Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rad51/AAA domain/KaiC/ATPase family associated with various cellular activities (AAA) - putative

Species:

Leishmania infantum

UniProt:

A4HUT5_LEIIN

TriTrypDb:

LINF_110007200

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUT5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	6
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	6
GO:0006974	DNA damage response	4	6
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	6
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	6
GO:0051716	cellular response to stimulus	2	6
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000730	DNA recombinase assembly	7	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0042148	strand invasion	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090735	DNA repair complex assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140299	small molecule sensor activity	1	7
GO:0140612	DNA damage sensor activity	2	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0140664	ATP-dependent DNA damage sensor activity	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0000150	DNA strand exchange activity	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.613
CLV_C14_Caspase3-7	228	232	PF00656	0.407
CLV_C14_Caspase3-7	239	243	PF00656	0.437
CLV_C14_Caspase3-7	4	8	PF00656	0.615
CLV_NRD_NRD_1	162	164	PF00675	0.269
CLV_NRD_NRD_1	20	22	PF00675	0.632
CLV_NRD_NRD_1	277	279	PF00675	0.258
CLV_PCSK_KEX2_1	162	164	PF00082	0.269
CLV_PCSK_KEX2_1	20	22	PF00082	0.632
CLV_PCSK_KEX2_1	277	279	PF00082	0.284
CLV_PCSK_KEX2_1	302	304	PF00082	0.269
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.269
CLV_PCSK_SKI1_1	387	391	PF00082	0.419
CLV_PCSK_SKI1_1	425	429	PF00082	0.576
DEG_APCC_DBOX_1	430	438	PF00400	0.453
DEG_COP1_1	505	515	PF00400	0.453
DEG_ODPH_VHL_1	489	501	PF01847	0.622
DEG_SCF_FBW7_2	29	35	PF00400	0.501
DEG_SPOP_SBC_1	138	142	PF00917	0.484
DOC_CKS1_1	29	34	PF01111	0.504
DOC_CYCLIN_yCln2_LP_2	437	443	PF00134	0.360
DOC_MAPK_gen_1	429	436	PF00069	0.477
DOC_PP1_RVXF_1	385	391	PF00149	0.421
DOC_PP1_RVXF_1	427	433	PF00149	0.527
DOC_PP2B_LxvP_1	144	147	PF13499	0.516
DOC_PP2B_LxvP_1	441	444	PF13499	0.371
DOC_PP2B_LxvP_1	451	454	PF13499	0.457
DOC_USP7_MATH_1	10	14	PF00917	0.602
DOC_USP7_MATH_1	130	134	PF00917	0.537
DOC_USP7_MATH_1	138	142	PF00917	0.480
DOC_USP7_MATH_1	209	213	PF00917	0.565
DOC_USP7_MATH_1	23	27	PF00917	0.501
DOC_USP7_MATH_1	352	356	PF00917	0.610
DOC_USP7_MATH_1	372	376	PF00917	0.460
DOC_USP7_MATH_1	410	414	PF00917	0.613
DOC_USP7_MATH_1	69	73	PF00917	0.736
DOC_WW_Pin1_4	109	114	PF00397	0.518
DOC_WW_Pin1_4	256	261	PF00397	0.516
DOC_WW_Pin1_4	28	33	PF00397	0.490
DOC_WW_Pin1_4	408	413	PF00397	0.637
DOC_WW_Pin1_4	436	441	PF00397	0.442
DOC_WW_Pin1_4	56	61	PF00397	0.500
DOC_WW_Pin1_4	88	93	PF00397	0.634
LIG_14-3-3_CanoR_1	163	173	PF00244	0.469
LIG_14-3-3_CanoR_1	277	281	PF00244	0.455
LIG_14-3-3_CanoR_1	328	338	PF00244	0.588
LIG_14-3-3_CanoR_1	39	45	PF00244	0.464
LIG_14-3-3_CanoR_1	452	458	PF00244	0.507
LIG_14-3-3_CanoR_1	51	61	PF00244	0.454
LIG_14-3-3_CanoR_1	64	71	PF00244	0.647
LIG_14-3-3_CanoR_1	97	105	PF00244	0.644
LIG_Actin_WH2_2	146	164	PF00022	0.469
LIG_Actin_WH2_2	386	402	PF00022	0.391
LIG_AP2alpha_2	505	507	PF02296	0.522
LIG_BIR_III_2	7	11	PF00653	0.640
LIG_BIR_III_4	123	127	PF00653	0.611
LIG_BIR_III_4	417	421	PF00653	0.560
LIG_BRCT_BRCA1_1	141	145	PF00533	0.461
LIG_BRCT_BRCA1_1	278	282	PF00533	0.414
LIG_BRCT_BRCA1_1	412	416	PF00533	0.622
LIG_CaM_IQ_9	295	311	PF13499	0.455
LIG_Clathr_ClatBox_1	266	270	PF01394	0.469
LIG_Clathr_ClatBox_1	501	505	PF01394	0.550
LIG_FHA_1	261	267	PF00498	0.466
LIG_FHA_1	4	10	PF00498	0.630
LIG_FHA_1	63	69	PF00498	0.599
LIG_FHA_2	195	201	PF00498	0.469
LIG_FHA_2	215	221	PF00498	0.383
LIG_FHA_2	491	497	PF00498	0.634
LIG_FHA_2	83	89	PF00498	0.695
LIG_LIR_Gen_1	508	517	PF02991	0.482
LIG_LIR_Nem_3	508	512	PF02991	0.499
LIG_LIR_Nem_3	514	518	PF02991	0.530
LIG_NRBOX	243	249	PF00104	0.469
LIG_PDZ_Class_2	513	518	PF00595	0.482
LIG_Pex14_1	353	357	PF04695	0.619
LIG_SH2_NCK_1	509	513	PF00017	0.470
LIG_SH2_STAP1	357	361	PF00017	0.534
LIG_SH2_STAT5	509	512	PF00017	0.436
LIG_SH3_1	409	415	PF00018	0.635
LIG_SH3_2	92	97	PF14604	0.553
LIG_SH3_3	364	370	PF00018	0.651
LIG_SH3_3	409	415	PF00018	0.635
LIG_SH3_3	461	467	PF00018	0.738
LIG_SH3_3	485	491	PF00018	0.597
LIG_SH3_3	89	95	PF00018	0.633
LIG_SUMO_SIM_anti_2	496	503	PF11976	0.592
LIG_SUMO_SIM_par_1	265	271	PF11976	0.469
LIG_SUMO_SIM_par_1	311	316	PF11976	0.469
LIG_SUMO_SIM_par_1	500	505	PF11976	0.567
LIG_TRAF2_1	217	220	PF00917	0.510
LIG_WRC_WIRS_1	512	517	PF05994	0.428
MOD_CDC14_SPxK_1	411	414	PF00782	0.616
MOD_CDC14_SPxK_1	94	97	PF00782	0.629
MOD_CDK_SPxK_1	408	414	PF00069	0.608
MOD_CDK_SPxK_1	91	97	PF00069	0.634
MOD_CK1_1	194	200	PF00069	0.250
MOD_CK1_1	259	265	PF00069	0.304
MOD_CK1_1	329	335	PF00069	0.640
MOD_CK1_1	355	361	PF00069	0.568
MOD_CK1_1	375	381	PF00069	0.468
MOD_CK1_1	482	488	PF00069	0.531
MOD_CK1_1	500	506	PF00069	0.383
MOD_CK2_1	214	220	PF00069	0.333
MOD_CK2_1	490	496	PF00069	0.760
MOD_CK2_1	82	88	PF00069	0.691
MOD_GlcNHglycan	119	122	PF01048	0.727
MOD_GlcNHglycan	128	131	PF01048	0.547
MOD_GlcNHglycan	132	135	PF01048	0.484
MOD_GlcNHglycan	205	208	PF01048	0.372
MOD_GlcNHglycan	211	214	PF01048	0.432
MOD_GlcNHglycan	24	28	PF01048	0.570
MOD_GlcNHglycan	255	259	PF01048	0.366
MOD_GlcNHglycan	361	364	PF01048	0.615
MOD_GlcNHglycan	404	407	PF01048	0.745
MOD_GlcNHglycan	484	487	PF01048	0.542
MOD_GlcNHglycan	71	74	PF01048	0.629
MOD_GSK3_1	115	122	PF00069	0.576
MOD_GSK3_1	126	133	PF00069	0.603
MOD_GSK3_1	145	152	PF00069	0.414
MOD_GSK3_1	172	179	PF00069	0.328
MOD_GSK3_1	205	212	PF00069	0.315
MOD_GSK3_1	221	228	PF00069	0.256
MOD_GSK3_1	256	263	PF00069	0.312
MOD_GSK3_1	293	300	PF00069	0.304
MOD_GSK3_1	327	334	PF00069	0.604
MOD_GSK3_1	355	362	PF00069	0.591
MOD_GSK3_1	372	379	PF00069	0.470
MOD_GSK3_1	453	460	PF00069	0.515
MOD_GSK3_1	507	514	PF00069	0.413
MOD_GSK3_1	52	59	PF00069	0.463
MOD_GSK3_1	79	86	PF00069	0.602
MOD_NEK2_1	1	6	PF00069	0.723
MOD_NEK2_1	104	109	PF00069	0.536
MOD_NEK2_1	117	122	PF00069	0.674
MOD_NEK2_1	276	281	PF00069	0.325
MOD_NEK2_1	294	299	PF00069	0.352
MOD_NEK2_1	313	318	PF00069	0.227
MOD_NEK2_1	326	331	PF00069	0.587
MOD_OFUCOSY	188	195	PF10250	0.270
MOD_PIKK_1	313	319	PF00454	0.284
MOD_PIKK_1	49	55	PF00454	0.553
MOD_PIKK_1	490	496	PF00454	0.626
MOD_PKA_2	126	132	PF00069	0.754
MOD_PKA_2	276	282	PF00069	0.284
MOD_PKA_2	327	333	PF00069	0.613
MOD_PKA_2	482	488	PF00069	0.476
MOD_PKA_2	63	69	PF00069	0.589
MOD_Plk_1	224	230	PF00069	0.248
MOD_Plk_1	23	29	PF00069	0.480
MOD_Plk_1	83	89	PF00069	0.695
MOD_Plk_2-3	225	231	PF00069	0.303
MOD_Plk_2-3	376	382	PF00069	0.551
MOD_Plk_4	225	231	PF00069	0.257
MOD_Plk_4	497	503	PF00069	0.618
MOD_Plk_4	511	517	PF00069	0.340
MOD_ProDKin_1	109	115	PF00069	0.522
MOD_ProDKin_1	256	262	PF00069	0.369
MOD_ProDKin_1	28	34	PF00069	0.498
MOD_ProDKin_1	408	414	PF00069	0.642
MOD_ProDKin_1	436	442	PF00069	0.444
MOD_ProDKin_1	56	62	PF00069	0.508
MOD_ProDKin_1	88	94	PF00069	0.630
MOD_SUMO_for_1	11	14	PF00179	0.628
TRG_DiLeu_BaEn_1	225	230	PF01217	0.248
TRG_DiLeu_BaEn_1	497	502	PF01217	0.600
TRG_DiLeu_BaEn_2	510	516	PF01217	0.412
TRG_ENDOCYTIC_2	509	512	PF00928	0.479
TRG_ER_diArg_1	161	163	PF00400	0.304
TRG_ER_diArg_1	20	22	PF00400	0.637
TRG_ER_diArg_1	276	278	PF00400	0.325
TRG_ER_diArg_1	428	431	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF4	Leptomonas seymouri	40%	100%
A0A3Q8IB69	Leishmania donovani	98%	99%
A4H9T5	Leishmania braziliensis	69%	100%
E9ANG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QH57	Leishmania major	89%	100%