Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUT2_LEIIN

TriTrypDb:

LINF_110006900

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.515
CLV_NRD_NRD_1	164	166	PF00675	0.542
CLV_NRD_NRD_1	90	92	PF00675	0.631
CLV_PCSK_KEX2_1	158	160	PF00082	0.515
CLV_PCSK_KEX2_1	164	166	PF00082	0.542
CLV_PCSK_KEX2_1	90	92	PF00082	0.578
CLV_PCSK_SKI1_1	150	154	PF00082	0.637
CLV_PCSK_SKI1_1	90	94	PF00082	0.522
CLV_Separin_Metazoa	77	81	PF03568	0.597
DEG_SPOP_SBC_1	37	41	PF00917	0.621
DOC_CYCLIN_RxL_1	87	97	PF00134	0.474
DOC_MAPK_gen_1	142	151	PF00069	0.620
DOC_MAPK_HePTP_8	141	153	PF00069	0.623
DOC_MAPK_MEF2A_6	144	153	PF00069	0.625
DOC_USP7_MATH_1	59	63	PF00917	0.705
DOC_USP7_MATH_1	9	13	PF00917	0.744
DOC_WW_Pin1_4	107	112	PF00397	0.797
DOC_WW_Pin1_4	13	18	PF00397	0.634
DOC_WW_Pin1_4	38	43	PF00397	0.728
LIG_BIR_II_1	1	5	PF00653	0.742
LIG_CaM_IQ_9	134	149	PF13499	0.517
LIG_FHA_1	13	19	PF00498	0.740
LIG_FHA_1	73	79	PF00498	0.541
LIG_FHA_2	126	132	PF00498	0.571
LIG_LIR_Gen_1	178	184	PF02991	0.473
LIG_LIR_Nem_3	178	184	PF02991	0.473
LIG_LIR_Nem_3	87	92	PF02991	0.623
LIG_PDZ_Class_2	179	184	PF00595	0.588
LIG_SH2_CRK	89	93	PF00017	0.636
LIG_SH2_PTP2	181	184	PF00017	0.496
LIG_SH2_STAT3	100	103	PF00017	0.728
LIG_SH2_STAT5	181	184	PF00017	0.496
LIG_SH3_3	16	22	PF00018	0.592
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.597
LIG_SUMO_SIM_par_1	28	33	PF11976	0.556
LIG_SUMO_SIM_par_1	91	97	PF11976	0.469
LIG_TRAF2_1	84	87	PF00917	0.559
MOD_CK1_1	112	118	PF00069	0.634
MOD_CK1_1	12	18	PF00069	0.710
MOD_CK1_1	125	131	PF00069	0.485
MOD_CK1_1	2	8	PF00069	0.623
MOD_CK2_1	125	131	PF00069	0.464
MOD_CK2_1	51	57	PF00069	0.781
MOD_GlcNHglycan	12	15	PF01048	0.691
MOD_GlcNHglycan	175	178	PF01048	0.578
MOD_GlcNHglycan	53	56	PF01048	0.642
MOD_GlcNHglycan	7	10	PF01048	0.650
MOD_GSK3_1	109	116	PF00069	0.660
MOD_GSK3_1	36	43	PF00069	0.741
MOD_GSK3_1	47	54	PF00069	0.658
MOD_GSK3_1	5	12	PF00069	0.638
MOD_GSK3_1	68	75	PF00069	0.653
MOD_N-GLC_1	2	7	PF02516	0.591
MOD_NEK2_1	175	180	PF00069	0.636
MOD_NEK2_1	51	56	PF00069	0.726
MOD_PIKK_1	99	105	PF00454	0.776
MOD_Plk_1	2	8	PF00069	0.737
MOD_Plk_1	68	74	PF00069	0.549
MOD_Plk_4	122	128	PF00069	0.643
MOD_ProDKin_1	107	113	PF00069	0.794
MOD_ProDKin_1	13	19	PF00069	0.691
MOD_ProDKin_1	38	44	PF00069	0.737
MOD_SUMO_for_1	169	172	PF00179	0.539
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.567
TRG_ENDOCYTIC_2	181	184	PF00928	0.496
TRG_ENDOCYTIC_2	89	92	PF00928	0.633
TRG_ER_diArg_1	157	159	PF00400	0.529
TRG_ER_diArg_1	89	91	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.769
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P1	Leptomonas seymouri	43%	100%
A0A3S7WRH9	Leishmania donovani	100%	100%
A4H9T8	Leishmania braziliensis	74%	100%
E9ANG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QH60	Leishmania major	89%	100%