Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spinocerebellar ataxia type 10 protein domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HUN5_LEIIN

TriTrypDb:

LINF_100019600

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HUN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.441
CLV_NRD_NRD_1	266	268	PF00675	0.338
CLV_NRD_NRD_1	97	99	PF00675	0.522
CLV_PCSK_KEX2_1	96	98	PF00082	0.514
CLV_PCSK_SKI1_1	169	173	PF00082	0.417
CLV_PCSK_SKI1_1	279	283	PF00082	0.300
CLV_Separin_Metazoa	121	125	PF03568	0.665
DOC_ANK_TNKS_1	96	103	PF00023	0.642
DOC_MAPK_MEF2A_6	23	32	PF00069	0.507
DOC_USP7_MATH_1	132	136	PF00917	0.564
DOC_USP7_MATH_1	2	6	PF00917	0.677
DOC_USP7_MATH_1	55	59	PF00917	0.645
DOC_USP7_UBL2_3	165	169	PF12436	0.480
DOC_USP7_UBL2_3	19	23	PF12436	0.533
DOC_WW_Pin1_4	103	108	PF00397	0.718
DOC_WW_Pin1_4	116	121	PF00397	0.675
LIG_14-3-3_CanoR_1	124	129	PF00244	0.565
LIG_14-3-3_CanoR_1	285	291	PF00244	0.541
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BIR_III_3	1	5	PF00653	0.642
LIG_BRCT_BRCA1_1	286	290	PF00533	0.580
LIG_Clathr_ClatBox_1	147	151	PF01394	0.476
LIG_deltaCOP1_diTrp_1	246	250	PF00928	0.487
LIG_FHA_2	116	122	PF00498	0.585
LIG_FHA_2	233	239	PF00498	0.476
LIG_FHA_2	59	65	PF00498	0.603
LIG_FHA_2	89	95	PF00498	0.493
LIG_LIR_Gen_1	173	180	PF02991	0.473
LIG_LIR_Gen_1	226	237	PF02991	0.580
LIG_LIR_Gen_1	246	255	PF02991	0.487
LIG_LIR_Gen_1	34	43	PF02991	0.525
LIG_LIR_Nem_3	173	177	PF02991	0.480
LIG_LIR_Nem_3	226	232	PF02991	0.580
LIG_LIR_Nem_3	246	250	PF02991	0.487
LIG_LIR_Nem_3	34	38	PF02991	0.534
LIG_Pex14_2	195	199	PF04695	0.467
LIG_SH2_NCK_1	47	51	PF00017	0.549
LIG_SH2_STAP1	47	51	PF00017	0.483
LIG_SH2_STAP1	88	92	PF00017	0.507
LIG_SH2_STAT5	162	165	PF00017	0.465
LIG_SH2_STAT5	179	182	PF00017	0.422
LIG_SH2_STAT5	194	197	PF00017	0.390
LIG_SUMO_SIM_anti_2	143	149	PF11976	0.416
LIG_SUMO_SIM_par_1	146	151	PF11976	0.417
LIG_SUMO_SIM_par_1	75	80	PF11976	0.480
LIG_WRC_WIRS_1	32	37	PF05994	0.542
MOD_CK1_1	106	112	PF00069	0.671
MOD_CK1_1	113	119	PF00069	0.598
MOD_CK1_1	143	149	PF00069	0.417
MOD_CK1_1	289	295	PF00069	0.580
MOD_CK1_1	34	40	PF00069	0.559
MOD_CK1_1	58	64	PF00069	0.637
MOD_CK2_1	115	121	PF00069	0.600
MOD_CK2_1	123	129	PF00069	0.541
MOD_CK2_1	88	94	PF00069	0.488
MOD_GlcNHglycan	232	235	PF01048	0.316
MOD_GlcNHglycan	257	261	PF01048	0.366
MOD_GlcNHglycan	292	295	PF01048	0.359
MOD_GlcNHglycan	57	60	PF01048	0.666
MOD_GSK3_1	106	113	PF00069	0.653
MOD_GSK3_1	284	291	PF00069	0.580
MOD_N-GLC_1	124	129	PF02516	0.600
MOD_N-GLC_1	208	213	PF02516	0.287
MOD_N-GLC_2	254	256	PF02516	0.287
MOD_NEK2_1	111	116	PF00069	0.685
MOD_NEK2_1	123	128	PF00069	0.534
MOD_NEK2_1	232	237	PF00069	0.479
MOD_NEK2_1	290	295	PF00069	0.556
MOD_PIKK_1	106	112	PF00454	0.740
MOD_PIKK_1	232	238	PF00454	0.580
MOD_PIKK_1	297	303	PF00454	0.673
MOD_PIKK_1	64	70	PF00454	0.583
MOD_PK_1	124	130	PF00069	0.535
MOD_PKA_2	123	129	PF00069	0.541
MOD_PKA_2	140	146	PF00069	0.371
MOD_PKA_2	223	229	PF00069	0.580
MOD_PKA_2	284	290	PF00069	0.580
MOD_Plk_1	124	130	PF00069	0.555
MOD_Plk_1	77	83	PF00069	0.500
MOD_Plk_1	88	94	PF00069	0.517
MOD_Plk_4	143	149	PF00069	0.458
MOD_Plk_4	152	158	PF00069	0.406
MOD_Plk_4	223	229	PF00069	0.547
MOD_Plk_4	88	94	PF00069	0.543
MOD_ProDKin_1	103	109	PF00069	0.721
MOD_ProDKin_1	116	122	PF00069	0.675
MOD_SUMO_for_1	199	202	PF00179	0.558
MOD_SUMO_rev_2	58	63	PF00179	0.663
TRG_DiLeu_BaEn_1	202	207	PF01217	0.487
TRG_DiLeu_BaEn_2	222	228	PF01217	0.539
TRG_DiLeu_BaEn_3	239	245	PF01217	0.500
TRG_DiLeu_LyEn_5	202	207	PF01217	0.537
TRG_ER_diArg_1	95	98	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX75	Leptomonas seymouri	76%	100%
A0A0S4KKL7	Bodo saltans	29%	87%
A0A1X0NS45	Trypanosomatidae	37%	100%
A0A3Q8IB48	Leishmania donovani	100%	100%
A0A422NBS9	Trypanosoma rangeli	41%	99%
A4H6B1	Leishmania braziliensis	93%	100%
C9ZVR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AND3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QH91	Leishmania major	97%	100%
V5B466	Trypanosoma cruzi	41%	88%