Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HUW6_LEIIN

TriTrypDb:

LINF_110010800

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HUW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUW6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.550
CLV_C14_Caspase3-7	480	484	PF00656	0.436
CLV_NRD_NRD_1	245	247	PF00675	0.455
CLV_NRD_NRD_1	388	390	PF00675	0.436
CLV_NRD_NRD_1	454	456	PF00675	0.436
CLV_PCSK_KEX2_1	191	193	PF00082	0.456
CLV_PCSK_KEX2_1	245	247	PF00082	0.464
CLV_PCSK_KEX2_1	309	311	PF00082	0.411
CLV_PCSK_KEX2_1	320	322	PF00082	0.411
CLV_PCSK_KEX2_1	454	456	PF00082	0.510
CLV_PCSK_KEX2_1	556	558	PF00082	0.436
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.456
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.397
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.434
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.436
CLV_PCSK_SKI1_1	204	208	PF00082	0.616
CLV_PCSK_SKI1_1	236	240	PF00082	0.478
CLV_PCSK_SKI1_1	298	302	PF00082	0.464
CLV_PCSK_SKI1_1	321	325	PF00082	0.222
CLV_PCSK_SKI1_1	38	42	PF00082	0.556
CLV_PCSK_SKI1_1	455	459	PF00082	0.436
CLV_PCSK_SKI1_1	543	547	PF00082	0.411
CLV_PCSK_SKI1_1	570	574	PF00082	0.655
DEG_SPOP_SBC_1	131	135	PF00917	0.730
DOC_CKS1_1	374	379	PF01111	0.513
DOC_MAPK_gen_1	36	43	PF00069	0.459
DOC_MAPK_MEF2A_6	524	532	PF00069	0.513
DOC_PP2B_LxvP_1	110	113	PF13499	0.626
DOC_USP7_MATH_1	131	135	PF00917	0.736
DOC_USP7_MATH_1	473	477	PF00917	0.374
DOC_USP7_MATH_1	78	82	PF00917	0.799
DOC_USP7_MATH_2	68	74	PF00917	0.594
DOC_USP7_UBL2_3	149	153	PF12436	0.802
DOC_WW_Pin1_4	373	378	PF00397	0.513
DOC_WW_Pin1_4	403	408	PF00397	0.459
LIG_14-3-3_CanoR_1	204	211	PF00244	0.616
LIG_14-3-3_CanoR_1	321	330	PF00244	0.222
LIG_14-3-3_CanoR_1	36	41	PF00244	0.453
LIG_14-3-3_CanoR_1	454	460	PF00244	0.372
LIG_14-3-3_CanoR_1	561	567	PF00244	0.513
LIG_Actin_WH2_2	293	311	PF00022	0.416
LIG_APCC_ABBA_1	349	354	PF00400	0.513
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_BIR_III_4	469	473	PF00653	0.397
LIG_BRCT_BRCA1_1	1	5	PF00533	0.649
LIG_BRCT_BRCA1_1	310	314	PF00533	0.494
LIG_BRCT_BRCA1_1	515	519	PF00533	0.513
LIG_BRCT_BRCA1_1	538	542	PF00533	0.411
LIG_BRCT_BRCA1_1	564	568	PF00533	0.513
LIG_BRCT_BRCA1_2	564	570	PF00533	0.436
LIG_deltaCOP1_diTrp_1	420	429	PF00928	0.513
LIG_FHA_1	195	201	PF00498	0.555
LIG_FHA_1	205	211	PF00498	0.524
LIG_FHA_1	299	305	PF00498	0.513
LIG_FHA_1	322	328	PF00498	0.249
LIG_FHA_1	431	437	PF00498	0.411
LIG_FHA_1	513	519	PF00498	0.513
LIG_FHA_2	374	380	PF00498	0.380
LIG_FHA_2	415	421	PF00498	0.411
LIG_FHA_2	478	484	PF00498	0.494
LIG_GBD_Chelix_1	253	261	PF00786	0.513
LIG_GBD_Chelix_1	46	54	PF00786	0.394
LIG_LIR_Apic_2	401	407	PF02991	0.411
LIG_LIR_Gen_1	120	131	PF02991	0.689
LIG_LIR_Gen_1	212	221	PF02991	0.567
LIG_LIR_Gen_1	27	37	PF02991	0.582
LIG_LIR_Gen_1	356	367	PF02991	0.424
LIG_LIR_Nem_3	2	8	PF02991	0.692
LIG_LIR_Nem_3	212	217	PF02991	0.555
LIG_LIR_Nem_3	27	32	PF02991	0.591
LIG_LIR_Nem_3	34	40	PF02991	0.444
LIG_LIR_Nem_3	356	362	PF02991	0.362
LIG_LIR_Nem_3	435	441	PF02991	0.513
LIG_LIR_Nem_3	521	526	PF02991	0.392
LIG_LIR_Nem_3	539	545	PF02991	0.482
LIG_LYPXL_yS_3	445	448	PF13949	0.513
LIG_MYND_3	11	15	PF01753	0.647
LIG_SH2_CRK	37	41	PF00017	0.527
LIG_SH2_SRC	364	367	PF00017	0.436
LIG_SH2_STAP1	251	255	PF00017	0.513
LIG_SH2_STAP1	291	295	PF00017	0.411
LIG_SH2_STAT5	142	145	PF00017	0.721
LIG_SH2_STAT5	194	197	PF00017	0.453
LIG_SH2_STAT5	201	204	PF00017	0.406
LIG_SH3_3	371	377	PF00018	0.513
LIG_SH3_3	434	440	PF00018	0.411
LIG_SH3_3	552	558	PF00018	0.513
LIG_SH3_3	88	94	PF00018	0.748
LIG_SUMO_SIM_par_1	231	237	PF11976	0.513
LIG_SUMO_SIM_par_1	365	371	PF11976	0.436
LIG_WRC_WIRS_1	542	547	PF05994	0.513
MOD_CK1_1	101	107	PF00069	0.720
MOD_CK1_1	119	125	PF00069	0.489
MOD_CK1_1	135	141	PF00069	0.661
MOD_CK1_1	152	158	PF00069	0.654
MOD_CK1_1	406	412	PF00069	0.399
MOD_CK1_1	506	512	PF00069	0.409
MOD_CK1_1	513	519	PF00069	0.415
MOD_CK1_1	537	543	PF00069	0.416
MOD_CK2_1	373	379	PF00069	0.349
MOD_CK2_1	541	547	PF00069	0.436
MOD_Cter_Amidation	189	192	PF01082	0.493
MOD_GlcNHglycan	137	140	PF01048	0.802
MOD_GlcNHglycan	283	286	PF01048	0.299
MOD_GlcNHglycan	310	313	PF01048	0.501
MOD_GlcNHglycan	327	330	PF01048	0.322
MOD_GlcNHglycan	353	358	PF01048	0.524
MOD_GlcNHglycan	473	476	PF01048	0.507
MOD_GlcNHglycan	501	504	PF01048	0.432
MOD_GlcNHglycan	8	11	PF01048	0.774
MOD_GlcNHglycan	80	83	PF01048	0.745
MOD_GSK3_1	131	138	PF00069	0.736
MOD_GSK3_1	149	156	PF00069	0.510
MOD_GSK3_1	296	303	PF00069	0.429
MOD_GSK3_1	321	328	PF00069	0.347
MOD_GSK3_1	394	401	PF00069	0.513
MOD_GSK3_1	420	427	PF00069	0.367
MOD_GSK3_1	473	480	PF00069	0.432
MOD_GSK3_1	499	506	PF00069	0.429
MOD_GSK3_1	537	544	PF00069	0.513
MOD_N-GLC_1	135	140	PF02516	0.795
MOD_NEK2_1	158	163	PF00069	0.658
MOD_NEK2_1	296	301	PF00069	0.433
MOD_NEK2_1	308	313	PF00069	0.511
MOD_NEK2_1	352	357	PF00069	0.411
MOD_NEK2_1	424	429	PF00069	0.411
MOD_NEK2_1	471	476	PF00069	0.299
MOD_NEK2_1	498	503	PF00069	0.433
MOD_NEK2_1	57	62	PF00069	0.584
MOD_NEK2_2	473	478	PF00069	0.436
MOD_PIKK_1	513	519	PF00454	0.513
MOD_PIKK_1	58	64	PF00454	0.686
MOD_PKA_1	455	461	PF00069	0.500
MOD_PKA_1	556	562	PF00069	0.436
MOD_PKA_2	101	107	PF00069	0.719
MOD_PKA_2	398	404	PF00069	0.436
MOD_PKA_2	506	512	PF00069	0.436
MOD_PKA_2	556	562	PF00069	0.411
MOD_Plk_1	119	125	PF00069	0.740
MOD_Plk_1	236	242	PF00069	0.513
MOD_Plk_1	353	359	PF00069	0.416
MOD_Plk_1	534	540	PF00069	0.394
MOD_Plk_1	570	576	PF00069	0.599
MOD_Plk_1	58	64	PF00069	0.763
MOD_Plk_2-3	541	547	PF00069	0.436
MOD_Plk_4	122	128	PF00069	0.738
MOD_Plk_4	24	30	PF00069	0.635
MOD_Plk_4	266	272	PF00069	0.410
MOD_Plk_4	36	42	PF00069	0.364
MOD_Plk_4	398	404	PF00069	0.486
MOD_Plk_4	444	450	PF00069	0.411
MOD_ProDKin_1	373	379	PF00069	0.513
MOD_ProDKin_1	403	409	PF00069	0.459
MOD_SUMO_rev_2	152	161	PF00179	0.640
MOD_SUMO_rev_2	489	494	PF00179	0.432
TRG_DiLeu_BaEn_2	540	546	PF01217	0.513
TRG_ENDOCYTIC_2	29	32	PF00928	0.588
TRG_ENDOCYTIC_2	291	294	PF00928	0.408
TRG_ENDOCYTIC_2	359	362	PF00928	0.438
TRG_ENDOCYTIC_2	364	367	PF00928	0.448
TRG_ENDOCYTIC_2	37	40	PF00928	0.431
TRG_ENDOCYTIC_2	445	448	PF00928	0.513
TRG_ENDOCYTIC_2	523	526	PF00928	0.411
TRG_ER_diArg_1	245	247	PF00400	0.446
TRG_ER_diArg_1	453	455	PF00400	0.436
TRG_ER_diArg_1	494	497	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	383	388	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I436	Leptomonas seymouri	40%	98%
A0A3Q8IB87	Leishmania donovani	99%	100%
A4H6H6	Leishmania braziliensis	77%	100%
E9ANJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QH29	Leishmania major	94%	100%