Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania infantum

UniProt:

A4HUV9_LEIIN

TriTrypDb:

LINF_110009700

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.528
CLV_NRD_NRD_1	451	453	PF00675	0.665
CLV_NRD_NRD_1	530	532	PF00675	0.636
CLV_PCSK_KEX2_1	451	453	PF00082	0.665
CLV_PCSK_KEX2_1	530	532	PF00082	0.636
CLV_PCSK_SKI1_1	149	153	PF00082	0.555
CLV_PCSK_SKI1_1	217	221	PF00082	0.501
CLV_PCSK_SKI1_1	364	368	PF00082	0.589
CLV_PCSK_SKI1_1	531	535	PF00082	0.623
CLV_PCSK_SKI1_1	61	65	PF00082	0.419
CLV_PCSK_SKI1_1	75	79	PF00082	0.490
DEG_APCC_DBOX_1	363	371	PF00400	0.483
DOC_CDC14_PxL_1	512	520	PF14671	0.612
DOC_CYCLIN_RxL_1	103	112	PF00134	0.424
DOC_CYCLIN_RxL_1	149	160	PF00134	0.444
DOC_CYCLIN_RxL_1	75	86	PF00134	0.369
DOC_CYCLIN_yCln2_LP_2	488	494	PF00134	0.609
DOC_MAPK_gen_1	149	159	PF00069	0.574
DOC_MAPK_gen_1	480	490	PF00069	0.595
DOC_MAPK_JIP1_4	61	67	PF00069	0.331
DOC_MAPK_MEF2A_6	152	159	PF00069	0.492
DOC_MAPK_MEF2A_6	364	371	PF00069	0.486
DOC_MAPK_MEF2A_6	483	492	PF00069	0.603
DOC_PP1_RVXF_1	150	157	PF00149	0.446
DOC_PP1_RVXF_1	362	369	PF00149	0.617
DOC_PP1_RVXF_1	393	399	PF00149	0.500
DOC_PP2B_LxvP_1	424	427	PF13499	0.570
DOC_PP2B_LxvP_1	488	491	PF13499	0.606
DOC_PP2B_LxvP_1	513	516	PF13499	0.596
DOC_USP7_MATH_1	129	133	PF00917	0.589
DOC_USP7_MATH_1	163	167	PF00917	0.630
DOC_USP7_MATH_1	199	203	PF00917	0.662
DOC_USP7_MATH_1	56	60	PF00917	0.354
DOC_WW_Pin1_4	194	199	PF00397	0.724
DOC_WW_Pin1_4	226	231	PF00397	0.511
DOC_WW_Pin1_4	242	247	PF00397	0.416
DOC_WW_Pin1_4	25	30	PF00397	0.548
DOC_WW_Pin1_4	404	409	PF00397	0.676
DOC_WW_Pin1_4	442	447	PF00397	0.612
LIG_14-3-3_CanoR_1	170	176	PF00244	0.492
LIG_14-3-3_CanoR_1	352	362	PF00244	0.493
LIG_14-3-3_CanoR_1	395	401	PF00244	0.579
LIG_14-3-3_CanoR_1	452	462	PF00244	0.703
LIG_14-3-3_CanoR_1	519	526	PF00244	0.648
LIG_14-3-3_CanoR_1	53	63	PF00244	0.503
LIG_14-3-3_CterR_2	545	548	PF00244	0.647
LIG_APCC_ABBAyCdc20_2	152	158	PF00400	0.436
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BIR_III_2	195	199	PF00653	0.590
LIG_Clathr_ClatBox_1	154	158	PF01394	0.498
LIG_eIF4E_1	236	242	PF01652	0.556
LIG_EVH1_1	513	517	PF00568	0.597
LIG_FHA_1	229	235	PF00498	0.561
LIG_FHA_1	243	249	PF00498	0.511
LIG_FHA_1	251	257	PF00498	0.380
LIG_FHA_1	261	267	PF00498	0.504
LIG_FHA_1	325	331	PF00498	0.596
LIG_FHA_1	358	364	PF00498	0.588
LIG_FHA_1	468	474	PF00498	0.516
LIG_FHA_1	76	82	PF00498	0.403
LIG_FHA_2	266	272	PF00498	0.616
LIG_FHA_2	275	281	PF00498	0.429
LIG_FHA_2	519	525	PF00498	0.650
LIG_IRF3_LxIS_1	125	131	PF10401	0.475
LIG_LIR_Gen_1	137	148	PF02991	0.488
LIG_LIR_Gen_1	41	50	PF02991	0.381
LIG_LIR_Gen_1	460	471	PF02991	0.531
LIG_LIR_Gen_1	82	92	PF02991	0.446
LIG_LIR_Nem_3	103	108	PF02991	0.346
LIG_LIR_Nem_3	137	143	PF02991	0.516
LIG_LIR_Nem_3	231	236	PF02991	0.589
LIG_LIR_Nem_3	306	311	PF02991	0.542
LIG_LIR_Nem_3	41	45	PF02991	0.374
LIG_LIR_Nem_3	524	528	PF02991	0.647
LIG_LIR_Nem_3	57	63	PF02991	0.433
LIG_LIR_Nem_3	82	88	PF02991	0.451
LIG_MYND_1	493	497	PF01753	0.617
LIG_NRBOX	358	364	PF00104	0.508
LIG_Pex14_1	381	385	PF04695	0.570
LIG_SH2_CRK	140	144	PF00017	0.476
LIG_SH2_CRK	85	89	PF00017	0.447
LIG_SH2_NCK_1	316	320	PF00017	0.523
LIG_SH2_PTP2	147	150	PF00017	0.546
LIG_SH2_STAP1	140	144	PF00017	0.476
LIG_SH2_STAT5	147	150	PF00017	0.456
LIG_SH2_STAT5	191	194	PF00017	0.658
LIG_SH2_STAT5	233	236	PF00017	0.508
LIG_SH2_STAT5	462	465	PF00017	0.535
LIG_SH2_STAT5	507	510	PF00017	0.600
LIG_SH2_STAT5	85	88	PF00017	0.321
LIG_SH3_2	514	519	PF14604	0.611
LIG_SH3_3	12	18	PF00018	0.592
LIG_SH3_3	123	129	PF00018	0.649
LIG_SH3_3	23	29	PF00018	0.456
LIG_SH3_3	243	249	PF00018	0.492
LIG_SH3_3	306	312	PF00018	0.456
LIG_SH3_3	366	372	PF00018	0.639
LIG_SH3_3	490	496	PF00018	0.611
LIG_SH3_3	511	517	PF00018	0.601
LIG_SH3_3	96	102	PF00018	0.481
LIG_Sin3_3	32	39	PF02671	0.335
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.427
LIG_SUMO_SIM_anti_2	356	363	PF11976	0.507
LIG_SUMO_SIM_anti_2	41	48	PF11976	0.347
LIG_SUMO_SIM_anti_2	66	72	PF11976	0.467
LIG_SUMO_SIM_par_1	218	226	PF11976	0.523
LIG_SUMO_SIM_par_1	295	302	PF11976	0.620
LIG_SUMO_SIM_par_1	531	536	PF11976	0.513
LIG_SUMO_SIM_par_1	61	66	PF11976	0.335
LIG_TRAF2_1	391	394	PF00917	0.635
LIG_TYR_ITIM	138	143	PF00017	0.597
LIG_TYR_ITIM	145	150	PF00017	0.438
LIG_TYR_ITIM	83	88	PF00017	0.441
LIG_WRC_WIRS_1	39	44	PF05994	0.477
MOD_CDC14_SPxK_1	445	448	PF00782	0.638
MOD_CDK_SPxK_1	442	448	PF00069	0.620
MOD_CK1_1	131	137	PF00069	0.611
MOD_CK1_1	226	232	PF00069	0.516
MOD_CK1_1	25	31	PF00069	0.542
MOD_CK1_1	54	60	PF00069	0.628
MOD_CK1_1	66	72	PF00069	0.413
MOD_CK2_1	218	224	PF00069	0.431
MOD_CK2_1	274	280	PF00069	0.467
MOD_CK2_1	518	524	PF00069	0.644
MOD_GlcNHglycan	160	164	PF01048	0.596
MOD_GlcNHglycan	201	204	PF01048	0.558
MOD_GlcNHglycan	411	414	PF01048	0.591
MOD_GlcNHglycan	477	480	PF01048	0.603
MOD_GlcNHglycan	5	8	PF01048	0.768
MOD_GSK3_1	109	116	PF00069	0.580
MOD_GSK3_1	124	131	PF00069	0.468
MOD_GSK3_1	13	20	PF00069	0.723
MOD_GSK3_1	159	166	PF00069	0.684
MOD_GSK3_1	260	267	PF00069	0.580
MOD_GSK3_1	270	277	PF00069	0.484
MOD_GSK3_1	353	360	PF00069	0.533
MOD_GSK3_1	438	445	PF00069	0.749
MOD_NEK2_1	1	6	PF00069	0.561
MOD_NEK2_1	133	138	PF00069	0.464
MOD_NEK2_1	211	216	PF00069	0.421
MOD_NEK2_1	265	270	PF00069	0.620
MOD_NEK2_1	286	291	PF00069	0.546
MOD_NEK2_1	299	304	PF00069	0.456
MOD_NEK2_1	467	472	PF00069	0.517
MOD_NEK2_1	518	523	PF00069	0.641
MOD_NEK2_1	63	68	PF00069	0.575
MOD_NEK2_1	81	86	PF00069	0.311
MOD_NEK2_2	324	329	PF00069	0.459
MOD_PIKK_1	228	234	PF00454	0.480
MOD_PIKK_1	250	256	PF00454	0.559
MOD_PIKK_1	258	264	PF00454	0.319
MOD_PIKK_1	518	524	PF00454	0.644
MOD_PIKK_1	8	14	PF00454	0.651
MOD_PK_1	13	19	PF00069	0.554
MOD_PKA_2	169	175	PF00069	0.549
MOD_PKA_2	447	453	PF00069	0.806
MOD_PKA_2	475	481	PF00069	0.570
MOD_PKA_2	518	524	PF00069	0.644
MOD_Plk_1	377	383	PF00069	0.586
MOD_Plk_1	535	541	PF00069	0.620
MOD_Plk_1	81	87	PF00069	0.367
MOD_Plk_2-3	218	224	PF00069	0.479
MOD_Plk_4	139	145	PF00069	0.422
MOD_Plk_4	211	217	PF00069	0.447
MOD_Plk_4	22	28	PF00069	0.502
MOD_Plk_4	270	276	PF00069	0.422
MOD_Plk_4	357	363	PF00069	0.458
MOD_Plk_4	38	44	PF00069	0.424
MOD_Plk_4	419	425	PF00069	0.653
MOD_Plk_4	458	464	PF00069	0.646
MOD_Plk_4	63	69	PF00069	0.441
MOD_ProDKin_1	194	200	PF00069	0.722
MOD_ProDKin_1	226	232	PF00069	0.503
MOD_ProDKin_1	242	248	PF00069	0.407
MOD_ProDKin_1	25	31	PF00069	0.540
MOD_ProDKin_1	404	410	PF00069	0.666
MOD_ProDKin_1	442	448	PF00069	0.620
TRG_DiLeu_BaEn_1	357	362	PF01217	0.507
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.463
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.333
TRG_ENDOCYTIC_2	140	143	PF00928	0.484
TRG_ENDOCYTIC_2	147	150	PF00928	0.456
TRG_ENDOCYTIC_2	85	88	PF00928	0.442
TRG_ER_diArg_1	530	532	PF00400	0.680
TRG_ER_diArg_1	539	542	PF00400	0.585
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAC4	Leptomonas seymouri	49%	81%
A0A3S5H6I5	Leishmania donovani	98%	100%
A4H6G4	Leishmania braziliensis	74%	82%