Endoplasmic reticulum vesicle transporter-domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter - putative

Species:

Leishmania infantum

UniProt:

A4HUR4_LEIIN

TriTrypDb:

LINF_110005100

Length:

368

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	10
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HUR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.281
CLV_NRD_NRD_1	211	213	PF00675	0.486
CLV_NRD_NRD_1	231	233	PF00675	0.474
CLV_NRD_NRD_1	277	279	PF00675	0.535
CLV_NRD_NRD_1	298	300	PF00675	0.411
CLV_PCSK_KEX2_1	211	213	PF00082	0.437
CLV_PCSK_KEX2_1	298	300	PF00082	0.415
CLV_PCSK_SKI1_1	283	287	PF00082	0.535
DOC_MAPK_gen_1	200	208	PF00069	0.226
DOC_MAPK_gen_1	298	305	PF00069	0.229
DOC_MAPK_MEF2A_6	200	208	PF00069	0.315
DOC_MAPK_MEF2A_6	298	305	PF00069	0.331
DOC_PP4_FxxP_1	2	5	PF00568	0.397
DOC_USP7_MATH_1	285	289	PF00917	0.329
DOC_USP7_MATH_2	142	148	PF00917	0.266
DOC_USP7_UBL2_3	109	113	PF12436	0.354
DOC_USP7_UBL2_3	165	169	PF12436	0.305
DOC_USP7_UBL2_3	257	261	PF12436	0.318
DOC_USP7_UBL2_3	279	283	PF12436	0.337
LIG_14-3-3_CanoR_1	329	339	PF00244	0.238
LIG_APCC_ABBA_1	161	166	PF00400	0.315
LIG_APCC_ABBA_1	60	65	PF00400	0.265
LIG_Clathr_ClatBox_1	313	317	PF01394	0.265
LIG_deltaCOP1_diTrp_1	358	366	PF00928	0.610
LIG_EVH1_2	134	138	PF00568	0.304
LIG_FHA_1	172	178	PF00498	0.220
LIG_FHA_1	264	270	PF00498	0.284
LIG_FHA_1	298	304	PF00498	0.229
LIG_FHA_1	90	96	PF00498	0.301
LIG_FHA_2	260	266	PF00498	0.315
LIG_FHA_2	98	104	PF00498	0.288
LIG_GBD_Chelix_1	342	350	PF00786	0.264
LIG_LIR_Gen_1	21	31	PF02991	0.379
LIG_LIR_Nem_3	136	141	PF02991	0.339
LIG_LIR_Nem_3	14	19	PF02991	0.389
LIG_LIR_Nem_3	162	167	PF02991	0.213
LIG_LIR_Nem_3	21	26	PF02991	0.400
LIG_LIR_Nem_3	213	219	PF02991	0.328
LIG_NRP_CendR_1	365	368	PF00754	0.350
LIG_Pex14_1	359	363	PF04695	0.563
LIG_Pex14_2	23	27	PF04695	0.184
LIG_Pex14_2	30	34	PF04695	0.163
LIG_Pex14_2	64	68	PF04695	0.265
LIG_SH2_SRC	290	293	PF00017	0.223
LIG_SH2_STAP1	290	294	PF00017	0.225
LIG_SH2_STAP1	46	50	PF00017	0.276
LIG_SH2_STAT3	176	179	PF00017	0.281
LIG_SH2_STAT3	292	295	PF00017	0.223
LIG_SH2_STAT5	176	179	PF00017	0.315
LIG_SH2_STAT5	268	271	PF00017	0.222
LIG_SH2_STAT5	39	42	PF00017	0.197
LIG_SH2_STAT5	91	94	PF00017	0.429
LIG_SH3_1	129	135	PF00018	0.305
LIG_SH3_3	129	135	PF00018	0.305
LIG_SH3_3	246	252	PF00018	0.202
LIG_SH3_3	63	69	PF00018	0.233
LIG_SH3_5	5	9	PF00018	0.407
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.239
LIG_SUMO_SIM_par_1	18	24	PF11976	0.241
MOD_CK1_1	189	195	PF00069	0.166
MOD_CK1_1	21	27	PF00069	0.241
MOD_CK1_1	259	265	PF00069	0.292
MOD_CK1_1	297	303	PF00069	0.362
MOD_CK2_1	144	150	PF00069	0.349
MOD_CK2_1	259	265	PF00069	0.315
MOD_CK2_1	285	291	PF00069	0.315
MOD_Cter_Amidation	126	129	PF01082	0.549
MOD_GlcNHglycan	135	138	PF01048	0.508
MOD_GlcNHglycan	146	149	PF01048	0.584
MOD_GlcNHglycan	188	191	PF01048	0.507
MOD_GlcNHglycan	253	256	PF01048	0.459
MOD_GlcNHglycan	291	295	PF01048	0.462
MOD_GSK3_1	189	196	PF00069	0.166
MOD_GSK3_1	251	258	PF00069	0.305
MOD_GSK3_1	259	266	PF00069	0.253
MOD_GSK3_1	273	280	PF00069	0.162
MOD_GSK3_1	286	293	PF00069	0.217
MOD_N-GLC_1	89	94	PF02516	0.497
MOD_NEK2_1	225	230	PF00069	0.223
MOD_NEK2_1	89	94	PF00069	0.333
MOD_NEK2_2	108	113	PF00069	0.437
MOD_NEK2_2	18	23	PF00069	0.184
MOD_PKA_2	186	192	PF00069	0.211
MOD_PKA_2	210	216	PF00069	0.315
MOD_PKA_2	242	248	PF00069	0.217
MOD_PKA_2	277	283	PF00069	0.305
MOD_PKA_2	297	303	PF00069	0.122
MOD_PKA_2	74	80	PF00069	0.315
MOD_Plk_1	11	17	PF00069	0.429
MOD_Plk_1	225	231	PF00069	0.211
MOD_Plk_1	237	243	PF00069	0.193
MOD_Plk_1	48	54	PF00069	0.217
MOD_Plk_4	156	162	PF00069	0.283
MOD_Plk_4	18	24	PF00069	0.229
MOD_Plk_4	189	195	PF00069	0.285
MOD_Plk_4	202	208	PF00069	0.305
MOD_SUMO_rev_2	196	202	PF00179	0.315
TRG_DiLeu_BaEn_1	265	270	PF01217	0.265
TRG_ENDOCYTIC_2	164	167	PF00928	0.265
TRG_ER_diArg_1	210	212	PF00400	0.301
TRG_ER_diArg_1	40	43	PF00400	0.302
TRG_NLS_MonoExtC_3	127	132	PF00514	0.276
TRG_NLS_MonoExtN_4	125	132	PF00514	0.333
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S9	Leptomonas seymouri	58%	93%
A0A0N0P4A5	Leptomonas seymouri	24%	90%
A0A0S4JE72	Bodo saltans	27%	92%
A0A0S4JXT2	Bodo saltans	34%	87%
A0A1X0NIB7	Trypanosomatidae	24%	94%
A0A1X0NVX1	Trypanosomatidae	44%	93%
A0A3Q8IGE1	Leishmania donovani	24%	79%
A0A3R7KGP9	Trypanosoma rangeli	24%	77%
A0A3R7MPC0	Trypanosoma rangeli	42%	94%
A0A3S5H6H6	Leishmania donovani	100%	100%
A4H9V6	Leishmania braziliensis	75%	100%
A4HJR2	Leishmania braziliensis	25%	100%
A4HL28	Leishmania braziliensis	22%	87%
A4I779	Leishmania infantum	24%	79%
A4I8K9	Leishmania infantum	22%	100%
C9ZMG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	91%
C9ZWM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	91%
D0A7P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
E9ANE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B273	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
P39727	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	89%
Q09895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	94%
Q4Q4N1	Leishmania major	23%	87%
Q4Q5Y6	Leishmania major	24%	100%
Q4QH78	Leishmania major	94%	100%
Q4R5C3	Macaca fascicularis	23%	98%
Q4R8X1	Macaca fascicularis	27%	96%
Q54DW2	Dictyostelium discoideum	23%	96%
Q5EAE0	Bos taurus	28%	96%
Q5R8G3	Pongo abelii	27%	96%
Q66KH2	Xenopus laevis	26%	95%
Q6NVS2	Xenopus tropicalis	27%	96%
Q7T2D4	Danio rerio	25%	98%
Q803I2	Danio rerio	28%	96%
Q96RQ1	Homo sapiens	23%	98%
Q9CQE7	Mus musculus	28%	96%
Q9Y282	Homo sapiens	27%	96%
V5AS26	Trypanosoma cruzi	24%	91%
V5BGJ7	Trypanosoma cruzi	42%	94%