Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUU5_LEIIN

TriTrypDb:

LINF_110008300

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.675
CLV_NRD_NRD_1	17	19	PF00675	0.666
CLV_NRD_NRD_1	4	6	PF00675	0.675
CLV_NRD_NRD_1	427	429	PF00675	0.578
CLV_PCSK_KEX2_1	13	15	PF00082	0.636
CLV_PCSK_KEX2_1	360	362	PF00082	0.621
CLV_PCSK_KEX2_1	4	6	PF00082	0.661
CLV_PCSK_KEX2_1	426	428	PF00082	0.633
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.561
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.637
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.633
DEG_SIAH_1	441	449	PF03145	0.615
DEG_SPOP_SBC_1	232	236	PF00917	0.644
DOC_CKS1_1	128	133	PF01111	0.670
DOC_USP7_MATH_1	109	113	PF00917	0.749
DOC_USP7_MATH_1	278	282	PF00917	0.648
DOC_USP7_MATH_1	291	295	PF00917	0.655
DOC_USP7_MATH_1	386	390	PF00917	0.677
DOC_USP7_MATH_1	405	409	PF00917	0.606
DOC_USP7_UBL2_3	100	104	PF12436	0.605
DOC_USP7_UBL2_3	6	10	PF12436	0.672
DOC_WW_Pin1_4	127	132	PF00397	0.682
DOC_WW_Pin1_4	162	167	PF00397	0.718
DOC_WW_Pin1_4	214	219	PF00397	0.563
DOC_WW_Pin1_4	220	225	PF00397	0.542
DOC_WW_Pin1_4	233	238	PF00397	0.597
DOC_WW_Pin1_4	273	278	PF00397	0.640
DOC_WW_Pin1_4	351	356	PF00397	0.763
DOC_WW_Pin1_4	362	367	PF00397	0.777
DOC_WW_Pin1_4	369	374	PF00397	0.621
DOC_WW_Pin1_4	79	84	PF00397	0.622
LIG_14-3-3_CanoR_1	136	140	PF00244	0.732
LIG_14-3-3_CanoR_1	61	70	PF00244	0.598
LIG_14-3-3_CterR_2	466	470	PF00244	0.564
LIG_Actin_WH2_2	190	206	PF00022	0.566
LIG_Actin_WH2_2	305	322	PF00022	0.545
LIG_BIR_III_4	250	254	PF00653	0.488
LIG_Clathr_ClatBox_1	263	267	PF01394	0.640
LIG_FHA_1	118	124	PF00498	0.657
LIG_FHA_1	240	246	PF00498	0.613
LIG_FHA_1	346	352	PF00498	0.555
LIG_FHA_2	128	134	PF00498	0.662
LIG_FHA_2	291	297	PF00498	0.508
LIG_GBD_Chelix_1	179	187	PF00786	0.549
LIG_HP1_1	448	452	PF01393	0.654
LIG_LIR_Apic_2	296	302	PF02991	0.563
LIG_LIR_Apic_2	411	416	PF02991	0.562
LIG_LIR_Gen_1	307	315	PF02991	0.443
LIG_LIR_Gen_1	348	357	PF02991	0.625
LIG_LIR_Nem_3	175	181	PF02991	0.584
LIG_LIR_Nem_3	196	201	PF02991	0.657
LIG_LIR_Nem_3	296	301	PF02991	0.561
LIG_LIR_Nem_3	307	313	PF02991	0.378
LIG_LIR_Nem_3	348	353	PF02991	0.679
LIG_SH2_CRK	125	129	PF00017	0.641
LIG_SH2_CRK	413	417	PF00017	0.576
LIG_SH2_NCK_1	125	129	PF00017	0.641
LIG_SH2_STAT5	178	181	PF00017	0.491
LIG_SH2_STAT5	417	420	PF00017	0.523
LIG_SH2_STAT5	47	50	PF00017	0.691
LIG_SH3_1	125	131	PF00018	0.637
LIG_SH3_3	125	131	PF00018	0.734
LIG_SH3_3	153	159	PF00018	0.691
LIG_SH3_3	321	327	PF00018	0.599
LIG_SUMO_SIM_par_1	261	267	PF11976	0.584
LIG_TRFH_1	256	260	PF08558	0.499
LIG_TRFH_1	298	302	PF08558	0.473
LIG_WW_3	322	326	PF00397	0.600
MOD_CDK_SPK_2	364	369	PF00069	0.727
MOD_CDK_SPxxK_3	351	358	PF00069	0.625
MOD_CDK_SPxxK_3	362	369	PF00069	0.675
MOD_CK1_1	118	124	PF00069	0.753
MOD_CK1_1	138	144	PF00069	0.620
MOD_CK1_1	188	194	PF00069	0.699
MOD_CK1_1	202	208	PF00069	0.535
MOD_CK1_1	233	239	PF00069	0.635
MOD_CK1_1	262	268	PF00069	0.599
MOD_CK1_1	279	285	PF00069	0.647
MOD_CK1_1	389	395	PF00069	0.590
MOD_CK1_1	408	414	PF00069	0.622
MOD_CK1_1	54	60	PF00069	0.769
MOD_CK2_1	79	85	PF00069	0.653
MOD_DYRK1A_RPxSP_1	369	373	PF00069	0.584
MOD_GlcNHglycan	111	114	PF01048	0.760
MOD_GlcNHglycan	117	120	PF01048	0.677
MOD_GlcNHglycan	140	143	PF01048	0.524
MOD_GlcNHglycan	204	207	PF01048	0.522
MOD_GlcNHglycan	293	296	PF01048	0.615
MOD_GlcNHglycan	428	431	PF01048	0.702
MOD_GlcNHglycan	89	92	PF01048	0.763
MOD_GSK3_1	123	130	PF00069	0.684
MOD_GSK3_1	181	188	PF00069	0.555
MOD_GSK3_1	189	196	PF00069	0.547
MOD_GSK3_1	258	265	PF00069	0.559
MOD_GSK3_1	279	286	PF00069	0.626
MOD_GSK3_1	389	396	PF00069	0.730
MOD_GSK3_1	50	57	PF00069	0.673
MOD_GSK3_1	66	73	PF00069	0.512
MOD_N-GLC_1	188	193	PF02516	0.593
MOD_N-GLC_1	70	75	PF02516	0.610
MOD_NEK2_1	123	128	PF00069	0.650
MOD_NEK2_1	150	155	PF00069	0.614
MOD_NEK2_1	305	310	PF00069	0.511
MOD_NEK2_1	52	57	PF00069	0.703
MOD_NEK2_2	199	204	PF00069	0.557
MOD_OFUCOSY	157	164	PF10250	0.598
MOD_PIKK_1	386	392	PF00454	0.629
MOD_PIKK_1	408	414	PF00454	0.539
MOD_PIKK_1	94	100	PF00454	0.598
MOD_PKA_1	426	432	PF00069	0.635
MOD_PKA_2	135	141	PF00069	0.699
MOD_PKA_2	426	432	PF00069	0.635
MOD_Plk_1	188	194	PF00069	0.564
MOD_Plk_4	145	151	PF00069	0.716
MOD_Plk_4	193	199	PF00069	0.545
MOD_Plk_4	259	265	PF00069	0.542
MOD_Plk_4	300	306	PF00069	0.490
MOD_ProDKin_1	127	133	PF00069	0.675
MOD_ProDKin_1	162	168	PF00069	0.717
MOD_ProDKin_1	214	220	PF00069	0.564
MOD_ProDKin_1	233	239	PF00069	0.667
MOD_ProDKin_1	273	279	PF00069	0.640
MOD_ProDKin_1	351	357	PF00069	0.762
MOD_ProDKin_1	362	368	PF00069	0.776
MOD_ProDKin_1	369	375	PF00069	0.618
MOD_ProDKin_1	79	85	PF00069	0.624
TRG_ENDOCYTIC_2	298	301	PF00928	0.478
TRG_ER_diArg_1	397	400	PF00400	0.683
TRG_NLS_MonoCore_2	3	8	PF00514	0.637
TRG_NLS_MonoExtC_3	9	14	PF00514	0.615
TRG_NLS_MonoExtN_4	4	9	PF00514	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY1	Leptomonas seymouri	33%	100%
A0A3Q8I8Z9	Leishmania donovani	99%	100%
A4H6F1	Leishmania braziliensis	64%	98%
E9ANI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4QH46	Leishmania major	80%	100%