LeishMANIAdb
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Optic atrophy 3 protein-domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Optic atrophy 3 protein-domain-containing protein
Gene product:
Optic atrophy 3 protein (OPA3) - putative
Species:
Leishmania infantum
UniProt:
A4HUU7_LEIIN
TriTrypDb:
LINF_110008500
Length:
398

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Optic atrophy 3 (OPA3), putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HUU7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUU7

Function

Biological processes
Term Name Level Count
GO:0019216 regulation of lipid metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0050789 regulation of biological process 2 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 321 323 PF00675 0.812
CLV_NRD_NRD_1 352 354 PF00675 0.725
CLV_PCSK_KEX2_1 32 34 PF00082 0.350
CLV_PCSK_KEX2_1 396 398 PF00082 0.677
CLV_PCSK_PC1ET2_1 32 34 PF00082 0.350
CLV_PCSK_PC1ET2_1 396 398 PF00082 0.677
CLV_PCSK_PC7_1 28 34 PF00082 0.410
CLV_PCSK_SKI1_1 15 19 PF00082 0.348
CLV_PCSK_SKI1_1 152 156 PF00082 0.376
CLV_PCSK_SKI1_1 32 36 PF00082 0.322
CLV_PCSK_SKI1_1 66 70 PF00082 0.327
CLV_PCSK_SKI1_1 8 12 PF00082 0.395
DEG_APCC_DBOX_1 151 159 PF00400 0.430
DEG_SPOP_SBC_1 108 112 PF00917 0.424
DEG_SPOP_SBC_1 98 102 PF00917 0.326
DOC_CYCLIN_RxL_1 149 157 PF00134 0.430
DOC_MAPK_gen_1 370 380 PF00069 0.650
DOC_PP4_FxxP_1 207 210 PF00568 0.430
DOC_USP7_MATH_1 108 112 PF00917 0.430
DOC_USP7_MATH_1 117 121 PF00917 0.365
DOC_USP7_MATH_1 129 133 PF00917 0.466
DOC_USP7_MATH_1 195 199 PF00917 0.392
DOC_USP7_MATH_1 261 265 PF00917 0.430
DOC_USP7_MATH_1 327 331 PF00917 0.615
DOC_USP7_MATH_1 98 102 PF00917 0.458
DOC_WW_Pin1_4 101 106 PF00397 0.287
DOC_WW_Pin1_4 140 145 PF00397 0.498
DOC_WW_Pin1_4 276 281 PF00397 0.656
LIG_14-3-3_CanoR_1 150 155 PF00244 0.376
LIG_14-3-3_CanoR_1 204 208 PF00244 0.455
LIG_14-3-3_CanoR_1 275 280 PF00244 0.645
LIG_14-3-3_CanoR_1 296 304 PF00244 0.590
LIG_14-3-3_CanoR_1 33 38 PF00244 0.361
LIG_14-3-3_CanoR_1 45 49 PF00244 0.300
LIG_Actin_WH2_2 278 294 PF00022 0.701
LIG_APCC_ABBA_1 208 213 PF00400 0.430
LIG_BRCT_BRCA1_1 173 177 PF00533 0.430
LIG_Clathr_ClatBox_1 236 240 PF01394 0.430
LIG_DLG_GKlike_1 150 158 PF00625 0.430
LIG_FHA_1 16 22 PF00498 0.405
LIG_FHA_1 173 179 PF00498 0.397
LIG_FHA_1 233 239 PF00498 0.430
LIG_FHA_1 292 298 PF00498 0.705
LIG_FHA_1 303 309 PF00498 0.570
LIG_FHA_1 34 40 PF00498 0.327
LIG_FHA_1 375 381 PF00498 0.664
LIG_FHA_2 181 187 PF00498 0.387
LIG_FHA_2 56 62 PF00498 0.430
LIG_LIR_Apic_2 206 210 PF02991 0.430
LIG_LIR_Gen_1 174 184 PF02991 0.424
LIG_LIR_Gen_1 198 208 PF02991 0.430
LIG_LIR_LC3C_4 235 239 PF02991 0.430
LIG_LIR_Nem_3 174 180 PF02991 0.440
LIG_LIR_Nem_3 198 203 PF02991 0.376
LIG_LIR_Nem_3 298 304 PF02991 0.613
LIG_NRBOX 232 238 PF00104 0.397
LIG_PCNA_yPIPBox_3 381 393 PF02747 0.579
LIG_Pex14_2 203 207 PF04695 0.430
LIG_Pex14_2 7 11 PF04695 0.430
LIG_SH2_CRK 230 234 PF00017 0.376
LIG_SH2_CRK 361 365 PF00017 0.765
LIG_SH2_SRC 361 364 PF00017 0.746
LIG_SH2_STAP1 172 176 PF00017 0.404
LIG_SH2_STAT3 160 163 PF00017 0.430
LIG_SH2_STAT5 230 233 PF00017 0.395
LIG_SH2_STAT5 37 40 PF00017 0.424
LIG_SH3_1 361 367 PF00018 0.689
LIG_SH3_3 14 20 PF00018 0.430
LIG_SH3_3 156 162 PF00018 0.430
LIG_SH3_3 345 351 PF00018 0.663
LIG_SH3_3 361 367 PF00018 0.726
LIG_SUMO_SIM_anti_2 235 240 PF11976 0.430
LIG_SUMO_SIM_par_1 234 240 PF11976 0.430
LIG_TRAF2_1 281 284 PF00917 0.681
LIG_TRAF2_1 335 338 PF00917 0.637
LIG_TYR_ITIM 228 233 PF00017 0.342
LIG_WW_3 362 366 PF00397 0.688
MOD_CDK_SPK_2 145 150 PF00069 0.410
MOD_CDK_SPxxK_3 145 152 PF00069 0.410
MOD_CK1_1 101 107 PF00069 0.397
MOD_CK1_1 111 117 PF00069 0.432
MOD_CK1_1 133 139 PF00069 0.446
MOD_CK1_1 140 146 PF00069 0.470
MOD_CK1_1 245 251 PF00069 0.411
MOD_CK1_1 316 322 PF00069 0.726
MOD_CK1_1 325 331 PF00069 0.735
MOD_CK2_1 180 186 PF00069 0.390
MOD_CK2_1 55 61 PF00069 0.382
MOD_CK2_1 97 103 PF00069 0.419
MOD_Cter_Amidation 320 323 PF01082 0.722
MOD_GlcNHglycan 111 114 PF01048 0.475
MOD_GlcNHglycan 119 122 PF01048 0.254
MOD_GlcNHglycan 139 142 PF01048 0.175
MOD_GlcNHglycan 197 200 PF01048 0.455
MOD_GlcNHglycan 247 250 PF01048 0.487
MOD_GlcNHglycan 297 300 PF01048 0.688
MOD_GlcNHglycan 325 328 PF01048 0.708
MOD_GlcNHglycan 329 332 PF01048 0.733
MOD_GlcNHglycan 344 347 PF01048 0.682
MOD_GlcNHglycan 50 53 PF01048 0.399
MOD_GSK3_1 104 111 PF00069 0.431
MOD_GSK3_1 113 120 PF00069 0.472
MOD_GSK3_1 129 136 PF00069 0.466
MOD_GSK3_1 150 157 PF00069 0.430
MOD_GSK3_1 168 175 PF00069 0.430
MOD_GSK3_1 228 235 PF00069 0.430
MOD_GSK3_1 24 31 PF00069 0.501
MOD_GSK3_1 291 298 PF00069 0.697
MOD_GSK3_1 322 329 PF00069 0.788
MOD_GSK3_1 44 51 PF00069 0.171
MOD_GSK3_1 93 100 PF00069 0.427
MOD_NEK2_1 154 159 PF00069 0.430
MOD_NEK2_1 178 183 PF00069 0.501
MOD_NEK2_1 203 208 PF00069 0.430
MOD_NEK2_1 291 296 PF00069 0.735
MOD_NEK2_1 342 347 PF00069 0.654
MOD_NEK2_1 48 53 PF00069 0.397
MOD_NEK2_2 172 177 PF00069 0.404
MOD_PKA_1 322 328 PF00069 0.802
MOD_PKA_2 203 209 PF00069 0.455
MOD_PKA_2 245 251 PF00069 0.430
MOD_PKA_2 291 297 PF00069 0.717
MOD_PKA_2 316 322 PF00069 0.717
MOD_PKA_2 44 50 PF00069 0.357
MOD_Plk_1 130 136 PF00069 0.385
MOD_Plk_1 172 178 PF00069 0.430
MOD_Plk_1 374 380 PF00069 0.644
MOD_Plk_4 154 160 PF00069 0.420
MOD_Plk_4 172 178 PF00069 0.430
MOD_Plk_4 203 209 PF00069 0.430
MOD_Plk_4 228 234 PF00069 0.376
MOD_Plk_4 374 380 PF00069 0.647
MOD_ProDKin_1 101 107 PF00069 0.287
MOD_ProDKin_1 140 146 PF00069 0.498
MOD_ProDKin_1 276 282 PF00069 0.661
MOD_SUMO_rev_2 260 266 PF00179 0.393
MOD_SUMO_rev_2 61 70 PF00179 0.326
TRG_DiLeu_BaEn_1 383 388 PF01217 0.572
TRG_DiLeu_BaEn_4 337 343 PF01217 0.643
TRG_ENDOCYTIC_2 230 233 PF00928 0.342
TRG_ER_diArg_1 149 152 PF00400 0.376
TRG_NES_CRM1_1 382 395 PF08389 0.605
TRG_Pf-PMV_PEXEL_1 152 156 PF00026 0.376

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2X1 Leptomonas seymouri 57% 93%
A0A3Q8I8X5 Leishmania donovani 100% 100%
A4H6F3 Leishmania braziliensis 74% 99%
E9ANI2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QH44 Leishmania major 91% 99%
V5BRK4 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS