Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cdc2-related kinase 8 - putative

Species:

Leishmania infantum

UniProt:

A4HUS3_LEIIN

TriTrypDb:

LINF_110006000

Length:

397

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

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Expansion

Sequence features

A4HUS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUS3

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.425
CLV_NRD_NRD_1	19	21	PF00675	0.580
CLV_NRD_NRD_1	343	345	PF00675	0.425
CLV_NRD_NRD_1	391	393	PF00675	0.463
CLV_NRD_NRD_1	97	99	PF00675	0.331
CLV_PCSK_KEX2_1	151	153	PF00082	0.425
CLV_PCSK_KEX2_1	21	23	PF00082	0.549
CLV_PCSK_KEX2_1	343	345	PF00082	0.425
CLV_PCSK_KEX2_1	391	393	PF00082	0.460
CLV_PCSK_KEX2_1	87	89	PF00082	0.332

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E2	Leptomonas seymouri	26%	100%
A0A0N0P2S2	Leptomonas seymouri	26%	71%
A0A0N0P2X9	Leptomonas seymouri	29%	100%
A0A0N0P3Z9	Leptomonas seymouri	29%	100%
A0A0N0P4P4	Leptomonas seymouri	69%	100%
A0A0N0P7D2	Leptomonas seymouri	29%	100%
A0A0N1HS61	Leptomonas seymouri	30%	100%
A0A0N1I0C1	Leptomonas seymouri	26%	89%
A0A0N1I0G1	Leptomonas seymouri	29%	100%
A0A0N1I2Z5	Leptomonas seymouri	27%	100%

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