DUF1421 domain-containing protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUZ1_LEIIN

TriTrypDb:

LINF_110013800

Length:

337

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 172, 176, 182

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HUZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	99	101	PF00082	0.514
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.514
CLV_PCSK_SKI1_1	68	72	PF00082	0.598
CLV_PCSK_SKI1_1	92	96	PF00082	0.502
DEG_Nend_UBRbox_2	1	3	PF02207	0.620
DEG_SIAH_1	176	184	PF03145	0.745
DOC_CKS1_1	5	10	PF01111	0.526
DOC_PP1_RVXF_1	66	73	PF00149	0.568
DOC_PP4_FxxP_1	72	75	PF00568	0.587
DOC_PP4_MxPP_1	201	204	PF00568	0.722
DOC_PP4_MxPP_1	288	291	PF00568	0.714
DOC_USP7_MATH_1	105	109	PF00917	0.537
DOC_USP7_MATH_1	169	173	PF00917	0.670
DOC_USP7_MATH_1	331	335	PF00917	0.650
DOC_WW_Pin1_4	173	178	PF00397	0.650
DOC_WW_Pin1_4	179	184	PF00397	0.642
DOC_WW_Pin1_4	4	9	PF00397	0.658
LIG_14-3-3_CanoR_1	170	177	PF00244	0.648
LIG_14-3-3_CanoR_1	317	323	PF00244	0.749
LIG_14-3-3_CanoR_1	68	73	PF00244	0.557
LIG_deltaCOP1_diTrp_1	225	233	PF00928	0.634
LIG_FHA_1	129	135	PF00498	0.457
LIG_FHA_1	69	75	PF00498	0.602
LIG_FHA_1	80	86	PF00498	0.408
LIG_LIR_Apic_2	71	75	PF02991	0.565
LIG_PTB_Apo_2	32	39	PF02174	0.640
LIG_SH2_NCK_1	322	326	PF00017	0.625
LIG_SH2_STAP1	295	299	PF00017	0.648
LIG_SH2_STAP1	54	58	PF00017	0.565
LIG_SH2_STAT3	221	224	PF00017	0.734
LIG_SH3_1	284	290	PF00018	0.663
LIG_SH3_3	2	8	PF00018	0.617
LIG_SH3_3	284	290	PF00018	0.609
LIG_SUMO_SIM_par_1	57	64	PF11976	0.550
LIG_TRAF2_1	23	26	PF00917	0.746
MOD_CK1_1	318	324	PF00069	0.743
MOD_CK2_1	58	64	PF00069	0.520
MOD_CK2_1	80	86	PF00069	0.518
MOD_GlcNHglycan	211	214	PF01048	0.702
MOD_GlcNHglycan	271	274	PF01048	0.665
MOD_GlcNHglycan	333	336	PF01048	0.661
MOD_GlcNHglycan	82	85	PF01048	0.515
MOD_GSK3_1	164	171	PF00069	0.582
MOD_N-GLC_1	68	73	PF02516	0.557
MOD_NEK2_1	143	148	PF00069	0.585
MOD_NEK2_1	302	307	PF00069	0.529
MOD_PIKK_1	143	149	PF00454	0.502
MOD_PIKK_1	162	168	PF00454	0.410
MOD_PIKK_1	169	175	PF00454	0.594
MOD_PIKK_1	315	321	PF00454	0.748
MOD_PKA_2	169	175	PF00069	0.642
MOD_Plk_1	116	122	PF00069	0.440
MOD_Plk_1	68	74	PF00069	0.555
MOD_Plk_4	58	64	PF00069	0.520
MOD_ProDKin_1	173	179	PF00069	0.649
MOD_ProDKin_1	181	187	PF00069	0.638
MOD_ProDKin_1	4	10	PF00069	0.658
TRG_DiLeu_BaEn_1	137	142	PF01217	0.589
TRG_DiLeu_BaEn_3	25	31	PF01217	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL54	Leptomonas seymouri	60%	71%
A0A3S7WRM1	Leishmania donovani	100%	100%
A4H6K6	Leishmania braziliensis	83%	100%
E9ANM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QGZ7	Leishmania major	98%	100%