ANK_REP_REGION domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Ankyrin repeat/Ankyrin repeats (many copies) - putative

Species:

Leishmania infantum

UniProt:

A4HUX9_LEIIN

TriTrypDb:

LINF_110012600

Length:

226

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HUX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	124	130	PF00089	0.369
CLV_NRD_NRD_1	207	209	PF00675	0.426
CLV_PCSK_KEX2_1	209	211	PF00082	0.413
CLV_PCSK_KEX2_1	213	215	PF00082	0.370
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.435
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.396
CLV_PCSK_SKI1_1	146	150	PF00082	0.376
CLV_PCSK_SKI1_1	62	66	PF00082	0.295
CLV_Separin_Metazoa	143	147	PF03568	0.454
DOC_MAPK_HePTP_8	16	28	PF00069	0.162
DOC_MAPK_MEF2A_6	19	28	PF00069	0.162
DOC_MAPK_MEF2A_6	46	53	PF00069	0.353
DOC_USP7_MATH_1	120	124	PF00917	0.376
DOC_USP7_UBL2_3	209	213	PF12436	0.420
DOC_WW_Pin1_4	199	204	PF00397	0.389
DOC_WW_Pin1_4	44	49	PF00397	0.313
DOC_WW_Pin1_4	77	82	PF00397	0.372
LIG_14-3-3_CanoR_1	114	120	PF00244	0.479
LIG_eIF4E_1	161	167	PF01652	0.406
LIG_FHA_1	162	168	PF00498	0.311
LIG_HCF-1_HBM_1	95	98	PF13415	0.525
LIG_LIR_Gen_1	10	21	PF02991	0.414
LIG_LIR_Nem_3	10	16	PF02991	0.297
LIG_SH2_CRK	212	216	PF00017	0.433
LIG_SH2_STAT3	107	110	PF00017	0.563
LIG_SH2_STAT5	12	15	PF00017	0.391
LIG_SH2_STAT5	205	208	PF00017	0.428
LIG_SH2_STAT5	82	85	PF00017	0.456
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.379
LIG_UBA3_1	93	99	PF00899	0.408
MOD_CK1_1	109	115	PF00069	0.606
MOD_CK1_1	8	14	PF00069	0.413
MOD_CK2_1	82	88	PF00069	0.459
MOD_GlcNHglycan	130	133	PF01048	0.313
MOD_GlcNHglycan	84	87	PF01048	0.499
MOD_GSK3_1	7	14	PF00069	0.347
MOD_N-GLC_1	5	10	PF02516	0.664
MOD_NEK2_1	115	120	PF00069	0.482
MOD_NEK2_1	128	133	PF00069	0.316
MOD_NEK2_2	101	106	PF00069	0.514
MOD_PIKK_1	106	112	PF00454	0.606
MOD_Plk_1	101	107	PF00069	0.518
MOD_Plk_1	120	126	PF00069	0.160
MOD_Plk_1	8	14	PF00069	0.373
MOD_Plk_4	120	126	PF00069	0.412
MOD_Plk_4	8	14	PF00069	0.373
MOD_ProDKin_1	199	205	PF00069	0.391
MOD_ProDKin_1	44	50	PF00069	0.313
MOD_ProDKin_1	77	83	PF00069	0.370
TRG_DiLeu_BaEn_1	143	148	PF01217	0.369
TRG_DiLeu_BaEn_1	59	64	PF01217	0.412
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.438
TRG_DiLeu_LyEn_5	143	148	PF01217	0.454
TRG_ENDOCYTIC_2	212	215	PF00928	0.438
TRG_NLS_MonoCore_2	207	212	PF00514	0.408
TRG_NLS_MonoExtC_3	208	213	PF00514	0.421
TRG_NLS_MonoExtN_4	208	214	PF00514	0.420
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU29	Leptomonas seymouri	73%	100%
A0A0S4JTV5	Bodo saltans	28%	85%
A0A1X0NV32	Trypanosomatidae	55%	100%
A0A3S7WRN0	Leishmania donovani	99%	100%
A0A422NQB4	Trypanosoma rangeli	53%	100%
A4H6J4	Leishmania braziliensis	91%	100%
E9ANL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O14593	Homo sapiens	25%	87%
O75832	Homo sapiens	27%	100%
P25963	Homo sapiens	31%	71%
P77736	Escherichia coli (strain K12)	33%	100%
Q06527	Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D)	30%	70%
Q08353	Sus scrofa	31%	72%
Q17QS6	Bos taurus	30%	69%
Q2KI79	Bos taurus	25%	72%
Q3SZE4	Bos taurus	26%	70%
Q4Q2I8	Leishmania major	27%	66%
Q4QH09	Leishmania major	98%	100%
Q4ULZ2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	26%	74%
Q502M6	Danio rerio	26%	76%
Q5RFS1	Pongo abelii	25%	70%
Q6AFL2	Leifsonia xyli subsp. xyli (strain CTCB07)	40%	89%
Q862Z2	Oryctolagus cuniculus	29%	69%
Q8N6D5	Homo sapiens	24%	75%
Q8VBX0	Mus musculus	29%	81%
Q8WWX0	Homo sapiens	30%	69%
Q8WXH4	Homo sapiens	25%	70%
Q8WXK3	Homo sapiens	29%	81%
Q8ZWC4	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	29%	88%
Q91974	Gallus gallus	28%	71%
Q96DX5	Homo sapiens	26%	77%
Q99PE2	Mus musculus	28%	72%
Q9CQ31	Mus musculus	27%	70%
Q9D1A4	Mus musculus	28%	69%
Q9H9E1	Homo sapiens	25%	72%
Q9WV06	Mus musculus	29%	69%
Q9Z2X3	Rattus norvegicus	28%	98%
V5BBG1	Trypanosoma cruzi	53%	100%