Putative fatty acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

delta-12 fatty acid desaturase

Species:

Leishmania infantum

UniProt:

A4HUP7_LEIIN

TriTrypDb:

LINF_100005000

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

A4HUP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUP7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	18
GO:0008152	metabolic process	1	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004768	stearoyl-CoA 9-desaturase activity	6	7
GO:0016215	acyl-CoA desaturase activity	5	7
GO:0016491	oxidoreductase activity	2	8
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	7
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.525
CLV_NRD_NRD_1	215	217	PF00675	0.333
CLV_PCSK_KEX2_1	215	217	PF00082	0.333
CLV_PCSK_SKI1_1	2	6	PF00082	0.357
CLV_PCSK_SKI1_1	20	24	PF00082	0.303
CLV_PCSK_SKI1_1	49	53	PF00082	0.257
DEG_Nend_UBRbox_1	1	4	PF02207	0.635
DOC_MAPK_gen_1	172	180	PF00069	0.316
DOC_MAPK_gen_1	6	15	PF00069	0.527
DOC_MAPK_MEF2A_6	229	237	PF00069	0.508
DOC_MAPK_MEF2A_6	9	17	PF00069	0.577
DOC_PP2B_LxvP_1	287	290	PF13499	0.451
DOC_PP4_FxxP_1	198	201	PF00568	0.289
DOC_USP7_MATH_1	123	127	PF00917	0.494
DOC_USP7_MATH_1	145	149	PF00917	0.278
DOC_USP7_MATH_2	379	385	PF00917	0.602
DOC_USP7_UBL2_3	2	6	PF12436	0.568
DOC_WW_Pin1_4	181	186	PF00397	0.290
DOC_WW_Pin1_4	221	226	PF00397	0.513
LIG_AP2alpha_1	48	52	PF02296	0.420
LIG_BRCT_BRCA1_1	223	227	PF00533	0.513
LIG_BRCT_BRCA1_2	223	229	PF00533	0.545
LIG_EH1_1	345	353	PF00400	0.525
LIG_FHA_1	158	164	PF00498	0.266
LIG_FHA_1	165	171	PF00498	0.260
LIG_FHA_1	182	188	PF00498	0.368
LIG_FHA_2	368	374	PF00498	0.521
LIG_GBD_Chelix_1	327	335	PF00786	0.272
LIG_HP1_1	185	189	PF01393	0.267
LIG_LIR_Apic_2	197	201	PF02991	0.251
LIG_LIR_Apic_2	373	379	PF02991	0.487
LIG_LIR_Gen_1	50	60	PF02991	0.351
LIG_LIR_Gen_1	86	95	PF02991	0.407
LIG_LIR_Nem_3	125	130	PF02991	0.513
LIG_LIR_Nem_3	197	203	PF02991	0.372
LIG_LIR_Nem_3	253	259	PF02991	0.311
LIG_LIR_Nem_3	272	278	PF02991	0.239
LIG_LIR_Nem_3	308	314	PF02991	0.474
LIG_LIR_Nem_3	317	321	PF02991	0.459
LIG_LIR_Nem_3	384	389	PF02991	0.592
LIG_LIR_Nem_3	50	55	PF02991	0.447
LIG_LIR_Nem_3	70	75	PF02991	0.261
LIG_LIR_Nem_3	86	90	PF02991	0.383
LIG_Pex14_1	42	46	PF04695	0.566
LIG_Pex14_2	196	200	PF04695	0.305
LIG_Pex14_2	48	52	PF04695	0.427
LIG_SH2_CRK	127	131	PF00017	0.543
LIG_SH2_CRK	311	315	PF00017	0.472
LIG_SH2_CRK	62	66	PF00017	0.336
LIG_SH2_GRB2like	321	324	PF00017	0.451
LIG_SH2_PTP2	265	268	PF00017	0.426
LIG_SH2_PTP2	376	379	PF00017	0.492
LIG_SH2_SRC	254	257	PF00017	0.459
LIG_SH2_SRC	376	379	PF00017	0.496
LIG_SH2_STAT5	203	206	PF00017	0.382
LIG_SH2_STAT5	265	268	PF00017	0.294
LIG_SH2_STAT5	269	272	PF00017	0.288
LIG_SH2_STAT5	278	281	PF00017	0.287
LIG_SH2_STAT5	292	295	PF00017	0.457
LIG_SH2_STAT5	321	324	PF00017	0.455
LIG_SH2_STAT5	35	38	PF00017	0.517
LIG_SH2_STAT5	356	359	PF00017	0.507
LIG_SH2_STAT5	376	379	PF00017	0.492
LIG_SH2_STAT5	46	49	PF00017	0.462
LIG_SH2_STAT5	58	61	PF00017	0.373
LIG_SH3_3	12	18	PF00018	0.505
LIG_SH3_3	165	171	PF00018	0.236
LIG_SH3_3	219	225	PF00018	0.447
LIG_SUMO_SIM_anti_2	12	17	PF11976	0.570
LIG_SUMO_SIM_par_1	176	184	PF11976	0.322
LIG_SUMO_SIM_par_1	191	197	PF11976	0.439
LIG_TYR_ITIM	60	65	PF00017	0.349
LIG_WRC_WIRS_1	195	200	PF05994	0.402
LIG_WRC_WIRS_1	386	391	PF05994	0.476
MOD_CK1_1	152	158	PF00069	0.299
MOD_CK2_1	359	365	PF00069	0.535
MOD_CK2_1	367	373	PF00069	0.508
MOD_Cter_Amidation	213	216	PF01082	0.345
MOD_GlcNHglycan	139	142	PF01048	0.252
MOD_GlcNHglycan	37	41	PF01048	0.357
MOD_GlcNHglycan	69	72	PF01048	0.374
MOD_GSK3_1	145	152	PF00069	0.303
MOD_GSK3_1	157	164	PF00069	0.272
MOD_GSK3_1	355	362	PF00069	0.473
MOD_GSK3_1	377	384	PF00069	0.590
MOD_N-GLC_1	322	327	PF02516	0.239
MOD_NEK2_1	137	142	PF00069	0.403
MOD_NEK2_1	277	282	PF00069	0.421
MOD_NEK2_1	36	41	PF00069	0.516
MOD_NEK2_1	367	372	PF00069	0.536
MOD_NEK2_2	96	101	PF00069	0.276
MOD_PIKK_1	207	213	PF00454	0.545
MOD_PIKK_1	330	336	PF00454	0.490
MOD_PKA_2	149	155	PF00069	0.247
MOD_PKA_2	214	220	PF00069	0.501
MOD_Plk_1	20	26	PF00069	0.581
MOD_Plk_1	322	328	PF00069	0.439
MOD_Plk_1	36	42	PF00069	0.555
MOD_Plk_2-3	359	365	PF00069	0.498
MOD_Plk_4	164	170	PF00069	0.289
MOD_Plk_4	277	283	PF00069	0.321
MOD_ProDKin_1	181	187	PF00069	0.290
MOD_ProDKin_1	221	227	PF00069	0.513
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.420
TRG_ENDOCYTIC_2	127	130	PF00928	0.545
TRG_ENDOCYTIC_2	259	262	PF00928	0.276
TRG_ENDOCYTIC_2	311	314	PF00928	0.472
TRG_ENDOCYTIC_2	338	341	PF00928	0.455
TRG_ENDOCYTIC_2	58	61	PF00928	0.264
TRG_ENDOCYTIC_2	62	65	PF00928	0.240
TRG_NES_CRM1_1	105	118	PF08389	0.299
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L0	Leptomonas seymouri	70%	100%
A0A0S4IVK0	Bodo saltans	51%	94%
A0A1X0NKF1	Trypanosomatidae	45%	85%
A0A3Q8I8P6	Leishmania donovani	100%	100%
A0A3S7X797	Leishmania donovani	75%	100%
A0A422MYL0	Trypanosoma rangeli	54%	94%
A3F5L2	Sorghum bicolor	36%	100%
A3F5L3	Sorghum bicolor	38%	100%
A4H5Y3	Leishmania braziliensis	90%	100%
A4H6C4	Leishmania braziliensis	90%	100%
A4HM35	Leishmania braziliensis	74%	100%
A4I9G8	Leishmania infantum	75%	100%
B4YQU1	Claviceps purpurea	35%	83%
C9ZJ57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	97%
E9ANE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B4G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
G5EGA5	Caenorhabditis elegans	29%	100%
O34653	Bacillus subtilis (strain 168)	23%	100%
O81931	Crepis alpina	34%	100%
P20388	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
P32291	Vigna radiata var. radiata	34%	100%
P46310	Arabidopsis thaliana	32%	88%
P46312	Arabidopsis thaliana	25%	88%
P46313	Arabidopsis thaliana	35%	100%
P48618	Brassica napus	32%	98%
P48619	Ricinus communis	32%	86%
P48620	Sesamum indicum	32%	88%
P48621	Glycine max	33%	87%
P48622	Arabidopsis thaliana	31%	91%
P48623	Arabidopsis thaliana	36%	100%
P48624	Brassica napus	34%	100%
P48625	Glycine max	32%	100%
P48626	Nicotiana tabacum	33%	100%
P48627	Brassica napus	25%	89%
P48630	Glycine max	37%	100%
P48631	Glycine max	36%	100%
P59668	Mortierella isabellina	42%	98%
Q39287	Brassica juncea	36%	100%
Q41131	Ricinus communis	35%	100%
Q4Q3K9	Leishmania major	75%	100%
Q4QH80	Leishmania major	98%	100%
Q54794	Arthrospira platensis	27%	100%
Q56VS4	Helianthus annuus	33%	89%
Q594P3	Sorghum bicolor	37%	100%
Q59J82	Mortierella alpina	36%	98%
Q6RS95	Dimorphotheca sinuata	33%	100%
Q6RS96	Dimorphotheca sinuata	31%	100%
Q84UB8	Punica granatum	35%	100%
Q84UB9	Trichosanthes kirilowii	35%	100%
Q84UC0	Trichosanthes kirilowii	35%	100%
Q84VT2	Punica granatum	37%	100%
Q8GZC2	Vernicia fordii	35%	100%
Q8GZC3	Vernicia fordii	37%	100%
Q9AT72	Calendula officinalis	37%	100%
Q9FPP7	Calendula officinalis	32%	100%
Q9FPP8	Calendula officinalis	32%	100%
Q9NEQ0	Caenorhabditis elegans	32%	98%
Q9SCG2	Calendula officinalis	33%	100%
Q9SP61	Momordica charantia	33%	99%
Q9SP62	Impatiens balsamina	32%	100%
Q9Y8H5	Mortierella alpina	42%	98%
V5BA48	Trypanosoma cruzi	56%	96%