Class I SAM-dependent methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Methyltransferase domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HUN7_LEIIN

TriTrypDb:

LINF_100020200

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUN7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	174	176	PF00082	0.411
CLV_PCSK_KEX2_1	83	85	PF00082	0.447
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.411
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.270
CLV_PCSK_SKI1_1	39	43	PF00082	0.497
DEG_MDM2_SWIB_1	155	162	PF02201	0.445
DOC_CYCLIN_yCln2_LP_2	148	154	PF00134	0.411
DOC_MAPK_gen_1	160	170	PF00069	0.383
DOC_MAPK_MEF2A_6	163	172	PF00069	0.399
DOC_MAPK_MEF2A_6	7	16	PF00069	0.465
DOC_USP7_MATH_1	124	128	PF00917	0.386
DOC_WW_Pin1_4	8	13	PF00397	0.529
DOC_WW_Pin1_4	82	87	PF00397	0.445
LIG_14-3-3_CanoR_1	220	229	PF00244	0.520
LIG_BRCT_BRCA1_1	31	35	PF00533	0.409
LIG_FHA_1	140	146	PF00498	0.411
LIG_FHA_1	171	177	PF00498	0.411
LIG_FHA_1	217	223	PF00498	0.548
LIG_FHA_2	138	144	PF00498	0.411
LIG_LIR_Apic_2	119	124	PF02991	0.405
LIG_LIR_Gen_1	133	144	PF02991	0.506
LIG_LIR_Gen_1	200	211	PF02991	0.373
LIG_LIR_Gen_1	237	246	PF02991	0.512
LIG_LIR_Gen_1	60	71	PF02991	0.422
LIG_LIR_Gen_1	76	82	PF02991	0.342
LIG_LIR_Nem_3	116	121	PF02991	0.352
LIG_LIR_Nem_3	133	139	PF02991	0.352
LIG_LIR_Nem_3	153	158	PF02991	0.426
LIG_LIR_Nem_3	200	206	PF02991	0.373
LIG_LIR_Nem_3	237	242	PF02991	0.505
LIG_LIR_Nem_3	60	66	PF02991	0.448
LIG_LIR_Nem_3	76	80	PF02991	0.342
LIG_Pex14_2	155	159	PF04695	0.445
LIG_PTB_Apo_2	182	189	PF02174	0.411
LIG_PTB_Phospho_1	182	188	PF10480	0.411
LIG_SH2_CRK	136	140	PF00017	0.411
LIG_SH2_STAP1	111	115	PF00017	0.369
LIG_SH2_STAP1	63	67	PF00017	0.484
LIG_SH2_STAT5	122	125	PF00017	0.364
LIG_SH2_STAT5	128	131	PF00017	0.369
LIG_SH2_STAT5	188	191	PF00017	0.411
LIG_SH2_STAT5	77	80	PF00017	0.393
LIG_SH3_1	83	89	PF00018	0.380
LIG_SH3_3	31	37	PF00018	0.427
LIG_SH3_3	83	89	PF00018	0.380
LIG_SH3_5	73	77	PF00018	0.445
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.375
LIG_SUMO_SIM_par_1	167	173	PF11976	0.399
LIG_TRAF2_1	44	47	PF00917	0.527
MOD_CK1_1	209	215	PF00069	0.524
MOD_CK2_1	137	143	PF00069	0.411
MOD_CK2_1	209	215	PF00069	0.490
MOD_CK2_1	40	46	PF00069	0.516
MOD_GlcNHglycan	106	109	PF01048	0.393
MOD_GlcNHglycan	222	225	PF01048	0.507
MOD_GlcNHglycan	243	246	PF01048	0.522
MOD_GlcNHglycan	43	46	PF01048	0.467
MOD_GSK3_1	150	157	PF00069	0.511
MOD_GSK3_1	186	193	PF00069	0.474
MOD_GSK3_1	209	216	PF00069	0.538
MOD_GSK3_1	78	85	PF00069	0.389
MOD_GSK3_1	8	15	PF00069	0.509
MOD_N-GLC_2	4	6	PF02516	0.511
MOD_NEK2_1	197	202	PF00069	0.466
MOD_NEK2_1	206	211	PF00069	0.377
MOD_NEK2_1	241	246	PF00069	0.520
MOD_NEK2_1	40	45	PF00069	0.526
MOD_NEK2_1	78	83	PF00069	0.270
MOD_NEK2_2	12	17	PF00069	0.523
MOD_Plk_1	124	130	PF00069	0.354
MOD_Plk_4	12	18	PF00069	0.577
MOD_Plk_4	150	156	PF00069	0.445
MOD_Plk_4	29	35	PF00069	0.259
MOD_ProDKin_1	8	14	PF00069	0.526
MOD_ProDKin_1	82	88	PF00069	0.445
MOD_SUMO_rev_2	43	50	PF00179	0.494
TRG_ENDOCYTIC_2	136	139	PF00928	0.515
TRG_ENDOCYTIC_2	63	66	PF00928	0.496
TRG_ENDOCYTIC_2	77	80	PF00928	0.411
TRG_ER_FFAT_2	133	143	PF00635	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF1	Leptomonas seymouri	61%	99%
A0A3S7WRE9	Leishmania donovani	100%	79%
A4H6B4	Leishmania braziliensis	72%	100%
E9ACR1	Leishmania major	91%	100%
E9AND6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%