DUF1861 family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861) - putative

Species:

Leishmania infantum

UniProt:

A4HUP3_LEIIN

TriTrypDb:

LINF_100020800

Length:

316

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUP3

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.365
CLV_NRD_NRD_1	107	109	PF00675	0.402
CLV_PCSK_KEX2_1	18	20	PF00082	0.416
CLV_PCSK_KEX2_1	57	59	PF00082	0.400
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.456
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.393
CLV_PCSK_SKI1_1	8	12	PF00082	0.486
DEG_COP1_1	75	84	PF00400	0.443
DOC_MAPK_gen_1	18	26	PF00069	0.448
DOC_MAPK_gen_1	224	232	PF00069	0.230
DOC_MAPK_MEF2A_6	19	28	PF00069	0.466
DOC_PP4_FxxP_1	155	158	PF00568	0.377
DOC_USP7_MATH_1	148	152	PF00917	0.446
DOC_USP7_MATH_1	271	275	PF00917	0.372
DOC_USP7_MATH_1	91	95	PF00917	0.410
LIG_14-3-3_CanoR_1	108	117	PF00244	0.378
LIG_14-3-3_CanoR_1	157	166	PF00244	0.373
LIG_14-3-3_CanoR_1	226	231	PF00244	0.233
LIG_AP2alpha_2	90	92	PF02296	0.396
LIG_APCC_ABBA_1	66	71	PF00400	0.361
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_BRCT_BRCA1_1	39	43	PF00533	0.377
LIG_FHA_1	176	182	PF00498	0.369
LIG_FHA_1	262	268	PF00498	0.294
LIG_FHA_1	83	89	PF00498	0.375
LIG_FHA_2	132	138	PF00498	0.389
LIG_FHA_2	167	173	PF00498	0.416
LIG_FHA_2	70	76	PF00498	0.377
LIG_LIR_Gen_1	116	126	PF02991	0.379
LIG_LIR_Gen_1	160	171	PF02991	0.359
LIG_LIR_Gen_1	75	84	PF02991	0.394
LIG_LIR_Nem_3	116	121	PF02991	0.395
LIG_LIR_Nem_3	160	166	PF02991	0.363
LIG_LIR_Nem_3	228	234	PF02991	0.393
LIG_LIR_Nem_3	255	260	PF02991	0.389
LIG_LIR_Nem_3	27	31	PF02991	0.403
LIG_LIR_Nem_3	285	290	PF02991	0.368
LIG_LIR_Nem_3	32	37	PF02991	0.389
LIG_LIR_Nem_3	49	55	PF02991	0.392
LIG_LIR_Nem_3	75	80	PF02991	0.394
LIG_PDZ_Class_2	311	316	PF00595	0.459
LIG_PTB_Apo_2	230	237	PF02174	0.379
LIG_Rb_LxCxE_1	137	156	PF01857	0.254
LIG_REV1ctd_RIR_1	119	127	PF16727	0.334
LIG_SH2_CRK	163	167	PF00017	0.377
LIG_SH2_CRK	234	238	PF00017	0.388
LIG_SH2_CRK	287	291	PF00017	0.377
LIG_SH2_GRB2like	231	234	PF00017	0.377
LIG_SH2_NCK_1	163	167	PF00017	0.377
LIG_SH2_STAP1	21	25	PF00017	0.386
LIG_SH2_STAP1	234	238	PF00017	0.365
LIG_SH2_STAT5	118	121	PF00017	0.383
LIG_SH2_STAT5	131	134	PF00017	0.367
LIG_SH2_STAT5	163	166	PF00017	0.448
LIG_SH2_STAT5	203	206	PF00017	0.387
LIG_SH2_STAT5	231	234	PF00017	0.377
LIG_SH3_2	258	263	PF14604	0.339
LIG_SH3_3	234	240	PF00018	0.377
LIG_SH3_3	255	261	PF00018	0.360
LIG_TRFH_1	236	240	PF08558	0.377
LIG_TYR_ITIM	232	237	PF00017	0.377
LIG_WRC_WIRS_1	25	30	PF05994	0.391
MOD_CK1_1	175	181	PF00069	0.417
MOD_CK1_1	217	223	PF00069	0.443
MOD_GlcNHglycan	206	209	PF01048	0.369
MOD_GlcNHglycan	273	276	PF01048	0.377
MOD_GlcNHglycan	287	290	PF01048	0.377
MOD_GSK3_1	153	160	PF00069	0.384
MOD_GSK3_1	20	27	PF00069	0.359
MOD_GSK3_1	37	44	PF00069	0.386
MOD_N-GLC_1	148	153	PF02516	0.245
MOD_N-GLC_1	232	237	PF02516	0.390
MOD_N-GLC_1	37	42	PF02516	0.381
MOD_NEK2_1	102	107	PF00069	0.374
MOD_NEK2_1	130	135	PF00069	0.284
MOD_NEK2_1	204	209	PF00069	0.410
MOD_NEK2_1	232	237	PF00069	0.387
MOD_NEK2_1	69	74	PF00069	0.382
MOD_NEK2_2	252	257	PF00069	0.340
MOD_PIKK_1	175	181	PF00454	0.434
MOD_PK_1	226	232	PF00069	0.230
MOD_PKA_1	108	114	PF00069	0.377
MOD_PKA_2	225	231	PF00069	0.230
MOD_PKA_2	296	302	PF00069	0.387
MOD_PKB_1	106	114	PF00069	0.377
MOD_Plk_1	232	238	PF00069	0.375
MOD_Plk_1	37	43	PF00069	0.351
MOD_Plk_1	75	81	PF00069	0.394
MOD_Plk_4	113	119	PF00069	0.400
MOD_Plk_4	20	26	PF00069	0.415
MOD_Plk_4	226	232	PF00069	0.386
MOD_Plk_4	82	88	PF00069	0.358
MOD_SUMO_for_1	262	265	PF00179	0.377
MOD_SUMO_for_1	96	99	PF00179	0.350
MOD_SUMO_rev_2	235	245	PF00179	0.356
MOD_SUMO_rev_2	3	13	PF00179	0.508
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.254
TRG_ENDOCYTIC_2	118	121	PF00928	0.418
TRG_ENDOCYTIC_2	163	166	PF00928	0.377
TRG_ENDOCYTIC_2	21	24	PF00928	0.419
TRG_ENDOCYTIC_2	234	237	PF00928	0.417
TRG_ENDOCYTIC_2	287	290	PF00928	0.377
TRG_ENDOCYTIC_2	52	55	PF00928	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	82%	100%
A0A0N1HYU8	Leptomonas seymouri	64%	99%
A0A0N1I429	Leptomonas seymouri	54%	97%
A0A0N1I5D6	Leptomonas seymouri	59%	100%
A0A0N1I720	Leptomonas seymouri	56%	100%
A0A0N1IL04	Leptomonas seymouri	62%	100%
A0A0N1PCE9	Leptomonas seymouri	51%	98%
A0A0R6XPC0	Leishmania donovani	64%	99%
A0A3Q8IHB3	Leishmania donovani	48%	98%
A0A3S5H6H4	Leishmania donovani	53%	96%
A0A3S5H6H5	Leishmania donovani	58%	100%
A0A3S7WRC9	Leishmania donovani	100%	100%
A0A3S7WRD5	Leishmania donovani	63%	100%
A0A3S7WRE8	Leishmania donovani	65%	100%
A4H6B5	Leishmania braziliensis	52%	100%
A4H6B6	Leishmania braziliensis	48%	100%
A4H6B7	Leishmania braziliensis	65%	100%
A4H6B8	Leishmania braziliensis	63%	100%
A4H6B9	Leishmania braziliensis	57%	100%
A4H6C0	Leishmania braziliensis	89%	100%
A4H6C1	Leishmania braziliensis	63%	100%
A4HUN8	Leishmania infantum	53%	100%
A4HUN9	Leishmania infantum	48%	100%
A4HUP0	Leishmania infantum	64%	100%
A4HUP1	Leishmania infantum	63%	100%
A4HUP2	Leishmania infantum	58%	100%
A4HUP4	Leishmania infantum	65%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QH83	Leishmania major	63%	100%
Q4QH84	Leishmania major	97%	100%
Q4QH85	Leishmania major	57%	100%
Q4QH86	Leishmania major	64%	100%
Q4QH87	Leishmania major	64%	100%
Q4QH88	Leishmania major	48%	100%
Q4QH89	Leishmania major	54%	100%