RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger - C3HC4 type (RING finger) containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HUM6_LEIIN

TriTrypDb:

LINF_100018700

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUM6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0005488	binding	1	11
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0061630	ubiquitin protein ligase activity	5	11
GO:0061659	ubiquitin-like protein ligase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.443
CLV_NRD_NRD_1	76	78	PF00675	0.548
CLV_PCSK_KEX2_1	234	236	PF00082	0.470
CLV_PCSK_KEX2_1	76	78	PF00082	0.579
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.367
CLV_PCSK_SKI1_1	271	275	PF00082	0.406
CLV_PCSK_SKI1_1	356	360	PF00082	0.345
DOC_CYCLIN_RxL_1	94	102	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.524
DOC_MAPK_gen_1	125	132	PF00069	0.548
DOC_MAPK_gen_1	271	279	PF00069	0.402
DOC_MAPK_gen_1	76	82	PF00069	0.501
DOC_PP2B_LxvP_1	162	165	PF13499	0.506
DOC_PP2B_LxvP_1	243	246	PF13499	0.396
DOC_PP4_FxxP_1	31	34	PF00568	0.474
DOC_USP7_MATH_1	118	122	PF00917	0.374
DOC_USP7_MATH_1	139	143	PF00917	0.584
DOC_USP7_MATH_1	253	257	PF00917	0.652
DOC_WW_Pin1_4	220	225	PF00397	0.691
DOC_WW_Pin1_4	247	252	PF00397	0.478
DOC_WW_Pin1_4	86	91	PF00397	0.635
LIG_14-3-3_CanoR_1	131	138	PF00244	0.589
LIG_14-3-3_CanoR_1	187	191	PF00244	0.383
LIG_14-3-3_CanoR_1	341	349	PF00244	0.302
LIG_14-3-3_CanoR_1	4	10	PF00244	0.626
LIG_14-3-3_CanoR_1	64	68	PF00244	0.405
LIG_14-3-3_CterR_2	356	360	PF00244	0.335
LIG_BRCT_BRCA1_1	34	38	PF00533	0.573
LIG_FHA_1	100	106	PF00498	0.475
LIG_FHA_1	149	155	PF00498	0.509
LIG_FHA_1	157	163	PF00498	0.516
LIG_FHA_1	180	186	PF00498	0.620
LIG_FHA_1	320	326	PF00498	0.271
LIG_FHA_1	69	75	PF00498	0.413
LIG_FHA_2	14	20	PF00498	0.565
LIG_FHA_2	147	153	PF00498	0.492
LIG_FHA_2	239	245	PF00498	0.377
LIG_FHA_2	3	9	PF00498	0.609
LIG_FHA_2	64	70	PF00498	0.436
LIG_LIR_Nem_3	189	193	PF02991	0.333
LIG_Pex14_2	27	31	PF04695	0.442
LIG_PTB_Apo_2	278	285	PF02174	0.489
LIG_PTB_Phospho_1	278	284	PF10480	0.486
LIG_SH2_CRK	190	194	PF00017	0.369
LIG_SH2_STAP1	173	177	PF00017	0.523
LIG_SH2_STAP1	49	53	PF00017	0.566
LIG_SH2_STAT5	240	243	PF00017	0.344
LIG_SH2_STAT5	28	31	PF00017	0.440
LIG_SH2_STAT5	353	356	PF00017	0.384
LIG_SH3_1	226	232	PF00018	0.529
LIG_SH3_2	229	234	PF14604	0.488
LIG_SH3_3	155	161	PF00018	0.469
LIG_SH3_3	226	232	PF00018	0.768
LIG_SH3_3	295	301	PF00018	0.568
LIG_SH3_3	40	46	PF00018	0.607
LIG_SH3_4	33	40	PF00018	0.456
LIG_SUMO_SIM_par_1	191	196	PF11976	0.315
LIG_SUMO_SIM_par_1	66	71	PF11976	0.455
LIG_TRAF2_1	245	248	PF00917	0.582
LIG_TRAF2_1	303	306	PF00917	0.510
LIG_TYR_ITIM	188	193	PF00017	0.336
LIG_TYR_ITIM	238	243	PF00017	0.363
LIG_UBA3_1	167	172	PF00899	0.532
LIG_WW_3	223	227	PF00397	0.578
MOD_CDK_SPxK_1	220	226	PF00069	0.599
MOD_CK1_1	84	90	PF00069	0.484
MOD_CK2_1	13	19	PF00069	0.576
MOD_CK2_1	2	8	PF00069	0.608
MOD_CK2_1	230	236	PF00069	0.633
MOD_CK2_1	238	244	PF00069	0.464
MOD_GlcNHglycan	134	137	PF01048	0.599
MOD_GlcNHglycan	83	86	PF01048	0.519
MOD_GSK3_1	148	155	PF00069	0.614
MOD_GSK3_1	175	182	PF00069	0.596
MOD_GSK3_1	220	227	PF00069	0.690
MOD_GSK3_1	253	260	PF00069	0.669
MOD_N-GLC_1	2	7	PF02516	0.651
MOD_N-GLC_1	206	211	PF02516	0.704
MOD_N-GLC_2	334	336	PF02516	0.349
MOD_N-GLC_2	345	347	PF02516	0.211
MOD_NEK2_1	132	137	PF00069	0.576
MOD_NEK2_1	180	185	PF00069	0.605
MOD_NEK2_1	68	73	PF00069	0.433
MOD_NEK2_1	99	104	PF00069	0.330
MOD_NMyristoyl	1	7	PF02799	0.608
MOD_PIKK_1	105	111	PF00454	0.499
MOD_PIKK_1	206	212	PF00454	0.680
MOD_PIKK_1	224	230	PF00454	0.778
MOD_PKA_2	186	192	PF00069	0.408
MOD_PKA_2	3	9	PF00069	0.629
MOD_PKA_2	340	346	PF00069	0.404
MOD_PKA_2	63	69	PF00069	0.438
MOD_Plk_1	320	326	PF00069	0.314
MOD_Plk_2-3	304	310	PF00069	0.537
MOD_Plk_2-3	63	69	PF00069	0.381
MOD_Plk_4	153	159	PF00069	0.554
MOD_Plk_4	238	244	PF00069	0.365
MOD_Plk_4	320	326	PF00069	0.272
MOD_Plk_4	63	69	PF00069	0.381
MOD_ProDKin_1	220	226	PF00069	0.695
MOD_ProDKin_1	247	253	PF00069	0.488
MOD_ProDKin_1	86	92	PF00069	0.633
MOD_SUMO_for_1	171	174	PF00179	0.546
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.428
TRG_ENDOCYTIC_2	190	193	PF00928	0.372
TRG_ENDOCYTIC_2	240	243	PF00928	0.344
TRG_ENDOCYTIC_2	28	31	PF00928	0.548
TRG_ER_diArg_1	113	116	PF00400	0.463
TRG_ER_diArg_1	124	127	PF00400	0.573
TRG_ER_diArg_1	75	77	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A9	Leptomonas seymouri	49%	93%
A0A1X0NRX0	Trypanosomatidae	35%	98%
A0A3R7KAZ9	Trypanosoma rangeli	35%	100%
A0A3S7WRB2	Leishmania donovani	99%	100%
A4H6A2	Leishmania braziliensis	78%	99%
C9ZVQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ANC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QHA0	Leishmania major	95%	100%
V5BTV5	Trypanosoma cruzi	37%	99%