Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUV4_LEIIN

TriTrypDb:

LINF_110009200

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	602	606	PF00656	0.674
CLV_C14_Caspase3-7	97	101	PF00656	0.659
CLV_MEL_PAP_1	253	259	PF00089	0.530
CLV_NRD_NRD_1	255	257	PF00675	0.547
CLV_NRD_NRD_1	314	316	PF00675	0.509
CLV_NRD_NRD_1	427	429	PF00675	0.453
CLV_NRD_NRD_1	456	458	PF00675	0.530
CLV_NRD_NRD_1	560	562	PF00675	0.461
CLV_PCSK_KEX2_1	255	257	PF00082	0.547
CLV_PCSK_KEX2_1	427	429	PF00082	0.451
CLV_PCSK_KEX2_1	456	458	PF00082	0.507
CLV_PCSK_KEX2_1	467	469	PF00082	0.526
CLV_PCSK_KEX2_1	480	482	PF00082	0.392
CLV_PCSK_KEX2_1	559	561	PF00082	0.470
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.559
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.547
CLV_PCSK_SKI1_1	282	286	PF00082	0.479
CLV_PCSK_SKI1_1	378	382	PF00082	0.505
CLV_PCSK_SKI1_1	412	416	PF00082	0.554
CLV_PCSK_SKI1_1	429	433	PF00082	0.328
CLV_PCSK_SKI1_1	463	467	PF00082	0.439
CLV_PCSK_SKI1_1	483	487	PF00082	0.498
CLV_PCSK_SKI1_1	51	55	PF00082	0.740
CLV_Separin_Metazoa	252	256	PF03568	0.530
DEG_SPOP_SBC_1	104	108	PF00917	0.472
DEG_SPOP_SBC_1	88	92	PF00917	0.749
DOC_AGCK_PIF_2	493	498	PF00069	0.393
DOC_CKS1_1	385	390	PF01111	0.559
DOC_CKS1_1	83	88	PF01111	0.767
DOC_MAPK_gen_1	225	232	PF00069	0.504
DOC_MAPK_gen_1	399	407	PF00069	0.509
DOC_MAPK_gen_1	424	432	PF00069	0.431
DOC_MAPK_gen_1	456	464	PF00069	0.404
DOC_MAPK_gen_1	559	567	PF00069	0.514
DOC_MAPK_HePTP_8	4	16	PF00069	0.628
DOC_MAPK_MEF2A_6	225	232	PF00069	0.481
DOC_MAPK_MEF2A_6	456	464	PF00069	0.477
DOC_MAPK_MEF2A_6	7	16	PF00069	0.540
DOC_PP1_RVXF_1	376	383	PF00149	0.546
DOC_PP1_RVXF_1	426	433	PF00149	0.495
DOC_PP4_FxxP_1	163	166	PF00568	0.345
DOC_PP4_FxxP_1	381	384	PF00568	0.537
DOC_USP7_MATH_1	104	108	PF00917	0.699
DOC_USP7_MATH_1	31	35	PF00917	0.707
DOC_USP7_MATH_1	52	56	PF00917	0.723
DOC_USP7_UBL2_3	448	452	PF12436	0.504
DOC_USP7_UBL2_3	463	467	PF12436	0.302
DOC_USP7_UBL2_3	584	588	PF12436	0.425
DOC_WW_Pin1_4	100	105	PF00397	0.734
DOC_WW_Pin1_4	130	135	PF00397	0.604
DOC_WW_Pin1_4	300	305	PF00397	0.686
DOC_WW_Pin1_4	324	329	PF00397	0.398
DOC_WW_Pin1_4	384	389	PF00397	0.562
DOC_WW_Pin1_4	45	50	PF00397	0.745
DOC_WW_Pin1_4	82	87	PF00397	0.752
LIG_14-3-3_CanoR_1	397	406	PF00244	0.599
LIG_14-3-3_CanoR_1	422	427	PF00244	0.501
LIG_14-3-3_CanoR_1	519	528	PF00244	0.467
LIG_14-3-3_CanoR_1	541	546	PF00244	0.493
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	302	306	PF00533	0.685
LIG_CtBP_PxDLS_1	443	447	PF00389	0.570
LIG_EVH1_2	126	130	PF00568	0.672
LIG_FHA_1	166	172	PF00498	0.468
LIG_FHA_1	260	266	PF00498	0.513
LIG_FHA_1	354	360	PF00498	0.517
LIG_FHA_1	385	391	PF00498	0.528
LIG_FHA_1	501	507	PF00498	0.509
LIG_FHA_2	342	348	PF00498	0.562
LIG_FHA_2	492	498	PF00498	0.488
LIG_FHA_2	95	101	PF00498	0.789
LIG_LIR_Gen_1	183	193	PF02991	0.577
LIG_LIR_Gen_1	199	208	PF02991	0.387
LIG_LIR_Gen_1	274	284	PF02991	0.508
LIG_LIR_Gen_1	332	341	PF02991	0.566
LIG_LIR_LC3C_4	135	139	PF02991	0.599
LIG_LIR_Nem_3	183	188	PF02991	0.581
LIG_LIR_Nem_3	199	204	PF02991	0.243
LIG_LIR_Nem_3	207	211	PF02991	0.460
LIG_LIR_Nem_3	220	226	PF02991	0.285
LIG_LIR_Nem_3	237	243	PF02991	0.299
LIG_LIR_Nem_3	245	250	PF02991	0.352
LIG_LIR_Nem_3	332	336	PF02991	0.552
LIG_LIR_Nem_3	364	370	PF02991	0.460
LIG_LIR_Nem_3	570	575	PF02991	0.443
LIG_Pex14_2	236	240	PF04695	0.349
LIG_REV1ctd_RIR_1	565	572	PF16727	0.491
LIG_SH2_CRK	267	271	PF00017	0.465
LIG_SH2_CRK	562	566	PF00017	0.416
LIG_SH2_GRB2like	185	188	PF00017	0.565
LIG_SH2_GRB2like	575	578	PF00017	0.407
LIG_SH2_PTP2	201	204	PF00017	0.387
LIG_SH2_SRC	185	188	PF00017	0.565
LIG_SH2_STAP1	244	248	PF00017	0.532
LIG_SH2_STAT3	275	278	PF00017	0.370
LIG_SH2_STAT3	492	495	PF00017	0.493
LIG_SH2_STAT5	177	180	PF00017	0.437
LIG_SH2_STAT5	185	188	PF00017	0.412
LIG_SH2_STAT5	201	204	PF00017	0.387
LIG_SH2_STAT5	275	278	PF00017	0.370
LIG_SH2_STAT5	461	464	PF00017	0.362
LIG_SH2_STAT5	492	495	PF00017	0.415
LIG_SH2_STAT5	566	569	PF00017	0.376
LIG_SH2_STAT5	575	578	PF00017	0.340
LIG_SH3_1	433	439	PF00018	0.522
LIG_SH3_3	121	127	PF00018	0.600
LIG_SH3_3	298	304	PF00018	0.718
LIG_SH3_3	382	388	PF00018	0.573
LIG_SH3_3	433	439	PF00018	0.465
LIG_SH3_3	506	512	PF00018	0.404
LIG_SH3_3	615	621	PF00018	0.704
LIG_SH3_3	80	86	PF00018	0.738
LIG_SUMO_SIM_anti_2	190	195	PF11976	0.420
LIG_SUMO_SIM_anti_2	229	234	PF11976	0.432
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.556
LIG_SUMO_SIM_par_1	149	155	PF11976	0.464
LIG_TRAF2_1	406	409	PF00917	0.451
LIG_TRAF2_1	599	602	PF00917	0.627
LIG_UBA3_1	474	480	PF00899	0.521
LIG_WRC_WIRS_1	205	210	PF05994	0.571
LIG_WW_3	125	129	PF00397	0.716
MOD_CDC14_SPxK_1	48	51	PF00782	0.636
MOD_CDK_SPK_2	326	331	PF00069	0.451
MOD_CDK_SPxK_1	45	51	PF00069	0.772
MOD_CDK_SPxxK_3	324	331	PF00069	0.464
MOD_CK1_1	103	109	PF00069	0.618
MOD_CK1_1	216	222	PF00069	0.459
MOD_CK1_1	326	332	PF00069	0.492
MOD_CK1_1	41	47	PF00069	0.687
MOD_CK1_1	500	506	PF00069	0.516
MOD_CK1_1	604	610	PF00069	0.683
MOD_CK1_1	611	617	PF00069	0.445
MOD_CK1_1	87	93	PF00069	0.662
MOD_CK2_1	211	217	PF00069	0.543
MOD_CK2_1	31	37	PF00069	0.657
MOD_CK2_1	317	323	PF00069	0.497
MOD_CK2_1	491	497	PF00069	0.494
MOD_CK2_1	87	93	PF00069	0.698
MOD_GlcNHglycan	134	137	PF01048	0.658
MOD_GlcNHglycan	144	147	PF01048	0.551
MOD_GlcNHglycan	213	216	PF01048	0.505
MOD_GlcNHglycan	319	322	PF01048	0.543
MOD_GlcNHglycan	40	43	PF01048	0.687
MOD_GlcNHglycan	499	502	PF01048	0.476
MOD_GlcNHglycan	58	61	PF01048	0.528
MOD_GlcNHglycan	589	592	PF01048	0.480
MOD_GlcNHglycan	610	613	PF01048	0.678
MOD_GlcNHglycan	629	632	PF01048	0.800
MOD_GSK3_1	12	19	PF00069	0.568
MOD_GSK3_1	209	216	PF00069	0.546
MOD_GSK3_1	300	307	PF00069	0.676
MOD_GSK3_1	32	39	PF00069	0.418
MOD_GSK3_1	41	48	PF00069	0.626
MOD_GSK3_1	52	59	PF00069	0.667
MOD_GSK3_1	541	548	PF00069	0.554
MOD_GSK3_1	597	604	PF00069	0.555
MOD_GSK3_1	84	91	PF00069	0.678
MOD_GSK3_1	99	106	PF00069	0.645
MOD_N-GLC_1	16	21	PF02516	0.540
MOD_N-GLC_1	520	525	PF02516	0.550
MOD_N-GLC_1	94	99	PF02516	0.775
MOD_NEK2_1	12	17	PF00069	0.526
MOD_NEK2_1	204	209	PF00069	0.559
MOD_NEK2_1	211	216	PF00069	0.548
MOD_NEK2_1	545	550	PF00069	0.423
MOD_NEK2_1	567	572	PF00069	0.456
MOD_NEK2_1	608	613	PF00069	0.646
MOD_NEK2_1	99	104	PF00069	0.693
MOD_PIKK_1	341	347	PF00454	0.585
MOD_PIKK_1	397	403	PF00454	0.627
MOD_PIKK_1	491	497	PF00454	0.494
MOD_PIKK_1	597	603	PF00454	0.611
MOD_PIKK_1	61	67	PF00454	0.740
MOD_PKB_1	395	403	PF00069	0.632
MOD_Plk_1	209	215	PF00069	0.538
MOD_Plk_1	361	367	PF00069	0.546
MOD_Plk_1	604	610	PF00069	0.625
MOD_Plk_4	386	392	PF00069	0.471
MOD_Plk_4	541	547	PF00069	0.487
MOD_ProDKin_1	100	106	PF00069	0.729
MOD_ProDKin_1	130	136	PF00069	0.604
MOD_ProDKin_1	300	306	PF00069	0.676
MOD_ProDKin_1	324	330	PF00069	0.395
MOD_ProDKin_1	384	390	PF00069	0.554
MOD_ProDKin_1	45	51	PF00069	0.746
MOD_ProDKin_1	82	88	PF00069	0.749
TRG_DiLeu_BaEn_1	309	314	PF01217	0.523
TRG_DiLeu_BaLyEn_6	526	531	PF01217	0.499
TRG_ENDOCYTIC_2	185	188	PF00928	0.568
TRG_ENDOCYTIC_2	201	204	PF00928	0.214
TRG_ENDOCYTIC_2	205	208	PF00928	0.467
TRG_ENDOCYTIC_2	319	322	PF00928	0.458
TRG_ENDOCYTIC_2	367	370	PF00928	0.383
TRG_ENDOCYTIC_2	461	464	PF00928	0.516
TRG_ENDOCYTIC_2	562	565	PF00928	0.403
TRG_ENDOCYTIC_2	566	569	PF00928	0.397
TRG_ENDOCYTIC_2	575	578	PF00928	0.360
TRG_ER_diArg_1	254	256	PF00400	0.543
TRG_ER_diArg_1	392	395	PF00400	0.520
TRG_ER_diArg_1	396	399	PF00400	0.525
TRG_ER_diArg_1	426	428	PF00400	0.410
TRG_ER_diArg_1	455	457	PF00400	0.500
TRG_ER_diArg_1	558	561	PF00400	0.450
TRG_NLS_Bipartite_1	467	484	PF00514	0.461
TRG_NLS_MonoExtN_4	479	484	PF00514	0.464
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU37	Leptomonas seymouri	55%	79%
A0A0S4IU07	Bodo saltans	38%	89%
A0A0S4J638	Bodo saltans	32%	88%
A0A1X0NQ80	Trypanosomatidae	31%	84%
A0A1X0NVF1	Trypanosomatidae	45%	97%
A0A3S5H6I4	Leishmania donovani	100%	100%
A0A422N1P2	Trypanosoma rangeli	30%	89%
A0A422NYN8	Trypanosoma rangeli	47%	93%
A4H6F9	Leishmania braziliensis	85%	100%
C9ZT00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	85%
D0A7K0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9ANI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QH37	Leishmania major	96%	100%
V5BNE0	Trypanosoma cruzi	31%	90%
V5DSY4	Trypanosoma cruzi	47%	94%