Structural protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Structural protein

Gene product:

Protein of unknown function (DUF1861) - putative

Species:

Leishmania infantum

UniProt:

A4HUP4_LEIIN

TriTrypDb:

LINF_100020900

Length:

311

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUP4

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.402
CLV_PCSK_KEX2_1	14	16	PF00082	0.416
CLV_PCSK_KEX2_1	53	55	PF00082	0.400
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.456
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.393
CLV_PCSK_SKI1_1	4	8	PF00082	0.449
DEG_COP1_1	71	79	PF00400	0.443
DOC_CDC14_PxL_1	73	81	PF14671	0.273
DOC_MAPK_gen_1	14	22	PF00069	0.448
DOC_MAPK_gen_1	152	161	PF00069	0.406
DOC_MAPK_MEF2A_6	15	24	PF00069	0.466
DOC_MAPK_MEF2A_6	154	163	PF00069	0.372
DOC_PP1_RVXF_1	179	186	PF00149	0.254
DOC_PP4_FxxP_1	185	188	PF00568	0.254
DOC_WW_Pin1_4	117	122	PF00397	0.352
LIG_APCC_ABBA_1	62	67	PF00400	0.361
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BRCT_BRCA1_1	229	233	PF00533	0.436
LIG_BRCT_BRCA1_1	35	39	PF00533	0.377
LIG_FHA_1	171	177	PF00498	0.369
LIG_FHA_1	222	228	PF00498	0.365
LIG_FHA_1	235	241	PF00498	0.361
LIG_FHA_2	118	124	PF00498	0.393
LIG_FHA_2	127	133	PF00498	0.389
LIG_FHA_2	153	159	PF00498	0.400
LIG_FHA_2	259	265	PF00498	0.226
LIG_FHA_2	66	72	PF00498	0.377
LIG_LIR_Apic_2	184	188	PF02991	0.441
LIG_LIR_Gen_1	224	233	PF02991	0.451
LIG_LIR_Gen_1	71	79	PF02991	0.394
LIG_LIR_Nem_3	111	116	PF02991	0.395
LIG_LIR_Nem_3	158	163	PF02991	0.361
LIG_LIR_Nem_3	190	194	PF02991	0.371
LIG_LIR_Nem_3	224	229	PF02991	0.388
LIG_LIR_Nem_3	23	27	PF02991	0.403
LIG_LIR_Nem_3	28	33	PF02991	0.389
LIG_LIR_Nem_3	280	285	PF02991	0.368
LIG_LIR_Nem_3	296	302	PF02991	0.410
LIG_LIR_Nem_3	45	51	PF02991	0.392
LIG_LIR_Nem_3	71	76	PF02991	0.394
LIG_MYND_3	259	263	PF01753	0.245
LIG_PTB_Apo_2	225	232	PF02174	0.379
LIG_SH2_CRK	282	286	PF00017	0.377
LIG_SH2_CRK	302	306	PF00017	0.267
LIG_SH2_GRB2like	226	229	PF00017	0.377
LIG_SH2_PTP2	226	229	PF00017	0.254
LIG_SH2_SRC	226	229	PF00017	0.371
LIG_SH2_STAP1	17	21	PF00017	0.386
LIG_SH2_STAT5	115	118	PF00017	0.384
LIG_SH2_STAT5	126	129	PF00017	0.367
LIG_SH2_STAT5	160	163	PF00017	0.440
LIG_SH2_STAT5	198	201	PF00017	0.387
LIG_SH2_STAT5	226	229	PF00017	0.377
LIG_SH2_STAT5	87	90	PF00017	0.353
LIG_SH3_2	253	258	PF14604	0.339
LIG_SH3_3	250	256	PF00018	0.360
LIG_TYR_ITSM	222	229	PF00017	0.406
LIG_WRC_WIRS_1	21	26	PF05994	0.391
MOD_CK2_1	117	123	PF00069	0.358
MOD_CK2_1	152	158	PF00069	0.397
MOD_GlcNHglycan	201	204	PF01048	0.369
MOD_GlcNHglycan	218	221	PF01048	0.313
MOD_GlcNHglycan	268	271	PF01048	0.377
MOD_GlcNHglycan	282	285	PF01048	0.377
MOD_GSK3_1	148	155	PF00069	0.384
MOD_GSK3_1	16	23	PF00069	0.359
MOD_GSK3_1	161	168	PF00069	0.360
MOD_GSK3_1	33	40	PF00069	0.386
MOD_N-GLC_1	213	218	PF02516	0.427
MOD_N-GLC_1	227	232	PF02516	0.390
MOD_N-GLC_1	33	38	PF02516	0.381
MOD_NEK2_1	199	204	PF00069	0.410
MOD_NEK2_1	65	70	PF00069	0.382
MOD_NEK2_1	97	102	PF00069	0.374
MOD_NEK2_2	247	252	PF00069	0.340
MOD_PKA_2	291	297	PF00069	0.387
MOD_Plk_1	227	233	PF00069	0.375
MOD_Plk_1	33	39	PF00069	0.351
MOD_Plk_1	71	77	PF00069	0.394
MOD_Plk_4	108	114	PF00069	0.400
MOD_Plk_4	16	22	PF00069	0.415
MOD_Plk_4	221	227	PF00069	0.386
MOD_ProDKin_1	117	123	PF00069	0.352
MOD_SUMO_for_1	91	94	PF00179	0.350
TRG_ENDOCYTIC_2	113	116	PF00928	0.418
TRG_ENDOCYTIC_2	160	163	PF00928	0.377
TRG_ENDOCYTIC_2	17	20	PF00928	0.419
TRG_ENDOCYTIC_2	226	229	PF00928	0.420
TRG_ENDOCYTIC_2	282	285	PF00928	0.377
TRG_ENDOCYTIC_2	302	305	PF00928	0.263
TRG_ENDOCYTIC_2	48	51	PF00928	0.405
TRG_NES_CRM1_1	132	144	PF08389	0.361
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	60%	98%
A0A0N1HYU8	Leptomonas seymouri	58%	98%
A0A0N1I429	Leptomonas seymouri	51%	95%
A0A0N1I5D6	Leptomonas seymouri	65%	99%
A0A0N1I720	Leptomonas seymouri	54%	99%
A0A0N1IL04	Leptomonas seymouri	79%	100%
A0A0N1PCE9	Leptomonas seymouri	53%	97%
A0A0R6XPC0	Leishmania donovani	54%	98%
A0A3Q8IHB3	Leishmania donovani	51%	97%
A0A3S5H6H4	Leishmania donovani	50%	95%
A0A3S5H6H5	Leishmania donovani	55%	99%
A0A3S7WRC9	Leishmania donovani	65%	98%
A0A3S7WRD5	Leishmania donovani	69%	99%
A0A3S7WRE8	Leishmania donovani	100%	100%
A4H6B5	Leishmania braziliensis	52%	100%
A4H6B6	Leishmania braziliensis	50%	100%
A4H6B7	Leishmania braziliensis	55%	100%
A4H6B8	Leishmania braziliensis	70%	100%
A4H6B9	Leishmania braziliensis	57%	100%
A4H6C0	Leishmania braziliensis	63%	100%
A4H6C1	Leishmania braziliensis	85%	100%
A4HUN8	Leishmania infantum	50%	100%
A4HUN9	Leishmania infantum	51%	100%
A4HUP0	Leishmania infantum	55%	100%
A4HUP1	Leishmania infantum	69%	100%
A4HUP2	Leishmania infantum	55%	99%
A4HUP3	Leishmania infantum	65%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	99%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QH83	Leishmania major	94%	100%
Q4QH84	Leishmania major	66%	100%
Q4QH85	Leishmania major	56%	99%
Q4QH86	Leishmania major	72%	100%
Q4QH87	Leishmania major	56%	100%
Q4QH88	Leishmania major	51%	100%
Q4QH89	Leishmania major	50%	100%