PUF nine target 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PUF nine target 1

Gene product:

PUF nine target 1

Species:

Leishmania infantum

UniProt:

A4HUY2_LEIIN

TriTrypDb:

LINF_110012900

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HUY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	600	604	PF00656	0.673
CLV_C14_Caspase3-7	617	621	PF00656	0.628
CLV_NRD_NRD_1	298	300	PF00675	0.508
CLV_NRD_NRD_1	351	353	PF00675	0.657
CLV_NRD_NRD_1	358	360	PF00675	0.706
CLV_NRD_NRD_1	4	6	PF00675	0.488
CLV_NRD_NRD_1	515	517	PF00675	0.529
CLV_PCSK_KEX2_1	298	300	PF00082	0.548
CLV_PCSK_KEX2_1	351	353	PF00082	0.658
CLV_PCSK_KEX2_1	357	359	PF00082	0.702
CLV_PCSK_KEX2_1	4	6	PF00082	0.491
CLV_PCSK_KEX2_1	510	512	PF00082	0.604
CLV_PCSK_KEX2_1	514	516	PF00082	0.578
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.605
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.601
CLV_PCSK_PC7_1	511	517	PF00082	0.573
CLV_PCSK_SKI1_1	320	324	PF00082	0.378
CLV_PCSK_SKI1_1	35	39	PF00082	0.357
CLV_PCSK_SKI1_1	392	396	PF00082	0.644
CLV_PCSK_SKI1_1	426	430	PF00082	0.656
CLV_PCSK_SKI1_1	510	514	PF00082	0.550
CLV_PCSK_SKI1_1	515	519	PF00082	0.558
CLV_PCSK_SKI1_1	583	587	PF00082	0.694
DEG_APCC_DBOX_1	239	247	PF00400	0.470
DEG_SPOP_SBC_1	404	408	PF00917	0.518
DEG_SPOP_SBC_1	613	617	PF00917	0.631
DOC_CYCLIN_RxL_1	387	397	PF00134	0.641
DOC_CYCLIN_RxL_1	4	16	PF00134	0.448
DOC_CYCLIN_RxL_1	580	588	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.580
DOC_MAPK_gen_1	181	188	PF00069	0.317
DOC_MAPK_gen_1	298	308	PF00069	0.513
DOC_MAPK_gen_1	32	42	PF00069	0.377
DOC_MAPK_gen_1	4	12	PF00069	0.372
DOC_PP1_RVXF_1	588	594	PF00149	0.603
DOC_PP2B_LxvP_1	431	434	PF13499	0.577
DOC_PP2B_LxvP_1	610	613	PF13499	0.738
DOC_PP2B_LxvP_1	631	634	PF13499	0.587
DOC_PP4_FxxP_1	182	185	PF00568	0.283
DOC_PP4_FxxP_1	258	261	PF00568	0.557
DOC_USP7_MATH_1	247	251	PF00917	0.491
DOC_USP7_MATH_1	374	378	PF00917	0.680
DOC_USP7_MATH_1	379	383	PF00917	0.785
DOC_USP7_MATH_1	403	407	PF00917	0.682
DOC_USP7_MATH_1	44	48	PF00917	0.357
DOC_USP7_MATH_1	536	540	PF00917	0.615
DOC_USP7_MATH_1	621	625	PF00917	0.678
DOC_USP7_MATH_1	87	91	PF00917	0.338
DOC_USP7_UBL2_3	510	514	PF12436	0.604
DOC_USP7_UBL2_3	518	522	PF12436	0.607
DOC_USP7_UBL2_3	64	68	PF12436	0.499
DOC_WW_Pin1_4	281	286	PF00397	0.617
