LeishMANIAdb
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DUF1861 family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF1861 family protein
Gene product:
Protein of unknown function (DUF1861) - putative
Species:
Leishmania infantum
UniProt:
A4HUP1_LEIIN
TriTrypDb:
LINF_100020600
Length:
315

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 42
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 24
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 42
NetGPI no yes: 0, no: 42
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUP1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUP1

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 100 102 PF00675 0.402
CLV_PCSK_KEX2_1 12 14 PF00082 0.416
CLV_PCSK_KEX2_1 51 53 PF00082 0.400
CLV_PCSK_PC1ET2_1 12 14 PF00082 0.456
CLV_PCSK_PC1ET2_1 51 53 PF00082 0.393
CLV_PCSK_SKI1_1 123 127 PF00082 0.356
CLV_PCSK_SKI1_1 2 6 PF00082 0.471
DEG_Nend_UBRbox_1 1 4 PF02207 0.477
DOC_CDC14_PxL_1 175 183 PF14671 0.433
DOC_MAPK_FxFP_2 307 310 PF00069 0.286
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P5W3 Leptomonas seymouri 61% 100%
A0A0N1HYU8 Leptomonas seymouri 62% 99%
A0A0N1I429 Leptomonas seymouri 52% 96%
A0A0N1I5D6 Leptomonas seymouri 79% 100%
A0A0N1I720 Leptomonas seymouri 56% 100%
A0A0N1IL04 Leptomonas seymouri 64% 100%
A0A0N1PCE9 Leptomonas seymouri 51% 98%
A0A0R6XPC0 Leishmania donovani 60% 99%
A0A3Q8IHB3 Leishmania donovani 50% 98%
A0A3S5H6H4 Leishmania donovani 52% 96%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS