LeishMANIAdb
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Leucine-rich repeat protein (LRRP)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine-rich repeat protein (LRRP)
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HUV5_LEIIN
TriTrypDb:
LINF_110009300
Length:
580

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 7
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4HUV5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUV5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0019899 enzyme binding 3 1
GO:0019900 kinase binding 4 1
GO:0019901 protein kinase binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 531 535 PF00656 0.616
CLV_NRD_NRD_1 180 182 PF00675 0.456
CLV_NRD_NRD_1 240 242 PF00675 0.574
CLV_NRD_NRD_1 340 342 PF00675 0.621
CLV_NRD_NRD_1 438 440 PF00675 0.464
CLV_NRD_NRD_1 445 447 PF00675 0.452
CLV_NRD_NRD_1 561 563 PF00675 0.686
CLV_NRD_NRD_1 7 9 PF00675 0.429
CLV_PCSK_KEX2_1 182 184 PF00082 0.447
CLV_PCSK_KEX2_1 340 342 PF00082 0.615
CLV_PCSK_KEX2_1 438 440 PF00082 0.469
CLV_PCSK_KEX2_1 445 447 PF00082 0.453
CLV_PCSK_KEX2_1 561 563 PF00082 0.550
CLV_PCSK_KEX2_1 6 8 PF00082 0.423
CLV_PCSK_PC1ET2_1 182 184 PF00082 0.447
CLV_PCSK_PC7_1 434 440 PF00082 0.458
CLV_PCSK_SKI1_1 182 186 PF00082 0.444
CLV_PCSK_SKI1_1 340 344 PF00082 0.590
DEG_APCC_DBOX_1 444 452 PF00400 0.517
DEG_Nend_UBRbox_3 1 3 PF02207 0.405
DEG_SPOP_SBC_1 210 214 PF00917 0.615
DEG_SPOP_SBC_1 221 225 PF00917 0.624
DEG_SPOP_SBC_1 315 319 PF00917 0.676
DEG_SPOP_SBC_1 549 553 PF00917 0.625
DOC_CYCLIN_RxL_1 179 186 PF00134 0.451
DOC_CYCLIN_RxL_1 26 40 PF00134 0.396
DOC_MAPK_gen_1 127 137 PF00069 0.431
DOC_MAPK_gen_1 181 190 PF00069 0.446
DOC_MAPK_gen_1 438 444 PF00069 0.488
DOC_MAPK_gen_1 445 453 PF00069 0.480
DOC_MAPK_HePTP_8 180 192 PF00069 0.446
DOC_MAPK_MEF2A_6 183 192 PF00069 0.442
DOC_MAPK_MEF2A_6 446 455 PF00069 0.499
DOC_PP1_RVXF_1 450 456 PF00149 0.396
DOC_PP2B_LxvP_1 190 193 PF13499 0.459
DOC_USP7_MATH_1 221 225 PF00917 0.607
DOC_USP7_MATH_1 306 310 PF00917 0.666
DOC_USP7_MATH_1 373 377 PF00917 0.647
DOC_USP7_MATH_1 471 475 PF00917 0.530
DOC_USP7_MATH_1 519 523 PF00917 0.697
DOC_USP7_MATH_1 533 537 PF00917 0.630
DOC_USP7_MATH_1 544 548 PF00917 0.582
DOC_USP7_MATH_1 549 553 PF00917 0.649
DOC_USP7_MATH_1 94 98 PF00917 0.329
DOC_WW_Pin1_4 287 292 PF00397 0.642
DOC_WW_Pin1_4 349 354 PF00397 0.637
DOC_WW_Pin1_4 358 363 PF00397 0.655
DOC_WW_Pin1_4 367 372 PF00397 0.699
DOC_WW_Pin1_4 391 396 PF00397 0.651
DOC_WW_Pin1_4 504 509 PF00397 0.665
DOC_WW_Pin1_4 529 534 PF00397 0.674
LIG_14-3-3_CanoR_1 183 192 PF00244 0.510
LIG_14-3-3_CanoR_1 211 220 PF00244 0.612
LIG_14-3-3_CanoR_1 253 262 PF00244 0.632
LIG_14-3-3_CanoR_1 300 308 PF00244 0.689
LIG_14-3-3_CanoR_1 364 370 PF00244 0.645
LIG_14-3-3_CanoR_1 380 389 PF00244 0.632
LIG_14-3-3_CanoR_1 429 437 PF00244 0.509
LIG_14-3-3_CanoR_1 8 14 PF00244 0.411
LIG_Actin_WH2_2 441 456 PF00022 0.412
LIG_BRCT_BRCA1_1 168 172 PF00533 0.438
LIG_Clathr_ClatBox_1 134 138 PF01394 0.445
LIG_FHA_1 116 122 PF00498 0.431
LIG_FHA_1 221 227 PF00498 0.604
LIG_FHA_1 324 330 PF00498 0.687
LIG_FHA_1 382 388 PF00498 0.620
LIG_FHA_2 120 126 PF00498 0.435
LIG_FHA_2 71 77 PF00498 0.402
LIG_Integrin_isoDGR_2 378 380 PF01839 0.635
LIG_LIR_Gen_1 104 111 PF02991 0.307
LIG_LIR_Gen_1 122 131 PF02991 0.357
LIG_LIR_Nem_3 104 108 PF02991 0.307
LIG_LIR_Nem_3 122 126 PF02991 0.355
LIG_NRBOX 24 30 PF00104 0.428
LIG_RPA_C_Fungi 452 464 PF08784 0.469
LIG_SH2_CRK 398 402 PF00017 0.608
LIG_SH2_SRC 123 126 PF00017 0.346
LIG_SH2_STAT5 123 126 PF00017 0.346
LIG_SH2_STAT5 310 313 PF00017 0.619
LIG_SH2_STAT5 42 45 PF00017 0.368
LIG_SH3_3 285 291 PF00018 0.612
LIG_SH3_3 399 405 PF00018 0.627
LIG_SH3_3 493 499 PF00018 0.593
LIG_SUMO_SIM_anti_2 164 169 PF11976 0.336
LIG_SUMO_SIM_anti_2 51 57 PF11976 0.307
LIG_SUMO_SIM_par_1 511 516 PF11976 0.598
LIG_SUMO_SIM_par_1 70 76 PF11976 0.405
LIG_TRAF2_1 257 260 PF00917 0.530
LIG_TYR_ITIM 121 126 PF00017 0.378
LIG_WRC_WIRS_1 10 15 PF05994 0.406
MOD_CDC14_SPxK_1 361 364 PF00782 0.594
MOD_CDK_SPK_2 287 292 PF00069 0.629
MOD_CDK_SPxK_1 358 364 PF00069 0.602
MOD_CDK_SPxxK_3 504 511 PF00069 0.819
MOD_CK1_1 161 167 PF00069 0.398
MOD_CK1_1 209 215 PF00069 0.622
MOD_CK1_1 225 231 PF00069 0.597
MOD_CK1_1 274 280 PF00069 0.663
MOD_CK1_1 290 296 PF00069 0.571
MOD_CK1_1 309 315 PF00069 0.546
MOD_CK1_1 322 328 PF00069 0.689
MOD_CK1_1 332 338 PF00069 0.623
MOD_CK1_1 357 363 PF00069 0.695
MOD_CK1_1 37 43 PF00069 0.376
MOD_CK1_1 382 388 PF00069 0.607
MOD_CK1_1 413 419 PF00069 0.581
MOD_CK1_1 474 480 PF00069 0.585
MOD_CK1_1 518 524 PF00069 0.615
MOD_CK1_1 553 559 PF00069 0.688
MOD_CK1_1 97 103 PF00069 0.341
MOD_CK2_1 191 197 PF00069 0.553
MOD_CK2_1 233 239 PF00069 0.678
MOD_CK2_1 70 76 PF00069 0.405
MOD_GlcNHglycan 168 171 PF01048 0.439
MOD_GlcNHglycan 173 176 PF01048 0.402
MOD_GlcNHglycan 247 250 PF01048 0.792
MOD_GlcNHglycan 255 258 PF01048 0.576
MOD_GlcNHglycan 304 307 PF01048 0.651
MOD_GlcNHglycan 311 314 PF01048 0.584
MOD_GlcNHglycan 321 324 PF01048 0.621
MOD_GlcNHglycan 354 357 PF01048 0.630
MOD_GlcNHglycan 476 479 PF01048 0.564
MOD_GlcNHglycan 516 520 PF01048 0.594
MOD_GlcNHglycan 541 544 PF01048 0.645
MOD_GlcNHglycan 546 549 PF01048 0.620
MOD_GSK3_1 115 122 PF00069 0.437
MOD_GSK3_1 201 208 PF00069 0.593
MOD_GSK3_1 216 223 PF00069 0.504
MOD_GSK3_1 225 232 PF00069 0.650
MOD_GSK3_1 245 252 PF00069 0.545
MOD_GSK3_1 261 268 PF00069 0.749
MOD_GSK3_1 286 293 PF00069 0.670
MOD_GSK3_1 302 309 PF00069 0.737
MOD_GSK3_1 315 322 PF00069 0.591
MOD_GSK3_1 352 359 PF00069 0.767
MOD_GSK3_1 379 386 PF00069 0.616
MOD_GSK3_1 515 522 PF00069 0.590
MOD_GSK3_1 529 536 PF00069 0.627
MOD_GSK3_1 544 551 PF00069 0.654
MOD_GSK3_1 572 579 PF00069 0.641
MOD_GSK3_1 97 104 PF00069 0.311
MOD_N-GLC_1 101 106 PF02516 0.307
MOD_N-GLC_1 115 120 PF02516 0.451
MOD_N-GLC_1 56 61 PF02516 0.280
MOD_NEK2_1 101 106 PF00069 0.321
MOD_NEK2_1 229 234 PF00069 0.622
MOD_NEK2_1 265 270 PF00069 0.642
MOD_NEK2_1 34 39 PF00069 0.347
MOD_NEK2_1 374 379 PF00069 0.604
MOD_NEK2_1 383 388 PF00069 0.636
MOD_NEK2_1 550 555 PF00069 0.684
MOD_NEK2_1 56 61 PF00069 0.280
MOD_NEK2_1 567 572 PF00069 0.490
MOD_NEK2_1 77 82 PF00069 0.364
MOD_NEK2_2 471 476 PF00069 0.537
MOD_PIKK_1 183 189 PF00454 0.503
MOD_PIKK_1 413 419 PF00454 0.488
MOD_PIKK_1 457 463 PF00454 0.442
MOD_PIKK_1 522 528 PF00454 0.720
MOD_PK_1 506 512 PF00069 0.632
MOD_PKA_2 210 216 PF00069 0.625
MOD_PKA_2 265 271 PF00069 0.652
MOD_PKA_2 299 305 PF00069 0.657
MOD_PKA_2 306 312 PF00069 0.596
MOD_PKA_2 347 353 PF00069 0.650
MOD_PKA_2 379 385 PF00069 0.674
MOD_PKA_2 428 434 PF00069 0.496
MOD_PKB_1 181 189 PF00069 0.508
MOD_Plk_1 101 107 PF00069 0.307
MOD_Plk_1 221 227 PF00069 0.604
MOD_Plk_1 229 235 PF00069 0.595
MOD_Plk_1 362 368 PF00069 0.714
MOD_Plk_4 119 125 PF00069 0.387
MOD_Plk_4 130 136 PF00069 0.375
MOD_Plk_4 163 169 PF00069 0.422
MOD_Plk_4 258 264 PF00069 0.649
MOD_Plk_4 306 312 PF00069 0.617
MOD_Plk_4 37 43 PF00069 0.354
MOD_Plk_4 383 389 PF00069 0.611
MOD_Plk_4 51 57 PF00069 0.358
MOD_ProDKin_1 287 293 PF00069 0.642
MOD_ProDKin_1 349 355 PF00069 0.640
MOD_ProDKin_1 358 364 PF00069 0.655
MOD_ProDKin_1 367 373 PF00069 0.697
MOD_ProDKin_1 391 397 PF00069 0.651
MOD_ProDKin_1 504 510 PF00069 0.662
MOD_ProDKin_1 529 535 PF00069 0.674
TRG_DiLeu_BaEn_1 23 28 PF01217 0.437
TRG_DiLeu_BaLyEn_6 174 179 PF01217 0.373
TRG_DiLeu_BaLyEn_6 180 185 PF01217 0.422
TRG_ENDOCYTIC_2 123 126 PF00928 0.369
TRG_ENDOCYTIC_2 398 401 PF00928 0.688
TRG_ER_diArg_1 180 183 PF00400 0.460
TRG_ER_diArg_1 339 341 PF00400 0.608
TRG_ER_diArg_1 437 439 PF00400 0.468
TRG_ER_diArg_1 444 446 PF00400 0.456
TRG_ER_diArg_1 5 8 PF00400 0.389
TRG_Pf-PMV_PEXEL_1 144 149 PF00026 0.377
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.419
TRG_Pf-PMV_PEXEL_1 183 187 PF00026 0.439
TRG_Pf-PMV_PEXEL_1 341 346 PF00026 0.608
TRG_Pf-PMV_PEXEL_1 446 450 PF00026 0.511
TRG_Pf-PMV_PEXEL_1 511 516 PF00026 0.598

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBI0 Leptomonas seymouri 51% 92%
A0A3Q8I916 Leishmania donovani 99% 100%
A4H6G0 Leishmania braziliensis 70% 100%
E9ANJ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QH36 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS