START domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

START domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HUZ7_LEIIN

TriTrypDb:

LINF_110014400

Length:

413

Annotations

Annotations by Jardim et al.

Lipid Metabolism, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUZ7

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	16
GO:0008289	lipid binding	2	16

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.421
CLV_NRD_NRD_1	36	38	PF00675	0.476
CLV_PCSK_KEX2_1	36	38	PF00082	0.476
CLV_PCSK_KEX2_1	94	96	PF00082	0.706
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.706
CLV_PCSK_PC7_1	32	38	PF00082	0.466
CLV_PCSK_SKI1_1	116	120	PF00082	0.447
DOC_CKS1_1	117	122	PF01111	0.434
DOC_MAPK_gen_1	36	42	PF00069	0.478
DOC_PP4_FxxP_1	65	68	PF00568	0.385

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4D8	Leptomonas seymouri	75%	100%
A0A0S4INS4	Bodo saltans	39%	100%
A0A1X0NV84	Trypanosomatidae	53%	100%
A0A3Q8IBA5	Leishmania donovani	100%	100%
A0A3Q8IJ21	Leishmania donovani	34%	100%
A0A422MZR8	Trypanosoma rangeli	49%	100%
A4H6L4	Leishmania braziliensis	79%	100%
A4I4Z0	Leishmania infantum	34%	100%
D0A7F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AED5	Leishmania major	33%	100%

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