LeishMANIAdb
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Inorganic diphosphatase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Inorganic diphosphatase
Gene product:
acidocalcisomal pyrophosphatase
Species:
Leishmania infantum
UniProt:
A4HUT3_LEIIN
TriTrypDb:
LINF_110007000
Length:
443

Annotations

Annotations by Jardim et al.

Acidocalcisome, Acidocalcisomal pyrophosphatase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0005829 cytosol 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HUT3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUT3

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0044237 cellular metabolic process 2 16
Molecular functions
Term Name Level Count
GO:0000287 magnesium ion binding 5 16
GO:0003824 catalytic activity 1 16
GO:0004427 inorganic diphosphate phosphatase activity 6 16
GO:0005488 binding 1 16
GO:0016462 pyrophosphatase activity 5 16
GO:0016787 hydrolase activity 2 16
GO:0016817 hydrolase activity, acting on acid anhydrides 3 16
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 16
GO:0043167 ion binding 2 16
GO:0043169 cation binding 3 16
GO:0046872 metal ion binding 4 16
GO:0005509 calcium ion binding 5 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 223 229 PF00089 0.399
CLV_NRD_NRD_1 11 13 PF00675 0.685
CLV_NRD_NRD_1 225 227 PF00675 0.467
CLV_NRD_NRD_1 434 436 PF00675 0.346
CLV_PCSK_KEX2_1 106 108 PF00082 0.514
CLV_PCSK_KEX2_1 224 226 PF00082 0.486
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.399
CLV_PCSK_SKI1_1 407 411 PF00082 0.225
CLV_PCSK_SKI1_1 435 439 PF00082 0.510
DOC_CKS1_1 205 210 PF01111 0.325
DOC_MAPK_DCC_7 335 344 PF00069 0.514
DOC_MAPK_gen_1 12 19 PF00069 0.693
DOC_MAPK_gen_1 128 136 PF00069 0.476
DOC_MAPK_gen_1 415 423 PF00069 0.419
DOC_MAPK_MEF2A_6 128 136 PF00069 0.409
DOC_PP4_FxxP_1 188 191 PF00568 0.394
DOC_USP7_UBL2_3 213 217 PF12436 0.441
DOC_USP7_UBL2_3 279 283 PF12436 0.410
DOC_USP7_UBL2_3 436 440 PF12436 0.408
DOC_WW_Pin1_4 204 209 PF00397 0.321
DOC_WW_Pin1_4 225 230 PF00397 0.296
DOC_WW_Pin1_4 41 46 PF00397 0.535
LIG_14-3-3_CanoR_1 111 118 PF00244 0.318
LIG_14-3-3_CanoR_1 30 34 PF00244 0.472
LIG_BIR_II_1 1 5 PF00653 0.591
LIG_BRCT_BRCA1_1 109 113 PF00533 0.400
LIG_BRCT_BRCA1_1 184 188 PF00533 0.386
LIG_deltaCOP1_diTrp_1 162 168 PF00928 0.314
LIG_deltaCOP1_diTrp_1 294 302 PF00928 0.453
LIG_FHA_1 158 164 PF00498 0.456
LIG_FHA_1 178 184 PF00498 0.568
LIG_FHA_1 307 313 PF00498 0.412
LIG_FHA_1 44 50 PF00498 0.620
LIG_FHA_1 67 73 PF00498 0.686
LIG_FHA_1 82 88 PF00498 0.535
LIG_FHA_1 99 105 PF00498 0.410
LIG_FHA_2 168 174 PF00498 0.506
LIG_FHA_2 241 247 PF00498 0.410
LIG_LIR_Apic_2 185 191 PF02991 0.389
LIG_LIR_Apic_2 5 10 PF02991 0.675
LIG_LIR_Gen_1 110 121 PF02991 0.413
LIG_LIR_Gen_1 146 155 PF02991 0.459
LIG_LIR_Gen_1 179 188 PF02991 0.471
LIG_LIR_Gen_1 228 237 PF02991 0.320
LIG_LIR_Nem_3 110 116 PF02991 0.399
LIG_LIR_Nem_3 146 152 PF02991 0.548
LIG_LIR_Nem_3 160 164 PF02991 0.304
LIG_LIR_Nem_3 179 184 PF02991 0.479
LIG_LIR_Nem_3 228 233 PF02991 0.322
LIG_LIR_Nem_3 273 278 PF02991 0.413
LIG_LIR_Nem_3 32 36 PF02991 0.597
LIG_LIR_Nem_3 357 361 PF02991 0.402
LIG_LIR_Nem_3 392 397 PF02991 0.432
LIG_PCNA_yPIPBox_3 359 373 PF02747 0.420
LIG_PDZ_Class_3 438 443 PF00595 0.470
LIG_Pex14_1 167 171 PF04695 0.408
LIG_Pex14_1 393 397 PF04695 0.425
LIG_Pex14_2 161 165 PF04695 0.296
LIG_Pex14_2 302 306 PF04695 0.468
LIG_PTAP_UEV_1 50 55 PF05743 0.512
LIG_SH2_CRK 253 257 PF00017 0.224
LIG_SH2_CRK 7 11 PF00017 0.676
LIG_SH2_SRC 123 126 PF00017 0.410
LIG_SH2_STAP1 419 423 PF00017 0.467
LIG_SH2_STAT3 192 195 PF00017 0.345
LIG_SH2_STAT5 123 126 PF00017 0.316
LIG_SH2_STAT5 135 138 PF00017 0.336
LIG_SH2_STAT5 215 218 PF00017 0.326
LIG_SH2_STAT5 236 239 PF00017 0.361
LIG_SH3_2 274 279 PF14604 0.460
LIG_SH3_3 234 240 PF00018 0.501
LIG_SH3_3 271 277 PF00018 0.450
LIG_SH3_3 362 368 PF00018 0.493
LIG_SH3_3 39 45 PF00018 0.626
LIG_SH3_3 48 54 PF00018 0.646
LIG_TRAF2_1 73 76 PF00917 0.679
LIG_TYR_ITIM 121 126 PF00017 0.407
LIG_UBA3_1 148 153 PF00899 0.509
MOD_CDK_SPxxK_3 204 211 PF00069 0.317
MOD_CK1_1 182 188 PF00069 0.427
MOD_CK1_1 2 8 PF00069 0.609
MOD_CK1_1 35 41 PF00069 0.551
MOD_CK2_1 240 246 PF00069 0.397
MOD_CMANNOS 165 168 PF00535 0.311
MOD_GlcNHglycan 113 116 PF01048 0.309
MOD_GlcNHglycan 184 187 PF01048 0.434
MOD_GlcNHglycan 317 320 PF01048 0.296
MOD_GlcNHglycan 51 54 PF01048 0.562
MOD_GSK3_1 107 114 PF00069 0.410
MOD_GSK3_1 138 145 PF00069 0.470
MOD_GSK3_1 167 174 PF00069 0.456
MOD_GSK3_1 182 189 PF00069 0.437
MOD_GSK3_1 302 309 PF00069 0.403
MOD_GSK3_1 54 61 PF00069 0.474
MOD_LATS_1 105 111 PF00433 0.420
MOD_N-GLC_1 138 143 PF02516 0.465
MOD_NEK2_1 100 105 PF00069 0.431
MOD_NEK2_1 116 121 PF00069 0.342
MOD_NEK2_1 19 24 PF00069 0.668
MOD_NEK2_1 65 70 PF00069 0.601
MOD_PIKK_1 116 122 PF00454 0.368
MOD_PIKK_1 138 144 PF00454 0.523
MOD_PIKK_1 98 104 PF00454 0.437
MOD_PKA_2 29 35 PF00069 0.469
MOD_Plk_1 116 122 PF00069 0.384
MOD_Plk_1 186 192 PF00069 0.438
MOD_Plk_1 415 421 PF00069 0.489
MOD_Plk_1 424 430 PF00069 0.429
MOD_Plk_2-3 76 82 PF00069 0.722
MOD_ProDKin_1 204 210 PF00069 0.311
MOD_ProDKin_1 225 231 PF00069 0.296
MOD_ProDKin_1 41 47 PF00069 0.533
MOD_SUMO_for_1 199 202 PF00179 0.495
MOD_SUMO_for_1 265 268 PF00179 0.425
MOD_SUMO_rev_2 145 155 PF00179 0.469
MOD_SUMO_rev_2 352 361 PF00179 0.425
MOD_SUMO_rev_2 44 52 PF00179 0.630
TRG_ENDOCYTIC_2 123 126 PF00928 0.419
TRG_ENDOCYTIC_2 253 256 PF00928 0.256
TRG_ENDOCYTIC_2 299 302 PF00928 0.411
TRG_ER_diArg_1 223 226 PF00400 0.491
TRG_ER_diLys_1 438 443 PF00400 0.513
TRG_NES_CRM1_1 355 367 PF08389 0.514
TRG_NLS_MonoExtC_3 434 439 PF00514 0.432
TRG_Pf-PMV_PEXEL_1 371 375 PF00026 0.212

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDG0 Leptomonas seymouri 81% 99%
A0A0S4JW75 Bodo saltans 61% 100%
A0A1X0NVA1 Trypanosomatidae 67% 100%
A0A1X0NVH4 Trypanosomatidae 72% 100%
A0A1X0NWW9 Trypanosomatidae 67% 100%
A0A3R7KMZ3 Trypanosoma rangeli 68% 100%
A0A3S7WRH5 Leishmania donovani 100% 100%
A4H3Q3 Leishmania braziliensis 38% 100%
A4H9T7 Leishmania braziliensis 94% 100%
D0A7N0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
D0A7N2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
E9ANG7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QH59 Leishmania major 98% 100%
V5BB26 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS