LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Tetratricopeptide repeat (TPR) protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Tetratricopeptide repeat (TPR) protein
Gene product:
tetratricopeptide repeat (TPR) protein
Species:
Leishmania infantum
UniProt:
A4HUW8_LEIIN
TriTrypDb:
LINF_110010600
Length:
407

Annotations

Annotations by Jardim et al.

Metal Binding, Tetratricopeptide repeat (TPR)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUW8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUW8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 245 249 PF00656 0.745
CLV_C14_Caspase3-7 59 63 PF00656 0.548
CLV_NRD_NRD_1 222 224 PF00675 0.376
CLV_NRD_NRD_1 237 239 PF00675 0.571
CLV_PCSK_FUR_1 220 224 PF00082 0.527
CLV_PCSK_KEX2_1 222 224 PF00082 0.376
CLV_PCSK_KEX2_1 237 239 PF00082 0.606
CLV_PCSK_KEX2_1 366 368 PF00082 0.561
CLV_PCSK_PC1ET2_1 366 368 PF00082 0.561
CLV_PCSK_PC7_1 233 239 PF00082 0.510
CLV_PCSK_SKI1_1 22 26 PF00082 0.484
CLV_PCSK_SKI1_1 233 237 PF00082 0.596
CLV_PCSK_SKI1_1 287 291 PF00082 0.594
CLV_PCSK_SKI1_1 305 309 PF00082 0.377
CLV_PCSK_SKI1_1 328 332 PF00082 0.469
CLV_PCSK_SKI1_1 4 8 PF00082 0.567
CLV_PCSK_SKI1_1 58 62 PF00082 0.502
DEG_SPOP_SBC_1 271 275 PF00917 0.698
DOC_CYCLIN_RxL_1 1 9 PF00134 0.466
DOC_CYCLIN_RxL_1 17 26 PF00134 0.476
DOC_CYCLIN_RxL_1 305 316 PF00134 0.560
DOC_PP1_RVXF_1 159 166 PF00149 0.527
DOC_PP1_SILK_1 233 238 PF00149 0.427
DOC_USP7_MATH_1 209 213 PF00917 0.381
DOC_USP7_MATH_1 231 235 PF00917 0.486
DOC_USP7_MATH_1 250 254 PF00917 0.440
DOC_USP7_MATH_1 271 275 PF00917 0.733
DOC_USP7_UBL2_3 4 8 PF12436 0.573
DOC_WW_Pin1_4 321 326 PF00397 0.631
LIG_14-3-3_CanoR_1 159 164 PF00244 0.495
LIG_14-3-3_CanoR_1 222 230 PF00244 0.448
LIG_Actin_WH2_2 148 163 PF00022 0.554
LIG_Actin_WH2_2 272 289 PF00022 0.499
LIG_Actin_WH2_2 343 360 PF00022 0.467
LIG_BRCT_BRCA1_1 161 165 PF00533 0.424
LIG_BRCT_BRCA1_1 71 75 PF00533 0.501
LIG_deltaCOP1_diTrp_1 110 116 PF00928 0.439
LIG_FHA_1 128 134 PF00498 0.411
LIG_FHA_1 316 322 PF00498 0.504
LIG_FHA_1 333 339 PF00498 0.444
LIG_FHA_2 116 122 PF00498 0.504
LIG_FHA_2 283 289 PF00498 0.566
LIG_FHA_2 57 63 PF00498 0.521
LIG_HCF-1_HBM_1 140 143 PF13415 0.398
LIG_LIR_Gen_1 314 325 PF02991 0.456
LIG_LIR_Gen_1 383 393 PF02991 0.560
LIG_LIR_Nem_3 314 320 PF02991 0.425
LIG_LIR_Nem_3 383 388 PF02991 0.578
LIG_LIR_Nem_3 72 78 PF02991 0.444
LIG_OCRL_FandH_1 115 127 PF00620 0.416
LIG_PCNA_yPIPBox_3 339 352 PF02747 0.530
LIG_PDZ_Class_1 402 407 PF00595 0.543
LIG_SH2_NCK_1 184 188 PF00017 0.444
LIG_SH2_SRC 122 125 PF00017 0.533
LIG_SH2_SRC 216 219 PF00017 0.507
LIG_SH2_SRC 42 45 PF00017 0.575
LIG_SH2_STAP1 33 37 PF00017 0.438
LIG_SH2_STAP1 95 99 PF00017 0.350
LIG_SH2_STAT3 193 196 PF00017 0.328
LIG_SH2_STAT5 122 125 PF00017 0.437
LIG_SH2_STAT5 42 45 PF00017 0.574
LIG_SUMO_SIM_par_1 130 136 PF11976 0.536
LIG_WRC_WIRS_1 382 387 PF05994 0.508
MOD_CDK_SPxxK_3 321 328 PF00069 0.510
MOD_CK1_1 131 137 PF00069 0.523
MOD_CK1_1 241 247 PF00069 0.682
MOD_CK1_1 274 280 PF00069 0.641
MOD_CK2_1 282 288 PF00069 0.580
MOD_GlcNHglycan 171 175 PF01048 0.441
MOD_GlcNHglycan 251 255 PF01048 0.704
MOD_GlcNHglycan 404 407 PF01048 0.595
MOD_GlcNHglycan 48 51 PF01048 0.653
MOD_GlcNHglycan 8 11 PF01048 0.625
MOD_GSK3_1 127 134 PF00069 0.459
MOD_GSK3_1 238 245 PF00069 0.640
MOD_GSK3_1 262 269 PF00069 0.694
MOD_GSK3_1 270 277 PF00069 0.734
MOD_GSK3_1 328 335 PF00069 0.578
MOD_GSK3_1 52 59 PF00069 0.575
MOD_N-GLC_1 128 133 PF02516 0.431
MOD_N-GLC_1 52 57 PF02516 0.558
MOD_NEK2_1 151 156 PF00069 0.545
MOD_NEK2_1 402 407 PF00069 0.621
MOD_NEK2_1 6 11 PF00069 0.532
MOD_NEK2_2 115 120 PF00069 0.487
MOD_NEK2_2 282 287 PF00069 0.453
MOD_PIKK_1 262 268 PF00454 0.694
MOD_PK_1 159 165 PF00069 0.525
MOD_Plk_1 127 133 PF00069 0.391
MOD_Plk_1 231 237 PF00069 0.469
MOD_Plk_1 315 321 PF00069 0.483
MOD_Plk_1 332 338 PF00069 0.497
MOD_Plk_1 68 74 PF00069 0.494
MOD_Plk_2-3 242 248 PF00069 0.727
MOD_Plk_4 128 134 PF00069 0.464
MOD_Plk_4 332 338 PF00069 0.540
MOD_Plk_4 384 390 PF00069 0.508
MOD_ProDKin_1 321 327 PF00069 0.627
MOD_SUMO_for_1 18 21 PF00179 0.575
MOD_SUMO_for_1 289 292 PF00179 0.521
MOD_SUMO_rev_2 322 330 PF00179 0.512
TRG_DiLeu_BaEn_4 354 360 PF01217 0.511
TRG_ENDOCYTIC_2 183 186 PF00928 0.465
TRG_ENDOCYTIC_2 218 221 PF00928 0.414
TRG_ER_diArg_1 158 161 PF00400 0.535
TRG_ER_diArg_1 221 223 PF00400 0.390
TRG_ER_diArg_1 236 238 PF00400 0.610
TRG_NES_CRM1_1 380 395 PF08389 0.529
TRG_Pf-PMV_PEXEL_1 22 26 PF00026 0.463

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P484 Leptomonas seymouri 61% 99%
A0A0S4JTW1 Bodo saltans 37% 100%
A0A1X0NV58 Trypanosomatidae 43% 100%
A0A3R7R950 Trypanosoma rangeli 42% 100%
A0A3S7WRL3 Leishmania donovani 100% 100%
A4H6G7 Leishmania braziliensis 81% 100%
D0A7J3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9ANJ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QH31 Leishmania major 96% 100%
V5BRL9 Trypanosoma cruzi 40% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS