Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate-Repressible Phosphate Permease-like protein

Species:

Leishmania infantum

UniProt:

A4HUP5_LEIIN

TriTrypDb:

LINF_100021000

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

A4HUP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUP5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	24
GO:0006811	monoatomic ion transport	4	24
GO:0006817	phosphate ion transport	7	24
GO:0006820	monoatomic anion transport	5	24
GO:0015698	inorganic anion transport	6	24
GO:0051179	localization	1	24
GO:0051234	establishment of localization	2	24
GO:0009987	cellular process	1	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0035435	phosphate ion transmembrane transport	6	3
GO:0055085	transmembrane transport	2	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098661	inorganic anion transmembrane transport	5	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	24
GO:0005315	inorganic phosphate transmembrane transporter activity	4	24
GO:0015291	secondary active transmembrane transporter activity	4	24
GO:0015293	symporter activity	5	24
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	24
GO:0022804	active transmembrane transporter activity	3	24
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.522
CLV_NRD_NRD_1	140	142	PF00675	0.501
CLV_NRD_NRD_1	274	276	PF00675	0.240
CLV_PCSK_KEX2_1	140	142	PF00082	0.458
CLV_PCSK_KEX2_1	188	190	PF00082	0.263
CLV_PCSK_KEX2_1	216	218	PF00082	0.463
CLV_PCSK_KEX2_1	248	250	PF00082	0.286
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.458
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.245
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.463
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.339
CLV_PCSK_SKI1_1	216	220	PF00082	0.471
CLV_PCSK_SKI1_1	287	291	PF00082	0.369
CLV_PCSK_SKI1_1	308	312	PF00082	0.263
CLV_PCSK_SKI1_1	41	45	PF00082	0.316
DEG_SPOP_SBC_1	112	116	PF00917	0.290
DEG_SPOP_SBC_1	433	437	PF00917	0.334
DOC_CKS1_1	407	412	PF01111	0.573
DOC_MAPK_gen_1	188	196	PF00069	0.463
DOC_MAPK_gen_1	324	334	PF00069	0.445
DOC_MAPK_MEF2A_6	189	198	PF00069	0.455
DOC_MAPK_MEF2A_6	370	378	PF00069	0.353
DOC_MAPK_MEF2A_6	458	465	PF00069	0.581
DOC_MAPK_NFAT4_5	458	466	PF00069	0.568
DOC_PP1_RVXF_1	214	221	PF00149	0.299
DOC_PP2B_LxvP_1	109	112	PF13499	0.479
DOC_PP4_FxxP_1	159	162	PF00568	0.319
DOC_SPAK_OSR1_1	177	181	PF12202	0.513
DOC_USP7_MATH_1	112	116	PF00917	0.319
DOC_USP7_MATH_1	299	303	PF00917	0.499
DOC_USP7_MATH_1	433	437	PF00917	0.334
DOC_USP7_UBL2_3	184	188	PF12436	0.438
DOC_USP7_UBL2_3	212	216	PF12436	0.263
DOC_USP7_UBL2_3	79	83	PF12436	0.263
DOC_WW_Pin1_4	158	163	PF00397	0.319
DOC_WW_Pin1_4	406	411	PF00397	0.487
LIG_14-3-3_CanoR_1	110	119	PF00244	0.463
LIG_14-3-3_CanoR_1	189	195	PF00244	0.494
LIG_14-3-3_CanoR_1	217	223	PF00244	0.306
LIG_14-3-3_CanoR_1	41	46	PF00244	0.526
LIG_Actin_WH2_2	203	221	PF00022	0.280
LIG_BIR_II_1	1	5	PF00653	0.392
LIG_BRCT_BRCA1_1	239	243	PF00533	0.348
LIG_BRCT_BRCA1_1	410	414	PF00533	0.340
LIG_BRCT_BRCA1_1	479	483	PF00533	0.375
LIG_CaM_NSCaTE_8	377	384	PF13499	0.349
LIG_deltaCOP1_diTrp_1	322	329	PF00928	0.463
LIG_FHA_1	114	120	PF00498	0.302
LIG_FHA_1	163	169	PF00498	0.425
LIG_FHA_1	191	197	PF00498	0.531
LIG_FHA_1	288	294	PF00498	0.460
LIG_FHA_1	363	369	PF00498	0.327
LIG_FHA_1	390	396	PF00498	0.313
LIG_FHA_1	435	441	PF00498	0.345
LIG_FHA_1	44	50	PF00498	0.411
LIG_FHA_1	470	476	PF00498	0.328
LIG_FHA_1	66	72	PF00498	0.272
LIG_GBD_Chelix_1	196	204	PF00786	0.334
LIG_IBAR_NPY_1	5	7	PF08397	0.367
LIG_LIR_Apic_2	157	162	PF02991	0.319
LIG_LIR_Apic_2	428	433	PF02991	0.334
LIG_LIR_Gen_1	107	113	PF02991	0.535
LIG_LIR_Gen_1	205	214	PF02991	0.319
LIG_LIR_Gen_1	451	462	PF02991	0.300
LIG_LIR_LC3C_4	419	424	PF02991	0.346
LIG_LIR_Nem_3	107	111	PF02991	0.535
LIG_LIR_Nem_3	143	148	PF02991	0.272
LIG_LIR_Nem_3	205	211	PF02991	0.324
LIG_LIR_Nem_3	240	246	PF02991	0.359
LIG_LIR_Nem_3	326	332	PF02991	0.476
LIG_LIR_Nem_3	451	457	PF02991	0.311
LIG_Pex14_2	203	207	PF04695	0.320
LIG_SH2_CRK	173	177	PF00017	0.264
LIG_SH2_CRK	192	196	PF00017	0.264
LIG_SH2_CRK	430	434	PF00017	0.379
LIG_SH2_CRK	90	94	PF00017	0.354
LIG_SH2_STAP1	321	325	PF00017	0.469
LIG_SH2_STAT5	192	195	PF00017	0.436
LIG_SH2_STAT5	331	334	PF00017	0.319
LIG_SH2_STAT5	7	10	PF00017	0.311
LIG_SH2_STAT5	86	89	PF00017	0.339
LIG_SH3_3	177	183	PF00018	0.437
LIG_SH3_3	404	410	PF00018	0.573
LIG_SH3_3	72	78	PF00018	0.363
LIG_Sin3_3	420	427	PF02671	0.435
LIG_SUMO_SIM_anti_2	403	409	PF11976	0.573
LIG_SUMO_SIM_anti_2	46	53	PF11976	0.431
LIG_SUMO_SIM_par_1	41	46	PF11976	0.498
LIG_SUMO_SIM_par_1	443	448	PF11976	0.334
LIG_SUMO_SIM_par_1	47	53	PF11976	0.308
LIG_SUMO_SIM_par_1	471	476	PF11976	0.347
LIG_TYR_ITIM	171	176	PF00017	0.411
LIG_UBA3_1	460	464	PF00899	0.327
LIG_ULM_U2AF65_1	216	221	PF00076	0.280
LIG_WRC_WIRS_1	16	21	PF05994	0.347
LIG_WRC_WIRS_1	204	209	PF05994	0.276
LIG_WRC_WIRS_1	390	395	PF05994	0.379
LIG_WRC_WIRS_1	423	428	PF05994	0.348
MOD_CDK_SPxK_1	406	412	PF00069	0.334
MOD_CK1_1	115	121	PF00069	0.290
MOD_CK1_1	18	24	PF00069	0.342
MOD_CK1_1	297	303	PF00069	0.356
MOD_CK1_1	347	353	PF00069	0.323
MOD_CK1_1	425	431	PF00069	0.345
MOD_CK1_1	69	75	PF00069	0.317
MOD_CK2_1	264	270	PF00069	0.287
MOD_CK2_1	292	298	PF00069	0.388
MOD_CK2_1	50	56	PF00069	0.331
MOD_GlcNHglycan	148	151	PF01048	0.509
MOD_GlcNHglycan	168	171	PF01048	0.169
MOD_GlcNHglycan	313	316	PF01048	0.472
MOD_GlcNHglycan	414	417	PF01048	0.314
MOD_GlcNHglycan	418	421	PF01048	0.312
MOD_GlcNHglycan	427	430	PF01048	0.283
MOD_GlcNHglycan	479	482	PF01048	0.336
MOD_GlcNHglycan	488	491	PF01048	0.484
MOD_GlcNHglycan	72	75	PF01048	0.309
MOD_GSK3_1	111	118	PF00069	0.326
MOD_GSK3_1	154	161	PF00069	0.329
MOD_GSK3_1	162	169	PF00069	0.319
MOD_GSK3_1	265	272	PF00069	0.424
MOD_GSK3_1	408	415	PF00069	0.344
MOD_GSK3_1	434	441	PF00069	0.318
MOD_GSK3_1	469	476	PF00069	0.351
MOD_GSK3_1	65	72	PF00069	0.340
MOD_NEK2_1	203	208	PF00069	0.295
MOD_NEK2_1	218	223	PF00069	0.382
MOD_NEK2_1	34	39	PF00069	0.364
MOD_NEK2_1	388	393	PF00069	0.348
MOD_NEK2_1	422	427	PF00069	0.334
MOD_NEK2_1	43	48	PF00069	0.392
MOD_NEK2_1	473	478	PF00069	0.371
MOD_PIKK_1	270	276	PF00454	0.278
MOD_PIKK_1	292	298	PF00454	0.276
MOD_PIKK_1	43	49	PF00454	0.435
MOD_PK_1	370	376	PF00069	0.300
MOD_PKA_2	264	270	PF00069	0.421
MOD_Plk_1	403	409	PF00069	0.310
MOD_Plk_4	104	110	PF00069	0.339
MOD_Plk_4	15	21	PF00069	0.347
MOD_Plk_4	154	160	PF00069	0.305
MOD_Plk_4	171	177	PF00069	0.305
MOD_Plk_4	203	209	PF00069	0.321
MOD_Plk_4	403	409	PF00069	0.411
MOD_Plk_4	445	451	PF00069	0.300
MOD_ProDKin_1	158	164	PF00069	0.319
MOD_ProDKin_1	406	412	PF00069	0.334
MOD_SUMO_rev_2	72	81	PF00179	0.300
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.304
TRG_ENDOCYTIC_2	173	176	PF00928	0.270
TRG_ENDOCYTIC_2	331	334	PF00928	0.289
TRG_ENDOCYTIC_2	7	10	PF00928	0.311
TRG_ENDOCYTIC_2	86	89	PF00928	0.321
TRG_ENDOCYTIC_2	90	93	PF00928	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S5	Leptomonas seymouri	68%	94%
A0A1X0NXY5	Trypanosomatidae	60%	93%
A0A3Q8I8Y3	Leishmania donovani	100%	100%
A0A3Q8IBK1	Leishmania donovani	62%	91%
A0A3R7K4N2	Trypanosoma rangeli	58%	100%
A0A3S5H545	Leishmania donovani	48%	86%
A4H5Y5	Leishmania braziliensis	92%	100%
A4H6C2	Leishmania braziliensis	92%	100%
A4HBH2	Leishmania braziliensis	61%	100%
A4HH06	Leishmania braziliensis	49%	100%
A4HYJ6	Leishmania infantum	62%	91%
C9ZHT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	96%
C9ZHU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	96%
E9ACJ5	Leishmania major	48%	100%
E9AG39	Leishmania infantum	48%	86%
E9AJT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AN09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9ANE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AUE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
O84698	Chlamydia trachomatis (strain D/UW-3/Cx)	32%	100%
P38361	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	86%
Q38954	Arabidopsis thaliana	33%	84%
Q4QH82	Leishmania major	99%	100%
Q4QHL7	Leishmania major	99%	100%
Q6PFM1	Danio rerio	31%	74%
Q9PLN5	Chlamydia muridarum (strain MoPn / Nigg)	32%	100%
Q9Z7M4	Chlamydia pneumoniae	31%	100%
Q9ZJC8	Helicobacter pylori (strain J99 / ATCC 700824)	30%	92%
V5DS90	Trypanosoma cruzi	59%	100%