Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF563) - putative

Species:

Leishmania infantum

UniProt:

A4HUW3_LEIIN

TriTrypDb:

LINF_110011100

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HUW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUW3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.445
CLV_MEL_PAP_1	585	591	PF00089	0.557
CLV_NRD_NRD_1	100	102	PF00675	0.703
CLV_NRD_NRD_1	327	329	PF00675	0.684
CLV_NRD_NRD_1	332	334	PF00675	0.612
CLV_NRD_NRD_1	387	389	PF00675	0.788
CLV_NRD_NRD_1	44	46	PF00675	0.481
CLV_NRD_NRD_1	6	8	PF00675	0.498
CLV_PCSK_FUR_1	629	633	PF00082	0.502
CLV_PCSK_KEX2_1	115	117	PF00082	0.659
CLV_PCSK_KEX2_1	327	329	PF00082	0.656
CLV_PCSK_KEX2_1	387	389	PF00082	0.787
CLV_PCSK_KEX2_1	44	46	PF00082	0.443
CLV_PCSK_KEX2_1	631	633	PF00082	0.562
CLV_PCSK_KEX2_1	8	10	PF00082	0.491
CLV_PCSK_KEX2_1	99	101	PF00082	0.704
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.663
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.508
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.491
CLV_PCSK_SKI1_1	415	419	PF00082	0.520
CLV_PCSK_SKI1_1	477	481	PF00082	0.474
CLV_PCSK_SKI1_1	600	604	PF00082	0.600
DEG_APCC_DBOX_1	414	422	PF00400	0.297
DOC_CYCLIN_RxL_1	474	484	PF00134	0.280
DOC_MAPK_FxFP_2	613	616	PF00069	0.403
DOC_MAPK_gen_1	259	267	PF00069	0.364
DOC_MAPK_gen_1	48	58	PF00069	0.500
DOC_MAPK_gen_1	548	555	PF00069	0.389
DOC_MAPK_JIP1_4	475	481	PF00069	0.245
DOC_MAPK_MEF2A_6	266	275	PF00069	0.396
DOC_MAPK_MEF2A_6	523	531	PF00069	0.347
DOC_PP1_RVXF_1	475	481	PF00149	0.208
DOC_PP2B_LxvP_1	308	311	PF13499	0.429
DOC_PP4_FxxP_1	102	105	PF00568	0.454
DOC_PP4_FxxP_1	196	199	PF00568	0.409
DOC_PP4_FxxP_1	345	348	PF00568	0.385
DOC_PP4_FxxP_1	613	616	PF00568	0.403
DOC_USP7_MATH_1	11	15	PF00917	0.772
DOC_USP7_MATH_1	114	118	PF00917	0.427
DOC_USP7_MATH_1	188	192	PF00917	0.419
DOC_USP7_MATH_1	206	210	PF00917	0.313
DOC_USP7_MATH_1	294	298	PF00917	0.398
DOC_USP7_MATH_1	355	359	PF00917	0.452
DOC_USP7_MATH_1	392	396	PF00917	0.451
DOC_USP7_MATH_1	489	493	PF00917	0.297
DOC_WW_Pin1_4	12	17	PF00397	0.703
DOC_WW_Pin1_4	198	203	PF00397	0.447
DOC_WW_Pin1_4	20	25	PF00397	0.658
DOC_WW_Pin1_4	212	217	PF00397	0.248
DOC_WW_Pin1_4	344	349	PF00397	0.472
DOC_WW_Pin1_4	351	356	PF00397	0.479
DOC_WW_Pin1_4	379	384	PF00397	0.600
DOC_WW_Pin1_4	429	434	PF00397	0.302
DOC_WW_Pin1_4	542	547	PF00397	0.410
LIG_14-3-3_CanoR_1	103	112	PF00244	0.467
LIG_14-3-3_CanoR_1	181	186	PF00244	0.453
LIG_14-3-3_CanoR_1	223	231	PF00244	0.399
LIG_14-3-3_CanoR_1	39	47	PF00244	0.614
LIG_14-3-3_CanoR_1	48	54	PF00244	0.594
LIG_Actin_WH2_2	280	298	PF00022	0.353
LIG_APCC_ABBA_1	622	627	PF00400	0.333
LIG_BRCT_BRCA1_1	358	362	PF00533	0.450
LIG_deltaCOP1_diTrp_1	423	429	PF00928	0.328
LIG_eIF4E_1	356	362	PF01652	0.489
LIG_eIF4E_1	474	480	PF01652	0.263
LIG_FHA_1	105	111	PF00498	0.464
LIG_FHA_1	247	253	PF00498	0.337
LIG_FHA_1	287	293	PF00498	0.424
LIG_FHA_1	310	316	PF00498	0.434
LIG_FHA_1	405	411	PF00498	0.418
LIG_FHA_1	482	488	PF00498	0.327
LIG_FHA_1	563	569	PF00498	0.476
LIG_FHA_1	617	623	PF00498	0.395
LIG_FHA_2	299	305	PF00498	0.445
LIG_Integrin_RGD_1	328	330	PF01839	0.631
LIG_KLC1_Yacidic_2	506	511	PF13176	0.297
LIG_LIR_Apic_2	194	199	PF02991	0.356
LIG_LIR_Gen_1	123	133	PF02991	0.463
LIG_LIR_Gen_1	282	292	PF02991	0.415
LIG_LIR_Nem_3	282	288	PF02991	0.417
LIG_MYND_3	410	414	PF01753	0.263
LIG_PTB_Apo_2	204	211	PF02174	0.416
LIG_PTB_Phospho_1	204	210	PF10480	0.421
LIG_SH2_CRK	577	581	PF00017	0.336
LIG_SH2_SRC	524	527	PF00017	0.288
LIG_SH2_STAP1	524	528	PF00017	0.316
LIG_SH2_STAT3	419	422	PF00017	0.328
LIG_SH2_STAT5	126	129	PF00017	0.442
LIG_SH2_STAT5	169	172	PF00017	0.375
LIG_SH2_STAT5	204	207	PF00017	0.474
LIG_SH2_STAT5	225	228	PF00017	0.375
LIG_SH2_STAT5	509	512	PF00017	0.321
LIG_SH3_2	383	388	PF14604	0.468
LIG_SH3_3	18	24	PF00018	0.645
LIG_SH3_3	196	202	PF00018	0.426
LIG_SH3_3	380	386	PF00018	0.578
LIG_SH3_3	561	567	PF00018	0.446
LIG_SH3_3	577	583	PF00018	0.433
LIG_SH3_3	590	596	PF00018	0.314
LIG_SUMO_SIM_par_1	567	572	PF11976	0.491
LIG_TRAF2_1	439	442	PF00917	0.382
LIG_TRAF2_1	596	599	PF00917	0.424
LIG_WRC_WIRS_1	615	620	PF05994	0.388
LIG_WRPW_2	555	558	PF00400	0.365
LIG_WW_3	384	388	PF00397	0.493
LIG_WW_3	545	549	PF00397	0.339
MOD_CDC14_SPxK_1	545	548	PF00782	0.364
MOD_CDK_SPK_2	198	203	PF00069	0.452
MOD_CDK_SPxK_1	542	548	PF00069	0.355
MOD_CK1_1	179	185	PF00069	0.463
MOD_CK1_1	191	197	PF00069	0.367
MOD_CK1_1	254	260	PF00069	0.490
MOD_CK1_1	390	396	PF00069	0.449
MOD_CK1_1	454	460	PF00069	0.331
MOD_CK1_1	461	467	PF00069	0.304
MOD_CK1_1	468	474	PF00069	0.353
MOD_CK1_1	562	568	PF00069	0.469
MOD_CK2_1	343	349	PF00069	0.440
MOD_CK2_1	436	442	PF00069	0.290
MOD_GlcNHglycan	112	115	PF01048	0.653
MOD_GlcNHglycan	116	119	PF01048	0.623
MOD_GlcNHglycan	188	191	PF01048	0.641
MOD_GlcNHglycan	193	196	PF01048	0.630
MOD_GlcNHglycan	296	299	PF01048	0.618
MOD_GlcNHglycan	336	340	PF01048	0.681
MOD_GlcNHglycan	41	44	PF01048	0.394
MOD_GlcNHglycan	454	457	PF01048	0.405
MOD_GlcNHglycan	605	608	PF01048	0.583
MOD_GSK3_1	110	117	PF00069	0.562
MOD_GSK3_1	127	134	PF00069	0.437
MOD_GSK3_1	206	213	PF00069	0.389
MOD_GSK3_1	251	258	PF00069	0.461
MOD_GSK3_1	294	301	PF00069	0.413
MOD_GSK3_1	351	358	PF00069	0.469
MOD_GSK3_1	451	458	PF00069	0.333
MOD_GSK3_1	461	468	PF00069	0.305
MOD_N-GLC_1	191	196	PF02516	0.612
MOD_N-GLC_1	206	211	PF02516	0.639
MOD_N-GLC_1	356	361	PF02516	0.657
MOD_N-GLC_1	374	379	PF02516	0.562
MOD_N-GLC_1	436	441	PF02516	0.540
MOD_N-GLC_1	489	494	PF02516	0.497
MOD_NEK2_1	110	115	PF00069	0.569
MOD_NEK2_1	335	340	PF00069	0.491
MOD_NEK2_1	361	366	PF00069	0.534
MOD_NEK2_1	403	408	PF00069	0.361
MOD_NEK2_1	465	470	PF00069	0.320
MOD_NEK2_1	602	607	PF00069	0.475
MOD_NEK2_1	71	76	PF00069	0.581
MOD_NEK2_2	32	37	PF00069	0.554
MOD_PIKK_1	127	133	PF00454	0.443
MOD_PIKK_1	136	142	PF00454	0.453
MOD_PIKK_1	309	315	PF00454	0.376
MOD_PIKK_1	361	367	PF00454	0.416
MOD_PIKK_1	387	393	PF00454	0.417
MOD_PIKK_1	465	471	PF00454	0.315
MOD_PIKK_1	562	568	PF00454	0.406
MOD_PIKK_1	69	75	PF00454	0.482
MOD_PKA_1	387	393	PF00069	0.399
MOD_PKA_2	176	182	PF00069	0.367
MOD_PKA_2	254	260	PF00069	0.526
MOD_PKA_2	387	393	PF00069	0.559
MOD_PKA_2	482	488	PF00069	0.322
MOD_PKB_1	37	45	PF00069	0.666
MOD_Plk_1	191	197	PF00069	0.436
MOD_Plk_1	206	212	PF00069	0.271
MOD_Plk_1	356	362	PF00069	0.458
MOD_Plk_1	374	380	PF00069	0.366
MOD_Plk_1	436	442	PF00069	0.297
MOD_Plk_1	489	495	PF00069	0.297
MOD_Plk_2-3	147	153	PF00069	0.374
MOD_Plk_4	124	130	PF00069	0.377
MOD_Plk_4	241	247	PF00069	0.386
MOD_Plk_4	311	317	PF00069	0.439
MOD_Plk_4	356	362	PF00069	0.492
MOD_Plk_4	455	461	PF00069	0.350
MOD_ProDKin_1	12	18	PF00069	0.703
MOD_ProDKin_1	198	204	PF00069	0.443
MOD_ProDKin_1	20	26	PF00069	0.653
MOD_ProDKin_1	212	218	PF00069	0.246
MOD_ProDKin_1	344	350	PF00069	0.472
MOD_ProDKin_1	351	357	PF00069	0.483
MOD_ProDKin_1	379	385	PF00069	0.600
MOD_ProDKin_1	429	435	PF00069	0.302
MOD_ProDKin_1	542	548	PF00069	0.415
TRG_DiLeu_BaEn_1	598	603	PF01217	0.399
TRG_ENDOCYTIC_2	126	129	PF00928	0.464
TRG_ENDOCYTIC_2	524	527	PF00928	0.342
TRG_ENDOCYTIC_2	577	580	PF00928	0.352
TRG_ENDOCYTIC_2	615	618	PF00928	0.330
TRG_ER_diArg_1	36	39	PF00400	0.642
TRG_ER_diArg_1	386	388	PF00400	0.476
TRG_ER_diArg_1	445	448	PF00400	0.265
TRG_ER_diArg_1	547	550	PF00400	0.383
TRG_ER_diArg_1	6	9	PF00400	0.674
TRG_ER_diArg_1	99	101	PF00400	0.504
TRG_NLS_MonoExtC_3	6	12	PF00514	0.696
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV1	Leptomonas seymouri	27%	100%
A0A0N1PD55	Leptomonas seymouri	48%	100%
A0A1X0NW39	Trypanosomatidae	23%	100%
A0A3Q8IHF7	Leishmania donovani	99%	100%
A4H6H9	Leishmania braziliensis	79%	100%
E9ANK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QH26	Leishmania major	93%	100%
V5BJI5	Trypanosoma cruzi	23%	100%