Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUM2_LEIIN

TriTrypDb:

LINF_100018200

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	228	230	PF00675	0.440
CLV_NRD_NRD_1	393	395	PF00675	0.547
CLV_NRD_NRD_1	48	50	PF00675	0.639
CLV_NRD_NRD_1	5	7	PF00675	0.675
CLV_NRD_NRD_1	83	85	PF00675	0.555
CLV_PCSK_KEX2_1	193	195	PF00082	0.566
CLV_PCSK_KEX2_1	228	230	PF00082	0.440
CLV_PCSK_KEX2_1	393	395	PF00082	0.547
CLV_PCSK_KEX2_1	48	50	PF00082	0.524
CLV_PCSK_KEX2_1	5	7	PF00082	0.675
CLV_PCSK_KEX2_1	83	85	PF00082	0.504
CLV_PCSK_KEX2_1	97	99	PF00082	0.583
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.566
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.630
CLV_PCSK_PC7_1	189	195	PF00082	0.557
CLV_PCSK_SKI1_1	194	198	PF00082	0.540
CLV_PCSK_SKI1_1	246	250	PF00082	0.522
CLV_PCSK_SKI1_1	350	354	PF00082	0.470
CLV_PCSK_SKI1_1	381	385	PF00082	0.534
CLV_PCSK_SKI1_1	402	406	PF00082	0.599
CLV_PCSK_SKI1_1	5	9	PF00082	0.665
CLV_PCSK_SKI1_1	84	88	PF00082	0.529
DEG_APCC_DBOX_1	166	174	PF00400	0.553
DEG_APCC_DBOX_1	228	236	PF00400	0.455
DEG_APCC_DBOX_1	4	12	PF00400	0.669
DOC_CDC14_PxL_1	278	286	PF14671	0.478
DOC_CYCLIN_yCln2_LP_2	173	179	PF00134	0.595
DOC_MAPK_DCC_7	113	121	PF00069	0.677
DOC_MAPK_DCC_7	62	71	PF00069	0.457
DOC_MAPK_gen_1	12	20	PF00069	0.620
DOC_MAPK_gen_1	228	234	PF00069	0.453
DOC_MAPK_gen_1	59	69	PF00069	0.564
DOC_MAPK_gen_1	83	93	PF00069	0.545
DOC_MAPK_MEF2A_6	113	121	PF00069	0.677
DOC_MAPK_MEF2A_6	14	22	PF00069	0.660
DOC_MAPK_MEF2A_6	155	162	PF00069	0.498
DOC_MAPK_MEF2A_6	344	353	PF00069	0.557
DOC_MAPK_MEF2A_6	62	71	PF00069	0.457
DOC_PP2B_LxvP_1	173	176	PF13499	0.531
DOC_PP2B_LxvP_1	196	199	PF13499	0.541
DOC_PP2B_LxvP_1	407	410	PF13499	0.791
DOC_PP4_FxxP_1	419	422	PF00568	0.589
DOC_USP7_MATH_1	251	255	PF00917	0.662
DOC_USP7_MATH_1	317	321	PF00917	0.589
DOC_USP7_MATH_2	231	237	PF00917	0.571
DOC_WW_Pin1_4	247	252	PF00397	0.575
DOC_WW_Pin1_4	342	347	PF00397	0.706
DOC_WW_Pin1_4	405	410	PF00397	0.749
LIG_14-3-3_CanoR_1	134	143	PF00244	0.594
LIG_14-3-3_CanoR_1	180	188	PF00244	0.621
LIG_14-3-3_CanoR_1	256	260	PF00244	0.593
LIG_14-3-3_CanoR_1	323	329	PF00244	0.786
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BRCT_BRCA1_1	3	7	PF00533	0.531
LIG_BRCT_BRCA1_2	3	9	PF00533	0.524
LIG_EH1_1	60	68	PF00400	0.403
LIG_eIF4E_1	334	340	PF01652	0.672
LIG_EVH1_1	419	423	PF00568	0.587
LIG_FHA_1	130	136	PF00498	0.633
LIG_FHA_1	17	23	PF00498	0.652
LIG_FHA_1	334	340	PF00498	0.749
LIG_FHA_1	58	64	PF00498	0.527
LIG_FHA_1	77	83	PF00498	0.547
LIG_FHA_2	343	349	PF00498	0.569
LIG_FHA_2	361	367	PF00498	0.547
LIG_FHA_2	374	380	PF00498	0.520
LIG_GBD_Chelix_1	127	135	PF00786	0.459
LIG_LIR_Gen_1	374	384	PF02991	0.536
LIG_LIR_Nem_3	288	293	PF02991	0.572
LIG_LYPXL_yS_3	275	278	PF13949	0.498
LIG_LYPXL_yS_3	293	296	PF13949	0.515
LIG_NRBOX	262	268	PF00104	0.488
LIG_Pex14_1	226	230	PF04695	0.444
LIG_PTB_Apo_2	55	62	PF02174	0.651
LIG_Rb_LxCxE_1	72	92	PF01857	0.538
LIG_RPA_C_Fungi	310	322	PF08784	0.703
LIG_SH2_SRC	242	245	PF00017	0.493
LIG_SH3_3	114	120	PF00018	0.636
LIG_SH3_3	291	297	PF00018	0.505
LIG_SH3_3	343	349	PF00018	0.678
LIG_SH3_3	406	412	PF00018	0.754
LIG_SH3_3	417	423	PF00018	0.675
LIG_SUMO_SIM_par_1	18	24	PF11976	0.567
LIG_SUMO_SIM_par_1	230	236	PF11976	0.560
LIG_TRAF2_1	204	207	PF00917	0.590
LIG_TRAF2_1	297	300	PF00917	0.482
LIG_TRAF2_1	330	333	PF00917	0.589
LIG_TRAF2_1	72	75	PF00917	0.534
LIG_TRAF2_2	104	109	PF00917	0.571
LIG_TYR_ITIM	273	278	PF00017	0.614
LIG_WRC_WIRS_1	238	243	PF05994	0.589
LIG_WRC_WIRS_1	353	358	PF05994	0.643
MOD_CK1_1	156	162	PF00069	0.702
MOD_CK1_1	250	256	PF00069	0.718
MOD_CK2_1	262	268	PF00069	0.590
MOD_CK2_1	360	366	PF00069	0.471
MOD_CK2_1	373	379	PF00069	0.461
MOD_CK2_1	40	46	PF00069	0.529
MOD_CK2_1	69	75	PF00069	0.561
MOD_GlcNHglycan	155	158	PF01048	0.735
MOD_GlcNHglycan	199	202	PF01048	0.591
MOD_GlcNHglycan	235	238	PF01048	0.572
MOD_GlcNHglycan	257	260	PF01048	0.570
MOD_GSK3_1	129	136	PF00069	0.608
MOD_GSK3_1	233	240	PF00069	0.577
MOD_GSK3_1	247	254	PF00069	0.464
MOD_GSK3_1	367	374	PF00069	0.642
MOD_N-GLC_1	57	62	PF02516	0.644
MOD_NEK2_1	1	6	PF00069	0.558
MOD_NEK2_1	143	148	PF00069	0.628
MOD_NEK2_1	340	345	PF00069	0.734
MOD_NEK2_1	352	357	PF00069	0.436
MOD_NEK2_1	96	101	PF00069	0.634
MOD_NEK2_2	237	242	PF00069	0.586
MOD_PIKK_1	371	377	PF00454	0.558
MOD_PKA_2	133	139	PF00069	0.605
MOD_PKA_2	212	218	PF00069	0.470
MOD_PKA_2	255	261	PF00069	0.595
MOD_PKA_2	322	328	PF00069	0.784
MOD_PKA_2	340	346	PF00069	0.484
MOD_Plk_1	57	63	PF00069	0.534
MOD_Plk_4	156	162	PF00069	0.651
MOD_Plk_4	237	243	PF00069	0.502
MOD_Plk_4	262	268	PF00069	0.590
MOD_ProDKin_1	247	253	PF00069	0.585
MOD_ProDKin_1	342	348	PF00069	0.700
MOD_ProDKin_1	405	411	PF00069	0.748
MOD_SUMO_rev_2	150	157	PF00179	0.483
MOD_SUMO_rev_2	240	248	PF00179	0.504
TRG_DiLeu_BaEn_1	300	305	PF01217	0.508
TRG_DiLeu_BaEn_2	2	8	PF01217	0.563
TRG_DiLeu_BaEn_4	268	274	PF01217	0.615
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.547
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.566
TRG_ENDOCYTIC_2	275	278	PF00928	0.498
TRG_ENDOCYTIC_2	293	296	PF00928	0.515
TRG_ENDOCYTIC_2	377	380	PF00928	0.529
TRG_ER_diArg_1	228	230	PF00400	0.440
TRG_ER_diArg_1	29	32	PF00400	0.487
TRG_ER_diArg_1	392	394	PF00400	0.559
TRG_ER_diArg_1	47	49	PF00400	0.507
TRG_ER_diArg_1	5	7	PF00400	0.675
TRG_ER_diArg_1	61	64	PF00400	0.383
TRG_ER_diArg_1	82	84	PF00400	0.524
TRG_NES_CRM1_1	214	227	PF08389	0.482
TRG_NLS_Bipartite_1	83	101	PF00514	0.435
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	393	398	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA4	Leptomonas seymouri	47%	100%
A0A3Q8IHA3	Leishmania donovani	100%	100%
A4H698	Leishmania braziliensis	70%	100%
E9ANC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QHA4	Leishmania major	90%	100%