LeishMANIAdb
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Nucleobase transporter

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleobase transporter
Gene product:
nucleobase transporter
Species:
Leishmania infantum
UniProt:
A4HUW2_LEIIN
TriTrypDb:
LINF_110011200
Length:
550

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Annotations by Jardim et al.

Transporters, Nucleobase transporter NT4

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 39
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 27
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0016020 membrane 2 28
GO:0110165 cellular anatomical entity 1 28
GO:0005886 plasma membrane 3 5

Phosphorylation

Promastigote: 268, 270
Promastigote/Amastigote: 366

Expansion

Sequence features

A4HUW2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUW2

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0015851 nucleobase transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 28
GO:0005337 nucleoside transmembrane transporter activity 4 28
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 28
GO:0022857 transmembrane transporter activity 2 28
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 28
GO:0015205 nucleobase transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 421 425 PF00656 0.290
CLV_NRD_NRD_1 216 218 PF00675 0.250
CLV_NRD_NRD_1 235 237 PF00675 0.419
CLV_NRD_NRD_1 248 250 PF00675 0.407
CLV_NRD_NRD_1 449 451 PF00675 0.265
CLV_NRD_NRD_1 454 456 PF00675 0.259
CLV_PCSK_KEX2_1 216 218 PF00082 0.267
CLV_PCSK_KEX2_1 449 451 PF00082 0.251
CLV_PCSK_SKI1_1 237 241 PF00082 0.439
CLV_PCSK_SKI1_1 303 307 PF00082 0.420
CLV_PCSK_SKI1_1 375 379 PF00082 0.433
CLV_PCSK_SKI1_1 443 447 PF00082 0.465
CLV_PCSK_SKI1_1 456 460 PF00082 0.285
CLV_PCSK_SKI1_1 465 469 PF00082 0.321
CLV_PCSK_SKI1_1 56 60 PF00082 0.451
DEG_SCF_FBW7_1 509 515 PF00400 0.430
DEG_SPOP_SBC_1 343 347 PF00917 0.604
DOC_CDC14_PxL_1 466 474 PF14671 0.267
DOC_CKS1_1 509 514 PF01111 0.471
DOC_CYCLIN_yClb1_LxF_4 56 62 PF00134 0.276
DOC_MAPK_DCC_7 465 474 PF00069 0.376
DOC_MAPK_gen_1 272 278 PF00069 0.623
DOC_MAPK_gen_1 393 400 PF00069 0.509
DOC_MAPK_MEF2A_6 465 474 PF00069 0.347
DOC_MIT_MIM_1 437 447 PF04212 0.248
DOC_PP1_RVXF_1 463 469 PF00149 0.354
DOC_PP2B_LxvP_1 106 109 PF13499 0.332
DOC_PP2B_PxIxI_1 413 419 PF00149 0.324
DOC_USP7_MATH_1 26 30 PF00917 0.385
DOC_USP7_MATH_1 419 423 PF00917 0.347
DOC_USP7_MATH_1 536 540 PF00917 0.397
DOC_USP7_UBL2_3 479 483 PF12436 0.230
DOC_WW_Pin1_4 48 53 PF00397 0.375
DOC_WW_Pin1_4 505 510 PF00397 0.395
LIG_14-3-3_CanoR_1 375 383 PF00244 0.539
LIG_14-3-3_CanoR_1 443 448 PF00244 0.297
LIG_14-3-3_CanoR_1 84 88 PF00244 0.483
LIG_Actin_WH2_2 158 176 PF00022 0.272
LIG_BIR_II_1 1 5 PF00653 0.502
LIG_BRCT_BRCA1_1 495 499 PF00533 0.359
LIG_BRCT_BRCA1_1 50 54 PF00533 0.334
LIG_BRCT_BRCA1_1 85 89 PF00533 0.505
LIG_Clathr_ClatBox_1 88 92 PF01394 0.469
LIG_Clathr_ClatBox_1 97 101 PF01394 0.355
LIG_EH1_1 61 69 PF00400 0.332
LIG_eIF4E_1 435 441 PF01652 0.266
LIG_FHA_1 10 16 PF00498 0.343
LIG_FHA_1 151 157 PF00498 0.473
LIG_FHA_1 184 190 PF00498 0.291
LIG_FHA_1 331 337 PF00498 0.656
LIG_FHA_1 377 383 PF00498 0.475
LIG_FHA_1 407 413 PF00498 0.393
LIG_FHA_1 426 432 PF00498 0.329
LIG_FHA_1 462 468 PF00498 0.248
LIG_FHA_1 509 515 PF00498 0.513
LIG_FHA_1 97 103 PF00498 0.260
LIG_FHA_2 344 350 PF00498 0.696
LIG_FHA_2 356 362 PF00498 0.713
LIG_FHA_2 376 382 PF00498 0.487
LIG_FHA_2 514 520 PF00498 0.503
LIG_GBD_Chelix_1 165 173 PF00786 0.332
LIG_IBAR_NPY_1 212 214 PF08397 0.470
LIG_LIR_Gen_1 139 149 PF02991 0.468
LIG_LIR_Gen_1 178 189 PF02991 0.348
LIG_LIR_Gen_1 424 435 PF02991 0.311
LIG_LIR_LC3C_4 12 16 PF02991 0.248
LIG_LIR_Nem_3 115 119 PF02991 0.281
LIG_LIR_Nem_3 139 144 PF02991 0.489
LIG_LIR_Nem_3 178 184 PF02991 0.336
LIG_LIR_Nem_3 188 194 PF02991 0.323
LIG_LIR_Nem_3 36 41 PF02991 0.383
LIG_LIR_Nem_3 409 413 PF02991 0.319
LIG_LIR_Nem_3 424 430 PF02991 0.311
LIG_LIR_Nem_3 446 451 PF02991 0.467
LIG_LYPXL_S_1 395 399 PF13949 0.271
LIG_LYPXL_S_1 412 416 PF13949 0.185
LIG_LYPXL_yS_3 396 399 PF13949 0.305
LIG_LYPXL_yS_3 413 416 PF13949 0.185
LIG_NRBOX 200 206 PF00104 0.256
LIG_PALB2_WD40_1 422 430 PF16756 0.230
LIG_Pex14_1 229 233 PF04695 0.538
LIG_Pex14_2 81 85 PF04695 0.501
LIG_PTB_Apo_2 135 142 PF02174 0.278
LIG_PTB_Phospho_1 135 141 PF10480 0.278
LIG_REV1ctd_RIR_1 302 311 PF16727 0.631
LIG_SH2_CRK 116 120 PF00017 0.316
LIG_SH2_CRK 181 185 PF00017 0.276
LIG_SH2_CRK 38 42 PF00017 0.285
LIG_SH2_CRK 62 66 PF00017 0.406
LIG_SH2_NCK_1 62 66 PF00017 0.340
LIG_SH2_STAP1 214 218 PF00017 0.490
LIG_SH2_STAP1 300 304 PF00017 0.624
LIG_SH2_STAT5 127 130 PF00017 0.342
LIG_SH2_STAT5 135 138 PF00017 0.357
LIG_SH2_STAT5 191 194 PF00017 0.303
LIG_SH2_STAT5 218 221 PF00017 0.562
LIG_SH2_STAT5 233 236 PF00017 0.601
LIG_SH2_STAT5 264 267 PF00017 0.669
LIG_SH2_STAT5 40 43 PF00017 0.335
LIG_SH2_STAT5 410 413 PF00017 0.292
LIG_SH2_STAT5 487 490 PF00017 0.355
LIG_SH2_STAT5 62 65 PF00017 0.311
LIG_SH3_3 143 149 PF00018 0.451
LIG_SH3_3 18 24 PF00018 0.260
LIG_SH3_3 207 213 PF00018 0.218
LIG_SH3_3 506 512 PF00018 0.453
LIG_Sin3_3 529 536 PF02671 0.237
LIG_SUMO_SIM_anti_2 164 170 PF11976 0.245
LIG_SUMO_SIM_anti_2 202 208 PF11976 0.290
LIG_SUMO_SIM_anti_2 63 69 PF11976 0.364
LIG_SUMO_SIM_anti_2 99 104 PF11976 0.345
LIG_SUMO_SIM_par_1 416 422 PF11976 0.261
LIG_SUMO_SIM_par_1 456 462 PF11976 0.292
LIG_TRAF2_1 314 317 PF00917 0.646
LIG_TYR_ITIM 189 194 PF00017 0.332
LIG_TYR_ITIM 411 416 PF00017 0.243
LIG_UBA3_1 471 479 PF00899 0.280
LIG_WRC_WIRS_1 403 408 PF05994 0.260
LIG_WRC_WIRS_1 78 83 PF05994 0.373
MOD_CK1_1 159 165 PF00069 0.326
MOD_CK1_1 29 35 PF00069 0.299
MOD_CK1_1 508 514 PF00069 0.471
MOD_CK2_1 265 271 PF00069 0.724
MOD_CK2_1 343 349 PF00069 0.654
MOD_CK2_1 375 381 PF00069 0.582
MOD_CK2_1 513 519 PF00069 0.462
MOD_GlcNHglycan 158 161 PF01048 0.374
MOD_GlcNHglycan 201 204 PF01048 0.278
MOD_GlcNHglycan 267 270 PF01048 0.544
MOD_GlcNHglycan 28 31 PF01048 0.564
MOD_GlcNHglycan 346 349 PF01048 0.453
MOD_GlcNHglycan 421 424 PF01048 0.475
MOD_GSK3_1 173 180 PF00069 0.301
MOD_GSK3_1 344 351 PF00069 0.669
MOD_GSK3_1 402 409 PF00069 0.350
MOD_GSK3_1 501 508 PF00069 0.284
MOD_GSK3_1 73 80 PF00069 0.297
MOD_N-GLC_1 330 335 PF02516 0.560
MOD_N-GLC_1 76 81 PF02516 0.347
MOD_N-GLC_2 367 369 PF02516 0.392
MOD_NEK2_1 136 141 PF00069 0.509
MOD_NEK2_1 156 161 PF00069 0.342
MOD_NEK2_1 173 178 PF00069 0.254
MOD_NEK2_1 185 190 PF00069 0.267
MOD_NEK2_1 222 227 PF00069 0.622
MOD_NEK2_1 265 270 PF00069 0.627
MOD_NEK2_1 406 411 PF00069 0.348
MOD_NEK2_1 459 464 PF00069 0.314
MOD_NEK2_1 493 498 PF00069 0.373
MOD_NEK2_1 9 14 PF00069 0.311
MOD_NEK2_1 91 96 PF00069 0.298
MOD_PIKK_1 183 189 PF00454 0.290
MOD_PIKK_1 312 318 PF00454 0.636
MOD_PIKK_1 353 359 PF00454 0.610
MOD_PKA_2 222 228 PF00069 0.520
MOD_PKA_2 83 89 PF00069 0.458
MOD_Plk_1 76 82 PF00069 0.345
MOD_Plk_1 91 97 PF00069 0.278
MOD_Plk_4 10 16 PF00069 0.339
MOD_Plk_4 161 167 PF00069 0.320
MOD_Plk_4 185 191 PF00069 0.287
MOD_Plk_4 29 35 PF00069 0.333
MOD_Plk_4 406 412 PF00069 0.328
MOD_Plk_4 426 432 PF00069 0.320
MOD_Plk_4 443 449 PF00069 0.274
MOD_Plk_4 501 507 PF00069 0.351
MOD_Plk_4 536 542 PF00069 0.414
MOD_Plk_4 60 66 PF00069 0.362
MOD_Plk_4 77 83 PF00069 0.283
MOD_ProDKin_1 48 54 PF00069 0.370
MOD_ProDKin_1 505 511 PF00069 0.395
MOD_SUMO_rev_2 267 274 PF00179 0.612
MOD_SUMO_rev_2 381 388 PF00179 0.536
TRG_DiLeu_BaLyEn_6 440 445 PF01217 0.351
TRG_DiLeu_BaLyEn_6 467 472 PF01217 0.429
TRG_ENDOCYTIC_2 116 119 PF00928 0.316
TRG_ENDOCYTIC_2 141 144 PF00928 0.487
TRG_ENDOCYTIC_2 181 184 PF00928 0.296
TRG_ENDOCYTIC_2 191 194 PF00928 0.336
TRG_ENDOCYTIC_2 38 41 PF00928 0.309
TRG_ENDOCYTIC_2 396 399 PF00928 0.305
TRG_ENDOCYTIC_2 413 416 PF00928 0.185
TRG_ENDOCYTIC_2 62 65 PF00928 0.352
TRG_ER_diArg_1 216 218 PF00400 0.466
TRG_ER_diArg_1 290 293 PF00400 0.611
TRG_ER_diArg_1 448 450 PF00400 0.483
TRG_Pf-PMV_PEXEL_1 263 267 PF00026 0.511

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 47% 100%
A0A0N1I1J0 Leptomonas seymouri 58% 100%
A0A0N1PBQ1 Leptomonas seymouri 37% 100%
A0A3Q8ICX7 Leishmania donovani 37% 100%
A0A3S7WTL0 Leishmania donovani 28% 100%
A0A3S7XAS5 Leishmania donovani 33% 100%
A4H6I0 Leishmania braziliensis 75% 100%
A4H7A5 Leishmania braziliensis 37% 90%
A4HG96 Leishmania braziliensis 24% 92%
A4HP60 Leishmania braziliensis 34% 93%
A4HVP9 Leishmania infantum 37% 100%
A4HWK9 Leishmania infantum 28% 100%
A4IDG6 Leishmania infantum 33% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AGM5 Leishmania infantum 28% 100%
E9AGM6 Leishmania infantum 28% 100%
E9AGM7 Leishmania infantum 28% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 90%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 92%
O76343 Leishmania donovani 28% 100%
Q4Q1M9 Leishmania major 33% 93%
Q4QF58 Leishmania major 27% 91%
Q4QF59 Leishmania major 27% 100%
Q4QG33 Leishmania major 36% 91%
Q4QH25 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS