00082	0.488
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.252
CLV_PCSK_PC7_1	243	249	PF00082	0.186
CLV_PCSK_SKI1_1	111	115	PF00082	0.275
CLV_PCSK_SKI1_1	169	173	PF00082	0.456
CLV_PCSK_SKI1_1	185	189	PF00082	0.236
CLV_PCSK_SKI1_1	608	612	PF00082	0.289
CLV_PCSK_SKI1_1	614	618	PF00082	0.280
CLV_PCSK_SKI1_1	624	628	PF00082	0.405
CLV_PCSK_SKI1_1	777	781	PF00082	0.314
CLV_PCSK_SKI1_1	797	801	PF00082	0.403
CLV_PCSK_SKI1_1	858	862	PF00082	0.452
CLV_PCSK_SKI1_1	86	90	PF00082	0.283
CLV_PCSK_SKI1_1	931	935	PF00082	0.446
DEG_APCC_DBOX_1	206	214	PF00400	0.347
DEG_COP1_1	333	342	PF00400	0.234
DEG_MDM2_SWIB_1	882	889	PF02201	0.459
DEG_ODPH_VHL_1	861	872	PF01847	0.323
DEG_SCF_FBW7_1	382	387	PF00400	0.234
DEG_SPOP_SBC_1	255	259	PF00917	0.274
DEG_SPOP_SBC_1	59	63	PF00917	0.369
DOC_CKS1_1	381	386	PF01111	0.274
DOC_CKS1_1	756	761	PF01111	0.406
DOC_CYCLIN_RxL_1	166	174	PF00134	0.274
DOC_CYCLIN_RxL_1	666	677	PF00134	0.478
DOC_MAPK_gen_1	141	148	PF00069	0.411
DOC_MAPK_gen_1	408	418	PF00069	0.302
DOC_MAPK_gen_1	69	76	PF00069	0.302
DOC_MAPK_HePTP_8	954	966	PF00069	0.345
DOC_MAPK_JIP1_4	669	675	PF00069	0.443
DOC_MAPK_MEF2A_6	111	120	PF00069	0.328
DOC_MAPK_MEF2A_6	400	409	PF00069	0.300
DOC_MAPK_MEF2A_6	411	418	PF00069	0.328
DOC_MAPK_MEF2A_6	826	834	PF00069	0.459
DOC_MAPK_MEF2A_6	931	938	PF00069	0.458
DOC_MAPK_MEF2A_6	957	966	PF00069	0.406
DOC_MAPK_NFAT4_5	931	939	PF00069	0.485
DOC_PP2B_LxvP_1	337	340	PF13499	0.369
DOC_PP2B_LxvP_1	363	366	PF13499	0.369
DOC_PP2B_LxvP_1	861	864	PF13499	0.334
DOC_PP2B_LxvP_1	870	873	PF13499	0.289
DOC_PP4_FxxP_1	16	19	PF00568	0.366
DOC_PP4_FxxP_1	381	384	PF00568	0.369
DOC_PP4_FxxP_1	401	404	PF00568	0.369
DOC_USP7_MATH_1	156	160	PF00917	0.365
DOC_USP7_MATH_1	253	257	PF00917	0.242
DOC_USP7_MATH_1	342	346	PF00917	0.428
DOC_USP7_MATH_1	59	63	PF00917	0.252
DOC_USP7_MATH_1	729	733	PF00917	0.689
DOC_USP7_MATH_1	817	821	PF00917	0.534
DOC_USP7_UBL2_3	150	154	PF12436	0.244
DOC_USP7_UBL2_3	169	173	PF12436	0.175
DOC_USP7_UBL2_3	396	400	PF12436	0.369
DOC_WW_Pin1_4	311	316	PF00397	0.366
DOC_WW_Pin1_4	380	385	PF00397	0.274
DOC_WW_Pin1_4	755	760	PF00397	0.499
DOC_WW_Pin1_4	838	843	PF00397	0.431
DOC_WW_Pin1_4	968	973	PF00397	0.414
DOC_WW_Pin1_4	99	104	PF00397	0.283
LIG_14-3-3_CanoR_1	32	41	PF00244	0.252
LIG_14-3-3_CanoR_1	350	356	PF00244	0.411
LIG_14-3-3_CanoR_1	417	427	PF00244	0.203
LIG_14-3-3_CanoR_1	614	619	PF00244	0.274
LIG_14-3-3_CanoR_1	625	635	PF00244	0.329
LIG_14-3-3_CanoR_1	797	802	PF00244	0.364
LIG_14-3-3_CanoR_1	909	917	PF00244	0.384
LIG_14-3-3_CanoR_1	957	962	PF00244	0.542
LIG_Actin_WH2_2	555	570	PF00022	0.258
LIG_APCC_ABBA_1	936	941	PF00400	0.408
LIG_BRCT_BRCA1_1	12	16	PF00533	0.455
LIG_BRCT_BRCA1_1	50	54	PF00533	0.302
LIG_Clathr_ClatBox_1	398	402	PF01394	0.369
LIG_Clathr_ClatBox_1	615	619	PF01394	0.274
LIG_EH1_1	208	216	PF00400	0.274
LIG_FHA_1	124	130	PF00498	0.320
LIG_FHA_1	220	226	PF00498	0.274
LIG_FHA_1	262	268	PF00498	0.353
LIG_FHA_1	350	356	PF00498	0.431
LIG_FHA_1	385	391	PF00498	0.368
LIG_FHA_1	481	487	PF00498	0.265
LIG_FHA_1	497	503	PF00498	0.275
LIG_FHA_1	596	602	PF00498	0.377
LIG_FHA_1	628	634	PF00498	0.547
LIG_FHA_1	794	800	PF00498	0.466
LIG_FHA_1	816	822	PF00498	0.372
LIG_FHA_1	841	847	PF00498	0.469
LIG_FHA_1	865	871	PF00498	0.335
LIG_FHA_1	909	915	PF00498	0.468
LIG_FHA_1	951	957	PF00498	0.349
LIG_FHA_2	626	632	PF00498	0.553
LIG_FHA_2	817	823	PF00498	0.466
LIG_FHA_2	873	879	PF00498	0.415
LIG_FHA_2	96	102	PF00498	0.270
LIG_GBD_Chelix_1	390	398	PF00786	0.226
LIG_LIR_Apic_2	13	19	PF02991	0.355
LIG_LIR_Apic_2	892	897	PF02991	0.415
LIG_LIR_Gen_1	198	208	PF02991	0.218
LIG_LIR_Gen_1	219	226	PF02991	0.350
LIG_LIR_Gen_1	35	46	PF02991	0.354
LIG_LIR_Gen_1	369	379	PF02991	0.236
LIG_LIR_Gen_1	403	414	PF02991	0.283
LIG_LIR_Gen_1	51	60	PF02991	0.239
LIG_LIR_Gen_1	538	547	PF02991	0.346
LIG_LIR_Gen_1	750	760	PF02991	0.475
LIG_LIR_Gen_1	867	874	PF02991	0.370
LIG_LIR_Nem_3	198	204	PF02991	0.470
LIG_LIR_Nem_3	219	223	PF02991	0.259
LIG_LIR_Nem_3	35	41	PF02991	0.386
LIG_LIR_Nem_3	369	375	PF02991	0.283
LIG_LIR_Nem_3	383	389	PF02991	0.249
LIG_LIR_Nem_3	51	57	PF02991	0.232
LIG_LIR_Nem_3	538	542	PF02991	0.372
LIG_LIR_Nem_3	599	605	PF02991	0.360
LIG_LIR_Nem_3	750	756	PF02991	0.509
LIG_LIR_Nem_3	867	872	PF02991	0.523
LIG_LIR_Nem_3	884	889	PF02991	0.404
LIG_LYPXL_S_1	601	605	PF13949	0.234
LIG_LYPXL_yS_3	602	605	PF13949	0.234
LIG_NRBOX	167	173	PF00104	0.411
LIG_NRBOX	932	938	PF00104	0.327
LIG_PCNA_APIM_2	394	400	PF02747	0.369
LIG_PCNA_PIPBox_1	559	568	PF02747	0.369
LIG_PCNA_yPIPBox_3	583	594	PF02747	0.226
LIG_Pex14_1	220	224	PF04695	0.283
LIG_Pex14_2	12	16	PF04695	0.388
LIG_Pex14_2	397	401	PF04695	0.351
LIG_Pex14_2	882	886	PF04695	0.324
LIG_REV1ctd_RIR_1	608	618	PF16727	0.310
LIG_SH2_CRK	312	316	PF00017	0.369
LIG_SH2_CRK	38	42	PF00017	0.274
LIG_SH2_NCK_1	152	156	PF00017	0.274
LIG_SH2_PTP2	372	375	PF00017	0.274
LIG_SH2_SRC	199	202	PF00017	0.305
LIG_SH2_STAP1	351	355	PF00017	0.435
LIG_SH2_STAP1	434	438	PF00017	0.254
LIG_SH2_STAT3	646	649	PF00017	0.435
LIG_SH2_STAT5	11	14	PF00017	0.544
LIG_SH2_STAT5	139	142	PF00017	0.250
LIG_SH2_STAT5	199	202	PF00017	0.369
LIG_SH2_STAT5	224	227	PF00017	0.283
LIG_SH2_STAT5	295	298	PF00017	0.369
LIG_SH2_STAT5	351	354	PF00017	0.447
LIG_SH2_STAT5	372	375	PF00017	0.335
LIG_SH2_STAT5	389	392	PF00017	0.213
LIG_SH2_STAT5	406	409	PF00017	0.216
LIG_SH2_STAT5	434	437	PF00017	0.369
LIG_SH2_STAT5	539	542	PF00017	0.424
LIG_SH2_STAT5	566	569	PF00017	0.236
LIG_SH2_STAT5	710	713	PF00017	0.568
LIG_SH2_STAT5	73	76	PF00017	0.283
LIG_SH2_STAT5	859	862	PF00017	0.308
LIG_SH2_STAT5	869	872	PF00017	0.344
LIG_SH2_STAT5	918	921	PF00017	0.273
LIG_SH2_STAT5	939	942	PF00017	0.382
LIG_SH2_STAT5	976	979	PF00017	0.397
LIG_SH3_3	382	388	PF00018	0.374
LIG_SH3_3	753	759	PF00018	0.432
LIG_SH3_3	857	863	PF00018	0.435
LIG_SUMO_SIM_anti_2	314	320	PF11976	0.365
LIG_SUMO_SIM_anti_2	439	445	PF11976	0.271
LIG_SUMO_SIM_anti_2	481	488	PF11976	0.226
LIG_SUMO_SIM_anti_2	508	513	PF11976	0.315
LIG_SUMO_SIM_anti_2	538	544	PF11976	0.372
LIG_SUMO_SIM_anti_2	828	834	PF11976	0.467
LIG_SUMO_SIM_par_1	314	320	PF11976	0.369
LIG_SUMO_SIM_par_1	358	364	PF11976	0.347
LIG_SUMO_SIM_par_1	614	619	PF11976	0.333
LIG_SUMO_SIM_par_1	959	965	PF11976	0.322
LIG_TRAF2_1	698	701	PF00917	0.561
LIG_TRFH_1	859	863	PF08558	0.343
LIG_TRFH_1	869	873	PF08558	0.477
LIG_TYR_ITAM	599	615	PF00017	0.234
LIG_TYR_ITIM	537	542	PF00017	0.242
LIG_TYR_ITIM	71	76	PF00017	0.283
LIG_UBA3_1	164	173	PF00899	0.285
MOD_CDK_SPxxK_3	99	106	PF00069	0.283
MOD_CK1_1	159	165	PF00069	0.340
MOD_CK1_1	254	260	PF00069	0.329
MOD_CK1_1	58	64	PF00069	0.324
MOD_CK1_1	595	601	PF00069	0.280
MOD_CK1_1	665	671	PF00069	0.477
MOD_CK1_1	715	721	PF00069	0.637
MOD_CK1_1	732	738	PF00069	0.567
MOD_CK1_1	746	752	PF00069	0.604
MOD_CK1_1	905	911	PF00069	0.506
MOD_CK1_1	965	971	PF00069	0.573
MOD_CK2_1	24	30	PF00069	0.310
MOD_CK2_1	260	266	PF00069	0.314
MOD_CK2_1	528	534	PF00069	0.376
MOD_CK2_1	625	631	PF00069	0.511
MOD_CK2_1	695	701	PF00069	0.692
MOD_CK2_1	816	822	PF00069	0.568
MOD_CK2_1	872	878	PF00069	0.470
MOD_GlcNHglycan	134	139	PF01048	0.411
MOD_GlcNHglycan	159	162	PF01048	0.294
MOD_GlcNHglycan	181	184	PF01048	0.275
MOD_GlcNHglycan	319	322	PF01048	0.261
MOD_GlcNHglycan	34	37	PF01048	0.269
MOD_GlcNHglycan	56	60	PF01048	0.291
MOD_GlcNHglycan	568	571	PF01048	0.412
MOD_GlcNHglycan	579	582	PF01048	0.404
MOD_GlcNHglycan	594	597	PF01048	0.287
MOD_GlcNHglycan	62	65	PF01048	0.300
MOD_GlcNHglycan	654	657	PF01048	0.447
MOD_GlcNHglycan	697	700	PF01048	0.786
MOD_GlcNHglycan	717	720	PF01048	0.760
MOD_GlcNHglycan	773	776	PF01048	0.537
MOD_GlcNHglycan	967	970	PF01048	0.588
MOD_GSK3_1	123	130	PF00069	0.458
MOD_GSK3_1	251	258	PF00069	0.380
MOD_GSK3_1	328	335	PF00069	0.268
MOD_GSK3_1	380	387	PF00069	0.345
MOD_GSK3_1	528	535	PF00069	0.377
MOD_GSK3_1	55	62	PF00069	0.277
MOD_GSK3_1	708	715	PF00069	0.753
MOD_GSK3_1	724	731	PF00069	0.553
MOD_GSK3_1	739	746	PF00069	0.616
MOD_GSK3_1	747	754	PF00069	0.574
MOD_GSK3_1	769	776	PF00069	0.384
MOD_GSK3_1	793	800	PF00069	0.419
MOD_GSK3_1	905	912	PF00069	0.580
MOD_GSK3_1	95	102	PF00069	0.283
MOD_LATS_1	795	801	PF00433	0.444
MOD_N-GLC_1	156	161	PF02516	0.274
MOD_N-GLC_1	64	69	PF02516	0.280
MOD_N-GLC_1	715	720	PF02516	0.678
MOD_N-GLC_1	729	734	PF02516	0.455
MOD_N-GLC_2	684	686	PF02516	0.468
MOD_NEK2_1	133	138	PF00069	0.347
MOD_NEK2_1	267	272	PF00069	0.202
MOD_NEK2_1	328	333	PF00069	0.335
MOD_NEK2_1	442	447	PF00069	0.369
MOD_NEK2_1	471	476	PF00069	0.220
MOD_NEK2_1	505	510	PF00069	0.378
MOD_NEK2_1	60	65	PF00069	0.236
MOD_NEK2_1	769	774	PF00069	0.357
MOD_NEK2_1	77	82	PF00069	0.269
MOD_NEK2_1	793	798	PF00069	0.361
MOD_NEK2_1	889	894	PF00069	0.455
MOD_NEK2_2	597	602	PF00069	0.274
MOD_NEK2_2	64	69	PF00069	0.226
MOD_PIKK_1	24	30	PF00454	0.236
MOD_PIKK_1	645	651	PF00454	0.533
MOD_PIKK_1	769	775	PF00454	0.319
MOD_PKA_2	349	355	PF00069	0.402
MOD_PKA_2	908	914	PF00069	0.394
MOD_PKA_2	956	962	PF00069	0.445
MOD_Plk_1	134	140	PF00069	0.390
MOD_Plk_1	218	224	PF00069	0.376
MOD_Plk_1	299	305	PF00069	0.369
MOD_Plk_1	342	348	PF00069	0.274
MOD_Plk_1	48	54	PF00069	0.330
MOD_Plk_1	480	486	PF00069	0.369
MOD_Plk_1	55	61	PF00069	0.296
MOD_Plk_1	64	70	PF00069	0.203
MOD_Plk_1	729	735	PF00069	0.546
MOD_Plk_1	77	83	PF00069	0.272
MOD_Plk_1	828	834	PF00069	0.465
MOD_Plk_1	84	90	PF00069	0.265
MOD_Plk_4	116	122	PF00069	0.332
MOD_Plk_4	195	201	PF00069	0.369
MOD_Plk_4	219	225	PF00069	0.387
MOD_Plk_4	351	357	PF00069	0.316
MOD_Plk_4	452	458	PF00069	0.347
MOD_Plk_4	49	55	PF00069	0.401
MOD_Plk_4	507	513	PF00069	0.395
MOD_Plk_4	532	538	PF00069	0.317
MOD_Plk_4	597	603	PF00069	0.237
MOD_Plk_4	739	745	PF00069	0.699
MOD_Plk_4	752	758	PF00069	0.427
MOD_Plk_4	828	834	PF00069	0.535
MOD_Plk_4	889	895	PF00069	0.638
MOD_Plk_4	90	96	PF00069	0.411
MOD_Plk_4	957	963	PF00069	0.407
MOD_ProDKin_1	311	317	PF00069	0.366
MOD_ProDKin_1	380	386	PF00069	0.274
MOD_ProDKin_1	755	761	PF00069	0.503
MOD_ProDKin_1	838	844	PF00069	0.435
MOD_ProDKin_1	968	974	PF00069	0.409
MOD_ProDKin_1	99	105	PF00069	0.283
MOD_SUMO_for_1	399	402	PF00179	0.299
MOD_SUMO_for_1	407	410	PF00179	0.269
MOD_SUMO_rev_2	820	828	PF00179	0.528
TRG_DiLeu_BaEn_1	343	348	PF01217	0.340
TRG_DiLeu_BaEn_1	410	415	PF01217	0.328
TRG_DiLeu_BaEn_1	829	834	PF01217	0.408
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.397
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.514
TRG_DiLeu_BaLyEn_6	944	949	PF01217	0.442
TRG_DiLeu_LyEn_5	343	348	PF01217	0.234
TRG_ENDOCYTIC_2	201	204	PF00928	0.202
TRG_ENDOCYTIC_2	372	375	PF00928	0.240
TRG_ENDOCYTIC_2	38	41	PF00928	0.390
TRG_ENDOCYTIC_2	406	409	PF00928	0.246
TRG_ENDOCYTIC_2	43	46	PF00928	0.354
TRG_ENDOCYTIC_2	539	542	PF00928	0.392
TRG_ENDOCYTIC_2	602	605	PF00928	0.350
TRG_ENDOCYTIC_2	612	615	PF00928	0.255
TRG_ENDOCYTIC_2	73	76	PF00928	0.301
TRG_ENDOCYTIC_2	869	872	PF00928	0.391
TRG_ER_diArg_1	140	142	PF00400	0.260
TRG_ER_diArg_1	245	248	PF00400	0.218
TRG_ER_diArg_1	291	293	PF00400	0.242
TRG_ER_diArg_1	336	339	PF00400	0.460
TRG_ER_diArg_1	783	786	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.236
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.234
TRG_Pf-PMV_PEXEL_1	672	677	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	797	802	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	947	951	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P942	Leptomonas seymouri	66%	100%
A0A0S4IS43	Bodo saltans	33%	100%
A0A1X0NUY1	Trypanosomatidae	37%	100%
A0A3Q8I939	Leishmania donovani	100%	100%
A0A3Q8IK57	Leishmania donovani	30%	100%
A0A3R7L5L0	Trypanosoma rangeli	39%	100%
A4H6M5	Leishmania braziliensis	82%	100%
A4HQJ9	Leishmania braziliensis	28%	100%
A4ICB7	Leishmania infantum	30%	100%
E9ANP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AUB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O43079	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P36000	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q4Q078	Leishmania major	29%	100%
Q4QGY0	Leishmania major	93%	100%
Q54X82	Dictyostelium discoideum	29%	100%
Q9LDK9	Arabidopsis thaliana	22%	100%
V5BRU9	Trypanosoma cruzi	37%	100%