LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

GRIP domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GRIP domain-containing protein
Gene product:
GRIP domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HUR9_LEIIN
TriTrypDb:
LINF_110005600 *
Length:
1334

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HUR9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUR9

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 1
GO:0003774 cytoskeletal motor activity 1 1
GO:0003777 microtubule motor activity 2 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0005524 ATP binding 5 1
GO:0008017 microtubule binding 5 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1
GO:0017076 purine nucleotide binding 4 1
GO:0030554 adenyl nucleotide binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032559 adenyl ribonucleotide binding 5 1
GO:0035639 purine ribonucleoside triphosphate binding 4 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:0097367 carbohydrate derivative binding 2 1
GO:0140657 ATP-dependent activity 1 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1015 1019 PF00656 0.327
CLV_C14_Caspase3-7 1224 1228 PF00656 0.444
CLV_C14_Caspase3-7 403 407 PF00656 0.388
CLV_C14_Caspase3-7 449 453 PF00656 0.444
CLV_C14_Caspase3-7 495 499 PF00656 0.402
CLV_C14_Caspase3-7 541 545 PF00656 0.401
CLV_C14_Caspase3-7 633 637 PF00656 0.409
CLV_C14_Caspase3-7 679 683 PF00656 0.394
CLV_C14_Caspase3-7 725 729 PF00656 0.400
CLV_C14_Caspase3-7 771 775 PF00656 0.400
CLV_C14_Caspase3-7 863 867 PF00656 0.406
CLV_C14_Caspase3-7 909 913 PF00656 0.398
CLV_C14_Caspase3-7 955 959 PF00656 0.377
CLV_NRD_NRD_1 1168 1170 PF00675 0.425
CLV_PCSK_KEX2_1 1142 1144 PF00082 0.448
CLV_PCSK_KEX2_1 1254 1256 PF00082 0.406
CLV_PCSK_PC1ET2_1 1142 1144 PF00082 0.418
CLV_PCSK_PC1ET2_1 1254 1256 PF00082 0.406
CLV_PCSK_SKI1_1 1000 1004 PF00082 0.379
CLV_PCSK_SKI1_1 3 7 PF00082 0.510
CLV_PCSK_SKI1_1 595 599 PF00082 0.386
CLV_PCSK_SKI1_1 62 66 PF00082 0.464
CLV_PCSK_SKI1_1 825 829 PF00082 0.406
CLV_Separin_Metazoa 1112 1116 PF03568 0.393
DEG_APCC_KENBOX_2 1247 1251 PF00400 0.432
DEG_Nend_UBRbox_2 1 3 PF02207 0.516
DOC_MAPK_gen_1 352 360 PF00069 0.370
DOC_MAPK_gen_1 44 51 PF00069 0.406
DOC_MAPK_MEF2A_6 1275 1284 PF00069 0.402
DOC_PP2B_LxvP_1 320 323 PF13499 0.457
DOC_USP7_MATH_1 1025 1029 PF00917 0.372
DOC_USP7_MATH_1 1094 1098 PF00917 0.373
DOC_USP7_MATH_1 1205 1209 PF00917 0.466
DOC_USP7_MATH_1 299 303 PF00917 0.594
DOC_USP7_MATH_1 338 342 PF00917 0.387
DOC_USP7_MATH_1 400 404 PF00917 0.377
DOC_USP7_MATH_1 446 450 PF00917 0.387
DOC_USP7_MATH_1 492 496 PF00917 0.401
DOC_USP7_MATH_1 538 542 PF00917 0.398
DOC_USP7_MATH_1 630 634 PF00917 0.401
DOC_USP7_MATH_1 676 680 PF00917 0.394
DOC_USP7_MATH_1 722 726 PF00917 0.395
DOC_USP7_MATH_1 768 772 PF00917 0.395
DOC_USP7_MATH_1 860 864 PF00917 0.400
DOC_USP7_MATH_1 906 910 PF00917 0.396
DOC_USP7_MATH_1 952 956 PF00917 0.373
DOC_USP7_UBL2_3 58 62 PF12436 0.418
DOC_USP7_UBL2_3 582 586 PF12436 0.372
DOC_USP7_UBL2_3 812 816 PF12436 0.374
DOC_USP7_UBL2_3 996 1000 PF12436 0.375
DOC_WW_Pin1_4 1043 1048 PF00397 0.426
DOC_WW_Pin1_4 1194 1199 PF00397 0.541
DOC_WW_Pin1_4 284 289 PF00397 0.539
DOC_WW_Pin1_4 318 323 PF00397 0.722
DOC_WW_Pin1_4 91 96 PF00397 0.484
LIG_14-3-3_CanoR_1 1012 1020 PF00244 0.356
LIG_14-3-3_CanoR_1 1026 1034 PF00244 0.341
LIG_14-3-3_CanoR_1 1143 1151 PF00244 0.424
LIG_14-3-3_CanoR_1 310 320 PF00244 0.504
LIG_Actin_WH2_2 1102 1119 PF00022 0.408
LIG_BRCT_BRCA1_1 340 344 PF00533 0.391
LIG_deltaCOP1_diTrp_1 1071 1078 PF00928 0.405
LIG_FHA_1 1087 1093 PF00498 0.392
LIG_FHA_1 1156 1162 PF00498 0.389
LIG_FHA_1 361 367 PF00498 0.347
LIG_FHA_1 46 52 PF00498 0.352
LIG_FHA_1 92 98 PF00498 0.472
LIG_FHA_2 1144 1150 PF00498 0.426
LIG_FHA_2 1222 1228 PF00498 0.440
LIG_FHA_2 1309 1315 PF00498 0.270
LIG_FHA_2 134 140 PF00498 0.407
LIG_FHA_2 26 32 PF00498 0.407
LIG_FHA_2 54 60 PF00498 0.402
LIG_FHA_2 63 69 PF00498 0.366
LIG_GBD_Chelix_1 32 40 PF00786 0.407
LIG_HCF-1_HBM_1 325 328 PF13415 0.502
LIG_LIR_Gen_1 45 51 PF02991 0.381
LIG_LIR_Nem_3 1075 1081 PF02991 0.394
LIG_LIR_Nem_3 45 50 PF02991 0.434
LIG_MYND_1 318 322 PF01753 0.469
LIG_PCNA_yPIPBox_3 1254 1268 PF02747 0.417
LIG_REV1ctd_RIR_1 2 11 PF16727 0.497
LIG_SH2_CRK 47 51 PF00017 0.408
LIG_SH2_SRC 151 154 PF00017 0.366
LIG_SH2_STAP1 47 51 PF00017 0.370
LIG_SH2_STAT5 1091 1094 PF00017 0.396
LIG_SH2_STAT5 1267 1270 PF00017 0.410
LIG_SH2_STAT5 1286 1289 PF00017 0.140
LIG_SH2_STAT5 1294 1297 PF00017 0.215
LIG_SH2_STAT5 151 154 PF00017 0.366
LIG_SH2_STAT5 47 50 PF00017 0.408
LIG_SH3_3 1325 1331 PF00018 0.429
LIG_SH3_3 287 293 PF00018 0.576
LIG_SUMO_SIM_anti_2 17 23 PF11976 0.430
LIG_SUMO_SIM_anti_2 272 281 PF11976 0.400
LIG_SUMO_SIM_par_1 47 52 PF11976 0.377
LIG_TRAF2_1 1136 1139 PF00917 0.353
LIG_TRAF2_1 15 18 PF00917 0.439
LIG_TRAF2_1 182 185 PF00917 0.449
LIG_TRAF2_1 237 240 PF00917 0.494
LIG_TRAF2_1 322 325 PF00917 0.495
LIG_TRAF2_1 597 600 PF00917 0.397
LIG_TRAF2_1 827 830 PF00917 0.406
LIG_UBA3_1 140 148 PF00899 0.340
LIG_WRC_WIRS_1 1222 1227 PF05994 0.465
MOD_CDK_SPxxK_3 91 98 PF00069 0.476
MOD_CK1_1 1119 1125 PF00069 0.439
MOD_CK1_1 1197 1203 PF00069 0.509
MOD_CK1_1 1228 1234 PF00069 0.454
MOD_CK1_1 241 247 PF00069 0.460
MOD_CK1_1 316 322 PF00069 0.514
MOD_CK1_1 67 73 PF00069 0.432
MOD_CK1_1 991 997 PF00069 0.345
MOD_CK2_1 1043 1049 PF00069 0.420
MOD_CK2_1 1050 1056 PF00069 0.360
MOD_CK2_1 1133 1139 PF00069 0.387
MOD_CK2_1 1143 1149 PF00069 0.423
MOD_CK2_1 128 134 PF00069 0.374
MOD_CK2_1 1308 1314 PF00069 0.270
MOD_CK2_1 179 185 PF00069 0.621
MOD_CK2_1 220 226 PF00069 0.451
MOD_CK2_1 234 240 PF00069 0.451
MOD_CK2_1 25 31 PF00069 0.481
MOD_CK2_1 277 283 PF00069 0.510
MOD_CK2_1 318 324 PF00069 0.508
MOD_CK2_1 5 11 PF00069 0.424
MOD_CK2_1 53 59 PF00069 0.404
MOD_CK2_1 577 583 PF00069 0.370
MOD_CK2_1 807 813 PF00069 0.339
MOD_CK2_1 86 92 PF00069 0.440
MOD_CK2_1 991 997 PF00069 0.379
MOD_GlcNHglycan 1000 1003 PF01048 0.335
MOD_GlcNHglycan 1036 1039 PF01048 0.376
MOD_GlcNHglycan 1096 1099 PF01048 0.417
MOD_GlcNHglycan 1123 1126 PF01048 0.360
MOD_GlcNHglycan 1203 1206 PF01048 0.506
MOD_GlcNHglycan 223 226 PF01048 0.515
MOD_GlcNHglycan 301 304 PF01048 0.703
MOD_GlcNHglycan 313 316 PF01048 0.619
MOD_GlcNHglycan 87 91 PF01048 0.411
MOD_GSK3_1 1039 1046 PF00069 0.395
MOD_GSK3_1 1156 1163 PF00069 0.358
MOD_GSK3_1 1197 1204 PF00069 0.530
MOD_GSK3_1 1221 1228 PF00069 0.463
MOD_GSK3_1 1232 1239 PF00069 0.407
MOD_GSK3_1 128 135 PF00069 0.567
MOD_GSK3_1 234 241 PF00069 0.484
MOD_GSK3_1 294 301 PF00069 0.623
MOD_GSK3_1 309 316 PF00069 0.619
MOD_GSK3_1 45 52 PF00069 0.405
MOD_N-GLC_1 1201 1206 PF02516 0.482
MOD_N-GLC_1 1259 1264 PF02516 0.364
MOD_N-GLC_1 204 209 PF02516 0.419
MOD_N-GLC_1 227 232 PF02516 0.359
MOD_N-GLC_1 284 289 PF02516 0.540
MOD_NEK2_1 1034 1039 PF00069 0.361
MOD_NEK2_1 1225 1230 PF00069 0.615
MOD_NEK2_1 1236 1241 PF00069 0.526
MOD_NEK2_1 1313 1318 PF00069 0.240
MOD_NEK2_1 277 282 PF00069 0.471
MOD_NEK2_1 49 54 PF00069 0.434
MOD_NEK2_1 5 10 PF00069 0.483
MOD_NEK2_1 988 993 PF00069 0.334
MOD_PIKK_1 1143 1149 PF00454 0.425
MOD_PIKK_1 1181 1187 PF00454 0.489
MOD_PIKK_1 1228 1234 PF00454 0.454
MOD_PIKK_1 151 157 PF00454 0.345
MOD_PIKK_1 294 300 PF00454 0.614
MOD_PIKK_1 74 80 PF00454 0.419
MOD_PKA_1 1142 1148 PF00069 0.454
MOD_PKA_1 6 12 PF00069 0.482
MOD_PKA_2 1011 1017 PF00069 0.362
MOD_PKA_2 1025 1031 PF00069 0.334
MOD_PKA_2 1094 1100 PF00069 0.366
MOD_PKA_2 1142 1148 PF00069 0.454
MOD_PKA_2 1149 1155 PF00069 0.401
MOD_PKA_2 1228 1234 PF00069 0.454
MOD_PKA_2 277 283 PF00069 0.510
MOD_PKA_2 309 315 PF00069 0.533
MOD_Plk_1 1074 1080 PF00069 0.340
MOD_Plk_1 1119 1125 PF00069 0.510
MOD_Plk_1 1201 1207 PF00069 0.480
MOD_Plk_1 1259 1265 PF00069 0.318
MOD_Plk_1 133 139 PF00069 0.408
MOD_Plk_1 204 210 PF00069 0.407
MOD_Plk_1 227 233 PF00069 0.360
MOD_Plk_1 263 269 PF00069 0.424
MOD_Plk_1 278 284 PF00069 0.459
MOD_Plk_1 67 73 PF00069 0.399
MOD_Plk_1 988 994 PF00069 0.339
MOD_Plk_2-3 1149 1155 PF00069 0.449
MOD_Plk_2-3 1221 1227 PF00069 0.431
MOD_Plk_2-3 199 205 PF00069 0.427
MOD_Plk_2-3 234 240 PF00069 0.423
MOD_Plk_2-3 362 368 PF00069 0.378
MOD_Plk_4 1205 1211 PF00069 0.475
MOD_Plk_4 1221 1227 PF00069 0.376
MOD_Plk_4 1259 1265 PF00069 0.318
MOD_Plk_4 1308 1314 PF00069 0.270
MOD_Plk_4 212 218 PF00069 0.479
MOD_Plk_4 227 233 PF00069 0.369
MOD_Plk_4 45 51 PF00069 0.399
MOD_Plk_4 988 994 PF00069 0.326
MOD_ProDKin_1 1043 1049 PF00069 0.426
MOD_ProDKin_1 1194 1200 PF00069 0.530
MOD_ProDKin_1 284 290 PF00069 0.540
MOD_ProDKin_1 318 324 PF00069 0.719
MOD_ProDKin_1 91 97 PF00069 0.479
MOD_SUMO_for_1 1253 1256 PF00179 0.407
MOD_SUMO_for_1 15 18 PF00179 0.439
MOD_SUMO_rev_2 1136 1144 PF00179 0.416
MOD_SUMO_rev_2 182 191 PF00179 0.456
MOD_SUMO_rev_2 37 45 PF00179 0.400
TRG_DiLeu_BaEn_1 17 22 PF01217 0.431
TRG_DiLeu_BaEn_4 17 23 PF01217 0.400
TRG_DiLeu_BaEn_4 417 423 PF01217 0.365
TRG_DiLeu_BaEn_4 463 469 PF01217 0.459
TRG_DiLeu_BaEn_4 509 515 PF01217 0.465
TRG_DiLeu_BaEn_4 601 607 PF01217 0.428
TRG_DiLeu_BaEn_4 647 653 PF01217 0.460
TRG_DiLeu_BaEn_4 693 699 PF01217 0.431
TRG_DiLeu_BaEn_4 739 745 PF01217 0.430
TRG_DiLeu_BaEn_4 831 837 PF01217 0.420
TRG_DiLeu_BaEn_4 877 883 PF01217 0.468
TRG_DiLeu_BaEn_4 923 929 PF01217 0.450
TRG_ENDOCYTIC_2 47 50 PF00928 0.373
TRG_ER_diArg_1 1161 1164 PF00400 0.390
TRG_ER_diArg_1 69 72 PF00400 0.421
TRG_NES_CRM1_1 142 153 PF08389 0.398
TRG_NES_CRM1_1 265 279 PF08389 0.574
TRG_Pf-PMV_PEXEL_1 1288 1292 PF00026 0.270
TRG_Pf-PMV_PEXEL_1 236 240 PF00026 0.415
TRG_Pf-PMV_PEXEL_1 62 66 PF00026 0.522

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H6H7 Leishmania donovani 89% 89%
A4H9V1 Leishmania braziliensis 64% 100%
C9ZVU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 94%
E9ANF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
Q4QH73 Leishmania major 69% 93%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS