LeishMANIAdb
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SURP motif domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SURP motif domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HV02_LEIIN
TriTrypDb:
LINF_110015300
Length:
377

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 323

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HV02
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HV02

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 3
GO:0043167 ion binding 2 3
GO:0043169 cation binding 3 3
GO:0046872 metal ion binding 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 118 120 PF00675 0.423
CLV_NRD_NRD_1 20 22 PF00675 0.528
CLV_NRD_NRD_1 341 343 PF00675 0.592
CLV_NRD_NRD_1 354 356 PF00675 0.550
CLV_NRD_NRD_1 357 359 PF00675 0.534
CLV_NRD_NRD_1 49 51 PF00675 0.539
CLV_NRD_NRD_1 83 85 PF00675 0.528
CLV_PCSK_FUR_1 338 342 PF00082 0.680
CLV_PCSK_FUR_1 352 356 PF00082 0.558
CLV_PCSK_KEX2_1 279 281 PF00082 0.452
CLV_PCSK_KEX2_1 308 310 PF00082 0.613
CLV_PCSK_KEX2_1 340 342 PF00082 0.524
CLV_PCSK_KEX2_1 354 356 PF00082 0.590
CLV_PCSK_KEX2_1 357 359 PF00082 0.612
CLV_PCSK_KEX2_1 49 51 PF00082 0.550
CLV_PCSK_KEX2_1 83 85 PF00082 0.528
CLV_PCSK_KEX2_1 87 89 PF00082 0.468
CLV_PCSK_PC1ET2_1 279 281 PF00082 0.452
CLV_PCSK_PC1ET2_1 308 310 PF00082 0.613
CLV_PCSK_PC1ET2_1 87 89 PF00082 0.445
CLV_PCSK_PC7_1 83 89 PF00082 0.459
CLV_PCSK_SKI1_1 119 123 PF00082 0.406
CLV_PCSK_SKI1_1 159 163 PF00082 0.589
CLV_PCSK_SKI1_1 172 176 PF00082 0.659
CLV_PCSK_SKI1_1 308 312 PF00082 0.612
CLV_Separin_Metazoa 64 68 PF03568 0.413
DEG_SPOP_SBC_1 54 58 PF00917 0.447
DOC_CYCLIN_yClb5_NLxxxL_5 22 30 PF00134 0.553
DOC_MAPK_gen_1 21 28 PF00069 0.553
DOC_MAPK_MEF2A_6 21 30 PF00069 0.552
DOC_MAPK_NFAT4_5 21 29 PF00069 0.515
DOC_USP7_MATH_1 20 24 PF00917 0.511
DOC_USP7_MATH_1 298 302 PF00917 0.640
DOC_USP7_MATH_1 327 331 PF00917 0.648
DOC_USP7_UBL2_3 132 136 PF12436 0.540
DOC_USP7_UBL2_3 184 188 PF12436 0.637
DOC_USP7_UBL2_3 311 315 PF12436 0.616
DOC_WW_Pin1_4 233 238 PF00397 0.648
DOC_WW_Pin1_4 318 323 PF00397 0.676
DOC_WW_Pin1_4 333 338 PF00397 0.524
DOC_WW_Pin1_4 66 71 PF00397 0.446
LIG_FHA_1 234 240 PF00498 0.583
LIG_FHA_1 25 31 PF00498 0.452
LIG_FHA_1 253 259 PF00498 0.388
LIG_FHA_1 55 61 PF00498 0.549
LIG_FHA_2 191 197 PF00498 0.641
LIG_LIR_Gen_1 154 161 PF02991 0.600
LIG_LIR_Gen_1 254 265 PF02991 0.531
LIG_LIR_Gen_1 61 70 PF02991 0.538
LIG_LIR_Nem_3 154 160 PF02991 0.547
LIG_LIR_Nem_3 164 170 PF02991 0.472
LIG_LIR_Nem_3 254 260 PF02991 0.462
LIG_LIR_Nem_3 61 65 PF02991 0.480
LIG_LIR_Nem_3 69 75 PF02991 0.445
LIG_NRP_CendR_1 374 377 PF00754 0.591
LIG_SH2_PTP2 257 260 PF00017 0.525
LIG_SH2_STAT5 257 260 PF00017 0.460
LIG_SH2_STAT5 265 268 PF00017 0.397
LIG_SH3_1 150 156 PF00018 0.570
LIG_SH3_3 150 156 PF00018 0.667
LIG_SH3_3 222 228 PF00018 0.555
LIG_SH3_3 255 261 PF00018 0.478
LIG_SH3_3 282 288 PF00018 0.460
LIG_SH3_4 311 318 PF00018 0.618
LIG_SUMO_SIM_anti_2 219 226 PF11976 0.540
LIG_TRAF2_1 121 124 PF00917 0.495
LIG_TRAF2_1 144 147 PF00917 0.587
LIG_TRAF2_1 217 220 PF00917 0.400
LIG_TRAF2_1 261 264 PF00917 0.406
MOD_CDK_SPK_2 333 338 PF00069 0.639
MOD_CDK_SPK_2 66 71 PF00069 0.431
MOD_CDK_SPxxK_3 333 340 PF00069 0.517
MOD_CK1_1 251 257 PF00069 0.545
MOD_CK1_1 336 342 PF00069 0.527
MOD_CK1_1 34 40 PF00069 0.458
MOD_CK1_1 370 376 PF00069 0.637
MOD_CK2_1 184 190 PF00069 0.559
MOD_CK2_1 214 220 PF00069 0.438
MOD_CK2_1 345 351 PF00069 0.633
MOD_DYRK1A_RPxSP_1 333 337 PF00069 0.523
MOD_GlcNHglycan 216 219 PF01048 0.411
MOD_GlcNHglycan 250 253 PF01048 0.660
MOD_GlcNHglycan 268 271 PF01048 0.450
MOD_GlcNHglycan 280 283 PF01048 0.390
MOD_GlcNHglycan 33 36 PF01048 0.468
MOD_GlcNHglycan 51 54 PF01048 0.531
MOD_GlcNHglycan 57 60 PF01048 0.519
MOD_GlcNHglycan 75 78 PF01048 0.395
MOD_GSK3_1 191 198 PF00069 0.655
MOD_GSK3_1 199 206 PF00069 0.540
MOD_GSK3_1 20 27 PF00069 0.576
MOD_GSK3_1 228 235 PF00069 0.625
MOD_GSK3_1 248 255 PF00069 0.509
MOD_GSK3_1 30 37 PF00069 0.408
MOD_GSK3_1 327 334 PF00069 0.743
MOD_GSK3_1 336 343 PF00069 0.635
MOD_GSK3_1 346 353 PF00069 0.646
MOD_GSK3_1 49 56 PF00069 0.494
MOD_N-GLC_1 24 29 PF02516 0.561
MOD_N-GLC_1 252 257 PF02516 0.377
MOD_N-GLC_1 31 36 PF02516 0.525
MOD_N-GLC_1 318 323 PF02516 0.659
MOD_NEK2_1 232 237 PF00069 0.556
MOD_NEK2_1 30 35 PF00069 0.410
MOD_NEK2_1 65 70 PF00069 0.421
MOD_PIKK_1 87 93 PF00454 0.343
MOD_PK_1 272 278 PF00069 0.519
MOD_PKA_1 278 284 PF00069 0.459
MOD_PKA_1 340 346 PF00069 0.648
MOD_PKA_1 49 55 PF00069 0.510
MOD_PKA_1 87 93 PF00069 0.466
MOD_PKA_2 20 26 PF00069 0.502
MOD_PKA_2 340 346 PF00069 0.648
MOD_PKA_2 370 376 PF00069 0.595
MOD_PKA_2 49 55 PF00069 0.566
MOD_PKA_2 87 93 PF00069 0.380
MOD_PKB_1 318 326 PF00069 0.516
MOD_PKB_1 338 346 PF00069 0.539
MOD_Plk_1 162 168 PF00069 0.504
MOD_Plk_1 24 30 PF00069 0.556
MOD_Plk_1 252 258 PF00069 0.487
MOD_Plk_1 263 269 PF00069 0.406
MOD_Plk_4 253 259 PF00069 0.569
MOD_Plk_4 272 278 PF00069 0.279
MOD_ProDKin_1 233 239 PF00069 0.648
MOD_ProDKin_1 318 324 PF00069 0.678
MOD_ProDKin_1 333 339 PF00069 0.516
MOD_ProDKin_1 66 72 PF00069 0.448
MOD_SUMO_for_1 161 164 PF00179 0.590
MOD_SUMO_for_1 183 186 PF00179 0.633
MOD_SUMO_rev_2 171 177 PF00179 0.655
MOD_SUMO_rev_2 178 185 PF00179 0.670
TRG_DiLeu_BaEn_1 220 225 PF01217 0.416
TRG_DiLeu_BaEn_2 146 152 PF01217 0.565
TRG_ENDOCYTIC_2 257 260 PF00928 0.546
TRG_ER_diArg_1 317 320 PF00400 0.662
TRG_ER_diArg_1 337 340 PF00400 0.576
TRG_ER_diArg_1 352 355 PF00400 0.595
TRG_ER_diArg_1 82 84 PF00400 0.530
TRG_NLS_MonoExtC_3 307 312 PF00514 0.608
TRG_NLS_MonoExtN_4 306 312 PF00514 0.557
TRG_Pf-PMV_PEXEL_1 120 124 PF00026 0.402
TRG_Pf-PMV_PEXEL_1 42 46 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7D2 Leptomonas seymouri 54% 84%
A0A1X0NWL9 Trypanosomatidae 33% 80%
A0A3R7LWS6 Trypanosoma rangeli 34% 81%
A0A3S7WRS1 Leishmania donovani 99% 100%
A4H6L9 Leishmania braziliensis 86% 100%
E9ANN7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QGY6 Leishmania major 95% 100%
V5DT45 Trypanosoma cruzi 36% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS