Sec20-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sec20 - putative

Species:

Leishmania infantum

UniProt:

A4HUU1_LEIIN

TriTrypDb:

LINF_110007900

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4HUU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUU1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	10
GO:0016192	vesicle-mediated transport	4	10
GO:0048193	Golgi vesicle transport	5	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10

Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	10
GO:0030674	protein-macromolecule adaptor activity	2	10
GO:0060090	molecular adaptor activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	238	244	PF00089	0.453
CLV_NRD_NRD_1	138	140	PF00675	0.372
CLV_PCSK_KEX2_1	138	140	PF00082	0.372
CLV_PCSK_PC7_1	134	140	PF00082	0.358
CLV_PCSK_SKI1_1	138	142	PF00082	0.380
CLV_PCSK_SKI1_1	175	179	PF00082	0.275
CLV_PCSK_SKI1_1	181	185	PF00082	0.279
CLV_PCSK_SKI1_1	227	231	PF00082	0.270
DEG_APCC_DBOX_1	133	141	PF00400	0.624
DEG_Nend_UBRbox_2	1	3	PF02207	0.697
DEG_SPOP_SBC_1	159	163	PF00917	0.703
DOC_CYCLIN_RxL_1	172	182	PF00134	0.468
DOC_CYCLIN_RxL_1	224	234	PF00134	0.470
DOC_MAPK_gen_1	121	130	PF00069	0.605
DOC_MAPK_gen_1	224	232	PF00069	0.489
DOC_MAPK_gen_1	55	65	PF00069	0.611
DOC_MAPK_MEF2A_6	235	242	PF00069	0.482
DOC_MAPK_MEF2A_6	25	33	PF00069	0.653
DOC_MAPK_NFAT4_5	235	243	PF00069	0.494
DOC_USP7_MATH_1	110	114	PF00917	0.758
DOC_USP7_MATH_1	173	177	PF00917	0.476
DOC_USP7_MATH_1	199	203	PF00917	0.488
DOC_WW_Pin1_4	10	15	PF00397	0.759
DOC_WW_Pin1_4	101	106	PF00397	0.738
DOC_WW_Pin1_4	108	113	PF00397	0.758
DOC_WW_Pin1_4	17	22	PF00397	0.740
LIG_14-3-3_CanoR_1	165	174	PF00244	0.659
LIG_14-3-3_CanoR_1	181	187	PF00244	0.557
LIG_14-3-3_CanoR_1	224	230	PF00244	0.480
LIG_14-3-3_CanoR_1	241	249	PF00244	0.259
LIG_Actin_WH2_2	123	140	PF00022	0.639
LIG_Actin_WH2_2	225	243	PF00022	0.470
LIG_FHA_1	2	8	PF00498	0.692
LIG_FHA_1	24	30	PF00498	0.682
LIG_FHA_1	264	270	PF00498	0.485
LIG_FHA_1	54	60	PF00498	0.655
LIG_FHA_2	118	124	PF00498	0.705
LIG_FHA_2	153	159	PF00498	0.696
LIG_FHA_2	268	274	PF00498	0.457
LIG_FHA_2	77	83	PF00498	0.561
LIG_LIR_Gen_1	265	274	PF02991	0.515
LIG_LIR_Nem_3	265	271	PF02991	0.489
LIG_NRBOX	173	179	PF00104	0.470
LIG_PCNA_yPIPBox_3	223	235	PF02747	0.465
LIG_PDZ_Class_3	269	274	PF00595	0.470
LIG_SH2_PTP2	268	271	PF00017	0.479
LIG_SH2_STAT5	253	256	PF00017	0.316
LIG_SH2_STAT5	268	271	PF00017	0.410
LIG_SH3_3	11	17	PF00018	0.750
LIG_SH3_3	18	24	PF00018	0.729
LIG_SUMO_SIM_par_1	228	234	PF11976	0.453
LIG_TRAF2_1	120	123	PF00917	0.674
LIG_TRFH_1	260	264	PF08558	0.474
LIG_UBA3_1	183	190	PF00899	0.491
LIG_WW_3	22	26	PF00397	0.622
MOD_CDK_SPxxK_3	101	108	PF00069	0.733
MOD_CK1_1	15	21	PF00069	0.728
MOD_CK1_1	163	169	PF00069	0.703
MOD_CK1_1	182	188	PF00069	0.546
MOD_CK1_1	201	207	PF00069	0.390
MOD_CK1_1	99	105	PF00069	0.741
MOD_CK2_1	117	123	PF00069	0.692
MOD_CK2_1	214	220	PF00069	0.543
MOD_CK2_1	267	273	PF00069	0.450
MOD_CK2_1	76	82	PF00069	0.581
MOD_GlcNHglycan	162	165	PF01048	0.514
MOD_GlcNHglycan	17	20	PF01048	0.516
MOD_GlcNHglycan	242	245	PF01048	0.425
MOD_GlcNHglycan	98	101	PF01048	0.555
MOD_GSK3_1	104	111	PF00069	0.788
MOD_GSK3_1	159	166	PF00069	0.736
MOD_GSK3_1	173	180	PF00069	0.475
MOD_GSK3_1	204	211	PF00069	0.555
MOD_GSK3_1	263	270	PF00069	0.443
MOD_N-GLC_1	152	157	PF02516	0.511
MOD_N-GLC_1	53	58	PF02516	0.477
MOD_NEK2_1	1	6	PF00069	0.687
MOD_NEK2_1	177	182	PF00069	0.475
MOD_NEK2_1	208	213	PF00069	0.493
MOD_NEK2_1	225	230	PF00069	0.475
MOD_NEK2_1	240	245	PF00069	0.216
MOD_NEK2_1	44	49	PF00069	0.599
MOD_PIKK_1	53	59	PF00454	0.601
MOD_PKA_2	240	246	PF00069	0.316
MOD_Plk_2-3	152	158	PF00069	0.680
MOD_Plk_4	263	269	PF00069	0.451
MOD_ProDKin_1	10	16	PF00069	0.758
MOD_ProDKin_1	101	107	PF00069	0.741
MOD_ProDKin_1	108	114	PF00069	0.757
MOD_ProDKin_1	17	23	PF00069	0.737
MOD_SUMO_rev_2	182	191	PF00179	0.551
TRG_ENDOCYTIC_2	127	130	PF00928	0.633
TRG_ENDOCYTIC_2	268	271	PF00928	0.479
TRG_ER_diArg_1	137	139	PF00400	0.564
TRG_ER_diArg_1	88	91	PF00400	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V7	Leptomonas seymouri	61%	100%
A0A1X0NV60	Trypanosomatidae	47%	100%
A0A3S5ISC5	Trypanosoma rangeli	39%	100%
A0A3S7WRJ0	Leishmania donovani	100%	100%
A4H9S8	Leishmania braziliensis	83%	100%
E9ANH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QH50	Leishmania major	95%	100%
V5BBG4	Trypanosoma cruzi	42%	100%