Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others - putative

Species:

Leishmania infantum

UniProt:

A4HUN2_LEIIN

TriTrypDb:

LINF_100019300

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HUN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUN2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.506
CLV_NRD_NRD_1	14	16	PF00675	0.606
CLV_NRD_NRD_1	170	172	PF00675	0.317
CLV_NRD_NRD_1	60	62	PF00675	0.481
CLV_NRD_NRD_1	67	69	PF00675	0.537
CLV_PCSK_FUR_1	67	71	PF00082	0.459
CLV_PCSK_KEX2_1	109	111	PF00082	0.494
CLV_PCSK_KEX2_1	14	16	PF00082	0.606
CLV_PCSK_KEX2_1	170	172	PF00082	0.421
CLV_PCSK_KEX2_1	60	62	PF00082	0.481
CLV_PCSK_KEX2_1	67	69	PF00082	0.537
CLV_PCSK_KEX2_1	91	93	PF00082	0.300
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.582
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.300
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DEG_SPOP_SBC_1	37	41	PF00917	0.484
DOC_USP7_MATH_1	27	31	PF00917	0.657
DOC_USP7_MATH_1	37	41	PF00917	0.550
DOC_WW_Pin1_4	177	182	PF00397	0.286
DOC_WW_Pin1_4	51	56	PF00397	0.457
LIG_14-3-3_CanoR_1	48	58	PF00244	0.573
LIG_FHA_2	73	79	PF00498	0.331
LIG_Integrin_RGDW_4	76	79	PF00362	0.331
LIG_LIR_Apic_2	120	124	PF02991	0.391
LIG_LIR_Apic_2	154	160	PF02991	0.272
LIG_MYND_1	102	106	PF01753	0.460
LIG_SH2_STAT5	46	49	PF00017	0.514
LIG_SH3_2	147	152	PF14604	0.506
LIG_SH3_3	105	111	PF00018	0.518
LIG_SH3_3	141	147	PF00018	0.453
LIG_SH3_3	21	27	PF00018	0.516
LIG_SH3_3	97	103	PF00018	0.298
LIG_Sin3_3	21	28	PF02671	0.489
LIG_WRC_WIRS_1	47	52	PF05994	0.480
LIG_WW_2	102	105	PF00397	0.447
LIG_WW_2	147	150	PF00397	0.529
MOD_CK1_1	177	183	PF00069	0.294
MOD_CK1_1	40	46	PF00069	0.570
MOD_CK1_1	49	55	PF00069	0.447
MOD_CK2_1	87	93	PF00069	0.325
MOD_GlcNHglycan	176	179	PF01048	0.302
MOD_GlcNHglycan	29	32	PF01048	0.590
MOD_GSK3_1	151	158	PF00069	0.577
MOD_GSK3_1	36	43	PF00069	0.689
MOD_GSK3_1	68	75	PF00069	0.611
MOD_LATS_1	66	72	PF00433	0.523
MOD_N-GLC_2	42	44	PF02516	0.470
MOD_NEK2_1	174	179	PF00069	0.281
MOD_NEK2_1	36	41	PF00069	0.694
MOD_PKA_1	109	115	PF00069	0.462
MOD_PKA_1	68	74	PF00069	0.631
MOD_PKA_2	109	115	PF00069	0.462
MOD_PKB_1	70	78	PF00069	0.633
MOD_Plk_1	152	158	PF00069	0.451
MOD_Plk_4	152	158	PF00069	0.451
MOD_Plk_4	42	48	PF00069	0.631
MOD_ProDKin_1	177	183	PF00069	0.286
MOD_ProDKin_1	51	57	PF00069	0.453
MOD_SUMO_rev_2	180	187	PF00179	0.560
TRG_ER_diArg_1	108	110	PF00400	0.497
TRG_ER_diArg_1	13	15	PF00400	0.594
TRG_ER_diArg_1	170	172	PF00400	0.379
TRG_ER_diArg_1	60	62	PF00400	0.460
TRG_ER_diArg_1	67	70	PF00400	0.504
TRG_NLS_MonoExtC_3	67	72	PF00514	0.656
TRG_NLS_MonoExtN_4	67	72	PF00514	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKB7	Leptomonas seymouri	27%	68%
A0A0N1PC91	Leptomonas seymouri	64%	100%
A0A1X0NQG6	Trypanosomatidae	81%	92%
A0A3R7KWS8	Trypanosoma rangeli	82%	72%
A0A3S7WRC4	Leishmania donovani	99%	100%
A4H6A8	Leishmania braziliensis	79%	100%
C9ZJT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	66%
C9ZVR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AND0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QH94	Leishmania major	95%	100%