LeishMANIAdb
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Cilia- and flagella-associated protein 45

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Cilia- and flagella-associated protein 45
Gene product:
Tumour suppressor - Mitostatin - putative
Species:
Leishmania infantum
UniProt:
A4HUM7_LEIIN
TriTrypDb:
LINF_100018800
Length:
480

Annotations

Annotations by Jardim et al.

Flagella, Tumour suppressor, Mitostatin, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 3
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0120025 plasma membrane bounded cell projection 3 2

Expansion

Sequence features

A4HUM7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUM7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 16 18 PF00675 0.514
CLV_NRD_NRD_1 192 194 PF00675 0.236
CLV_NRD_NRD_1 211 213 PF00675 0.176
CLV_NRD_NRD_1 24 26 PF00675 0.481
CLV_NRD_NRD_1 240 242 PF00675 0.243
CLV_NRD_NRD_1 246 248 PF00675 0.235
CLV_NRD_NRD_1 274 276 PF00675 0.278
CLV_NRD_NRD_1 299 301 PF00675 0.303
CLV_NRD_NRD_1 329 331 PF00675 0.243
CLV_NRD_NRD_1 340 342 PF00675 0.195
CLV_NRD_NRD_1 405 407 PF00675 0.252
CLV_NRD_NRD_1 427 429 PF00675 0.224
CLV_NRD_NRD_1 440 442 PF00675 0.225
CLV_NRD_NRD_1 456 458 PF00675 0.152
CLV_NRD_NRD_1 472 474 PF00675 0.420
CLV_NRD_NRD_1 82 84 PF00675 0.501
CLV_PCSK_FUR_1 209 213 PF00082 0.320
CLV_PCSK_FUR_1 297 301 PF00082 0.309
CLV_PCSK_FUR_1 327 331 PF00082 0.235
CLV_PCSK_FUR_1 403 407 PF00082 0.320
CLV_PCSK_FUR_1 425 429 PF00082 0.236
CLV_PCSK_KEX2_1 15 17 PF00082 0.572
CLV_PCSK_KEX2_1 153 155 PF00082 0.248
CLV_PCSK_KEX2_1 192 194 PF00082 0.284
CLV_PCSK_KEX2_1 211 213 PF00082 0.251
CLV_PCSK_KEX2_1 240 242 PF00082 0.233
CLV_PCSK_KEX2_1 246 248 PF00082 0.219
CLV_PCSK_KEX2_1 299 301 PF00082 0.303
CLV_PCSK_KEX2_1 329 331 PF00082 0.229
CLV_PCSK_KEX2_1 340 342 PF00082 0.212
CLV_PCSK_KEX2_1 405 407 PF00082 0.320
CLV_PCSK_KEX2_1 425 427 PF00082 0.114
CLV_PCSK_KEX2_1 472 474 PF00082 0.528
CLV_PCSK_KEX2_1 81 83 PF00082 0.515
CLV_PCSK_PC1ET2_1 153 155 PF00082 0.252
CLV_PCSK_SKI1_1 118 122 PF00082 0.519
CLV_PCSK_SKI1_1 472 476 PF00082 0.481
DEG_APCC_DBOX_1 471 479 PF00400 0.553
DOC_MAPK_gen_1 263 271 PF00069 0.448
DOC_MAPK_gen_1 297 306 PF00069 0.520
DOC_MAPK_gen_1 472 478 PF00069 0.593
DOC_PP2B_LxvP_1 465 468 PF13499 0.435
DOC_USP7_MATH_1 34 38 PF00917 0.517
DOC_USP7_UBL2_3 372 376 PF12436 0.507
LIG_14-3-3_CanoR_1 16 24 PF00244 0.563
LIG_BIR_II_1 1 5 PF00653 0.553
LIG_CaM_IQ_9 227 243 PF13499 0.507
LIG_CaM_IQ_9 386 402 PF13499 0.520
LIG_FHA_1 402 408 PF00498 0.507
LIG_FHA_1 6 12 PF00498 0.584
LIG_FHA_2 39 45 PF00498 0.462
LIG_FHA_2 70 76 PF00498 0.646
LIG_FHA_2 98 104 PF00498 0.527
