LeishMANIAdb
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AB hydrolase-1 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AB hydrolase-1 domain-containing protein
Gene product:
Alpha/beta hydrolase family - putative
Species:
Leishmania infantum
UniProt:
A4HUZ4_LEIIN
TriTrypDb:
LINF_110014100
Length:
472

Annotations

LeishMANIAdb annotations

Posesses a conserved AB hydrolase domain. Due to the distribution of hydrophilic / hydrophobic amino acids, it likely only has a perimembrane helix, not a full TM one.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 23
NetGPI no yes: 0, no: 23
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A4HUZ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUZ4

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 3
GO:0008152 metabolic process 1 3
GO:0009987 cellular process 1 3
GO:0044237 cellular metabolic process 2 3
GO:0044238 primary metabolic process 2 3
GO:0044255 cellular lipid metabolic process 3 3
GO:0071704 organic substance metabolic process 2 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016298 lipase activity 4 3
GO:0016787 hydrolase activity 2 5
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0034338 short-chain carboxylesterase activity 5 3
GO:0047372 acylglycerol lipase activity 5 3
GO:0052689 carboxylic ester hydrolase activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 69 75 PF00089 0.467
CLV_NRD_NRD_1 326 328 PF00675 0.523
CLV_NRD_NRD_1 71 73 PF00675 0.538
CLV_PCSK_FUR_1 68 72 PF00082 0.450
CLV_PCSK_KEX2_1 70 72 PF00082 0.454
CLV_PCSK_SKI1_1 25 29 PF00082 0.330
CLV_PCSK_SKI1_1 328 332 PF00082 0.528
CLV_PCSK_SKI1_1 334 338 PF00082 0.564
CLV_PCSK_SKI1_1 346 350 PF00082 0.515
CLV_PCSK_SKI1_1 463 467 PF00082 0.506
CLV_PCSK_SKI1_1 55 59 PF00082 0.546
CLV_Separin_Metazoa 209 213 PF03568 0.377
DEG_APCC_DBOX_1 333 341 PF00400 0.358
DEG_Nend_UBRbox_1 1 4 PF02207 0.588
DEG_SCF_FBW7_2 443 449 PF00400 0.365
DEG_SPOP_SBC_1 135 139 PF00917 0.400
DOC_CDC14_PxL_1 166 174 PF14671 0.311
DOC_CDC14_PxL_1 20 28 PF14671 0.338
DOC_CKS1_1 239 244 PF01111 0.392
DOC_CKS1_1 286 291 PF01111 0.372
DOC_CKS1_1 443 448 PF01111 0.365
DOC_MAPK_DCC_7 238 247 PF00069 0.400
DOC_MAPK_gen_1 394 402 PF00069 0.295
DOC_MAPK_gen_1 68 77 PF00069 0.252
DOC_MAPK_MEF2A_6 12 20 PF00069 0.439
DOC_MAPK_MEF2A_6 243 252 PF00069 0.331
DOC_MAPK_MEF2A_6 394 402 PF00069 0.259
DOC_PP1_RVXF_1 161 168 PF00149 0.341
DOC_PP1_RVXF_1 23 29 PF00149 0.302
DOC_PP1_RVXF_1 4 10 PF00149 0.453
DOC_PP2B_LxvP_1 127 130 PF13499 0.322
DOC_PP2B_LxvP_1 208 211 PF13499 0.379
DOC_PP2B_LxvP_1 390 393 PF13499 0.227
DOC_PP2B_PxIxI_1 245 251 PF00149 0.376
DOC_PP4_FxxP_1 167 170 PF00568 0.327
DOC_PP4_FxxP_1 349 352 PF00568 0.394
DOC_PP4_FxxP_1 376 379 PF00568 0.309
DOC_PP4_FxxP_1 73 76 PF00568 0.357
DOC_USP7_MATH_1 100 104 PF00917 0.369
DOC_USP7_MATH_1 135 139 PF00917 0.482
DOC_USP7_MATH_1 185 189 PF00917 0.289
DOC_USP7_MATH_1 415 419 PF00917 0.279
DOC_USP7_MATH_1 421 425 PF00917 0.243
DOC_WW_Pin1_4 136 141 PF00397 0.462
DOC_WW_Pin1_4 143 148 PF00397 0.490
DOC_WW_Pin1_4 203 208 PF00397 0.307
DOC_WW_Pin1_4 238 243 PF00397 0.411
DOC_WW_Pin1_4 285 290 PF00397 0.332
DOC_WW_Pin1_4 350 355 PF00397 0.301
DOC_WW_Pin1_4 375 380 PF00397 0.330
DOC_WW_Pin1_4 394 399 PF00397 0.291
DOC_WW_Pin1_4 442 447 PF00397 0.272
LIG_14-3-3_CanoR_1 2 9 PF00244 0.572
LIG_14-3-3_CanoR_1 307 313 PF00244 0.415
LIG_14-3-3_CanoR_1 358 365 PF00244 0.335
LIG_14-3-3_CanoR_1 420 430 PF00244 0.231
LIG_BRCT_BRCA1_1 214 218 PF00533 0.345
LIG_CSL_BTD_1 390 393 PF09270 0.347
LIG_eIF4E_1 21 27 PF01652 0.391
LIG_FHA_1 176 182 PF00498 0.324
LIG_FHA_1 2 8 PF00498 0.570
LIG_FHA_1 203 209 PF00498 0.334
LIG_FHA_1 217 223 PF00498 0.248
LIG_FHA_1 395 401 PF00498 0.238
LIG_FHA_1 427 433 PF00498 0.345
LIG_FHA_2 204 210 PF00498 0.368
LIG_FHA_2 215 221 PF00498 0.312
LIG_IBAR_NPY_1 426 428 PF08397 0.218
LIG_Integrin_RGD_1 451 453 PF01839 0.549
LIG_LIR_Apic_2 125 131 PF02991 0.395
LIG_LIR_Gen_1 297 308 PF02991 0.359
LIG_LIR_Nem_3 297 303 PF02991 0.354
LIG_LIR_Nem_3 311 317 PF02991 0.400
LIG_LIR_Nem_3 416 422 PF02991 0.349
LIG_LIR_Nem_3 425 431 PF02991 0.325
LIG_Pex14_2 214 218 PF04695 0.327
LIG_SH2_CRK 314 318 PF00017 0.344
LIG_SH2_CRK 85 89 PF00017 0.283
LIG_SH2_GRB2like 368 371 PF00017 0.388
LIG_SH2_NCK_1 300 304 PF00017 0.351
LIG_SH2_NCK_1 383 387 PF00017 0.247
LIG_SH2_SRC 126 129 PF00017 0.252
LIG_SH2_SRC 368 371 PF00017 0.228
LIG_SH2_STAP1 109 113 PF00017 0.325
LIG_SH2_STAP1 318 322 PF00017 0.330
LIG_SH2_STAP1 428 432 PF00017 0.208
LIG_SH2_STAT3 117 120 PF00017 0.344
LIG_SH2_STAT3 229 232 PF00017 0.240
LIG_SH2_STAT5 126 129 PF00017 0.367
LIG_SH2_STAT5 180 183 PF00017 0.291
LIG_SH2_STAT5 224 227 PF00017 0.286
LIG_SH2_STAT5 229 232 PF00017 0.306
LIG_SH2_STAT5 262 265 PF00017 0.291
LIG_SH2_STAT5 368 371 PF00017 0.269
LIG_SH2_STAT5 428 431 PF00017 0.271
LIG_SH3_1 102 108 PF00018 0.269
LIG_SH3_3 102 108 PF00018 0.334
LIG_SH3_3 283 289 PF00018 0.383
LIG_SH3_3 293 299 PF00018 0.320
LIG_SH3_3 429 435 PF00018 0.272
LIG_SH3_3 45 51 PF00018 0.440
LIG_SUMO_SIM_anti_2 56 61 PF11976 0.356
LIG_SUMO_SIM_par_1 291 297 PF11976 0.320
LIG_TRAF2_1 378 381 PF00917 0.269
LIG_TYR_ITIM 312 317 PF00017 0.314
MOD_CDK_SPK_2 238 243 PF00069 0.309
MOD_CK1_1 133 139 PF00069 0.511
MOD_CK1_1 151 157 PF00069 0.376
MOD_CK1_1 40 46 PF00069 0.528
MOD_CK2_1 203 209 PF00069 0.464
MOD_CK2_1 214 220 PF00069 0.397
MOD_CK2_1 375 381 PF00069 0.357
MOD_CK2_1 452 458 PF00069 0.419
MOD_CMANNOS 34 37 PF00535 0.310
MOD_GlcNHglycan 102 105 PF01048 0.422
MOD_GlcNHglycan 153 156 PF01048 0.514
MOD_GlcNHglycan 214 217 PF01048 0.360
MOD_GlcNHglycan 282 285 PF01048 0.494
MOD_GlcNHglycan 290 293 PF01048 0.328
MOD_GlcNHglycan 308 311 PF01048 0.296
MOD_GSK3_1 1 8 PF00069 0.567
MOD_GSK3_1 129 136 PF00069 0.518
MOD_GSK3_1 139 146 PF00069 0.607
MOD_GSK3_1 212 219 PF00069 0.336
MOD_GSK3_1 288 295 PF00069 0.326
MOD_N-GLC_1 173 178 PF02516 0.436
MOD_N-GLC_1 369 374 PF02516 0.431
MOD_NEK2_1 148 153 PF00069 0.449
MOD_NEK2_1 173 178 PF00069 0.396
MOD_NEK2_1 214 219 PF00069 0.358
MOD_NEK2_1 308 313 PF00069 0.440
MOD_PK_1 358 364 PF00069 0.370
MOD_PKA_2 1 7 PF00069 0.470
MOD_PKA_2 306 312 PF00069 0.323
MOD_PKA_2 357 363 PF00069 0.409
MOD_PKA_2 40 46 PF00069 0.533
MOD_Plk_1 318 324 PF00069 0.305
MOD_Plk_1 415 421 PF00069 0.524
MOD_Plk_1 55 61 PF00069 0.432
MOD_Plk_4 255 261 PF00069 0.325
MOD_Plk_4 308 314 PF00069 0.392
MOD_Plk_4 426 432 PF00069 0.370
MOD_Plk_4 55 61 PF00069 0.481
MOD_Plk_4 93 99 PF00069 0.340
MOD_ProDKin_1 136 142 PF00069 0.595
MOD_ProDKin_1 143 149 PF00069 0.634
MOD_ProDKin_1 203 209 PF00069 0.382
MOD_ProDKin_1 238 244 PF00069 0.526
MOD_ProDKin_1 285 291 PF00069 0.410
MOD_ProDKin_1 350 356 PF00069 0.359
MOD_ProDKin_1 375 381 PF00069 0.410
MOD_ProDKin_1 394 400 PF00069 0.353
MOD_ProDKin_1 442 448 PF00069 0.328
TRG_DiLeu_BaEn_1 456 461 PF01217 0.381
TRG_DiLeu_BaLyEn_6 243 248 PF01217 0.458
TRG_DiLeu_BaLyEn_6 385 390 PF01217 0.264
TRG_ENDOCYTIC_2 300 303 PF00928 0.440
TRG_ENDOCYTIC_2 314 317 PF00928 0.423
TRG_ER_diArg_1 393 396 PF00400 0.411
TRG_ER_diArg_1 67 70 PF00400 0.534
TRG_ER_diArg_1 71 73 PF00400 0.325
TRG_Pf-PMV_PEXEL_1 111 115 PF00026 0.475
TRG_Pf-PMV_PEXEL_1 261 265 PF00026 0.305
TRG_Pf-PMV_PEXEL_1 315 319 PF00026 0.418
TRG_Pf-PMV_PEXEL_1 346 350 PF00026 0.459
TRG_Pf-PMV_PEXEL_1 420 425 PF00026 0.460

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L7 Leptomonas seymouri 30% 100%
A0A0N1HZ60 Leptomonas seymouri 66% 100%
A0A0N1I523 Leptomonas seymouri 29% 100%
A0A0N1I5Q2 Leptomonas seymouri 35% 93%
A0A0N1I7U8 Leptomonas seymouri 31% 100%
A0A0S4JMS7 Bodo saltans 31% 100%
A0A0S4JTS9 Bodo saltans 30% 100%
A0A1X0NEW5 Trypanosomatidae 31% 100%
A0A1X0NSK7 Trypanosomatidae 31% 100%
A0A1X0NUZ6 Trypanosomatidae 30% 100%
A0A3S5H6J1 Leishmania donovani 100% 100%
A0A3S7X2V6 Leishmania donovani 32% 100%
A0A422NB49 Trypanosoma rangeli 34% 100%
A0A422NQC5 Trypanosoma rangeli 37% 100%
A4H6L0 Leishmania braziliensis 35% 97%
A4HHU6 Leishmania braziliensis 31% 100%
A4I4Z6 Leishmania infantum 32% 100%
C9ZPB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9ANM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9ANM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B0C6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
P38295 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
Q02891 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
Q03649 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
Q0VC00 Bos taurus 25% 100%
Q18610 Caenorhabditis elegans 21% 100%
Q24093 Drosophila melanogaster 23% 100%
Q3T0A0 Bos taurus 25% 100%
Q40863 Picea glauca 28% 100%
Q4Q7V8 Leishmania major 30% 98%
Q4QGZ4 Leishmania major 96% 100%
Q4QGZ5 Leishmania major 35% 100%
Q5RK23 Rattus norvegicus 24% 100%
Q8WU67 Homo sapiens 25% 100%
Q91ZH7 Mus musculus 25% 100%
Q96SE0 Homo sapiens 24% 100%
Q9QZC8 Mus musculus 23% 100%
V5AZF4 Trypanosoma cruzi 34% 100%
V5BBC2 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS