LeishMANIAdb
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Putative aminopeptidase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative aminopeptidase
Gene product:
aminopeptidase - putative
Species:
Leishmania infantum
UniProt:
A4HUX3_LEIIN
TriTrypDb:
LINF_110012000
Length:
535

Annotations

Annotations by Jardim et al.

Proteases, aminopeptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 8
Pissara et al. yes yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 12
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 22
GO:0110165 cellular anatomical entity 1 22
GO:0005654 nucleoplasm 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HUX3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUX3

PDB structure(s): 5nth_A

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 22
GO:0006807 nitrogen compound metabolic process 2 22
GO:0008152 metabolic process 1 22
GO:0019538 protein metabolic process 3 22
GO:0043170 macromolecule metabolic process 3 22
GO:0044238 primary metabolic process 2 22
GO:0071704 organic substance metabolic process 2 22
GO:1901564 organonitrogen compound metabolic process 3 22
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 22
GO:0004177 aminopeptidase activity 5 22
GO:0005488 binding 1 22
GO:0008233 peptidase activity 3 22
GO:0008235 metalloexopeptidase activity 5 22
GO:0008237 metallopeptidase activity 4 22
GO:0008238 exopeptidase activity 4 22
GO:0016787 hydrolase activity 2 22
GO:0030145 manganese ion binding 6 22
GO:0043167 ion binding 2 22
GO:0043169 cation binding 3 22
GO:0046872 metal ion binding 4 22
GO:0046914 transition metal ion binding 5 22
GO:0070006 metalloaminopeptidase activity 6 22
GO:0140096 catalytic activity, acting on a protein 2 22

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 89 91 PF00675 0.171
CLV_PCSK_KEX2_1 2 4 PF00082 0.448
CLV_PCSK_PC1ET2_1 2 4 PF00082 0.448
CLV_PCSK_SKI1_1 165 169 PF00082 0.425
CLV_PCSK_SKI1_1 185 189 PF00082 0.334
CLV_PCSK_SKI1_1 334 338 PF00082 0.401
CLV_PCSK_SKI1_1 389 393 PF00082 0.271
CLV_PCSK_SKI1_1 59 63 PF00082 0.305
CLV_Separin_Metazoa 191 195 PF03568 0.269
DEG_COP1_1 400 409 PF00400 0.382
DEG_Nend_UBRbox_1 1 4 PF02207 0.331
DOC_CKS1_1 217 222 PF01111 0.377
DOC_CYCLIN_yCln2_LP_2 452 458 PF00134 0.314
DOC_MAPK_gen_1 500 508 PF00069 0.364
DOC_MAPK_gen_1 90 98 PF00069 0.293
DOC_MAPK_MEF2A_6 173 182 PF00069 0.304
DOC_MAPK_MEF2A_6 500 508 PF00069 0.301
DOC_PP1_RVXF_1 57 64 PF00149 0.169
DOC_PP4_FxxP_1 501 504 PF00568 0.286
DOC_PP4_FxxP_1 63 66 PF00568 0.241
DOC_USP7_MATH_1 103 107 PF00917 0.327
DOC_USP7_MATH_1 124 128 PF00917 0.379
DOC_USP7_MATH_1 141 145 PF00917 0.303
DOC_USP7_MATH_1 423 427 PF00917 0.380
DOC_USP7_MATH_1 484 488 PF00917 0.267
DOC_USP7_MATH_1 511 515 PF00917 0.373
DOC_USP7_UBL2_3 169 173 PF12436 0.420
DOC_WW_Pin1_4 216 221 PF00397 0.329
DOC_WW_Pin1_4 466 471 PF00397 0.318
DOC_WW_Pin1_4 477 482 PF00397 0.284
LIG_14-3-3_CanoR_1 185 193 PF00244 0.370
LIG_14-3-3_CanoR_1 194 199 PF00244 0.383
LIG_14-3-3_CanoR_1 26 32 PF00244 0.456
LIG_14-3-3_CanoR_1 340 349 PF00244 0.334
LIG_14-3-3_CanoR_1 475 481 PF00244 0.279
LIG_14-3-3_CanoR_1 5 10 PF00244 0.432
LIG_14-3-3_CanoR_1 90 98 PF00244 0.384
LIG_Actin_WH2_2 40 56 PF00022 0.194
LIG_BIR_III_4 385 389 PF00653 0.271
LIG_BRCT_BRCA1_1 497 501 PF00533 0.292
LIG_BRCT_BRCA1_1 59 63 PF00533 0.277
LIG_CtBP_PxDLS_1 249 255 PF00389 0.306
LIG_DLG_GKlike_1 113 121 PF00625 0.368
LIG_FHA_1 175 181 PF00498 0.335
LIG_FHA_1 187 193 PF00498 0.417
LIG_FHA_1 350 356 PF00498 0.293
LIG_FHA_2 28 34 PF00498 0.263
LIG_FHA_2 382 388 PF00498 0.271
LIG_FHA_2 81 87 PF00498 0.421
LIG_LIR_Apic_2 275 281 PF02991 0.362
LIG_LIR_Apic_2 464 470 PF02991 0.314
LIG_LIR_Apic_2 498 504 PF02991 0.284
LIG_LIR_Apic_2 60 66 PF02991 0.281
LIG_LIR_Gen_1 226 237 PF02991 0.259
LIG_LIR_Gen_1 30 37 PF02991 0.419
LIG_LIR_Gen_1 341 351 PF02991 0.398
LIG_LIR_Nem_3 226 232 PF02991 0.259
LIG_LIR_Nem_3 254 260 PF02991 0.279
LIG_LIR_Nem_3 30 34 PF02991 0.368
LIG_LIR_Nem_3 341 346 PF02991 0.398
LIG_LIR_Nem_3 451 457 PF02991 0.271
LIG_LIR_Nem_3 526 532 PF02991 0.413
LIG_LYPXL_yS_3 454 457 PF13949 0.286
LIG_Pex14_2 501 505 PF04695 0.338
LIG_Pex14_3 527 532 PF04695 0.235
LIG_SH2_CRK 257 261 PF00017 0.279
LIG_SH2_CRK 278 282 PF00017 0.362
LIG_SH2_CRK 467 471 PF00017 0.317
LIG_SH2_NCK_1 229 233 PF00017 0.377
LIG_SH2_NCK_1 93 97 PF00017 0.169
LIG_SH2_SRC 229 232 PF00017 0.219
LIG_SH2_STAP1 160 164 PF00017 0.428
LIG_SH2_STAP1 229 233 PF00017 0.279
LIG_SH2_STAP1 236 240 PF00017 0.221
LIG_SH2_STAP1 432 436 PF00017 0.228
LIG_SH2_STAT3 171 174 PF00017 0.450
LIG_SH2_STAT5 137 140 PF00017 0.310
LIG_SH2_STAT5 160 163 PF00017 0.353
LIG_SH2_STAT5 18 21 PF00017 0.479
LIG_SH2_STAT5 458 461 PF00017 0.310
LIG_SH2_STAT5 491 494 PF00017 0.281
LIG_SH2_STAT5 64 67 PF00017 0.278
LIG_SH2_STAT5 93 96 PF00017 0.294
LIG_SH3_3 135 141 PF00018 0.369
LIG_SH3_3 214 220 PF00018 0.251
LIG_Sin3_3 329 336 PF02671 0.401
LIG_SUMO_SIM_anti_2 368 375 PF11976 0.333
LIG_SUMO_SIM_anti_2 378 385 PF11976 0.333
LIG_TRAF2_1 127 130 PF00917 0.280
LIG_TYR_ITIM 227 232 PF00017 0.377
LIG_TYR_ITIM 452 457 PF00017 0.286
MOD_CK1_1 27 33 PF00069 0.379
MOD_CK1_1 35 41 PF00069 0.402
MOD_CK1_1 375 381 PF00069 0.279
MOD_CK1_1 480 486 PF00069 0.357
MOD_CK1_1 514 520 PF00069 0.315
MOD_CK1_1 57 63 PF00069 0.329
MOD_CK2_1 113 119 PF00069 0.400
MOD_CK2_1 124 130 PF00069 0.338
MOD_CK2_1 381 387 PF00069 0.271
MOD_CK2_1 431 437 PF00069 0.366
MOD_CK2_1 5 11 PF00069 0.416
MOD_CK2_1 80 86 PF00069 0.377
MOD_Cter_Amidation 88 91 PF01082 0.169
MOD_GlcNHglycan 15 18 PF01048 0.334
MOD_GlcNHglycan 321 324 PF01048 0.376
MOD_GlcNHglycan 374 377 PF01048 0.279
MOD_GlcNHglycan 448 451 PF01048 0.286
MOD_GlcNHglycan 482 485 PF01048 0.370
MOD_GSK3_1 101 108 PF00069 0.316
MOD_GSK3_1 20 27 PF00069 0.330
MOD_GSK3_1 310 317 PF00069 0.333
MOD_GSK3_1 479 486 PF00069 0.319
MOD_GSK3_1 514 521 PF00069 0.342
MOD_GSK3_1 53 60 PF00069 0.227
MOD_N-GLC_1 27 32 PF02516 0.352
MOD_N-GLC_1 347 352 PF02516 0.384
MOD_NEK2_1 223 228 PF00069 0.259
MOD_NEK2_1 319 324 PF00069 0.375
MOD_NEK2_1 338 343 PF00069 0.126
MOD_NEK2_1 474 479 PF00069 0.245
MOD_NEK2_1 53 58 PF00069 0.240
MOD_NEK2_2 77 82 PF00069 0.356
MOD_PIKK_1 186 192 PF00454 0.436
MOD_PK_1 194 200 PF00069 0.251
MOD_PK_1 5 11 PF00069 0.459
MOD_PKA_2 474 480 PF00069 0.279
MOD_PKA_2 53 59 PF00069 0.136
MOD_PKB_1 3 11 PF00069 0.423
MOD_Plk_1 10 16 PF00069 0.395
MOD_Plk_1 242 248 PF00069 0.241
MOD_Plk_1 27 33 PF00069 0.260
MOD_Plk_1 347 353 PF00069 0.395
MOD_Plk_1 54 60 PF00069 0.339
MOD_Plk_1 94 100 PF00069 0.356
MOD_Plk_4 223 229 PF00069 0.372
MOD_Plk_4 242 248 PF00069 0.169
MOD_Plk_4 5 11 PF00069 0.459
MOD_Plk_4 523 529 PF00069 0.306
MOD_Plk_4 57 63 PF00069 0.262
MOD_ProDKin_1 216 222 PF00069 0.329
MOD_ProDKin_1 466 472 PF00069 0.318
MOD_ProDKin_1 477 483 PF00069 0.284
MOD_SUMO_for_1 247 250 PF00179 0.367
TRG_DiLeu_BaEn_4 129 135 PF01217 0.186
TRG_ENDOCYTIC_2 229 232 PF00928 0.377
TRG_ENDOCYTIC_2 257 260 PF00928 0.271
TRG_ENDOCYTIC_2 454 457 PF00928 0.296
TRG_ENDOCYTIC_2 93 96 PF00928 0.327
TRG_NES_CRM1_1 202 214 PF08389 0.394
TRG_NLS_MonoCore_2 1 6 PF00514 0.335
TRG_Pf-PMV_PEXEL_1 82 86 PF00026 0.320

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8E6 Leptomonas seymouri 41% 100%
A0A0N1PAS4 Leptomonas seymouri 76% 99%
A0A0S4IQ79 Bodo saltans 42% 100%
A0A1X0NWR5 Trypanosomatidae 50% 100%
A0A1X0P4M9 Trypanosomatidae 39% 100%
A0A3R7JY84 Trypanosoma rangeli 50% 100%
A0A3R7N130 Trypanosoma rangeli 41% 96%
A0A3S7WRP1 Leishmania donovani 100% 100%
A0A3S7X742 Leishmania donovani 44% 100%
A0RKB5 Bacillus thuringiensis (strain Al Hakam) 31% 100%
A1VP99 Polaromonas naphthalenivorans (strain CJ2) 29% 100%
A2SH61 Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1) 31% 100%
A4H6I8 Leishmania braziliensis 85% 100%
A4HLW7 Leishmania braziliensis 44% 97%
A4I996 Leishmania infantum 44% 100%
A5VPM3 Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512) 34% 100%
A6T0V4 Janthinobacterium sp. (strain Marseille) 31% 100%
A6TWW9 Alkaliphilus metalliredigens (strain QYMF) 28% 100%
A6X259 Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) 34% 100%
A9IIK3 Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) 31% 100%
B1LVC3 Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1) 30% 100%
B2FMS4 Stenotrophomonas maltophilia (strain K279a) 32% 100%
B2J3G8 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 31% 100%
B2JET5 Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815) 29% 100%
B3R663 Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1) 32% 100%
B4SJ73 Stenotrophomonas maltophilia (strain R551-3) 32% 100%
B5F9Q6 Aliivibrio fischeri (strain MJ11) 30% 100%
B8D7Q4 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7) 30% 100%
B8D9F2 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain 5A) 30% 100%
C1EX85 Bacillus cereus (strain 03BB102) 31% 100%
C3M9C8 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 30% 100%
C4K346 Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT) 30% 100%
C4LA51 Tolumonas auensis (strain DSM 9187 / TA4) 31% 100%
C5CCM4 Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) 34% 100%
D0A654 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 95%
D0A7H3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9ANK8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9B496 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 97%
P28838 Homo sapiens 29% 100%
P57448 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 30% 100%
P57823 Pasteurella multocida (strain Pm70) 32% 100%
Q0K7F5 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 33% 100%
Q1LJJ6 Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) 32% 100%
Q2KWX0 Bordetella avium (strain 197N) 29% 100%
Q2YB18 Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71) 30% 100%
Q315M7 Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20) 29% 100%
Q3A831 Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) 33% 100%
Q3B4B5 Chlorobium luteolum (strain DSM 273 / BCRC 81028 / 2530) 32% 100%
Q3M9J6 Trichormus variabilis (strain ATCC 29413 / PCC 7937) 29% 100%
Q46XT9 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) 32% 100%
Q4Q3T0 Leishmania major 44% 97%
Q4QH17 Leishmania major 96% 100%
Q5E7T8 Aliivibrio fischeri (strain ATCC 700601 / ES114) 31% 100%
Q5FFZ5 Ehrlichia ruminantium (strain Gardel) 30% 100%
Q5HAP2 Ehrlichia ruminantium (strain Welgevonden) 30% 100%
Q5R7G6 Pongo abelii 38% 100%
Q68XM6 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 31% 100%
Q6AFG2 Leifsonia xyli subsp. xyli (strain CTCB07) 31% 100%
Q6NG90 Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) 36% 100%
Q6NSR8 Mus musculus 38% 100%
Q72YG1 Bacillus cereus (strain ATCC 10987 / NRS 248) 32% 100%
Q73YK2 Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) 31% 100%
Q7W5K6 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) 30% 100%
Q8G1M4 Brucella suis biovar 1 (strain 1330) 34% 100%
Q8K9I0 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 30% 100%
Q8NDH3 Homo sapiens 38% 100%
Q8YG99 Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) 34% 100%
Q984S1 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 30% 100%
Q9JTI8 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) 32% 100%
Q9KTX5 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 32% 100%
Q9Y935 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 29% 100%
V5BTR1 Trypanosoma cruzi 41% 96%
V5BWE3 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS