Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUX1_LEIIN

TriTrypDb:

LINF_110011700

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 589

Expansion

Sequence features

A4HUX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUX1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.666
CLV_C14_Caspase3-7	178	182	PF00656	0.634
CLV_C14_Caspase3-7	187	191	PF00656	0.530
CLV_NRD_NRD_1	28	30	PF00675	0.417
CLV_NRD_NRD_1	382	384	PF00675	0.494
CLV_NRD_NRD_1	392	394	PF00675	0.525
CLV_NRD_NRD_1	455	457	PF00675	0.623
CLV_NRD_NRD_1	497	499	PF00675	0.562
CLV_NRD_NRD_1	581	583	PF00675	0.637
CLV_NRD_NRD_1	77	79	PF00675	0.669
CLV_PCSK_KEX2_1	265	267	PF00082	0.475
CLV_PCSK_KEX2_1	28	30	PF00082	0.616
CLV_PCSK_KEX2_1	382	384	PF00082	0.494
CLV_PCSK_KEX2_1	392	394	PF00082	0.525
CLV_PCSK_KEX2_1	455	457	PF00082	0.623
CLV_PCSK_KEX2_1	496	498	PF00082	0.571
CLV_PCSK_KEX2_1	581	583	PF00082	0.644
CLV_PCSK_KEX2_1	77	79	PF00082	0.590
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.466
CLV_PCSK_PC7_1	492	498	PF00082	0.640
CLV_PCSK_SKI1_1	294	298	PF00082	0.589
CLV_PCSK_SKI1_1	37	41	PF00082	0.548
DEG_SCF_TRCP1_1	588	593	PF00400	0.651
DEG_SPOP_SBC_1	142	146	PF00917	0.528
DEG_SPOP_SBC_1	338	342	PF00917	0.695
DEG_SPOP_SBC_1	433	437	PF00917	0.592
DEG_SPOP_SBC_1	512	516	PF00917	0.634
DEG_SPOP_SBC_1	95	99	PF00917	0.597
DOC_ANK_TNKS_1	77	84	PF00023	0.626
DOC_CKS1_1	278	283	PF01111	0.567
DOC_CKS1_1	287	292	PF01111	0.465
DOC_PP1_RVXF_1	237	243	PF00149	0.502
DOC_USP7_MATH_1	123	127	PF00917	0.686
DOC_USP7_MATH_1	136	140	PF00917	0.590
DOC_USP7_MATH_1	141	145	PF00917	0.545
DOC_USP7_MATH_1	154	158	PF00917	0.538
DOC_USP7_MATH_1	208	212	PF00917	0.598
DOC_USP7_MATH_1	288	292	PF00917	0.539
DOC_USP7_MATH_1	339	343	PF00917	0.623
DOC_USP7_MATH_1	434	438	PF00917	0.709
DOC_USP7_MATH_1	511	515	PF00917	0.775
DOC_USP7_MATH_1	71	75	PF00917	0.659
DOC_USP7_UBL2_3	155	159	PF12436	0.643
DOC_WW_Pin1_4	137	142	PF00397	0.674
DOC_WW_Pin1_4	150	155	PF00397	0.608
DOC_WW_Pin1_4	200	205	PF00397	0.646
DOC_WW_Pin1_4	268	273	PF00397	0.567
DOC_WW_Pin1_4	277	282	PF00397	0.487
DOC_WW_Pin1_4	286	291	PF00397	0.432
DOC_WW_Pin1_4	425	430	PF00397	0.642
DOC_WW_Pin1_4	498	503	PF00397	0.738
DOC_WW_Pin1_4	513	518	PF00397	0.785
LIG_14-3-3_CanoR_1	362	367	PF00244	0.427
LIG_APCC_ABBAyCdc20_2	383	389	PF00400	0.510
LIG_BRCT_BRCA1_1	125	129	PF00533	0.596
LIG_BRCT_BRCA1_1	194	198	PF00533	0.611
LIG_BRCT_BRCA1_1	436	440	PF00533	0.627
LIG_BRCT_BRCA1_1	500	504	PF00533	0.647
LIG_eIF4E_1	592	598	PF01652	0.633
LIG_FHA_1	184	190	PF00498	0.566
LIG_FHA_1	22	28	PF00498	0.439
LIG_FHA_1	274	280	PF00498	0.586
LIG_FHA_1	326	332	PF00498	0.640
LIG_FHA_2	176	182	PF00498	0.589
LIG_FHA_2	287	293	PF00498	0.588
LIG_FHA_2	363	369	PF00498	0.407
LIG_Integrin_RGD_1	164	166	PF01839	0.572
LIG_LIR_Apic_2	410	416	PF02991	0.716
LIG_LIR_Gen_1	333	339	PF02991	0.651
LIG_LIR_Gen_1	48	57	PF02991	0.377
LIG_LIR_Nem_3	282	287	PF02991	0.471
LIG_LIR_Nem_3	320	324	PF02991	0.611
LIG_LIR_Nem_3	333	338	PF02991	0.518
LIG_LIR_Nem_3	355	361	PF02991	0.435
LIG_LIR_Nem_3	437	443	PF02991	0.693
LIG_LIR_Nem_3	48	52	PF02991	0.416
LIG_Pex14_2	129	133	PF04695	0.581
LIG_PTB_Apo_2	373	380	PF02174	0.572
LIG_PTB_Apo_2	482	489	PF02174	0.635
LIG_PTB_Phospho_1	373	379	PF10480	0.569
LIG_PTB_Phospho_1	482	488	PF10480	0.634
LIG_SH2_CRK	223	227	PF00017	0.643
LIG_SH2_CRK	269	273	PF00017	0.536
LIG_SH2_CRK	335	339	PF00017	0.653
LIG_SH2_CRK	426	430	PF00017	0.623
LIG_SH2_GRB2like	473	476	PF00017	0.667
LIG_SH2_GRB2like	483	486	PF00017	0.597
LIG_SH2_NCK_1	223	227	PF00017	0.552
LIG_SH2_NCK_1	335	339	PF00017	0.618
LIG_SH2_NCK_1	499	503	PF00017	0.626
LIG_SH2_PTP2	49	52	PF00017	0.344
LIG_SH2_STAP1	335	339	PF00017	0.618
LIG_SH2_STAT3	567	570	PF00017	0.691
LIG_SH2_STAT5	379	382	PF00017	0.576
LIG_SH2_STAT5	49	52	PF00017	0.344
LIG_SH3_3	210	216	PF00018	0.674
LIG_SH3_3	249	255	PF00018	0.455
LIG_SH3_3	275	281	PF00018	0.559
LIG_SH3_3	326	332	PF00018	0.529
LIG_SH3_4	155	162	PF00018	0.619
LIG_SUMO_SIM_par_1	327	334	PF11976	0.560
LIG_SUMO_SIM_par_1	89	94	PF11976	0.602
LIG_TYR_ITIM	47	52	PF00017	0.426
MOD_CDC14_SPxK_1	271	274	PF00782	0.520
MOD_CDK_SPK_2	150	155	PF00069	0.688
MOD_CDK_SPxK_1	268	274	PF00069	0.528
MOD_CK1_1	137	143	PF00069	0.591
MOD_CK1_1	14	20	PF00069	0.533
MOD_CK1_1	340	346	PF00069	0.597
MOD_CK1_1	395	401	PF00069	0.686
MOD_CK1_1	407	413	PF00069	0.623
MOD_CK1_1	435	441	PF00069	0.602
MOD_CK1_1	537	543	PF00069	0.638
MOD_CK1_1	568	574	PF00069	0.631
MOD_CK1_1	96	102	PF00069	0.617
MOD_CK2_1	244	250	PF00069	0.525
MOD_CK2_1	286	292	PF00069	0.591
MOD_CK2_1	473	479	PF00069	0.738
MOD_CK2_1	546	552	PF00069	0.677
MOD_CK2_1	58	64	PF00069	0.487
MOD_GlcNHglycan	113	116	PF01048	0.617
MOD_GlcNHglycan	13	16	PF01048	0.482
MOD_GlcNHglycan	145	148	PF01048	0.652
MOD_GlcNHglycan	156	159	PF01048	0.767
MOD_GlcNHglycan	193	197	PF01048	0.765
MOD_GlcNHglycan	246	249	PF01048	0.467
MOD_GlcNHglycan	406	409	PF01048	0.632
MOD_GlcNHglycan	410	413	PF01048	0.669
MOD_GlcNHglycan	451	454	PF01048	0.618
MOD_GlcNHglycan	479	483	PF01048	0.689
MOD_GlcNHglycan	588	591	PF01048	0.603
MOD_GlcNHglycan	60	63	PF01048	0.498
MOD_GlcNHglycan	84	88	PF01048	0.628
MOD_GSK3_1	137	144	PF00069	0.637
MOD_GSK3_1	150	157	PF00069	0.644
MOD_GSK3_1	175	182	PF00069	0.679
MOD_GSK3_1	188	195	PF00069	0.755
MOD_GSK3_1	196	203	PF00069	0.657
MOD_GSK3_1	273	280	PF00069	0.649
MOD_GSK3_1	348	355	PF00069	0.559
MOD_GSK3_1	392	399	PF00069	0.582
MOD_GSK3_1	404	411	PF00069	0.672
MOD_GSK3_1	432	439	PF00069	0.620
MOD_GSK3_1	498	505	PF00069	0.696
MOD_GSK3_1	537	544	PF00069	0.618
MOD_GSK3_1	586	593	PF00069	0.631
MOD_GSK3_1	60	67	PF00069	0.539
MOD_GSK3_1	7	14	PF00069	0.562
MOD_GSK3_1	94	101	PF00069	0.596
MOD_N-GLC_1	227	232	PF02516	0.579
MOD_N-GLC_1	404	409	PF02516	0.609
MOD_N-GLC_1	484	489	PF02516	0.634
MOD_NEK2_1	129	134	PF00069	0.564
MOD_NEK2_1	192	197	PF00069	0.554
MOD_NEK2_1	258	263	PF00069	0.499
MOD_NEK2_1	324	329	PF00069	0.506
MOD_NEK2_1	337	342	PF00069	0.628
MOD_NEK2_1	352	357	PF00069	0.423
MOD_NEK2_1	387	392	PF00069	0.514
MOD_NEK2_1	404	409	PF00069	0.586
MOD_NEK2_1	565	570	PF00069	0.569
MOD_NEK2_1	586	591	PF00069	0.593
MOD_NEK2_2	124	129	PF00069	0.641
MOD_OFUCOSY	53	59	PF10250	0.493
MOD_PIKK_1	294	300	PF00454	0.726
MOD_PIKK_1	414	420	PF00454	0.656
MOD_PIKK_1	565	571	PF00454	0.681
MOD_PK_1	393	399	PF00069	0.492
MOD_PKA_1	392	398	PF00069	0.564
MOD_PKA_2	392	398	PF00069	0.564
MOD_PKA_2	537	543	PF00069	0.646
MOD_PKA_2	546	552	PF00069	0.599
MOD_PKA_2	64	70	PF00069	0.611
MOD_Plk_1	324	330	PF00069	0.488
MOD_Plk_1	484	490	PF00069	0.635
MOD_Plk_2-3	181	187	PF00069	0.743
MOD_Plk_2-3	188	194	PF00069	0.642
MOD_Plk_4	124	130	PF00069	0.599
MOD_Plk_4	325	331	PF00069	0.557
MOD_Plk_4	348	354	PF00069	0.622
MOD_Plk_4	362	368	PF00069	0.380
MOD_ProDKin_1	137	143	PF00069	0.675
MOD_ProDKin_1	150	156	PF00069	0.608
MOD_ProDKin_1	200	206	PF00069	0.646
MOD_ProDKin_1	268	274	PF00069	0.570
MOD_ProDKin_1	277	283	PF00069	0.490
MOD_ProDKin_1	286	292	PF00069	0.431
MOD_ProDKin_1	425	431	PF00069	0.638
MOD_ProDKin_1	498	504	PF00069	0.739
MOD_ProDKin_1	513	519	PF00069	0.784
MOD_SUMO_rev_2	32	39	PF00179	0.403
TRG_DiLeu_BaLyEn_6	514	519	PF01217	0.557
TRG_ENDOCYTIC_2	223	226	PF00928	0.642
TRG_ENDOCYTIC_2	321	324	PF00928	0.625
TRG_ENDOCYTIC_2	335	338	PF00928	0.525
TRG_ENDOCYTIC_2	49	52	PF00928	0.412
TRG_ER_diArg_1	219	222	PF00400	0.597
TRG_ER_diArg_1	27	29	PF00400	0.412
TRG_ER_diArg_1	391	393	PF00400	0.507
TRG_ER_diArg_1	496	498	PF00400	0.615
TRG_NES_CRM1_1	35	48	PF08389	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T4	Leptomonas seymouri	46%	100%
A0A3Q8I8Z7	Leishmania donovani	100%	100%
A4H6I6	Leishmania braziliensis	69%	100%
E9ANK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QH20	Leishmania major	91%	100%