MARVEL domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUM1_LEIIN

TriTrypDb:

LINF_100018100

Length:

177

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0018995	host cellular component	2	1
GO:0033643	host cell part	3	1
GO:0033644	host cell membrane	4	1

Expansion

Sequence features

A4HUM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUM1

Function

Biological processes
Term	Name	Level	Count
GO:0016032	viral process	1	1
GO:0019042	viral latency	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	45	47	PF00082	0.623
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.646
CLV_PCSK_SKI1_1	151	155	PF00082	0.355
CLV_PCSK_SKI1_1	158	162	PF00082	0.370
DEG_Nend_UBRbox_3	1	3	PF02207	0.616
DOC_MAPK_MEF2A_6	77	84	PF00069	0.574
DOC_MAPK_RevD_3	32	46	PF00069	0.480
DOC_PP1_RVXF_1	149	156	PF00149	0.552
DOC_USP7_UBL2_3	10	14	PF12436	0.595
DOC_USP7_UBL2_3	117	121	PF12436	0.487
LIG_14-3-3_CanoR_1	151	156	PF00244	0.568
LIG_FHA_1	37	43	PF00498	0.310
LIG_FHA_1	66	72	PF00498	0.480
LIG_FHA_1	93	99	PF00498	0.411
LIG_FHA_2	129	135	PF00498	0.362
LIG_FHA_2	152	158	PF00498	0.577
LIG_PCNA_yPIPBox_3	149	158	PF02747	0.557
LIG_SH2_STAP1	86	90	PF00017	0.378
LIG_SH2_STAT3	86	89	PF00017	0.471
LIG_SUMO_SIM_par_1	134	140	PF11976	0.447
LIG_SUMO_SIM_par_1	24	29	PF11976	0.378
LIG_SUMO_SIM_par_1	34	39	PF11976	0.322
LIG_SUMO_SIM_par_1	63	68	PF11976	0.408
LIG_SUMO_SIM_par_1	94	100	PF11976	0.404
LIG_UBA3_1	160	165	PF00899	0.474
LIG_WRC_WIRS_1	152	157	PF05994	0.463
MOD_CK1_1	99	105	PF00069	0.420
MOD_CK2_1	128	134	PF00069	0.447
MOD_GSK3_1	119	126	PF00069	0.521
MOD_GSK3_1	36	43	PF00069	0.336
MOD_GSK3_1	65	72	PF00069	0.408
MOD_GSK3_1	92	99	PF00069	0.408
MOD_NEK2_1	145	150	PF00069	0.503
MOD_NEK2_1	16	21	PF00069	0.474
MOD_NEK2_1	36	41	PF00069	0.150
MOD_NEK2_1	65	70	PF00069	0.447
MOD_NEK2_1	96	101	PF00069	0.355
MOD_NEK2_2	40	45	PF00069	0.565
MOD_PIKK_1	119	125	PF00454	0.500
MOD_PIKK_1	145	151	PF00454	0.394
MOD_PIKK_1	171	177	PF00454	0.625
MOD_PKA_2	80	86	PF00069	0.447
MOD_Plk_4	137	143	PF00069	0.466
MOD_Plk_4	151	157	PF00069	0.392
MOD_Plk_4	69	75	PF00069	0.325
MOD_Plk_4	80	86	PF00069	0.348
MOD_Plk_4	92	98	PF00069	0.366
MOD_SUMO_for_1	44	47	PF00179	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX82	Leptomonas seymouri	77%	100%
A0A0S4INN4	Bodo saltans	42%	99%
A0A1X0NQE8	Trypanosomatidae	60%	100%
A0A3R7KZM5	Trypanosoma rangeli	59%	100%
A0A3S7WRC6	Leishmania donovani	100%	100%
A4H697	Leishmania braziliensis	86%	100%
C9ZVP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ANB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QHA5	Leishmania major	97%	100%