Chromatin-remodeling ATPase INO80

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUN4_LEIIN

TriTrypDb:

LINF_100019500

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HUN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.491
CLV_MEL_PAP_1	260	266	PF00089	0.435
CLV_NRD_NRD_1	148	150	PF00675	0.516
CLV_NRD_NRD_1	286	288	PF00675	0.498
CLV_NRD_NRD_1	341	343	PF00675	0.526
CLV_NRD_NRD_1	427	429	PF00675	0.507
CLV_NRD_NRD_1	436	438	PF00675	0.472
CLV_NRD_NRD_1	52	54	PF00675	0.529
CLV_NRD_NRD_1	563	565	PF00675	0.533
CLV_PCSK_FUR_1	425	429	PF00082	0.565
CLV_PCSK_KEX2_1	25	27	PF00082	0.528
CLV_PCSK_KEX2_1	341	343	PF00082	0.613
CLV_PCSK_KEX2_1	381	383	PF00082	0.483
CLV_PCSK_KEX2_1	427	429	PF00082	0.474
CLV_PCSK_KEX2_1	436	438	PF00082	0.502
CLV_PCSK_KEX2_1	449	451	PF00082	0.613
CLV_PCSK_KEX2_1	52	54	PF00082	0.464
CLV_PCSK_KEX2_1	563	565	PF00082	0.533
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.424
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.479
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.636
CLV_PCSK_PC7_1	432	438	PF00082	0.522
CLV_PCSK_SKI1_1	102	106	PF00082	0.476
CLV_PCSK_SKI1_1	26	30	PF00082	0.510
CLV_PCSK_SKI1_1	42	46	PF00082	0.400
CLV_PCSK_SKI1_1	484	488	PF00082	0.706
CLV_PCSK_SKI1_1	61	65	PF00082	0.468
DEG_Nend_UBRbox_1	1	4	PF02207	0.566
DEG_SPOP_SBC_1	488	492	PF00917	0.562
DOC_CKS1_1	158	163	PF01111	0.694
DOC_CYCLIN_RxL_1	99	106	PF00134	0.425
DOC_MAPK_gen_1	29	37	PF00069	0.470
DOC_MAPK_gen_1	447	457	PF00069	0.478
DOC_MAPK_MEF2A_6	235	243	PF00069	0.398
DOC_MAPK_RevD_3	274	288	PF00069	0.433
DOC_PP1_RVXF_1	198	204	PF00149	0.394
DOC_PP1_RVXF_1	380	387	PF00149	0.516
DOC_USP7_MATH_1	159	163	PF00917	0.662
DOC_USP7_MATH_1	206	210	PF00917	0.532
DOC_USP7_MATH_1	295	299	PF00917	0.417
DOC_USP7_MATH_1	318	322	PF00917	0.449
DOC_USP7_MATH_1	488	492	PF00917	0.547
DOC_USP7_MATH_1	553	557	PF00917	0.573
DOC_USP7_UBL2_3	25	29	PF12436	0.543
DOC_WW_Pin1_4	157	162	PF00397	0.662
DOC_WW_Pin1_4	226	231	PF00397	0.496
DOC_WW_Pin1_4	534	539	PF00397	0.467
LIG_14-3-3_CanoR_1	2	10	PF00244	0.516
LIG_14-3-3_CanoR_1	200	204	PF00244	0.493
LIG_14-3-3_CanoR_1	242	252	PF00244	0.512
LIG_14-3-3_CanoR_1	263	271	PF00244	0.492
LIG_14-3-3_CanoR_1	290	297	PF00244	0.487
LIG_14-3-3_CanoR_1	302	308	PF00244	0.365
LIG_14-3-3_CanoR_1	358	364	PF00244	0.567
LIG_14-3-3_CanoR_1	42	50	PF00244	0.501
LIG_14-3-3_CanoR_1	467	473	PF00244	0.486
LIG_14-3-3_CanoR_1	497	502	PF00244	0.668
LIG_Actin_WH2_2	273	289	PF00022	0.454
LIG_BIR_III_4	88	92	PF00653	0.426
LIG_BRCT_BRCA1_1	161	165	PF00533	0.516
LIG_FHA_1	234	240	PF00498	0.417
LIG_FHA_2	227	233	PF00498	0.547
LIG_LIR_Gen_1	185	193	PF02991	0.432
LIG_LIR_Gen_1	495	506	PF02991	0.535
LIG_LIR_Nem_3	185	189	PF02991	0.368
LIG_LIR_Nem_3	495	501	PF02991	0.519
LIG_LYPXL_S_1	267	271	PF13949	0.530
LIG_LYPXL_yS_3	268	271	PF13949	0.529
LIG_NRBOX	100	106	PF00104	0.424
LIG_PCNA_PIPBox_1	462	471	PF02747	0.484
LIG_PCNA_yPIPBox_3	458	469	PF02747	0.487
LIG_RPA_C_Fungi	285	297	PF08784	0.484
LIG_SH2_CRK	498	502	PF00017	0.574
LIG_SH2_CRK	526	530	PF00017	0.530
LIG_SH2_STAP1	353	357	PF00017	0.582
LIG_SH2_STAP1	498	502	PF00017	0.643
LIG_SH2_STAT3	396	399	PF00017	0.412
LIG_SH2_STAT3	435	438	PF00017	0.524
LIG_SH2_STAT5	498	501	PF00017	0.613
LIG_SH3_3	266	272	PF00018	0.518
LIG_SUMO_SIM_anti_2	303	310	PF11976	0.369
LIG_SUMO_SIM_par_1	135	142	PF11976	0.465
LIG_TRAF2_1	209	212	PF00917	0.375
LIG_TRAF2_1	279	282	PF00917	0.400
LIG_TRAF2_1	417	420	PF00917	0.473
LIG_UBA3_1	454	461	PF00899	0.455
MOD_CDK_SPxxK_3	534	541	PF00069	0.424
MOD_CK1_1	11	17	PF00069	0.543
MOD_CK1_1	253	259	PF00069	0.424
MOD_CK1_1	306	312	PF00069	0.490
MOD_CK1_1	492	498	PF00069	0.569
MOD_CK2_1	206	212	PF00069	0.375
MOD_CK2_1	306	312	PF00069	0.471
MOD_CK2_1	33	39	PF00069	0.535
MOD_CK2_1	359	365	PF00069	0.493
MOD_CK2_1	43	49	PF00069	0.443
MOD_Cter_Amidation	50	53	PF01082	0.443
MOD_GlcNHglycan	128	131	PF01048	0.638
MOD_GlcNHglycan	161	164	PF01048	0.557
MOD_GlcNHglycan	208	211	PF01048	0.569
MOD_GlcNHglycan	245	248	PF01048	0.508
MOD_GlcNHglycan	251	255	PF01048	0.472
MOD_GlcNHglycan	26	29	PF01048	0.448
MOD_GlcNHglycan	264	267	PF01048	0.396
MOD_GlcNHglycan	272	275	PF01048	0.511
MOD_GlcNHglycan	312	315	PF01048	0.517
MOD_GlcNHglycan	400	403	PF01048	0.393
MOD_GlcNHglycan	491	494	PF01048	0.683
MOD_GlcNHglycan	5	8	PF01048	0.641
MOD_GlcNHglycan	550	553	PF01048	0.555
MOD_GlcNHglycan	97	101	PF01048	0.591
MOD_GSK3_1	103	110	PF00069	0.489
MOD_GSK3_1	126	133	PF00069	0.596
MOD_GSK3_1	303	310	PF00069	0.482
MOD_GSK3_1	488	495	PF00069	0.541
MOD_GSK3_1	497	504	PF00069	0.532
MOD_N-GLC_1	303	308	PF02516	0.408
MOD_NEK2_1	1	6	PF00069	0.671
MOD_NEK2_1	115	120	PF00069	0.567
MOD_NEK2_1	124	129	PF00069	0.579
MOD_NEK2_1	189	194	PF00069	0.442
MOD_NEK2_1	243	248	PF00069	0.598
MOD_NEK2_1	250	255	PF00069	0.539
MOD_NEK2_1	300	305	PF00069	0.477
MOD_NEK2_1	486	491	PF00069	0.566
MOD_NEK2_1	501	506	PF00069	0.551
MOD_NEK2_1	96	101	PF00069	0.526
MOD_NEK2_2	33	38	PF00069	0.472
MOD_PIKK_1	103	109	PF00454	0.594
MOD_PIKK_1	290	296	PF00454	0.589
MOD_PKA_1	24	30	PF00069	0.551
MOD_PKA_2	1	7	PF00069	0.542
MOD_PKA_2	199	205	PF00069	0.436
MOD_PKA_2	262	268	PF00069	0.559
MOD_PKA_2	359	365	PF00069	0.582
MOD_PKA_2	442	448	PF00069	0.514
MOD_PKA_2	496	502	PF00069	0.633
MOD_PKA_2	548	554	PF00069	0.499
MOD_Plk_1	11	17	PF00069	0.633
MOD_Plk_1	211	217	PF00069	0.421
MOD_Plk_1	280	286	PF00069	0.406
MOD_Plk_1	303	309	PF00069	0.393
MOD_Plk_1	78	84	PF00069	0.579
MOD_Plk_1	96	102	PF00069	0.350
MOD_Plk_2-3	84	90	PF00069	0.458
MOD_Plk_4	501	507	PF00069	0.529
MOD_ProDKin_1	157	163	PF00069	0.657
MOD_ProDKin_1	226	232	PF00069	0.494
MOD_ProDKin_1	534	540	PF00069	0.459
MOD_SUMO_rev_2	419	424	PF00179	0.565
TRG_DiLeu_BaEn_1	312	317	PF01217	0.524
TRG_DiLeu_BaEn_4	281	287	PF01217	0.410
TRG_ENDOCYTIC_2	268	271	PF00928	0.423
TRG_ENDOCYTIC_2	353	356	PF00928	0.585
TRG_ENDOCYTIC_2	498	501	PF00928	0.592
TRG_ENDOCYTIC_2	526	529	PF00928	0.529
TRG_ER_diArg_1	333	336	PF00400	0.579
TRG_ER_diArg_1	357	360	PF00400	0.406
TRG_ER_diArg_1	389	392	PF00400	0.406
TRG_ER_diArg_1	425	428	PF00400	0.579
TRG_ER_diArg_1	435	437	PF00400	0.534
TRG_ER_diArg_1	521	524	PF00400	0.532
TRG_ER_diArg_1	562	564	PF00400	0.523
TRG_NES_CRM1_1	232	245	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W6	Leptomonas seymouri	54%	100%
A0A1X0NRY0	Trypanosomatidae	31%	97%
A0A3Q8I7T8	Leishmania donovani	99%	100%
A0A3R7MBP9	Trypanosoma rangeli	28%	97%
A4H6B0	Leishmania braziliensis	78%	100%
C9ZVR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	98%
E9AND2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QH92	Leishmania major	93%	100%
V5BJP6	Trypanosoma cruzi	29%	92%