LIG_PCNA_yPIPBox_3 376 387 PF02747 0.515
LIG_REV1ctd_RIR_1 1 11 PF16727 0.651
LIG_SH2_STAT3 161 164 PF00017 0.489
LIG_SH2_STAT3 280 283 PF00017 0.489
LIG_SH2_STAT5 180 183 PF00017 0.520
LIG_SH2_STAT5 206 209 PF00017 0.462
LIG_SH2_STAT5 280 283 PF00017 0.435
LIG_SH2_STAT5 335 338 PF00017 0.520
LIG_SH3_3 8 14 PF00018 0.533
LIG_SUMO_SIM_anti_2 412 417 PF11976 0.435
LIG_SUMO_SIM_anti_2 43 49 PF11976 0.443
LIG_TRAF2_1 100 103 PF00917 0.590
LIG_TRAF2_1 76 79 PF00917 0.567
LIG_WW_3 12 16 PF00397 0.486
MOD_CK2_1 38 44 PF00069 0.452
MOD_CK2_1 69 75 PF00069 0.598
MOD_CK2_1 97 103 PF00069 0.612
MOD_GlcNHglycan 350 353 PF01048 0.262
MOD_GlcNHglycan 36 39 PF01048 0.590
MOD_GlcNHglycan 60 63 PF01048 0.597
MOD_GSK3_1 34 41 PF00069 0.495
MOD_GSK3_1 56 63 PF00069 0.671
MOD_N-GLC_1 5 10 PF02516 0.460
MOD_NEK2_1 60 65 PF00069 0.617
MOD_PKA_2 34 40 PF00069 0.488
MOD_PKA_2 348 354 PF00069 0.503
MOD_PKB_1 15 23 PF00069 0.575
MOD_Plk_1 156 162 PF00069 0.458
MOD_Plk_1 409 415 PF00069 0.424
MOD_Plk_4 156 162 PF00069 0.382
MOD_SUMO_rev_2 122 131 PF00179 0.448
MOD_SUMO_rev_2 228 236 PF00179 0.507
MOD_SUMO_rev_2 268 278 PF00179 0.448
MOD_SUMO_rev_2 452 459 PF00179 0.526
TRG_DiLeu_BaEn_1 115 120 PF01217 0.456
TRG_DiLeu_BaEn_3 381 387 PF01217 0.435
TRG_DiLeu_BaEn_4 293 299 PF01217 0.382
TRG_DiLeu_BaEn_4 435 441 PF01217 0.509
TRG_ER_diArg_1 14 17 PF00400 0.576
TRG_ER_diArg_1 185 188 PF00400 0.520
TRG_ER_diArg_1 209 212 PF00400 0.520
TRG_ER_diArg_1 239 241 PF00400 0.444
TRG_ER_diArg_1 246 248 PF00400 0.422
TRG_ER_diArg_1 297 300 PF00400 0.513
TRG_ER_diArg_1 326 329 PF00400 0.453
TRG_ER_diArg_1 403 406 PF00400 0.520
TRG_ER_diArg_1 425 428 PF00400 0.424
TRG_ER_diArg_1 471 473 PF00400 0.504
TRG_ER_diArg_1 81 83 PF00400 0.548
TRG_NES_CRM1_1 221 234 PF08389 0.551
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.320
TRG_Pf-PMV_PEXEL_1 246 250 PF00026 0.235
TRG_Pf-PMV_PEXEL_1 385 390 PF00026 0.302
TRG_Pf-PMV_PEXEL_1 405 409 PF00026 0.114
TRG_Pf-PMV_PEXEL_1 457 461 PF00026 0.223

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5W7 Leptomonas seymouri 78% 100%
A0A0S4INS9 Bodo saltans 46% 98%
A0A1X0NS36 Trypanosomatidae 57% 100%
A0A3S7WRD8 Leishmania donovani 100% 100%
A0A422NGP1 Trypanosoma rangeli 54% 100%
A0A480NP79 Sus scrofa 31% 87%
A4H6A3 Leishmania braziliensis 91% 100%
A8I9E8 Chlamydomonas reinhardtii 44% 96%
C9ZVQ8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9ANC5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q32LN4 Bos taurus 31% 87%
Q4QH99 Leishmania major 97% 100%
Q9D9U9 Mus musculus 36% 87%
Q9UL16 Homo sapiens 31% 87%
V5BJP2 Trypanosoma cruzi 57% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS