Putative DNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative DNA ligase

Gene product:

DNA ligase - putative

Species:

Leishmania infantum

UniProt:

A4HUV6_LEIIN

TriTrypDb:

LINF_110009400

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUV6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003909	DNA ligase activity	4	8
GO:0003910	DNA ligase (ATP) activity	5	8
GO:0016874	ligase activity	2	11
GO:0016886	ligase activity, forming phosphoric ester bonds	3	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.567
CLV_C14_Caspase3-7	164	168	PF00656	0.701
CLV_C14_Caspase3-7	181	185	PF00656	0.703
CLV_C14_Caspase3-7	54	58	PF00656	0.543
CLV_NRD_NRD_1	170	172	PF00675	0.789
CLV_NRD_NRD_1	175	177	PF00675	0.806
CLV_NRD_NRD_1	353	355	PF00675	0.695
CLV_NRD_NRD_1	445	447	PF00675	0.761
CLV_NRD_NRD_1	463	465	PF00675	0.638
CLV_NRD_NRD_1	498	500	PF00675	0.645
CLV_NRD_NRD_1	527	529	PF00675	0.587
CLV_NRD_NRD_1	690	692	PF00675	0.676
CLV_PCSK_KEX2_1	170	172	PF00082	0.790
CLV_PCSK_KEX2_1	175	177	PF00082	0.809
CLV_PCSK_KEX2_1	445	447	PF00082	0.761
CLV_PCSK_KEX2_1	463	465	PF00082	0.593
CLV_PCSK_KEX2_1	498	500	PF00082	0.645
CLV_PCSK_KEX2_1	527	529	PF00082	0.566
CLV_PCSK_KEX2_1	690	692	PF00082	0.718
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.656
CLV_PCSK_PC7_1	171	177	PF00082	0.531
CLV_PCSK_SKI1_1	175	179	PF00082	0.687
CLV_PCSK_SKI1_1	468	472	PF00082	0.636
CLV_PCSK_SKI1_1	528	532	PF00082	0.555
CLV_PCSK_SKI1_1	539	543	PF00082	0.584
CLV_PCSK_SKI1_1	545	549	PF00082	0.525
CLV_PCSK_SKI1_1	558	562	PF00082	0.319
DEG_SCF_FBW7_1	605	610	PF00400	0.673
DOC_CDC14_PxL_1	217	225	PF14671	0.488
DOC_CYCLIN_RxL_1	552	565	PF00134	0.524
DOC_MAPK_DCC_7	218	228	PF00069	0.379
DOC_MAPK_gen_1	463	473	PF00069	0.670
DOC_MAPK_gen_1	566	576	PF00069	0.545
DOC_MAPK_MEF2A_6	466	475	PF00069	0.704
DOC_MAPK_NFAT4_5	468	476	PF00069	0.696
DOC_PP2B_LxvP_1	241	244	PF13499	0.614
DOC_PP2B_LxvP_1	431	434	PF13499	0.668
DOC_PP4_FxxP_1	229	232	PF00568	0.507
DOC_PP4_FxxP_1	61	64	PF00568	0.381
DOC_USP7_MATH_1	177	181	PF00917	0.715
DOC_USP7_MATH_1	32	36	PF00917	0.773
DOC_USP7_MATH_1	537	541	PF00917	0.643
DOC_USP7_MATH_1	607	611	PF00917	0.674
DOC_USP7_MATH_1	623	627	PF00917	0.749
DOC_USP7_MATH_1	704	708	PF00917	0.604
DOC_USP7_UBL2_3	263	267	PF12436	0.645
DOC_USP7_UBL2_3	421	425	PF12436	0.652
DOC_USP7_UBL2_3	562	566	PF12436	0.513
DOC_USP7_UBL2_3	614	618	PF12436	0.680
DOC_WW_Pin1_4	100	105	PF00397	0.584
DOC_WW_Pin1_4	232	237	PF00397	0.600
DOC_WW_Pin1_4	24	29	PF00397	0.761
DOC_WW_Pin1_4	302	307	PF00397	0.595
DOC_WW_Pin1_4	324	329	PF00397	0.503
DOC_WW_Pin1_4	354	359	PF00397	0.690
DOC_WW_Pin1_4	482	487	PF00397	0.763
DOC_WW_Pin1_4	60	65	PF00397	0.397
DOC_WW_Pin1_4	603	608	PF00397	0.710
DOC_WW_Pin1_4	702	707	PF00397	0.510
DOC_WW_Pin1_4	80	85	PF00397	0.469
LIG_14-3-3_CanoR_1	204	209	PF00244	0.622
LIG_14-3-3_CanoR_1	283	292	PF00244	0.500
LIG_14-3-3_CanoR_1	310	315	PF00244	0.520
LIG_14-3-3_CanoR_1	340	345	PF00244	0.651
LIG_14-3-3_CanoR_1	38	46	PF00244	0.480
LIG_14-3-3_CanoR_1	539	547	PF00244	0.630
LIG_14-3-3_CanoR_1	70	75	PF00244	0.408
LIG_Actin_WH2_2	424	439	PF00022	0.677
LIG_APCC_ABBA_1	398	403	PF00400	0.475
LIG_BIR_II_1	1	5	PF00653	0.526
LIG_BIR_III_4	182	186	PF00653	0.624
LIG_BRCT_BRCA1_1	204	208	PF00533	0.478
LIG_BRCT_BRCA1_1	629	633	PF00533	0.470
LIG_Clathr_ClatBox_1	120	124	PF01394	0.462
LIG_FHA_1	189	195	PF00498	0.407
LIG_FHA_1	25	31	PF00498	0.551
LIG_FHA_1	285	291	PF00498	0.460
LIG_FHA_1	3	9	PF00498	0.623
LIG_FHA_1	345	351	PF00498	0.644
LIG_FHA_1	392	398	PF00498	0.479
LIG_FHA_1	568	574	PF00498	0.648
LIG_FHA_2	148	154	PF00498	0.582
LIG_FHA_2	511	517	PF00498	0.723
LIG_FHA_2	546	552	PF00498	0.651
LIG_FHA_2	623	629	PF00498	0.591
LIG_FHA_2	721	727	PF00498	0.553
LIG_FHA_2	77	83	PF00498	0.533
LIG_Integrin_RGD_1	493	495	PF01839	0.626
LIG_LIR_Apic_2	111	116	PF02991	0.409
LIG_LIR_Apic_2	73	77	PF02991	0.566
LIG_LIR_Gen_1	191	200	PF02991	0.394
LIG_LIR_Gen_1	718	729	PF02991	0.473
LIG_LIR_Nem_3	107	113	PF02991	0.392
LIG_LIR_Nem_3	191	196	PF02991	0.385
LIG_LIR_Nem_3	551	557	PF02991	0.452
LIG_LIR_Nem_3	630	636	PF02991	0.506
LIG_LIR_Nem_3	718	724	PF02991	0.456
LIG_LYPXL_yS_3	554	557	PF13949	0.557
LIG_MYND_1	555	559	PF01753	0.589
LIG_NRBOX	316	322	PF00104	0.367
LIG_NRBOX	661	667	PF00104	0.441
LIG_PCNA_PIPBox_1	658	667	PF02747	0.441
LIG_PCNA_yPIPBox_3	652	666	PF02747	0.494
LIG_Pex14_2	189	193	PF04695	0.548
LIG_SH2_CRK	113	117	PF00017	0.522
LIG_SH2_CRK	384	388	PF00017	0.456
LIG_SH2_CRK	716	720	PF00017	0.412
LIG_SH2_NCK_1	40	44	PF00017	0.594
LIG_SH2_PTP2	74	77	PF00017	0.550
LIG_SH2_SRC	219	222	PF00017	0.486
LIG_SH2_SRC	401	404	PF00017	0.549
LIG_SH2_SRC	74	77	PF00017	0.521
LIG_SH2_STAT3	146	149	PF00017	0.496
LIG_SH2_STAT3	634	637	PF00017	0.388
LIG_SH2_STAT5	146	149	PF00017	0.387
LIG_SH2_STAT5	219	222	PF00017	0.368
LIG_SH2_STAT5	316	319	PF00017	0.466
LIG_SH2_STAT5	401	404	PF00017	0.450
LIG_SH2_STAT5	74	77	PF00017	0.542
LIG_SH3_1	218	224	PF00018	0.422
LIG_SH3_1	498	504	PF00018	0.646
LIG_SH3_3	218	224	PF00018	0.494
LIG_SH3_3	237	243	PF00018	0.666
LIG_SH3_3	360	366	PF00018	0.594
LIG_SH3_3	498	504	PF00018	0.759
LIG_SH3_3	53	59	PF00018	0.549
LIG_SH3_3	571	577	PF00018	0.492
LIG_SH3_3	645	651	PF00018	0.425
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.570
LIG_SUMO_SIM_anti_2	516	521	PF11976	0.641
LIG_SUMO_SIM_par_1	4	10	PF11976	0.577
LIG_SxIP_EBH_1	375	388	PF03271	0.512
LIG_TRAF2_1	157	160	PF00917	0.507
LIG_TRAF2_1	211	214	PF00917	0.410
LIG_TYR_ITIM	382	387	PF00017	0.406
LIG_UBA3_1	556	562	PF00899	0.453
LIG_WW_3	172	176	PF00397	0.577
MOD_CDC14_SPxK_1	705	708	PF00782	0.566
MOD_CDK_SPK_2	24	29	PF00069	0.659
MOD_CDK_SPK_2	60	65	PF00069	0.388
MOD_CDK_SPxK_1	702	708	PF00069	0.584
MOD_CDK_SPxxK_3	324	331	PF00069	0.431
MOD_CK1_1	253	259	PF00069	0.648
MOD_CK1_1	284	290	PF00069	0.390
MOD_CK1_1	343	349	PF00069	0.669
MOD_CK1_1	591	597	PF00069	0.713
MOD_CK1_1	722	728	PF00069	0.529
MOD_CK1_1	90	96	PF00069	0.765
MOD_CK2_1	510	516	PF00069	0.707
MOD_CK2_1	622	628	PF00069	0.560
MOD_CK2_1	720	726	PF00069	0.467
MOD_CK2_1	76	82	PF00069	0.542
MOD_Cter_Amidation	461	464	PF01082	0.722
MOD_Cter_Amidation	525	528	PF01082	0.658
MOD_Cter_Amidation	612	615	PF01082	0.807
MOD_GlcNHglycan	196	199	PF01048	0.386
MOD_GlcNHglycan	252	255	PF01048	0.596
MOD_GlcNHglycan	337	340	PF01048	0.396
MOD_GlcNHglycan	34	37	PF01048	0.742
MOD_GlcNHglycan	342	345	PF01048	0.482
MOD_GlcNHglycan	367	370	PF01048	0.636
MOD_GlcNHglycan	459	463	PF01048	0.807
MOD_GlcNHglycan	532	535	PF01048	0.627
MOD_GlcNHglycan	625	628	PF01048	0.662
MOD_GlcNHglycan	629	632	PF01048	0.508
MOD_GlcNHglycan	666	669	PF01048	0.618
MOD_GlcNHglycan	680	683	PF01048	0.679
MOD_GlcNHglycan	84	87	PF01048	0.660
MOD_GSK3_1	104	111	PF00069	0.343
MOD_GSK3_1	34	41	PF00069	0.740
MOD_GSK3_1	340	347	PF00069	0.584
MOD_GSK3_1	386	393	PF00069	0.472
MOD_GSK3_1	572	579	PF00069	0.510
MOD_GSK3_1	584	591	PF00069	0.512
MOD_GSK3_1	603	610	PF00069	0.494
MOD_GSK3_1	623	630	PF00069	0.685
MOD_GSK3_1	704	711	PF00069	0.596
MOD_GSK3_1	715	722	PF00069	0.402
MOD_GSK3_1	76	83	PF00069	0.589
MOD_GSK3_1	93	100	PF00069	0.766
MOD_N-GLC_1	284	289	PF02516	0.557
MOD_N-GLC_1	302	307	PF02516	0.429
MOD_N-GLC_1	38	43	PF02516	0.600
MOD_N-GLC_1	646	651	PF02516	0.484
MOD_NEK2_1	152	157	PF00069	0.620
MOD_NEK2_1	18	23	PF00069	0.673
MOD_NEK2_1	194	199	PF00069	0.378
MOD_NEK2_1	203	208	PF00069	0.469
MOD_NEK2_1	390	395	PF00069	0.531
MOD_NEK2_1	450	455	PF00069	0.677
MOD_NEK2_1	471	476	PF00069	0.666
MOD_NEK2_1	584	589	PF00069	0.570
MOD_NEK2_1	646	651	PF00069	0.496
MOD_NEK2_1	715	720	PF00069	0.421
MOD_NEK2_2	105	110	PF00069	0.538
MOD_NEK2_2	680	685	PF00069	0.632
MOD_PIKK_1	269	275	PF00454	0.577
MOD_PIKK_1	305	311	PF00454	0.397
MOD_PIKK_1	391	397	PF00454	0.565
MOD_PK_1	731	737	PF00069	0.563
MOD_PKA_1	614	620	PF00069	0.746
MOD_PKA_2	203	209	PF00069	0.559
MOD_PKA_2	436	442	PF00069	0.666
MOD_PKA_2	450	456	PF00069	0.776
MOD_PKA_2	689	695	PF00069	0.697
MOD_PKB_1	202	210	PF00069	0.544
MOD_Plk_1	135	141	PF00069	0.530
MOD_Plk_1	600	606	PF00069	0.623
MOD_Plk_1	646	652	PF00069	0.494
MOD_Plk_4	135	141	PF00069	0.466
MOD_Plk_4	657	663	PF00069	0.493
MOD_ProDKin_1	100	106	PF00069	0.575
MOD_ProDKin_1	232	238	PF00069	0.618
MOD_ProDKin_1	24	30	PF00069	0.764
MOD_ProDKin_1	302	308	PF00069	0.586
MOD_ProDKin_1	324	330	PF00069	0.500
MOD_ProDKin_1	354	360	PF00069	0.685
MOD_ProDKin_1	482	488	PF00069	0.764
MOD_ProDKin_1	60	66	PF00069	0.395
MOD_ProDKin_1	603	609	PF00069	0.711
MOD_ProDKin_1	702	708	PF00069	0.509
MOD_ProDKin_1	80	86	PF00069	0.472
MOD_SUMO_rev_2	610	620	PF00179	0.569
TRG_DiLeu_BaEn_1	125	130	PF01217	0.349
TRG_DiLeu_BaEn_4	125	131	PF01217	0.332
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.568
TRG_DiLeu_BaLyEn_6	556	561	PF01217	0.448
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.515
TRG_DiLeu_LyEn_5	125	130	PF01217	0.408
TRG_ENDOCYTIC_2	118	121	PF00928	0.482
TRG_ENDOCYTIC_2	384	387	PF00928	0.461
TRG_ENDOCYTIC_2	554	557	PF00928	0.439
TRG_ENDOCYTIC_2	716	719	PF00928	0.400
TRG_ER_diArg_1	174	176	PF00400	0.740
TRG_ER_diArg_1	445	448	PF00400	0.703
TRG_ER_diArg_1	463	466	PF00400	0.729
TRG_ER_diArg_1	497	499	PF00400	0.643
TRG_ER_diArg_1	568	571	PF00400	0.601
TRG_NLS_MonoExtC_3	169	174	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	558	563	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN9	Leptomonas seymouri	51%	97%
A0A1X0NVK9	Trypanosomatidae	35%	100%
A0A3R7NRR1	Trypanosoma rangeli	37%	100%
A0A3S7WRI1	Leishmania donovani	99%	100%
A4H6G1	Leishmania braziliensis	76%	100%
D0A7J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ANJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QH35	Leishmania major	91%	100%
V5BB55	Trypanosoma cruzi	36%	100%