DOC_WW_Pin1_4	408	413	PF00397	0.589
DOC_WW_Pin1_4	429	434	PF00397	0.604
DOC_WW_Pin1_4	530	535	PF00397	0.637
DOC_WW_Pin1_4	576	581	PF00397	0.716
LIG_14-3-3_CanoR_1	109	113	PF00244	0.377
LIG_14-3-3_CanoR_1	231	235	PF00244	0.451
LIG_14-3-3_CanoR_1	277	282	PF00244	0.697
LIG_14-3-3_CanoR_1	35	43	PF00244	0.422
LIG_14-3-3_CanoR_1	590	594	PF00244	0.637
LIG_14-3-3_CanoR_1	636	644	PF00244	0.701
LIG_BRCT_BRCA1_1	379	383	PF00533	0.629
LIG_CtBP_PxDLS_1	447	451	PF00389	0.587
LIG_CtBP_PxDLS_1	607	611	PF00389	0.521
LIG_FHA_1	147	153	PF00498	0.289
LIG_FHA_1	208	214	PF00498	0.283
LIG_FHA_1	328	334	PF00498	0.533
LIG_FHA_1	580	586	PF00498	0.536
LIG_FHA_1	626	632	PF00498	0.700
LIG_FHA_2	162	168	PF00498	0.317
LIG_FHA_2	204	210	PF00498	0.345
LIG_FHA_2	489	495	PF00498	0.503
LIG_FHA_2	598	604	PF00498	0.590
LIG_Integrin_RGD_1	202	204	PF01839	0.377
LIG_LIR_Apic_2	180	185	PF02991	0.283
LIG_LIR_Apic_2	233	238	PF02991	0.563
LIG_LIR_Apic_2	256	261	PF02991	0.591
LIG_LIR_Gen_1	101	110	PF02991	0.378
LIG_LIR_Gen_1	123	133	PF02991	0.386
LIG_LIR_Gen_1	167	176	PF02991	0.348
LIG_LIR_Gen_1	204	213	PF02991	0.283
LIG_LIR_Gen_1	463	473	PF02991	0.352
LIG_LIR_Gen_1	494	502	PF02991	0.562
LIG_LIR_Gen_1	75	81	PF02991	0.430
LIG_LIR_Nem_3	101	105	PF02991	0.341
LIG_LIR_Nem_3	123	129	PF02991	0.386
LIG_LIR_Nem_3	167	171	PF02991	0.348
LIG_LIR_Nem_3	204	208	PF02991	0.263
LIG_LIR_Nem_3	233	237	PF02991	0.540
LIG_LIR_Nem_3	463	468	PF02991	0.355
LIG_LIR_Nem_3	75	80	PF02991	0.401
LIG_LIR_Nem_3	90	94	PF02991	0.232
LIG_PCNA_yPIPBox_3	516	530	PF02747	0.575
LIG_PCNA_yPIPBox_3	623	636	PF02747	0.589
LIG_PDZ_Class_1	648	653	PF00595	0.636
LIG_Pex14_2	131	135	PF04695	0.283
LIG_Pex14_2	80	84	PF04695	0.367
LIG_RPA_C_Fungi	354	366	PF08784	0.654
LIG_SH2_CRK	235	239	PF00017	0.556
LIG_SH2_CRK	66	70	PF00017	0.490
LIG_SH2_NCK_1	229	233	PF00017	0.437
LIG_SH2_NCK_1	235	239	PF00017	0.462
LIG_SH2_PTP2	102	105	PF00017	0.434
LIG_SH2_STAP1	481	485	PF00017	0.445
LIG_SH2_STAT3	481	484	PF00017	0.545
LIG_SH2_STAT5	102	105	PF00017	0.340
LIG_SH2_STAT5	151	154	PF00017	0.283
LIG_SH2_STAT5	196	199	PF00017	0.283
LIG_SH2_STAT5	219	222	PF00017	0.340
LIG_SH2_STAT5	328	331	PF00017	0.381
LIG_SH2_STAT5	91	94	PF00017	0.300
LIG_SH3_1	279	285	PF00018	0.680
LIG_SH3_3	279	285	PF00018	0.680
LIG_SH3_3	498	504	PF00018	0.583
LIG_SH3_3	574	580	PF00018	0.596
LIG_Sin3_3	126	133	PF02671	0.348
LIG_SUMO_SIM_par_1	286	291	PF11976	0.648
LIG_SUMO_SIM_par_1	321	327	PF11976	0.372
LIG_SUMO_SIM_par_1	601	611	PF11976	0.517
LIG_SUMO_SIM_par_1	627	632	PF11976	0.568
LIG_SxIP_EBH_1	466	476	PF03271	0.396
LIG_TRAF2_1	457	460	PF00917	0.461
LIG_UBA3_1	322	326	PF00899	0.402
LIG_WRC_WIRS_1	77	82	PF05994	0.357
LIG_WW_3	1	5	PF00397	0.481
MOD_CDK_SPK_2	530	535	PF00069	0.637
MOD_CDK_SPK_2	576	581	PF00069	0.595
MOD_CDK_SPxxK_3	576	583	PF00069	0.540
MOD_CK1_1	177	183	PF00069	0.315
MOD_CK1_1	327	333	PF00069	0.578
MOD_CK1_1	377	383	PF00069	0.707
MOD_CK1_1	449	455	PF00069	0.576
MOD_CK1_1	496	502	PF00069	0.540
MOD_CK1_1	506	512	PF00069	0.526
MOD_CK1_1	539	545	PF00069	0.604
MOD_CK1_1	579	585	PF00069	0.552
MOD_CK1_1	592	598	PF00069	0.549
MOD_CK1_1	602	608	PF00069	0.574
MOD_CK1_1	615	621	PF00069	0.555
MOD_CK1_1	625	631	PF00069	0.648
MOD_CK1_1	639	645	PF00069	0.674
MOD_CK2_1	280	286	PF00069	0.640
MOD_CK2_1	454	460	PF00069	0.454
MOD_CK2_1	488	494	PF00069	0.475
MOD_CMANNOS	23	26	PF00535	0.346
MOD_Cter_Amidation	355	358	PF01082	0.660
MOD_GlcNHglycan	176	179	PF01048	0.286
MOD_GlcNHglycan	272	275	PF01048	0.794
MOD_GlcNHglycan	290	293	PF01048	0.583
MOD_GlcNHglycan	370	373	PF01048	0.694
MOD_GlcNHglycan	377	380	PF01048	0.699
MOD_GlcNHglycan	456	459	PF01048	0.425
MOD_GlcNHglycan	494	498	PF01048	0.610
MOD_GlcNHglycan	541	544	PF01048	0.609
MOD_GlcNHglycan	562	565	PF01048	0.782
MOD_GlcNHglycan	571	574	PF01048	0.510
MOD_GlcNHglycan	610	613	PF01048	0.633
MOD_GlcNHglycan	650	653	PF01048	0.639
MOD_GSK3_1	170	177	PF00069	0.348
MOD_GSK3_1	203	210	PF00069	0.312
MOD_GSK3_1	247	254	PF00069	0.542
MOD_GSK3_1	277	284	PF00069	0.735
MOD_GSK3_1	308	315	PF00069	0.509
MOD_GSK3_1	374	381	PF00069	0.690
MOD_GSK3_1	404	411	PF00069	0.646
MOD_GSK3_1	44	51	PF00069	0.363
MOD_GSK3_1	446	453	PF00069	0.773
MOD_GSK3_1	476	483	PF00069	0.549
MOD_GSK3_1	530	537	PF00069	0.618
MOD_GSK3_1	589	596	PF00069	0.601
MOD_GSK3_1	597	604	PF00069	0.605
MOD_GSK3_1	608	615	PF00069	0.774
MOD_GSK3_1	621	628	PF00069	0.631
MOD_GSK3_1	639	646	PF00069	0.686
MOD_LATS_1	144	150	PF00433	0.317
MOD_N-GLC_1	174	179	PF02516	0.377
MOD_N-GLC_1	597	602	PF02516	0.622
MOD_N-GLC_1	622	627	PF02516	0.617
MOD_NEK2_1	13	18	PF00069	0.385
MOD_NEK2_1	288	293	PF00069	0.650
MOD_NEK2_1	308	313	PF00069	0.317
MOD_NEK2_1	436	441	PF00069	0.706
MOD_NEK2_1	450	455	PF00069	0.574
MOD_NEK2_1	488	493	PF00069	0.463
MOD_NEK2_1	545	550	PF00069	0.491
MOD_NEK2_1	591	596	PF00069	0.658
MOD_NEK2_1	608	613	PF00069	0.613
MOD_NEK2_1	614	619	PF00069	0.551
MOD_NEK2_1	76	81	PF00069	0.348
MOD_NEK2_2	622	627	PF00069	0.577
MOD_PIKK_1	253	259	PF00454	0.494
MOD_PIKK_1	480	486	PF00454	0.438
MOD_PK_1	476	482	PF00069	0.528
MOD_PKA_2	108	114	PF00069	0.377
MOD_PKA_2	230	236	PF00069	0.474
MOD_PKA_2	294	300	PF00069	0.522
MOD_PKA_2	589	595	PF00069	0.666
MOD_PKB_1	357	365	PF00069	0.685
MOD_Plk_1	174	180	PF00069	0.368
MOD_Plk_1	18	24	PF00069	0.447
MOD_Plk_1	203	209	PF00069	0.298
MOD_Plk_1	247	253	PF00069	0.499
MOD_Plk_1	308	314	PF00069	0.512
MOD_Plk_1	426	432	PF00069	0.599
MOD_Plk_1	493	499	PF00069	0.541
MOD_Plk_1	602	608	PF00069	0.667
MOD_Plk_1	622	628	PF00069	0.577
MOD_Plk_2-3	48	54	PF00069	0.453
MOD_Plk_4	230	236	PF00069	0.455
MOD_Plk_4	308	314	PF00069	0.497
MOD_Plk_4	324	330	PF00069	0.369
MOD_Plk_4	476	482	PF00069	0.528
MOD_Plk_4	625	631	PF00069	0.666
MOD_Plk_4	76	82	PF00069	0.356
MOD_ProDKin_1	281	287	PF00069	0.616
MOD_ProDKin_1	408	414	PF00069	0.587
MOD_ProDKin_1	429	435	PF00069	0.603
MOD_ProDKin_1	530	536	PF00069	0.637
MOD_ProDKin_1	576	582	PF00069	0.715
MOD_SUMO_rev_2	315	322	PF00179	0.442
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.589
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.338
TRG_ENDOCYTIC_2	102	105	PF00928	0.340
TRG_ENDOCYTIC_2	168	171	PF00928	0.348
TRG_ENDOCYTIC_2	495	498	PF00928	0.565
TRG_ENDOCYTIC_2	66	69	PF00928	0.393
TRG_ER_diArg_1	298	301	PF00400	0.683
TRG_ER_diArg_1	3	5	PF00400	0.456
TRG_ER_diArg_1	351	353	PF00400	0.655
TRG_ER_diArg_1	357	359	PF00400	0.699
TRG_ER_diArg_1	580	583	PF00400	0.603
TRG_NLS_MonoExtC_3	513	518	PF00514	0.595
TRG_NLS_MonoExtN_4	511	518	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	358	363	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	583	588	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q1	Leptomonas seymouri	74%	100%
A0A3S5H6I9	Leishmania donovani	100%	100%
A0A422NQF9	Trypanosoma rangeli	46%	100%
A4H6J7	Leishmania braziliensis	81%	98%
D0A7G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ANL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QH06	Leishmania major	92%	100%