LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
PAB1-binding protein - putative
Species:
Leishmania infantum
UniProt:
A4HUM3_LEIIN
TriTrypDb:
LINF_100018400
Length:
523

Annotations

Annotations by Jardim et al.

RNA Processing, PAB1-binding Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0099080 supramolecular complex 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HUM3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUM3

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0034063 stress granule assembly 7 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0140694 non-membrane-bounded organelle assembly 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 10
GO:0003723 RNA binding 4 10
GO:0005488 binding 1 10
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 41 45 PF00656 0.290
CLV_C14_Caspase3-7 478 482 PF00656 0.740
CLV_C14_Caspase3-7 68 72 PF00656 0.354
CLV_NRD_NRD_1 229 231 PF00675 0.586
CLV_NRD_NRD_1 498 500 PF00675 0.723
CLV_PCSK_KEX2_1 223 225 PF00082 0.655
CLV_PCSK_KEX2_1 498 500 PF00082 0.709
CLV_PCSK_PC1ET2_1 223 225 PF00082 0.647
CLV_PCSK_SKI1_1 179 183 PF00082 0.380
CLV_PCSK_SKI1_1 310 314 PF00082 0.573
CLV_PCSK_SKI1_1 93 97 PF00082 0.537
DEG_Nend_Nbox_1 1 3 PF02207 0.641
DEG_SPOP_SBC_1 234 238 PF00917 0.670
DOC_CYCLIN_yClb5_NLxxxL_5 190 196 PF00134 0.380
DOC_MAPK_MEF2A_6 12 20 PF00069 0.268
DOC_PP1_RVXF_1 115 122 PF00149 0.519
DOC_PP2B_LxvP_1 279 282 PF13499 0.676
DOC_PP4_FxxP_1 305 308 PF00568 0.608
DOC_PP4_MxPP_1 423 426 PF00568 0.644
DOC_SPAK_OSR1_1 148 152 PF12202 0.386
DOC_USP7_MATH_1 219 223 PF00917 0.587
DOC_USP7_MATH_1 235 239 PF00917 0.624
DOC_USP7_MATH_1 285 289 PF00917 0.717
DOC_USP7_MATH_1 298 302 PF00917 0.513
DOC_USP7_MATH_1 308 312 PF00917 0.529
DOC_USP7_MATH_1 4 8 PF00917 0.580
DOC_USP7_MATH_1 417 421 PF00917 0.597
DOC_USP7_MATH_1 479 483 PF00917 0.652
DOC_USP7_UBL2_3 519 523 PF12436 0.595
DOC_WW_Pin1_4 244 249 PF00397 0.596
DOC_WW_Pin1_4 294 299 PF00397 0.593
DOC_WW_Pin1_4 300 305 PF00397 0.596
DOC_WW_Pin1_4 433 438 PF00397 0.757
DOC_WW_Pin1_4 98 103 PF00397 0.618
LIG_14-3-3_CanoR_1 349 354 PF00244 0.585
LIG_BIR_III_4 218 222 PF00653 0.624
LIG_deltaCOP1_diTrp_1 332 339 PF00928 0.605
LIG_eIF4E_1 15 21 PF01652 0.268
LIG_EVH1_1 279 283 PF00568 0.676
LIG_FHA_1 159 165 PF00498 0.268
LIG_FHA_1 187 193 PF00498 0.285
LIG_FHA_1 201 207 PF00498 0.284
LIG_FHA_1 22 28 PF00498 0.386
LIG_FHA_1 301 307 PF00498 0.610
LIG_FHA_1 492 498 PF00498 0.641
LIG_FHA_2 152 158 PF00498 0.277
LIG_FHA_2 160 166 PF00498 0.255
LIG_FHA_2 178 184 PF00498 0.268
LIG_FHA_2 227 233 PF00498 0.653
LIG_FHA_2 41 47 PF00498 0.279
LIG_LIR_Apic_2 303 308 PF02991 0.610
LIG_LIR_Apic_2 324 330 PF02991 0.515
LIG_LIR_Apic_2 345 350 PF02991 0.659
LIG_LIR_Gen_1 137 145 PF02991 0.488
LIG_LIR_Gen_1 14 25 PF02991 0.293
LIG_LIR_Nem_3 137 143 PF02991 0.497
LIG_LIR_Nem_3 14 20 PF02991 0.293
LIG_PAM2_1 296 308 PF00658 0.540
LIG_RPA_C_Fungi 37 49 PF08784 0.380
LIG_SH2_CRK 327 331 PF00017 0.527
LIG_SH2_CRK 347 351 PF00017 0.672
LIG_SH2_CRK 362 366 PF00017 0.448
LIG_SH2_GRB2like 17 20 PF00017 0.268
LIG_SH2_NCK_1 327 331 PF00017 0.585
LIG_SH2_NCK_1 347 351 PF00017 0.684
LIG_SH2_SRC 84 87 PF00017 0.380
LIG_SH2_STAP1 160 164 PF00017 0.268
LIG_SH2_STAP1 340 344 PF00017 0.585
LIG_SH2_STAP1 84 88 PF00017 0.380
LIG_SH2_STAT5 15 18 PF00017 0.268
LIG_SH2_STAT5 160 163 PF00017 0.268
LIG_SH2_STAT5 205 208 PF00017 0.386
LIG_SH3_3 238 244 PF00018 0.652
LIG_SH3_3 264 270 PF00018 0.663
LIG_SH3_3 274 280 PF00018 0.573
LIG_SH3_3 292 298 PF00018 0.540
LIG_SH3_3 301 307 PF00018 0.623
LIG_SH3_3 363 369 PF00018 0.627
LIG_SH3_3 423 429 PF00018 0.628
LIG_SH3_3 449 455 PF00018 0.596
LIG_SUMO_SIM_par_1 23 29 PF11976 0.386
LIG_TYR_ITIM 13 18 PF00017 0.268
LIG_UBA3_1 87 93 PF00899 0.386
LIG_WRC_WIRS_1 309 314 PF05994 0.579
LIG_WW_2 270 273 PF00397 0.487
MOD_CDC14_SPxK_1 436 439 PF00782 0.700
MOD_CDK_SPxK_1 433 439 PF00069 0.697
MOD_CK1_1 134 140 PF00069 0.599
MOD_CK1_1 167 173 PF00069 0.268
MOD_CK1_1 222 228 PF00069 0.672
MOD_CK1_1 345 351 PF00069 0.546
MOD_CK1_1 447 453 PF00069 0.585
MOD_CK1_1 73 79 PF00069 0.381
MOD_CK2_1 151 157 PF00069 0.268
MOD_CK2_1 177 183 PF00069 0.380
MOD_CK2_1 226 232 PF00069 0.650
MOD_Cter_Amidation 517 520 PF01082 0.686
MOD_GlcNHglycan 185 189 PF01048 0.341
MOD_GlcNHglycan 224 227 PF01048 0.588
MOD_GlcNHglycan 237 240 PF01048 0.649
MOD_GlcNHglycan 288 291 PF01048 0.715
MOD_GlcNHglycan 300 303 PF01048 0.449
MOD_GlcNHglycan 477 480 PF01048 0.670
MOD_GlcNHglycan 481 485 PF01048 0.628
MOD_GlcNHglycan 67 70 PF01048 0.386
MOD_GSK3_1 222 229 PF00069 0.638
MOD_GSK3_1 294 301 PF00069 0.585
MOD_GSK3_1 345 352 PF00069 0.569
MOD_GSK3_1 455 462 PF00069 0.738
MOD_GSK3_1 475 482 PF00069 0.435
MOD_GSK3_1 61 68 PF00069 0.331
MOD_N-GLC_1 4 9 PF02516 0.570
MOD_NEK2_1 159 164 PF00069 0.278
MOD_NEK2_1 38 43 PF00069 0.328
MOD_PIKK_1 447 453 PF00454 0.703
MOD_PKA_2 219 225 PF00069 0.623
MOD_PKA_2 444 450 PF00069 0.649
MOD_Plk_1 342 348 PF00069 0.536
MOD_Plk_1 76 82 PF00069 0.301
MOD_Plk_2-3 115 121 PF00069 0.603
MOD_Plk_4 21 27 PF00069 0.386
MOD_Plk_4 291 297 PF00069 0.744
MOD_Plk_4 308 314 PF00069 0.452
MOD_Plk_4 315 321 PF00069 0.486
MOD_Plk_4 349 355 PF00069 0.721
MOD_ProDKin_1 244 250 PF00069 0.596
MOD_ProDKin_1 294 300 PF00069 0.593
MOD_ProDKin_1 433 439 PF00069 0.758
MOD_ProDKin_1 98 104 PF00069 0.619
MOD_SUMO_rev_2 109 119 PF00179 0.641
MOD_SUMO_rev_2 165 170 PF00179 0.380
MOD_SUMO_rev_2 85 95 PF00179 0.380
TRG_DiLeu_BaEn_2 50 56 PF01217 0.380
TRG_DiLeu_BaEn_4 274 280 PF01217 0.684
TRG_ENDOCYTIC_2 15 18 PF00928 0.268
TRG_ENDOCYTIC_2 84 87 PF00928 0.268
TRG_ER_diArg_1 497 499 PF00400 0.706
TRG_ER_diLys_1 519 523 PF00400 0.749
TRG_NLS_MonoExtC_3 494 499 PF00514 0.703
TRG_NLS_MonoExtN_4 492 499 PF00514 0.644

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I433 Leptomonas seymouri 69% 100%
A0A1X0NQC5 Trypanosomatidae 35% 95%
A0A3S5H6H2 Leishmania donovani 100% 100%
A0A422NGM0 Trypanosoma rangeli 37% 95%
A4H699 Leishmania braziliensis 89% 100%
E9ANC1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QHA3 Leishmania major 97% 100%
V5DKQ2 Trypanosoma cruzi 37% 95%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS